Patents by Inventor Xiaojun Zhang

Xiaojun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7247654
    Abstract: The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: July 24, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: E. Scott Priestley, Xiaojun Zhang
  • Publication number: 20070003539
    Abstract: The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, Y, Z, R7, R8, R9, and R11 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
    Type: Application
    Filed: June 22, 2006
    Publication date: January 4, 2007
    Applicant: Bristol-Myers Squibb Company
    Inventors: Xiaojun Zhang, Alexandra Nirschl, Yan Zou, Eldon Priestley
  • Patent number: 7122559
    Abstract: Compounds having the formula (I), or a stereoisomer or pharmaceutically-acceptable salt, or hydrate thereof, are useful as factor VIIa inhibitors, wherein X is —NR6S(O)pR16; W is hydrogen or —(CR7R8)q—W1; W1 is hydrogen or a bond with R6; Z is a 5-membered heteroaryl group, a five to six membered heterocyclo or cycloalkyl group, a 9 to 10 membered bicyclic aryl or heteroaryl, or a six membered aryl or heteroaryl, and R1, R2, R3, R6, R7, and R16 are as defined in the specification.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: October 17, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter W. Glunz, Gregory S. Bisacchi, George C. Morton, Alexandra A. Holubec, E. Scott Priestley, Xiaojun Zhang, Uwe D. Treuner
  • Publication number: 20060166997
    Abstract: The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
    Type: Application
    Filed: January 9, 2006
    Publication date: July 27, 2006
    Inventors: Xiaojun Zhang, Eldon Priestley, Alexandra Nirschl, Yan Zou
  • Patent number: 7037911
    Abstract: The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel amino-bicyclic pyrazinone and pyridinone compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: May 2, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventor: Xiaojun Zhang
  • Publication number: 20050038030
    Abstract: The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel amino-bicyclic pyrazinone and pyridinone compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
    Type: Application
    Filed: June 19, 2003
    Publication date: February 17, 2005
    Inventor: Xiaojun Zhang
  • Publication number: 20050009895
    Abstract: The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
    Type: Application
    Filed: June 1, 2004
    Publication date: January 13, 2005
    Inventors: E. Priestley, Xiaojun Zhang
  • Publication number: 20040204412
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: February 10, 2004
    Publication date: October 14, 2004
    Inventors: Peter W. Glunz, Gregory S. Bisacchi, George C. Morton, Alexandra A. Holubec, E. Scott Priestley, Xiaojun Zhang, Uwe D. Treuner
  • Patent number: 6699855
    Abstract: The present invention relates to compounds of Formula (I): wherein A1 is methylene, ethylene or propylene group and A2 is N or CR5, or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HCV NS3 protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: March 2, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiaojun Zhang, Wei Han
  • Publication number: 20020065248
    Abstract: The present invention relates to compounds of Formula (I): 1
    Type: Application
    Filed: February 28, 2001
    Publication date: May 30, 2002
    Inventors: Xiaojun Zhang, Wei Han
  • Patent number: 6278955
    Abstract: A system and method for automatically adjusting the blade of a motor grader to an operator programmed blade position. The method includes the steps of: providing an electronic controller and blade controls having position sensors; monitoring the output of the position sensors to ascertain the position of the blade controls; receiving a first input signal for setting a memory blade position; determining the memory blade position based on the output of the position sensors; receiving a second input signal for requesting the memory blade position; determining the present blade position based on the output of the position sensors; and producing a control signal for actuating the blade controls to move the blade from the present blade position to the memory blade position.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: August 21, 2001
    Assignee: Caterpillar Inc.
    Inventors: Matthew A. Hartman, Mark D. Shane, Daniel E. Shearer, Xiaojun Zhang
  • Patent number: 6129156
    Abstract: A system and method for automatically moving the blade of a motor grader from a present blade position to a mirror image position. The method includes the steps of: providing an electronic controller, blade controls having position sensors, and an input switch; obtaining information from the position sensors indicating the position of the blade controls; determining the present blade position; receiving an input signal from the input switch requesting a mirror image position; calculating the mirror image position of the present blade position; and producing a control signal for actuating the blade controls to move the blade from the present blade position to the mirror image position.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: October 10, 2000
    Assignee: Caterpillar Inc.
    Inventors: Susan M. Boast, Michael I. Cline, Matthew A. Hartman, Xiaojun Zhang, Mark D. Shane, Daniel E. Shearer
  • Patent number: 6028524
    Abstract: A system and method for monitoring the position of a motor grader blade relative to a motor grader frame. The method includes the steps of: providing an electronic controller, blade controls having position sensors, and frame controls having position sensors; monitoring the output of the position sensors to ascertain the position of the blade controls and the frame controls; receiving an input signal requesting a repositioning of the blade or the frame; determining the present blade position and the present frame position; calculating a future blade position and a future frame position based on the repositioning request; predicting an intersection of the future blade position and the future frame position; and producing an action to prevent the intersection of the future blade position and the future frame position.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: February 22, 2000
    Assignee: Caterpillar Inc.
    Inventors: Matthew A. Hartman, Xiaojun Zhang, Mark D. Shane, Daniel E. Shearer