Abstract: Disclosed are quinazoline compounds inhibiting ErbBs (e.g. HER2), pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds which are useful in treating diseases associated ErbBs. The compound and the pharmaceutical composition can effectively treat diseases associated ErbBs (especially HER2), including cancer.

Abstract: The present invention relates to the field of nucleic acid sequence replication including PCR. Specifically, the present invention relates to methods and compositions for amplifying one or more target sequences from one or more template sequences. In particular, the present invention provides novel primer designs to enhance specificity of PCR reactions. The present invention also provides methods and compositions to perform the selection of specific sequence sections using specific primers and the amplification of all selected sequence sections using a pair of common primers in a single reaction tube.

Abstract: A composite material includes a porous foam, having a density of less than 1 g/cm3, with a polymer matrix including chitosan, chitin, or chitosan oligosaccharide, and a first laminate adhered to a first surface of the porous foam.

Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, that are useful as DNA-PK inhibitors. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (I), and methods of using such compounds or compositions to treat DNA-PK related disorder (e.g., cancer).

Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, that are useful as JAK kinase inhibitors. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula (I), and methods of using such compounds or compositions to treat respiratory conditions (e.g., asthma or COPD).

Abstract: There are provided compounds of Formula I, and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for inhibition or modulation of the activity of cyclin dependent kinases (CDK) and/or glycogen synthase kinase-3 (GSK-3), for the treatment of disease states or conditions mediated by cyclin dependent kinases and/or glycogen synthase kinase-3, including cancers.

Abstract: The present invention relates to cyclopentane compounds of Formula (I), physical forms thereof, processes for their production and their use in medicine.

Abstract: The disclosure provides a device for purification, sterilization and deodorization of air. The device includes a housing, a sterilization and disinfection device, a fan, a deodorization device, and a photocatalyst reactor. The housing is in a barrel shape and includes a side wall including a plurality of air inlets. The fan is disposed on one end of the housing. The deodorization device, the photocatalyst reactor and the sterilization and disinfection device are disposed in the housing.

Abstract: The present invention relates to cyclopentane compounds of Formula (I), physical forms thereof, processes for their production and their use in medicine.

Abstract: A stereo calibration method for a movable vision system. The movable vision system involved in the method comprises at least two photography components, at least one calculation component, and at least one control component. The method comprises: placing a calibration template in front of photography components; rotating the photography components by degrees of freedom of motion; obtaining one or more groups of images including calibration template features, and obtaining corresponding position information at the degrees of freedom of motion when the images are obtained; obtaining, by means of calculation, a calibration result of the photography components and the degrees of freedom of motion, i.e.

Abstract: A safety drilling system for preventing collapse of water-sensitive formation in the upper part of a high-pressure saltwater layer, which includes a wellhead equipment, a downhole drilling tool, a first injection pipeline, a second injection pipeline, a first return pipeline and a second return pipeline. Upon encountering a high-pressure saltwater layer while drilling, the system injects heavy mud into the annulus of a wellhead through the first injection pipeline to form a heavy mud cap, such that a fluid column pressure in the annulus balances the pressure of the high-pressure saltwater layer. In this case, a fluid column pressure in a drill string is lower than the pressure of the high-pressure saltwater layer.

Abstract: There are provided compounds of Formula I, and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for inhibition or modulation of the activity of cyclin dependent kinases (CDK) and/or glycogen synthase kinase-3 (GSK-3), for the treatment of disease states or conditions mediated by cyclin dependent kinases and/or glycogen synthase kinase-3, including cancers.

Abstract: Disclosed is a calibration method for a multi-degree-of-freedom movable vision system. A calibration template is placed in front of a camera component, each degree of freedom of movement of the camera component is rotated, several images including features of the calibration template are recorded using the camera component, position information of each degree of freedom of movement when the corresponding images are acquired is also recorded, and calibration results of the camera component and each degree of freedom of movement are calculated using a calculation component. The movable vision system comprises the camera component, the calculation component and a control component.

Abstract: The user wearable devices are configured to allow attendees of events to exchange their information upon a simultaneous input into their respective device. The simultaneous inputs initiate a verification that the two users are registered for and present at the same event before initiating a pairing through single direction short range antennas. The simultaneous inputs can also verify whether the two users are facing one another and an appropriate distance apart to coordinate the simultaneous input.

Abstract: The present invention provides a recombinant eukaryotic cell expressing one or more heterologous double strand break (DSB) repair proteins in an amount effective for enhancing DSB repair in the cell. The recombinant eukaryotic cell may express a recombinant product of interest. Also provided are methods for enhancing double strand break (DSB) repair in eukaryotic cells, establishing host cells for production of a recombinant product of interest, producing a recombinant product of interest, improving production of a recombinant product of interest by eukaryotic cells, and/or investigating suitability of eukaryotic cells as host cells for producing a recombinant product of interest.

Abstract: The present invention discloses a UI integrating method, a UI navigating method and a electronic device, computer readable storage medium, relates to the technical field of IM, which comprises: A) presenting a first communication UI for a first contact on said display for said electronic device, said first communication UI comprising a message area; B) outputting a plurality of messages with the first contact via at least one communication network to said message area at least partially in response to an operation of an operation interface for the at least one communication network by a user, thereby improving accessibility of the electronic device.

Abstract: The present invention provides a recombinant eukaryotic cell expressing one or more heterologous double strand break (DSB) repair proteins in an amount effective for enhancing DSB repair in the cell. The recombinant eukaryotic cell may express a recombinant product of interest. Also provided are methods for enhancing double strand break (DSB) repair in eukaryotic cells, establishing host cells for production of a recombinant product of interest, producing a recombinant product of interest, improving production of a recombinant product of interest by eukaryotic cells, and/or investigating suitability of eukaryotic cells as host cells for producing a recombinant product of interest.

Abstract: The present disclosure novel pyrazine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.

Abstract: Disclosed are compounds inhibiting ErbBs (e.g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat ErbBs (especially mutant forms of ErbBs) or BTK associated diseases, including cancer.

Abstract: A composite material includes a polymer matrix with a polymer having D-glucosamine monomer units and 50% or fewer N-acetyl-D-glucosamine monomer units. A salt can be disposed in the polymer matrix. A dispersed phase is disposed in the polymer matrix with the salt, and the dispersed phase and the polymer matrix form a porous composite foam. The porous composite foam includes, by weight, 0.5-3 times the dispersed phase to the polymer matrix, and the porous composite foam has a density of less than 1 g/cm3.