Abstract: A multi-functional automatic switching circuit for direct current ice melting and a switching method thereof are provided. The automatic switching circuit comprises at least one sub-switching circuit. The sub-switching circuit comprises a six-pulse current converter (R) with no saturable reactor, six reactors (L1a, L1b, L1c, L2a, L2b, and L2c), three three-phase knife switches (Sac1, Sac2, and Sac3), and five single-phase knife switches (SV1, SV2, SV3, SV4, and SV5). The sub-switching circuits in series connection or parallel connection, four direct current side switching knife switches (Sdc1, Sdc2, Sdc3, and Sdc4), an isolation knife switch (K), a breaker (QF) and a control and protection system (CP) may form an automatic switching circuit for six-pulse or twelve-pulse direct current ice melting.

Abstract: Disclosed is a dihydropyrimido fused ring derivative as a HBV inhibitor, and in particular relates to a compound shown as formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Techniques for accurate, low-complexity, scalable indoor localization. Low-complexity anchor nodes generate acoustic beacon signals, which are passively detectable by a mobile device, which may be unmodified smartphones operating in an acoustic frequency range. The acoustic beacon signals are modulated via codes in a boundary band of audio and ultrasound frequencies, imperceptible to humans yet detectable via a voice microphone of an unmodified smartphone. An application on the mobile device passively captures the acoustic beacon signals and determines relative distances to the anchor nodes. Localization and distance update techniques, implemented on the mobile device and/or a remote server, determines and updates in real-time the location of the mobile device. The system may be scalable to support any number of mobile devices.

Abstract: A method for producing a silicon steel normalizing substrate comprises: steelmaking, hot rolling and normalizing steps. The normalizing step uses a normalizing furnace having a nonoxidizing heating furnace section. The nonoxidizing heating furnace section comprises more than 3 furnace zones. An energy investment ratio of the furnace zones used in the nonoxidizing heating furnace section is adjusted, so as to control an excess coefficient ? of the nonoxidizing heating furnace section to be within a range of 0.8??<1.0.

Abstract: Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor ? (ROR?) activity. This modulation has numerous effects, including inhibition of TH-17 cell function and/or TH-17 cell activity, and inhibition of re-stimulation of TH-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of ROR? results in stimulation of TH-17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).

Abstract: This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

Abstract: Techniques and systems are disclosed for enhancing the flexibility and resiliency of mobile social networking platforms. Techniques enable dynamic, user-defined check-in points with mobile devices so that users may define ad hoc, location-based communities. Techniques may also selectively determine an appropriate location-sensing mechanism to improve location accuracy or privacy, or to compensate for unavailable location-sensing capabilities. The techniques may assist social networking platforms to have a greater range of check-in options and to enable communication that may not rely on traditional network connectivity. In some cases, devices belonging to participators outside the member group may be used to locate a member who has moved outside the detection zone of a check-in point. In some cases, the participators' devices might not be directly connected to the lost member device but instead are connected via one or more “hops” of indirect communication with other participator devices.

Abstract: Disclosed is a dihydropyrimido fused ring derivative as a HBV inhibitor, and in particular relates to a compound shown as formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Embodiments of the present disclosure relate to video recommendation, and disclose a single-account multiple-preference recommendation method for a video website and an electronic device, where the single-account multiple-preference recommendation method for a video website includes: detecting an account which a user logs into, and displaying one or more associated sub-accounts of the account; detecting which sub-account the user selects from the one or more associated sub-accounts; determining, according to the selected sub-account, a recommended candidate video associated with the sub-account; and selecting a video from the recommended candidate video and pushing the selected video to the user. The single-account multiple-preference recommendation method for a video website provided in the embodiments of the present disclosure greatly improves user experience, and resolves the problem of inaccurate recommendation for single account and multiple users.

Abstract: Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor ? (ROR?) activity. This modulation has numerous effects, including inhibition of TH-17 cell function and/or TH-17 cell activity, and inhibition of re-stimulation of TH-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of ROR? results in stimulation of TH-17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).

Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

Abstract: An apparatus for generating a giant electrorheological (ER) effect includes an upper high voltage electrode and a lower high voltage electrode, the upper high voltage electrode and the lower high voltage electrode each covered with a water-absorbing material and have water absorbed thereon. The apparatus also includes a fluid channel formed by layers and positioned in a gap between the upper high voltage electrode and the lower high voltage electrode; a pressure sensor positioned at one of the high voltage electrodes; a pump to flow silicon oil through the fluid channel; and a high voltage source configured to apply a voltage to the upper high voltage electrode. A method for generating a ER utilizes the apparatus.

Abstract: A sodium-ion battery that includes an anode comprising hard carbon and lithium; and an electrolyte composition comprising an ether solvent and a sodium salt.

Abstract: Disclosed are nanoparticles, such as carbon nanotubes or other graphitic sheet materials having extended aromatic surfaces, which are used to deliver active agents such as drugs, labels or dyes (termed for convenience a “drug”) to the interior of cells. The nanoparticles are functionalized by a hydrophilic polymer or adsorption of an amphiphilic molecule to render them stable in suspension. The drug is therefore capable of release in the cell exterior. The drug is more rapidly released at lower pH, as found e.g., in tumor cells. The drug may also be linked to a branched chain hydrophilic polymer, so that each polymer molecule carries more than one drug bound by a cleavable linker.

Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFR?, PDGFR?) kinases.

Abstract: An insulator is disclosed, which includes an insulating surface. A part of the insulating surface is applied with a conductive coating having a specific resistivity. A conductive coating region having the specific resistivity and a nonconductive coating region are configured that: in a dry environment, no continuous conductive channel exists between upper and lower fittings of the insulator. The value of the leakage current that can be caused by the conductive coating region having the specific resistivity on the insulating surface enables the insulating surface to reach an ice-proof temperature in an icing climate condition. Also, a power transmission apparatus in which the insulator is adopted is disclosed. In an icing climate condition, the conductive coating can achieve the function of increasing the value of the leakage current on the surface of the insulator, so as to prevent the ice formation.

Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

Abstract: Techniques for accurate, low-complexity, scalable indoor localization. Low-complexity anchor nodes generate acoustic beacon signals, which are passively detectable by a mobile device, which may be unmodified smartphones operating in an acoustic frequency range. The acoustic beacon signals are modulated via codes in a boundary band of audio and ultrasound frequencies, imperceptible to humans yet detectable via a voice microphone of an unmodified smartphone. An application on the mobile device passively captures the acoustic beacon signals and determines relative distances to the anchor nodes. Localization and distance update techniques, implemented on the mobile device and/or a remote server, determines and updates in real-time the location of the mobile device. The system may be scalable to support any number of mobile devices.

Abstract: A computer account management system includes: an account management subsystem; an information asset management subsystem; an authentication (integrated) subsystem; a service (integrated) subsystem; and an account portal subsystem; wherein the account management subsystem manages information of physical accounts and logical account numbers; wherein the information asset management subsystem manages data information resources generated by network activities of physical account information; wherein the authentication subsystem provides an authentication integrated interface to the physical account numbers; wherein the service subsystem is a customizable interface which is open to internet or local network; wherein the account portal provides interfaces and tools of login, service list management of services subscribed or bought by the account, account information management and information asset management.