Patents by Inventor Xiaolin Chen

Xiaolin Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200048265
    Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110? activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lympho
    Type: Application
    Filed: October 17, 2019
    Publication date: February 13, 2020
    Applicant: Amgen Inc.
    Inventors: Yi CHEN, Timothy D. CUSHING, Jason A. DUQUETTE, Felix GONZALEZ LOPEZ DE TURISO, Xiaolin HAO, Xiao HE, Brian S. LUCAS, Lawrence R. MCGEE, Andreas REICHELT, Robert M. RZASA, Jennifer L. SEGANISH, Youngsook SHIN, Dawei ZHANG
  • Patent number: 10551429
    Abstract: The present invention provides a method for detecting the anti-island protection performance of an inverter. An RLC circuit is serially connected between the inverter and a grid connection switch, the resonant frequency of the RLC load is set as three different numerical values for enabling the same to present resistance, capacitance and inductance, and a time value from the disconnection of the grid connection switch to the operation stop of the inverter under detection is recorded after a fundamental current value of the grid connection switch is set to a different value each time; and weighted calculation is performed on the time value to obtain a test result and grade evaluation of the anti-island protection ability of the inverter.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: February 4, 2020
    Assignees: CHINA ELECTRIC POWER RESEARCH INSTITUTE, STATE GRID CORPORATION OF CHINA
    Inventors: Fei Zheng, Mei Chen, Xiaolin Zhang, Junjun Zhang, Jingsheng Huang, Zhilei Chen, Wei Dong
  • Publication number: 20200034472
    Abstract: A database system comprises a persistent storage device, a log node including a memory and a processor, and a plurality of database nodes. A database node includes a cache memory configured to store a database instance, and a processor configured to initiate a database transaction by sending a snapshot request to the log node, the snapshot request including a list of pages that were either replaced or newly loaded in the cache memory. The log node processor is configured to send a snapshot response to the database node, wherein the snapshot response includes a snapshot of the database and a list of changed pages of the database instances. The database node processor is configured to update the status of the pages in cached memory according to the snapshot response and perform the database transaction.
    Type: Application
    Filed: July 27, 2018
    Publication date: January 30, 2020
    Inventors: Le Cai, Jianjun Chen, Yang Sun, Xiaolin Du, Jun Chen, Yu Chen, Chunfeng Pei
  • Patent number: 10542876
    Abstract: The present invention relates to a multidirectional turning endoscope, which includes an insertion portion (2), an endoscope handle (4) and a bending driving portion (3); wherein: the bending driving portion includes a left-right driving rod, an up-down driving rod, a rotation shaft, a left turning wheel (17), a right turning wheel (18) and a spring (19); the rotation shaft includes a left half shaft (15) and a right half shaft (16); the external surface of the left half shaft and the external surface of the right half shaft respectively have a left outer conical face and a right outer conical face, a left conical cylinder and a right conical cylinder (20) are respectively sleeved to the left outer conical face and a right outer conical face; a spring (19) is located at an axial direction of the left half shaft and the right half shaft.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: January 28, 2020
    Assignee: YOUCARE TECHNOLOGY CO., LTD.(WUHAN)
    Inventors: Shaogang Wang, Xiao Yu, Yeyun Mao, Zhangqun Ye, Jian Huang, Jianxing Li, Xu Zhang, Jihong Liu, Yiran Huang, Lin Qi, Xiuheng Liu, Xiaoping Zhang, Tongzu Liu, Kunjie Wang, Xiaolin Guo, Qi Chen, Lei Song, Yaohui Wu, Ying Li, Xuecheng Hu, Gang Long
  • Patent number: 10538890
    Abstract: A hydraulic ship lift, including: a mechanical synchronizing system; a stabilizing and equalizing hydraulic driving system; and a self-feedback stabilizing system. The stabilizing and equalizing hydraulic driving system includes first resistance equalizing members arranged at corners of branch water pipes or/and second resistance equalizing members arranged at bifurcated pipes, circular forced ventilating mechanisms arranged at front of water delivery valves of a water delivery main pipe, and pressure-stabilizing and vibration-reducing boxes arranged behind the water delivery valves. The self-feedback stabilizing system includes a plurality of guide wheels; each guide wheel of the self-feedback stabilizing system is fixed on a ship reception chamber through a supporting mechanism.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: January 21, 2020
    Assignees: HUANENG LANCANG RIVER HYDROPOWER INC., POWER CHINA KUNMING ENGINEERING CORPORATION LIMITED, NANJING HYDRAULIC RESEARCH INSTITUTE, CHINA INSTITUTE OF WATER RESOURCES AND HYDROPOWER RESEARCH
    Inventors: Hongqi Ma, Yaan Hu, Zongliang Zhang, Xianghua Yuan, Zejiang Xiang, Yongping Al, Yimin Chuan, Guanqun Nan, Rui Zou, Zhaoxin Chen, Xiaolin Hu, Hongtao Zhang, Haibin Xiao, Qun Huang, Keheng Zhou, Xuexing Cao, Zichong Li, Renchao Ma, Yinan Cao, Yun Ling, Sisi Xie, Junyang Yu, Zhonghua Li, Yun Li, Guoxiang Xuan, Xin Wang, Xiujun Yan, Shu Xue, Chao Guo, Yue Huang, Yihong Wu, Rui Zhang, Dong Zhang, Jinxiong Zhang, Wenyuan Zhang, Hongwei Zhang, Jianbiao Gao
  • Publication number: 20200015119
    Abstract: The present invention is designed to prevent communication performance from dropping in long TTI when preemption of long TTI by short TTI occurs. According to one aspect of the present invention, a user terminal has a receiving section that receives downlink (DL) data based on downlink control information (DCI) in a first transmission time interval (TTI), a transmission section that transmits delivery acknowledgement information in response to the DL data, and a control section that controls timing of transmitting the delivery acknowledgement information when indication information regarding preemption of the first TTI by a second TTI shorter than the first TTI is received in the receiving section.
    Type: Application
    Filed: March 2, 2017
    Publication date: January 9, 2020
    Applicant: NTT DOCOMO, INC.
    Inventors: Kazuki Takeda, Satoshi Nagata, Qun Zhao, Xiaohang Chen, Xiaolin Hou, Huiling Jiang
  • Patent number: 10520402
    Abstract: The present disclosure relates to the technical field of safety detection, and in particular to a sample collecting and introducing device and a detection system. The sample collecting and introducing device provided by the present disclosure includes a sampling device for collecting a sample, and a semipermeable membrane device for extracting the sample collected by the sampling device and conveying the extracted sample to detection equipment, wherein the sampling device is provided with an air guide cavity, the air guide cavity is configured to guide airflow carrying the sample to flow to the semipermeable membrane device, the semipermeable membrane device is provided with a semipermeable membrane which is arranged outside the sampling device. In the present disclosure, the size of the semipermeable membrane is no longer limited by the sampling device, and therefore the difficulty of increasing the area of the semipermeable membrane is reduced.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: December 31, 2019
    Inventors: Qingjun Zhang, Yuanjing Li, Zhiqiang Chen, Ziran Zhao, Yinong Liu, Yaohong Liu, Ge Li, Biao Cao, Jingli Xie, Xiaolin Zhao, Qiufeng Ma
  • Publication number: 20190322747
    Abstract: An anti-PD-1 nano-antibody capable of blocking a binding interaction between PD-1 and a ligand thereof, PD-L1. Disclosed are the nano-antibody, a nucleotide sequence encoding the nano-antibody, a corresponding expression vector, a host cell expressing the nano-antibody, and a method of producing the nano-antibody. Also disclosed is a humanized PD-1 nano-antibody sequence. The humanized nano-antibody can block the binding interaction between PD-1 and the ligand thereof, PD-L1 while still retaining a high affinity.
    Type: Application
    Filed: September 11, 2017
    Publication date: October 24, 2019
    Inventors: Youling WU, Yujie ZHANG, Xiaolin CHEN, Binbin SHEN, Xiaoning SHEN
  • Patent number: 10433669
    Abstract: A bean grinder having a bean grinding chamber part, a dynamic grinding wheel, a static grinding wheel, and a residue removing plate. The bean grinding chamber part comprises a bean grinding chamber and a powder discharge channel. An inner wall of the bean grinding chamber is provided with a planar first inner wall disposed close to a powder discharge port and located at a rear side of the powder discharge port in a rotation direction of the dynamic grinding wheel. The first inner wall is tangent to a circle of the inner wall of the bean grinding chamber. An inner wall of the powder discharge channel comprises a second inner wall located at the side of the powder discharge port provided with the first inner wall, and the second inner wall is inclined outwards at a given angle ? with respect to the first inner wall.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: October 8, 2019
    Assignee: Vesta Electrical Appliance Manufacturing (Zhongshan) Co., Ltd.
    Inventors: Donglei Wang, Xuejun Chen, Xiaolin Chen, Dongping Lai
  • Publication number: 20190256548
    Abstract: Disclosed are a lanosterol prodrug compound, a pharmaceutically acceptable salt and an isomer thereof, and a pharmaceutical composition comprising the lanosterol prodrug compound and the use thereof in the preparation of a drug for treating cataracts. The lanosterol prodrug compound has a better permeability than lanosterol.
    Type: Application
    Filed: January 25, 2018
    Publication date: August 22, 2019
    Applicant: ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN UNIVERSITY
    Inventors: Yizhi LIU, Yandong WANG, Xiaolin LI, Zhi LUO, Liang SHEN, Lijuan HOU, Xinxin WEN, Haiying HE, Jian LI, Shuhui CHEN
  • Publication number: 20190206503
    Abstract: A shift register includes a pull-up control circuit, a pull-up circuit, a pull-down control circuit, a pull-down circuit, and a reset circuit. The pull-down circuit is connected to the pull-down node, the pull-up node, a second control terminal, a first voltage terminal, and a signal output terminal, and is configured to pull down potentials of the pull-up node and the signal output terminal to a potential of the first voltage terminal under the control of the pull-down node; moreover, the pull-down circuit is further configured to pull down potentials of the pull-up node and the signal output terminal to a potential of the first voltage terminal under the control of a signal from the second control terminal.
    Type: Application
    Filed: August 20, 2018
    Publication date: July 4, 2019
    Inventors: Yuanbo ZHANG, Xiaolin WANG, Zhuo XU, Shuai CHEN, Zhulin LIU
  • Publication number: 20190195751
    Abstract: The present disclosure relates to the technical field of safety detection, and in particular to a sample collecting and introducing device and a detection system. The sample collecting and introducing device provided by the present disclosure includes a sampling device for collecting a sample, and a semipermeable membrane device for extracting the sample collected by the sampling device and conveying the extracted sample to detection equipment, wherein the sampling device is provided with an air guide cavity, the air guide cavity is configured to guide airflow carrying the sample to flow to the semipermeable membrane device, the semipermeable membrane device is provided with a semipermeable membrane which is arranged outside the sampling device. In the present disclosure, the size of the semipermeable membrane is no longer limited by the sampling device, and therefore the difficulty of increasing the area of the semipermeable membrane is reduced.
    Type: Application
    Filed: December 26, 2018
    Publication date: June 27, 2019
    Inventors: Qingjun ZHANG, Yuanjing LI, Zhiqiang CHEN, Ziran ZHAO, Yinong LIU, Yaohong LIU, Ge LI, Biao CAO, Jingli XIE, Xiaolin ZHAO, Qiufeng MA
  • Patent number: 10316089
    Abstract: The present invention relates to antibodies that bind human programmed cell death 1 (PD-1), and may be useful for treating cancer alone and in combination with chemotherapy and other cancer therapeutics.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: June 11, 2019
    Assignee: INNOVENT BIOLOGICS (SUZHOU) CO. LTD.
    Inventors: Hemanta Baruah, Cheng Chen, Xiaolin Liu, Andy Tsun, Dechao Michael Yu
  • Publication number: 20190159354
    Abstract: The invention discloses a head-mounted display apparatus. The head-mounted display comprises a headband module and a head-mounted display module, wherein the head-mounted display comprises an optical module, the headband comprises a connecting structure connected with the head-mounted display housing so as to adjust the wearing angle of the head-mounted display module; The optical module comprises a module housing, a left lens barrel mechanism, a right lens barrel mechanism, a left sight distance adjusting mechanism and a left pupillary distance adjusting mechanism for adjusting the sight distance and pupillary distance of the left lens barrel mechanism, a right sight distance adjusting mechanism and a right pupillary distance adjusting mechanism for adjusting the sight distance and pupillary distance of the right lens barrel mechanism. The head-mounted display can separately adjust the sight distance and pupillary distance of the left and right lens barrel mechanism, as well as the wearing angle.
    Type: Application
    Filed: January 22, 2019
    Publication date: May 23, 2019
    Inventors: Xiaolin Zheng, Jun Liu, Hao Chen
  • Publication number: 20190154952
    Abstract: The invention discloses an optical module and a head-mounted display apparatus. The optical module includes a left/right lens barrel mechanism, a left/right sight distance adjusting mechanism, and a left/right pupillary distance adjusting mechanism; The left lens barrel mechanism includes a left lens barrel assembly and a left display screen disposed behind the left lens barrel assembly through a left screen bracket; The left sight distance adjusting mechanism adjusts the distance between the left display screen and the left lens barrel assembly; The left pupillary distance adjusting mechanism drives the left lens barrel mechanism to move left and right. Symmetrically, the structure of the right side is the same as left. The optical module adjusts the sight distance/pupillary distance of left and right eye separately by the left and right sight distance adjusting mechanism/pupillary distance adjusting mechanism, so that images seen by both eyes are clearer.
    Type: Application
    Filed: January 22, 2019
    Publication date: May 23, 2019
    Inventors: Xiaolin Zheng, Jun Liu, Hao Chen
  • Patent number: 10296541
    Abstract: Provided in the present disclosure are a computer-implemented searching method and a server. The computer-implemented searching method includes: receiving, at one or more computing devices, a current searching term sent by a client; obtaining, at the one or more computing devices, a picture-expressible term contained in the current searching term; obtaining, at the one or more computing devices, a picture result according to the picture-expressible term; and sending, at the one or more computing devices, the picture result to the client. The present method improves the effect of the information expression of the search results.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: May 21, 2019
    Assignee: BAIDU ONLINE NETWORK TECHNOLOGY (BEIJING) CO., LTD.
    Inventors: Shouke Qin, You Han, Zeming Zhang, Zhiyang Chen, Xiaohua Cheng, Peizhi Xu, Xiaolin Ma, Yan Jiang, Shilei Wen, Shijia Chen, Xubin Li
  • Publication number: 20190147121
    Abstract: In one aspect, a fault injection environment and a formal property verification environment are combined in a single integrated flow that allows the user to go back and forth between the two tasks. A system that unifies formal property verification and fault injection includes user interfaces that support the unified use model. In one approach, the FPV tool is the master and its user interface is the primary interface for the user to set up, run and debug faults as well as checkers. This interface allows the user to interactively select the FPV properties and/or the faults to be used for fault analysis. The user interface may provide a view of the faults, for example by listing faults or summarizing faults by class, type, etc.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 16, 2019
    Inventors: Xiaolin Chen, Arunava Saha, Sandeep Jana, Pratik Mahajan, Jinnan Huang
  • Publication number: 20180364837
    Abstract: This application is directed to a touch detection device that has a plurality of sense electrodes, at least one force electrode, and a processing device electrically coupled to the sense electrodes and the force electrode. The sense electrodes are disposed substantially in parallel with the force electrode and separated therefrom by at least an air gap. While operating in a touch sensing state, the processing device leaves the force electrode electrically afloat, measures self-capacitance of each of a subset of sense electrodes, and detects a touch location of an object. While operating in a force sensing state, the processing device drives the force electrode by a transmit signal, measures mutual capacitance of each of a subset of sense electrodes with respect to the force electrode, and detects a touch force on a touch location when an object touches a top surface of the touch detection device.
    Type: Application
    Filed: July 18, 2018
    Publication date: December 20, 2018
    Inventors: Xiaolin Chen, Leilei Chen
  • Patent number: 10007063
    Abstract: In an example embodiment, a WDM array includes an optical filter, N common ports, N reflection ports, and N pass ports. The N common ports may be positioned to a first side of the optical filter. N may be greater than or equal to two. The N reflection ports may be positioned to the first side of the optical filter. The N pass ports may be positioned to a second side of the optical filter opposite the first side.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: June 26, 2018
    Assignee: FINISAR CORPORATION
    Inventors: Xiaolin Chen, Xucheng Wang, Fan Chen, Steven James Frisken
  • Publication number: 20170181568
    Abstract: A bean grinder having a bean grinding chamber part, a dynamic grinding wheel, a static grinding wheel, and a residue removing plate. The bean grinding chamber part comprises a bean grinding chamber and a powder discharge channel. An inner wall of the bean grinding chamber is provided with a planar first inner wall disposed close to a powder discharge port and located at a rear side of the powder discharge port in a rotation direction of the dynamic grinding wheel. The first inner wall is tangent to a circle of the inner wall of the bean grinding chamber. An inner wall of the powder discharge channel comprises a second inner wall located at the side of the powder discharge port provided with the first inner wall, and the second inner wall is inclined outwards at a given angle a with respect to the first inner wall.
    Type: Application
    Filed: November 3, 2016
    Publication date: June 29, 2017
    Inventors: Donglei WANG, Xuejun CHEN, Xiaolin CHEN, Dongping LAI