Patents by Inventor Xiaolin Wu
Xiaolin Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9121060Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is exType: GrantFiled: March 8, 2013Date of Patent: September 1, 2015Assignee: Illumina Cambridge LimitedInventors: John Milton, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
-
Patent number: 9085802Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: GrantFiled: January 28, 2014Date of Patent: July 21, 2015Assignee: Illumina Cambridge LimitedInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Marie Julia Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
-
Publication number: 20150182897Abstract: A filter tube for high temperature gas-solid separation is provided that has a first cylinder and a second cylinder coaxially nested in the first cylinder with the first cylinder arranged so that an opening thereof faces upward, a first connection flange provided at a periphery of the opening of the first cylinder, and a circular through-hole provided at a bottom of the first cylinder. The second cylinder is nested in the first cylinder so that an opening of the second cylinder faces downward. The second cylinder has an end at an opening thereof that is hermetically connected to the circular through-hole of the first cylinder. The second cylinder has a bottom, and the bottom of the second cylinder and the opening of the first cylinder are at the same horizontal level. An annular gas passage is formed between the first cylinder and the second cylinder.Type: ApplicationFiled: January 18, 2013Publication date: July 2, 2015Inventors: Zhongli Ji, Xiaolin Wu, Honghai Chen, Liang Yang, Zhiyi Xiong
-
Publication number: 20150165360Abstract: The present invention relates to a pulse-jet cleaning device for filter with a self-oscillating nozzle, in which a tube sheet of the filter is provided with a filtration unit thereon, with a cleaning gas chamber above the tube sheet and a dust-containing gas chamber under the tube sheet; and the pulse jet cleaning device includes an ejector and a back-flushing pipeline, with one end of the back-flushing pipeline connected to a back-flushing gas tank through a pulse back-flushing valve, the other end of the back-flushing pipeline being provided with a self-oscillating nozzle corresponding to the top portion of the ejector; and the self-oscillating nozzle includes a hollow cylindrical self oscillating chamber, which has a gas inlet at an upper end connected to the back-flushing pipeline and a gas outlet at a lower end.Type: ApplicationFiled: January 18, 2013Publication date: June 18, 2015Inventors: Zhongli Ji, Xiaolin Wu, Honghai Chen, Liang Yang, Zhiyi Xiong
-
Publication number: 20140349891Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction,Type: ApplicationFiled: January 28, 2014Publication date: November 27, 2014Applicant: ILLUMINA CAMBRIDGE LIMITEDInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Marie Julia Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
-
Publication number: 20140132744Abstract: An image/information display system and method based on temporal psychovisual modulation in the technical field of image/video processing and electro-optical display. The system includes a high speed display device and an auxiliary viewing device cooperating with each other and interacting with a human visual system. The auxiliary viewing device realizes the temporal amplitude modulation of the composition basic sequence by a method of controlling the light intensity transfer rate from the display plane of the high speed display device to the human eye. The present invention can not only display different pictures required individually by a plurality of users with the same display device but can also solve the problems of pictures being insufficiently bright and the number of pictures that can be generated being very low; such problems being unable to be overcome by the time division multiplexing method.Type: ApplicationFiled: June 21, 2012Publication date: May 15, 2014Applicant: EyElementTec Inc.Inventors: Xiaolin Wu, Guangtao Zhai
-
Patent number: 8715966Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: GrantFiled: April 19, 2012Date of Patent: May 6, 2014Assignee: Illumina Cambridge LimitedInventors: Liu Xiaohai, John Milton, Geoffrey Paul Smith, Colin Lloyd Barnes, Isabelle Marie Julia Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
-
Patent number: 8597881Abstract: Provided herein is a method for replacing the allyl group in a compound of formula R—O-allyl, R2N(allyl), RNH(allyl), RN(allyl)2 or R—S-allyl with a hydrogen, using a transition metal and one or more phosphine ligands.Type: GrantFiled: October 25, 2011Date of Patent: December 3, 2013Assignee: Illumina Cambridge LimitedInventors: John Milton, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
-
Publication number: 20130197209Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?) 2-F, the F is eType: ApplicationFiled: March 8, 2013Publication date: August 1, 2013Applicant: ILLUMINA CAMBRIDGE LIMITEDInventors: John MILTON, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Bames, Xiaohai Liu, Silke Ruediger
-
Publication number: 20120208194Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction,Type: ApplicationFiled: April 19, 2012Publication date: August 16, 2012Applicant: ILLUMINA CAMBRIDGE LIMITEDInventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Barnes, Isabelle Marie Julia Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
-
Publication number: 20120095201Abstract: Provided herein is a method for replacing the allyl group in a compound of formula R—O-allyl, R2N(allyl), RNH(allyl), RN(allyl)2 or R—S-allyl with a hydrogen, using a transition metal and one or more phosphine ligands.Type: ApplicationFiled: October 25, 2011Publication date: April 19, 2012Applicant: ILLUMINA CAMBRIDGE LIMITEDInventors: John MILTON, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
-
Publication number: 20120074621Abstract: A press quenching machine for steel plates includes a press bed structure, a hydraulic cylinder, a drive roller for advancing and stopping the steel plates, a fixed upper pressure head part, a bottom pressure head part movable up and down within the press bed structure, a plurality of upper pressed ribs provided on the upper pressure head part, and a plurality of bottom pressed ribs provided on the bottom pressure head part. The upper pressed ribs are crosswise arranged with the bottom pressed ribs, the upper and bottom pressed ribs have a density distribution according to a position of a special-shape plate for ensuring the flatness of the steel plates after quenching. In the press quenching machine, the transfer time and heat dissipation of the steel plates can be reduced, and no blind areas or soft spots exist. Therefore, the press quenching machine has a high yield and production efficiency.Type: ApplicationFiled: October 5, 2010Publication date: March 29, 2012Inventors: Zhanjun Wang, Xianjun Li, Wenliang Zhang, Shutian Ren, Xiaolin Wu
-
Patent number: 8071739Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is exType: GrantFiled: July 20, 2010Date of Patent: December 6, 2011Assignee: Illumina Cambridge LimitedInventors: John Milton, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
-
Publication number: 20100292452Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is exType: ApplicationFiled: July 20, 2010Publication date: November 18, 2010Inventors: John Milton, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
-
Patent number: 7771973Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O—Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is exType: GrantFiled: June 1, 2009Date of Patent: August 10, 2010Assignee: Illumina Cambridge LimitedInventors: John Milton, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
-
Publication number: 20090325172Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is exType: ApplicationFiled: June 1, 2009Publication date: December 31, 2009Inventors: John Milton, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
-
Patent number: 7566537Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.Type: GrantFiled: December 13, 2005Date of Patent: July 28, 2009Assignee: Illumina Cambridge LimitedInventors: Shankar Balasubramanian, Colin Barnes, Xiaohai Liu, John Milton, Harold Swerdlow, Xiaolin Wu
-
Patent number: 7541444Abstract: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3?-OH blocking group covalently attached thereto, such that the 3? carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R?)2-O—R?, —C(R?)2-N(R?)2, —C(R?)2-N(H)R?, —C(R?)2-S—R? and —C(R?)2-F, wherein each R? is or is part of a removable protecting group; each R? is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R?)2 represents an alkylidene group of formula ?C(R??)2 wherein each R?? may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R? is exchanged for H or, where Z is —C(R?)2-F, the F is exType: GrantFiled: August 22, 2003Date of Patent: June 2, 2009Assignee: Illumina Cambridge LimitedInventors: John Milton, Xiaolin Wu, Mark Smith, Joseph Brennan, Colin Barnes, Xiaohai Liu, Silke Ruediger
-
Publication number: 20090118128Abstract: The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5? end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.Type: ApplicationFiled: July 20, 2006Publication date: May 7, 2009Inventors: Xiaohai Liu, John Milton, Geoffrey Paul Smith, Colin Barnes, Isabelle Marie Julia Rasolonjatovo, Roberto Rigatti, Xiaolin Wu, Tobias William Barr Ost, Graham John Worsley, David James Earnshaw, Gerardo Turcatti, Anthony Romieu
-
Publication number: 20090088331Abstract: The present invention relates generally to methods of detecting and identifying known and unknown viruses using hybridization microarrays to essentially all known influenza virus nucleotide sequences of at least one type that infect at least one species, the sequencing of nucleotides which hybridize to the microarrays and analysis of the hybridized sequences with existing databases, thus identifying existing or new subtypes of viruses. The present invention also relates to methods of use of the microarrays of the invention for the detection of influenza viruses, including variant influenza viruses. The method includes the use of a non-specific PCR amplification method to amplify sample nucleic acids.Type: ApplicationFiled: November 7, 2007Publication date: April 2, 2009Applicant: Government of the United States of America, as represented by the Secretary, Dept. of Health andInventors: Xiaolin Wu, Cassio S. Baptista, David J. Munroe