Abstract: Provided is a nucleic acid encoding a chimeric CD3 fusion protein and an anti-CD3 based bispecific T cell activator (BiTA) element. Also provided are vectors, engineered immune cells comprising the nucleic acid, the usage thereof and methods for preventing tumor. BiTA secreted by CAB-T cells can simultaneously achieve activation of CAB-T cells and endogenous TCR complexes in non-engineered T cells in tumor, and exert an anti-tumor effect.

Abstract: A flexible display apparatus and a control method therefor. The flexible display apparatus comprises: a flexible display panel (10); a bending sensor (11), that is configured to sense bending information of the flexible display panel (10); and a processor, that is coupled to the bending sensor (11), configured to receive the bending information of the bending sensor (11), and determines whether the bending information is valid bending information, and if so, then a currently running application program is controlled according to the valid bending information to perform a corresponding operation. By bending the flexible display panel (10), an application program is controlled to perform a corresponding operation, achieving a convenient, accurate, and effective operation, and improving user experience.

Abstract: A battery module, a flexible display apparatus, and a mobile terminal are described. A battery module includes energy storage cells disposed along a first direction, a flexible connecting portion connected between adjacent energy storage cells for transmitting electric energy, and support housings corresponding to the energy storage cells in a one-to-one correspondence, a support housing being provided with an accommodation cavity that fits an energy storage cell. The first side of the support housing is provided with an opening, a width of the support housing in the first direction is gradually decreased from the second side to the first side, the second side is opposite to the first side. The battery module further includes a support spacer with preset flexibility, where the support housings are disposed on one side of the support spacer along the first direction, and connecting members with preset flexibility connected between adjacent supporting housings.

Abstract: The present disclosure provides a self-regulating electric heating film, including: an insulating isolation layer, an interdigital electrode arranged on the surface of the insulating isolation layer, a positive temperature coefficient coating covering the surface of a secondary electrode of the interdigital electrode, and an insulating protective layer covering the surface of a primary electrode of the interdigital electrode, wherein the positive temperature coefficient coating is not in contact with the primary electrode of the interdigital electrode, and the insulating protective layer overlaps the positive temperature coefficient coating.

Abstract: A flexible display device is described, including: a flexible display panel; a flexible battery arranged at a side of the flexible display panel away from a light emitting surface; and a heat dissipation assembly including a first heat dissipation sheet, the first heat dissipation sheet being arranged at a side of the flexible battery facing or away from the flexible display panel, and the first heat dissipation sheet having a bendable area.

Abstract: Disclosed is a nanobody against the human programmed death factor PD-LI. The antibody has the function of blocking the binding of PD-LI to the receptor PD-I. Disclosed are the nanobody and the gene sequence encoding the nanobody, the corresponding expression vector and the host cell capable of expressing the nanobody, and the method for producing the nanobody. At the same time, also disclosed is the sequence of the humanized PD-LI nanobody. The humanized nanobody still has the function of blocking the binding of PD-LI to PD-1, and has a relatively high affinity and a relatively good specificity.

Abstract: The present invention relates to a preparation comprising an anti-PCSK9 antibody and use thereof, and in particular to a pharmaceutical preparation comprising an antibody and/or an antibody fragment specifically binding to proprotein convertase subtilisin/kexin type 9 (PCSK9), a buffer, a viscosity inhibitor, and a surfactant. The present invention also relates to an anti-PCSK9 antibody. Furthermore, the present invention relates to therapeutic and diagnostic use of the preparation or the antibody.

Abstract: A display apparatus and an electronic device relating to the field of display technologies are provided. The display apparatus includes: a first housing, one end of which includes an opening; a second housing slidably connected to the first housing and configured to slide out of a cavity of the first housing via the opening of the first housing; a flexible display screen configured to slide out of the cavity of the first housing along with the second housing when the second housing slides out of the cavity of the first housing; and at least one elastic assembly configured to provide an elastic force to the second housing when the second housing slides out of the cavity of the first housing so that a second lateral outer surface is kept flush with the first lateral outer surface.

Abstract: The invention relates to a novel antibody and an antibody fragment thereof that specifically bind to ALG-3 and a composition comprising the antibody or the antibody fragment. In addition, the invention relates to a nucleic acid encoding the antibody or the antibody fragment thereof, a host cell comprising the nucleic acid, and related use. Furthermore, the invention relates to therapeutic and diagnostic use of the antibody and the antibody fragment. In particular, the invention relates to combination therapy of the antibodies and the antibody fragments described herein with other therapeutic agents, such as anti-PD-1 or anti-PD-L1 antibodies.

Abstract: In one aspect, the present application provides a computer-based method of measuring positional relationship between two teeth, comprising: obtaining a second 3D digital model representing a plurality of teeth under a second tooth arrangement, wherein the plurality of teeth comprise a first tooth and a second tooth; and measuring a value of a collision or a size of a gap between the first tooth and second tooth based on the second 3D digital model and in a predetermined first direction.

Abstract: Provided herein are pharmaceutical formulations for anti-PD-1 antibodies.

Abstract: The present disclosure discloses an adenovirus vectored vaccine for preventing SARS-CoV-2 infection, which comprises a nucleotide sequence as shown by SEQ ID NO: 1. According to some embodiments of the present disclosure, the vaccine comprises an S protein-coding nucleotide sequence which is easily expressed in human cells, and can produce more S proteins. The vaccine of the present disclosure is expected to be used as a recombinant viral vaccine for preventing SARS-CoV-2 infection. Some embodiments of the present disclosure have better safety.

Abstract: A system and method for processing volumetric video is disclosed. The process includes receiving three-dimensional mesh data and texture data defining three-dimensional and textural characteristics of a physical location captured as volumetric video, dividing the three-dimensional mesh data into sub-parts defining a mesh tile, each mesh tile making up only a portion of the three-dimensional mesh data, and identifying a sub-part of the texture data defining a texture tile, the texture tile corresponding to each of the sub-parts of the mesh tiles and including only texture data relevant to an associated mesh tile. The volumetric video may be encoded by encoding each mesh tile independent of the three-dimensional mesh data as a mesh tile video and each texture tile independent of the texture data as a texture tile video.

Abstract: In one aspect of the present application, a computer-implemented method for setting a local coordinate system of a tooth 3D digital model is provided, the method comprises: obtaining a first 3D digital model representing a first tooth, wherein the first 3D digital model is based on a world coordinate system; and setting a local coordinate system for the first 3D digital model using a first artificial neural network based on the first 3D digital model, where the first artificial neural network is a trained deep learning artificial neural network.

Abstract: In one aspect, the present application provides a computer-based method of measuring positional relationship between two teeth, comprising: obtaining a second 3D digital model representing a plurality of teeth under a second tooth arrangement, wherein the plurality of teeth comprise a first tooth and a second tooth; and measuring a value of a collision or a size of a gap between the first tooth and second tooth based on the second 3D digital model and in a predetermined first direction.

Abstract: A method for segmenting 3D digital model of jaw is provided. The method includes: obtaining a first 3D digital model of jaw; and segmenting the first 3D digital model of jaw using a trained deep artificial neural networks.

Abstract: Provided herein are pharmaceutical formulations for anti-PD-1 antibodies.

Abstract: The present invention relates to antibodies that bind human programmed cell death 1 (PD-1), and may be useful for treating cancer alone and in combination with chemotherapy and other cancer therapeutics.

Abstract: The present invention provides a method for three-dimensional reconstruction of fascicular structure of human peripheral nerve, which comprises the steps of: obtaining human peripheral nerve and preparing a peripheral nerve sample; immersing the peripheral nerve sample into a liquid; setting scan parameters of Micro-MRI, scanning the peripheral nerve sample by Micro-MRI, to acquire image data of the peripheral nerve sample in the liquid environment; and three-dimensional reconstructing a structural model of the peripheral nerve sample based on the image data. By means of the method according to the present invention, high-quality scanned images are obtained without destroying the morphology and physical and chemical properties of peripheral nerve, so as to obtain a precise three-dimensional visualization model of peripheral nerve fascicle.

Abstract: A system and method for processing volumetric video is disclosed. The process includes receiving three-dimensional mesh data and texture data defining three-dimensional and textural characteristics of a physical location captured as volumetric video, dividing the three-dimensional mesh data into sub-parts defining a mesh tile, each mesh tile making up only a portion of the three-dimensional mesh data, and identifying a sub-part of the texture data defining a texture tile, the texture tile corresponding to each of the sub-parts of the mesh tiles and including only texture data relevant to an associated mesh tile. The volumetric video may be encoded by encoding each mesh tile independent of the three-dimensional mesh data as a mesh tile video and each texture tile independent of the texture data as a texture tile video.