Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.

Abstract: An artificial cornea and an associated manufacturing method are disclosed. The artificial cornea has two sides, each of which has an associated microstructure. In an embodiment, microlines can be provided on an anterior side, and a posterior side can have micropores. Both the geometry of the microstructures and their dimensions can be customized for an individual patient. The geometry of the artificial cornea itself and its dimensions can also be customized as such. In addition, the lifetime of the artificial cornea can be significantly enhanced by adding co-polymer(s) into the hydrogel to strengthen its mechanical properties. Patient recovery can be aided by adding peptides into the artificial cornea surfaces to improve cell growth post-operation.

Abstract: A message reply method includes displaying a first user interface including a message list, receiving a first trigger operation performed by a user on a first message box in the message list, where the first trigger operation is for triggering replying to a first contact corresponding to the first message box, obtaining, based on the first trigger operation, a reply message to the first contact when the first user interface is displayed, and sending the reply message to the first contact such that a user may implement a reply to a contact in a message list without opening a specific chat page.

Abstract: Described herein is a weft-knitted spacer fabric and a preparation method thereof, a polyurethane foam composite material including the fabric, a preparation method of the composite material and its use in shoe materials. The weft-knitted spacer fabric consists of an upper surface layer, intermediate spacer yarns, and a lower surface layer, and the upper surface and the lower surface layer are connected by the tuck of the spacer yarns in the upper surface and the lower surface layer to form a three-dimensional structure in an integrated manner. The different selected tuck needle changes the connecting distance and the number of connections of the tuck, and the thickness of the spacer fabric and the arrangement density of the spacer yarns are changed by the action of the upper and lower surface layers of elastic yarns.

Abstract: The invention relates to a one-way rapid electromagnetic unloading device suitable for a true triaxial testing machine, comprising a first electromagnet, a second electromagnet, a first electromagnet mounting base, a second electromagnet mounting base and a restraining disc. A frame of the true triaxial testing machine is provided with a mounting hole for the unloading device. The first electromagnet mounting base is fixedly mounted in the mounting hole for the unloading device, and the first electromagnet is fixedly mounted on the first electromagnet mounting base. The restraining disc is fixedly mounted at an opening of the mounting hole for the unloading device, and the second electromagnet mounting base is located between the restraining disc and the first electromagnet. The second electromagnet is fixedly mounted on the second electromagnet mounting base and is opposite to the first electromagnet.

Abstract: The invention relates to a one-way rapid electromagnetic unloading device suitable for a true triaxial testing machine, comprising a first electromagnet, a second electromagnet, a first electromagnet mounting base, a second electromagnet mounting base and a restraining disc. A frame of the true triaxial testing machine is provided with a mounting hole for the unloading device. The first electromagnet mounting base is fixedly mounted in the mounting hole for the unloading device, and the first electromagnet is fixedly mounted on the first electromagnet mounting base. The restraining disc is fixedly mounted at an opening of the mounting hole for the unloading device, and the second electromagnet mounting base is located between the restraining disc and the first electromagnet. The second electromagnet is fixedly mounted on the second electromagnet mounting base and is opposite to the first electromagnet.

Abstract: A nerve guidance conduit includes one or more guidance channels formed as porous polymeric structures. The guidance channels are within an outer tubular structure that includes randomly-oriented nanofibers. The guidance channels may have electrospun nanofibers on their inner and outer surfaces in a parallel alignment with the guidance channels. Such aligned nanofibers may also be present on the inner surface of the outer tubular structure. The outer surfaces of the guidance channels and the inner surface of the tubular structure define additional guidance channels. Such a nerve guidance conduit provides augmented surface areas for providing directional guidance and enhancing peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods.

Abstract: A method for fabricating a flexible electronic device, including the steps of: providing channels on a rigid substrate; adhering a flexible substrate to the rigid substrate with an adhesive; fabricating an electronic device on the flexible substrate; injecting a chemical substance into the channels; and reacting the chemical substance with the adhesive and peeling the flexible substrate from the rigid substrate. The rigid substrate comprises a first surface, a second surface opposite the first surface, and a side wall extending between the first surface and the second surface. The channels are provided on the first surface of the rigid substrate. The channels are in communication with an injection port, the injection port is located on the side wall of the rigid substrate, and a portion of the side wall is located between the injection port and the first surface.

Abstract: A scaffold has a spiral configuration and gradient porosity designed to facilitate the healing of bone injuries. To make the scaffold, a sheet of polymeric material or the like is rolled into a spiral shape. In one embodiment, the resulting scaffold has an outer porous layer with high porosity, and a comparatively less porous inner layer in order to facilitate vascularization and promote recovery. The pores can be filled with a degradable polymer and/or growth factors, bioactive molecules, bactericidal drugs and/or other compositions to further promote recovery.

Abstract: An artificial cornea and an associated manufacturing method are disclosed. The artificial cornea has two sides, each of which has an associated microstructure. In an embodiment, microlines can be provided on an anterior side, and a posterior side can have micropores. Both the geometry of the microstructures and their dimensions can be customized for an individual patient. The geometry of the artificial cornea itself and its dimensions can also be customized as such. In addition, the lifetime of the artificial cornea can be significantly enhanced by adding co-polymer(s) into the hydrogel to strengthen its mechanical properties. Patient recovery can be aided by adding peptides into the artificial cornea surfaces to improve cell growth post-operation.

Abstract: The present invention discloses a rare earth permanent magnet material and a preparation method thereof The method comprises: a sintering treatment step: laying a composite powder for diffusion on the surface of a neodymium iron boron magnetic powder layer and carrying out spark plasma sintering treatment to obtain a neodymium iron boron magnet with a diffusion layer solidified on the surface thereof, wherein the compositional proportional formula of the composite powder for diffusion is H100-x-yMxQy, where H is one or more of a metal powder, a fluoride powder, or an oxide powder of Dy, Tb, Ho, and Gd, M is a Nd, Pr, or NdPr metal powder, and Q is one or more of Cu, Al, Zn, and Sn metal powders, x and y are respectively the atomic percentages of component M and component Q in the composite powder for diffusion, x is 0-20, and y is 0-40; and diffusion heat treatment and tempering steps.

Abstract: A method for preparing rare earth permanent magnet material, comprising: firstly weighing powders of three raw materials, H, M and Q, according to the atomic percentage content in general formula H100-x-yMxQy, and performing the mixing treatment and sieving treatment in a nitrogen gas or other oxygen-free environments to obtain a composite powder; then machining a sintered NdFeB magnet into a prescribed shape and size, and performing the surface cleaning and drying to obtain a NdFeB magnet to be treated; next, adhering the composite powder to the surface of the NdFeB magnet to be treated by static electricity in an oxygen-free environment; next performing a vacuum thermal treatment and tempering treatment sequentially thereby obtaining the rare earth permanent magnet material. For the above method, the efficiency is high and binding force between the heavy rare earth element attachments and the substrate magnet is strong, it is convenient for the residual powder materials to be recycled.

Abstract: Disclosed are a pixel circuit and a method for driving the pixel circuit. The pixel circuit includes a light-emitting diode; a driving transistor; a first transistor connected between a data line and the driving transistor, a gate electrode of the first transistor being connected to a first scanning line; a second transistor connected between a first power line and the driving transistor, a gate electrode of the second transistor being connected to a second scanning line; a third transistor connected between a gate electrode of the driving transistor and the second transistor, a gate electrode of the third transistor being connected to a third scanning line; and a driving capacitor connected between the gate electrode of the driving transistor and the first power line, in which the driving transistor is further connected to a second power line via the light-emitting diode.

Abstract: This application discloses a flexible substrate device that includes a flexible substrate and a plurality of electronic devices. The flexible substrate includes a top surface and a bottom surface opposite to the top surface, and the plurality of electronic devices formed on the top surface of the flexible substrate. The bottom surface further includes one or more strong adhesion regions and one or more normal adhesion regions that are distinct from the one or more strong adhesion regions. Each of the one or more strong adhesion regions and the one or more normal adhesion regions are configured to attach to a rigid carrier with first adhesion strength and second adhesion strength, respectively. The first adhesion strength is substantially larger than the second adhesion strength. In some embodiments, the flexible substrate device is a thin film transistor (TFT) device, and the plurality of electronic devices includes a TFT array.

Abstract: A nerve guidance conduit includes one or more guidance channels formed as porous polymeric structures. The guidance channels are within an outer tubular structure that includes randomly-oriented nanofibers. The guidance channels may have electrospun nanofibers on their inner and outer surfaces in a parallel alignment with the guidance channels. Such aligned nanofibers may also be present on the inner surface of the outer tubular structure. The outer surfaces of the guidance channels and the inner surface of the tubular structure define additional guidance channels. Such a nerve guidance conduit provides augmented surface areas for providing directional guidance and enhancing peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods.

Abstract: A method for operating a memory device includes the steps of providing a first voltage to a first transistor of a first memory cell and a third transistor of a second memory cell, providing a second voltage to a gate of a second transistor of the first memory cell and a gate of a fourth transistor of the second memory cell, and providing a third voltage to a gate of the first transistor of the first memory cell and a gate of the third transistor of the second memory cell. Other embodiments are also described.

Abstract: A capacitive touchscreen includes a substrate and a transparent conductive layer arranged on the substrate. The conductive layer includes a sensing area having a first side and a second side opposite to the first side. The capacitive touchscreen further includes multiple transparent and conductive first electrodes, multiple transparent and conductive second electrodes, and transparent and nonconductive patterns. Each first electrode includes a first trunk extending from the first side toward the second side. Each second electrode includes a second trunk and a wiring coupled to the second trunk. Both the second trunk and the wiring of each second electrode extend from the first side toward the second side. Each second trunk cooperates with a corresponding first trunks to be operable to sense a touched position. The transparent and nonconductive patterns are located between the first and second electrodes to electrically isolate the first electrodes from the second electrodes.

Abstract: A capacitive touchscreen includes a substrate and a transparent conductive layer arranged on the substrate. The conductive layer includes a sensing area. The sensing area has a first side and a second side opposite to the first side. The capacitive touchscreen further includes multiple transparent and conductive first electrodes, multiple transparent and conductive second electrodes, and transparent and nonconductive patterns. Each first electrode includes a first trunk extending from the first side toward the second side. Each second electrode includes a second trunk and a wiring coupled to the second trunk. Both the second trunk and the wiring extend from the first side toward the second side, and each second trunk cooperates with a corresponding first trunks to be operable to sense a touched position. The transparent and nonconductive patterns are located between the first and second electrodes to electrically isolate the first electrodes from the second electrodes.

Abstract: The present application provides a method for preparing a rare-earth permanent magnetic material with grain boundary diffusion using composite target by vapor deposition, in which the composite target is evaporated and attached to the surface of the NdFeB magnet, and in which medium-high temperature treatment and low temperature aging treatment are employed, resulting in that the coercive force of the magnet is improved significantly and the remanence and the magnetic energy product substantially are not reduced. The advantageous effects of the present application is as follows: the coercive force of the magnet is improved, and meanwhile the defects such as melting pits and crystal grain growth and the like caused by high temperature treatment for the long time are eliminated, and the usage amount of heavy rare-earth is greatly reduced, thereby lowering the cost of the product.