Abstract: The present invention provides an SSAO inhibitor and an application thereof in preparing a drug for treating a disease related to SSAO. In particular, the present invention provides a compound shown in formula (IV) and a pharmaceutically acceptable salt thereof.

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Abstract: This application relates to the field of communications technologies, and in particular, to a profile download technology. In a profile download method, a primary device obtains an embedded integrated circuit card identifier (EID) of a secondary device, where the EID is used by the primary device to obtain, from a mobile operator server, profile download information that matches the EID; receives the profile download information from the mobile operator server; and sends the profile download information to the secondary device, where the profile download information is used by the secondary device to download a profile from a profile management server, and the profile is installed in an embedded UICC (eUICC) of the secondary device after the download is complete.

Abstract: A call record synchronization method includes detecting, by a first terminal, an input operation for requesting to display a call record. The method further includes, after the first terminal detects the input operation, displaying, by the first terminal, a merged call record, where the merged call record is a call record obtained after merging of a call record of the first terminal and a call record of a second terminal. The merged call record includes a device identifier of the first terminal and/or a device identifier of the second terminal.

Abstract: The present invention provides a handheld sweeping and mopping structure, comprising a handle and a body shell, wherein a sweeping and mopping module, a water tank module, a driving module, a garbage collection module, a control module and a power supply module are provided inside the body shell. The handheld sweeping and mopping structure of the present invention can sweep the floor and also mop the floor, has higher efficiency and better effect than the conventional sweeping and mopping mode; and meanwhile, a disposable garbage box which is convenient to replace is used, and it is unnecessary to clean the garbage box repeatedly.

Abstract: Disclosed are a lanosterol prodrug compound, a pharmaceutically acceptable salt and an isomer thereof, and a pharmaceutical composition comprising the lanosterol prodrug compound and the use thereof in the preparation of a drug for treating cataracts. The lanosterol prodrug compound has a better permeability than lanosterol.

Abstract: Localized superconcentrated electrolytes (LSEs) for use in systems with silicon-based or carbon/silicon composite-based anodes are disclosed. The LSEs include an active salt, a nonaqueous solvent in which the active salt is soluble, and a diluent in which the active salt has a solubility at least 10 times less than solubility of the active salt in the nonaqueous solvent. Systems including the LSEs also are disclosed.

Abstract: Computer program products, methods, systems, apparatus, and computing entities provide a unique single-shot text detector that generates word-level text bounding boxes in an image by at least identifying text regions in the image via an automatically learned attention map and by conducting pixel-wise review of text; aggregating multi-scale inception features; generating, based at least in part on the multi-scale inception features, a set of aggregated inception features; and generating, using at least the set of aggregated inception features, the word-level text bounding boxes in the image.

Abstract: Disclosed in the present disclosure are a crystal form of a dihydropyrido ring compound, and preparation method and intermediate thereof.

Abstract: Embodiments of a safe, low-temperature reaction system and method for preparing porous silicon are disclosed. The porous silicon is prepared from porous silica, a low-melting metal halide, and a metal comprising aluminum, magnesium, or a combination thereof. Advantageously, embodiments of the disclosed methods can be performed at temperatures ?400° C. Silicon produced by the disclosed methods has a porosity that is equal to or greater than the porous silica precursor. The porous silicon is suitable for use in electrodes.

Abstract: Provided are cell culture apparatus and method. The cell culture apparatus comprises a culture column and a perfusion system, the culture column comprising a first and a second tube-connecting caps and a support for cells to attach and grow thereon. The first and the second tube-connecting caps are respectively provided with a perfusion inlet and a perfusion outlet; The perfusion system comprises a culture medium storage device, a perfusion tube and a perfusion pump. A complete and closed culture column is formed in the cell culture device after the cells are inoculated, and the culturing is completed by the perfusion system to avoid contamination.

Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

Abstract: Disclosed in the present disclosure are a crystal form of a dihydropyrido ring compound, and preparation method and intermediate thereof.

Abstract: Provided in the present invention is a method for constructing a high-resolution single cell Hi-C library with a large amount of information, comprising the following steps: Step B: obtain a small amount of fixed chromatin; Step C: digest the fixed chromatin in Step B to obtain fragments of the fixed chromatin; Step D: reconnect the fragments of the fixed chromatin in Step C directly to obtain reconnected fragments of the fixed chromatin; Step E: de-fix the reconnected fragments of the fixed chromatin in Step D to release DNA fragments; Step F: amplify the released DNA fragments in Step E to obtain amplified products; and Step H: construct a sequencing DNA library by using the amplified products as the DNA fragments to be sequenced.

Abstract: Techniques and systems are disclosed for enhancing the flexibility and resiliency of mobile social networking platforms. Techniques enable dynamic, user-defined check-in points with mobile devices so that users may define ad hoc, location-based communities. Techniques may also selectively determine an appropriate location-sensing mechanism to improve location accuracy or privacy, or to compensate for unavailable location-sensing capabilities. The techniques may assist social networking platforms to have a greater range of check-in options and to enable communication that may not rely on traditional network connectivity. In some cases, devices belonging to participators outside the member group may be used to locate a member who has moved outside the detection zone of a check-in point. In some cases, the participators' devices might not be directly connected to the lost member device but instead are connected via one or more “hops” of indirect communication with other participator devices.

Abstract: Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor ? (ROR?) activity. This modulation has numerous effects, including inhibition of TH-17 cell function and/or TH-17 cell activity, and inhibition of re-stimulation of TH-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of ROR? results in stimulation of TH-17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).

Abstract: Disclosed are a preparation method of an orexin receptor antagonist compound 5-3, Crystalline forms I-IV of an orexin receptor antagonist compound 5-3 are provided. Also provided are processes of the preparing the orexin receptor antagonist compound 5-3 and its crystalline forms, as well as methods of using the crystalline forms I-IV for treating an orexin-related disease.

Abstract: Embodiments of a safe, low-temperature reaction system and method for preparing porous silicon are disclosed. The porous silicon is prepared from porous silica, a low-melting metal halide, and a metal comprising aluminum, magnesium, or a combination thereof. Advantageously, embodiments of the disclosed methods can be performed at temperatures 400° C. Silicon produced by the disclosed methods has a porosity that is equal to or greater than the porous silica precursor. The porous silicon is suitable for use in electrodes.

Abstract: A modeling method and system for a diode clamped cascaded multi-level converter. All corresponding diodes of each bridge arm are equivalent to an auxiliary diode; all corresponding capacitors of each bridge arm are equivalent to a controlled voltage source; and power modules of each bridge arm are connected in series to be equivalent to an equivalent module, the equivalent module comprising a loss resistor and a composite equivalent model connected to the loss resistor. Since a plurality of components, at the same positions, in each power module of each bridge arm of the diode clamped cascaded multi-level converter are equivalent to a component, the node voltage equation order can be reduced, the simulation efficiency is improved, and the simulation efficiency cannot be reduced with the increase in the number of power modules.

Abstract: Disclosed are dispersed graphene sheets, ribbons, graphene molecules and the like which are pristine in the plane, i.e., free of significant defects and chemical modifications such as oxidation. The materials could be functionalized at the edges. These materials are dispersed in solutions rather than in aggregated or insoluble forms as their parent starting materials. Also disclosed is a method comprising the steps of intercalating an insoluble graphitic material. The method may comprise exfoliating graphite and re-intercalating the resultant material with an acid composition, such as oleum, and a strong organic base such as tetrabutylammonium hydroxide in a solvent solution to form a homogenous suspension, which is then agitated to form dispersed graphene materials. The materials may be solubilized with a hydrophilic polymer and can be further manipulated by transfer into different solvents, formation of films, application to optical and electronic devices, and other applications.