Abstract: Provided is a sulfonamide derivate represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing said derivative, and the use thereof as a therapeutic agent, especially as a Lysine Acetyl Transferase (KAT) inhibitor and the use of same in the preparation of a medicament for the treatment and/or prevention of cancer.

Abstract: In accordance with at least selected embodiments, a battery separator or separator membrane comprises one or more co-extruded multi-microlayer membranes optionally laminated or adhered to another polymer membrane. The separators described herein may provide improved strength, for example, improved puncture strength, particularly at a certain thickness, and may exhibit improved shutdown and/or a reduced propensity to split.

Abstract: Improved battery separators, base films or membranes, batteries, cells, devices, systems, vehicles, and/or methods of making and/or using such separators, films or membranes, batteries, cells, devices, systems, vehicles, and/or methods of enhancing battery or cell charge rates, charge capacity, and/or discharge rates, and/or methods of improving batteries, systems including such batteries, vehicles including such batteries and/or systems, and/or the like; biaxially oriented porous membranes, composites including biaxially oriented porous membranes, biaxially oriented microporous membranes, biaxially oriented macroporous membranes, battery separators with improved charge capacities and the related methods and methods of manufacture, methods of use, and the like; flat sheet membranes, liquid retention media; dry process separators; biaxially stretched separators; dry process biaxially stretched separators having a thickness range between about 5 ?m and 50 ?m, preferably between about 10 ?m and 25 ?m, having imp

Abstract: Microporous battery separator membranes, separators, batteries including such membranes, separators are provided. A battery separator for a secondary or rechargeable lithium battery may have low Electrical resistance of less than 0.95 ohm-cm2. The inventive battery separator membrane may provide a means to achieve an improved level of battery performance in a rechargeable or secondary lithium battery based on a possibly synergistic combination of low Electrical resistance, low Gurley, low tortuosity, and/or a unique trapezoid shaped pore. Certain multilayer embodiments (by way of example only, a trilayer membrane made of two polypropylene layers with a polyethylene layer in between), the inventive microporous membrane or battery separator may have excellent onset and rate of thermal shutdown performance.

Abstract: Provided are an antigen-binding molecule specifically binding to PSMA and CD3, and a pharmaceutical use thereof. The antigen-binding molecule can be used for treating tumor-related diseases.

Abstract: An improved multilayer laminated microporous battery separator for a lithium ion secondary battery, and/or a method of making or using this separator is provided. The preferred inventive dry process separator is a tri-layer laminated Polypropylene/Polyethylene/Polypropylene microporous membrane with a thickness range of 12 ?m to 30 ?m having improved puncture strength and low electrical resistance for improved cycling and charge performance in a lithium ion battery. In addition, the preferred inventive separator's or membrane's low Electrical Resistance and high porosity provides superior charge rate performance in a lithium battery for high power applications.

Abstract: In accordance with at least selected embodiments, a battery separator or separator membrane comprises one or more co-extruded multi-microlayer membranes optionally laminated or adhered to another polymer membrane. The separators described herein may provide improved strength, for example, improved puncture strength, particularly at a certain thickness, and may exhibit improved shutdown and/or a reduced propensity to split.

Abstract: The present application provides a coated separator, a preparation method for coated separator, and a battery. The coated separator includes a base film and a coating layer structure arranged on the base film; the coating layer structure includes multiple material layers and includes one-dimensional nanomaterials and ceramic particles; and an average length of the one-dimensional nanomaterials in each material layer decreases layer by layer in a direction away from the base film.

Abstract: Novel or improved microporous single or multilayer battery separator membranes, separators, batteries including such membranes or separators, methods of making such membranes, separators, and/or batteries, and/or methods of using such membranes, separators and/or batteries are provided. In accordance with at least certain embodiments, a multilayer dry process polyethylene/polypropylene/polyethylene microporous separator which is manufactured using the inventive process which includes machine direction stretching followed by transverse direction stretching and a subsequent calendering step as a means to reduce the thickness of the multilayer microporous membrane, to reduce the percent porosity of the multilayer microporous membrane in a controlled manner and/or to improve transverse direction tensile strength.

Abstract: Provided are a coated separator, a preparation method of a coated separator, and a battery, which relates to mixing first nanofibers having similar sizes in a first coating layer and mixing second nanofibers having similar sizes in a second coating layer and setting the first coating layer to be a mixture of large-size first nanofibers and large-particle-diameter first ceramic particles and setting the second coating layer to be a mixture of small-size second nanofibers and small-particle-diameter second ceramic particles.

Abstract: Disclosed herein are novel or improved microporous battery separator membranes, separators, batteries including such separators, methods of making such membranes, separators, and/or batteries, and/or methods of using such membranes, separators and/or batteries. Further disclosed are laminated multilayer polyolefin membranes with exterior layers comprising one or more polyethylenes, which exterior layers are designed to provide an exterior surface that has a low pin removal force. Further disclosed are battery separator membranes having increased electrolyte absorption capacity at the separator/electrode interface region, which may improve cycling. Further disclosed are battery separator membranes having improved adhesion to any number of coatings. Also described are battery separator membranes having a tunable thermal shutdown where the onset temperature of thermal shutdown may be raised or lowered and the rate of thermal shutdown may be changed or increased.

Abstract: The present invention relates to a fused tricyclic compound, a preparation method therefor, and an application thereof in medicine. Specifically, the present invention relates to a fused tricyclic compound represented by general formula (1), a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof as a therapeutic agent, particularly a use as a TLR7/8/9 inhibitor and a use in preparing a drug for the treatment and/or prevention of inflammatory and autoimmune diseases. The definition of each group in general formula (1) is as defined in the description.

Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.

Abstract: A method for extracting Raman characteristic peaks employing improved principal component analysis comprising: using a confocal microscopic Raman-spectroscopic instrument to collect Raman spectroscopic data from surfaces of pork and beef samples; and performing preprocessing on the Raman spectroscopic data, performing principal component analysis, establishing a principal component loading scatter plot, extracting dot characteristics from the principal component loading scatter plot, analyzing same, and performing filtering on the dot characteristics to obtain Raman characteristic peaks. The method for extracting Raman characteristic peaks employing improved principal component analysis is used to extract Raman characteristic peaks from pork and beef samples, and then the Raman characteristic peaks are inputted into a classifier to undergo classification, thereby achieving high accuracy and quick classification.

Abstract: Novel or improved microporous single or multilayer battery separator membranes, separators, batteries including such membranes or separators, methods of making such membranes, separators, and/or batteries, and/or methods of using such membranes, separators and/or batteries are provided. In accordance with at least certain embodiments, a multilayer dry process polyethylene/polypropylene/polyethylene microporous separator which is manufactured using the inventive process which includes machine direction stretching followed by transverse direction stretching and a subsequent calendering step as a means to reduce the thickness of the multilayer microporous membrane, to reduce the percent porosity of the multilayer microporous membrane in a controlled manner and/or to improve transverse direction tensile strength.

Abstract: In accordance with at least selected aspects, objects or embodiments, optimized, novel or improved membranes, battery separators, batteries, and/or systems and/or related methods of manufacture, use and/or optimization are provided. In accordance with at least selected embodiments, the present invention is related to novel or improved battery separators that prevent dendrite growth, prevent internal shorts due to dendrite growth, or both, batteries incorporating such separators, systems incorporating such batteries, and/or related methods of manufacture, use and/or optimization thereof. In accordance with at least certain embodiments, the present invention is related to novel or improved ultra thin or super thin membranes or battery separators, and/or lithium primary batteries, cells or packs incorporating such separators, and/or systems incorporating such batteries, cells or packs.

Abstract: The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.

Abstract: A prediction-based system and method for trajectory planning of autonomous vehicles is configured to: receive data from a training data collection system, the training data including perception data and context data corresponding to human driving behaviors; perform a training phase for training a trajectory prediction module using the training data; receive perception data associated with a host vehicle; and perform an operational phase for extracting host vehicle feature data and proximate vehicle context data from the perception data, generating a proposed trajectory for the host vehicle, using the trained trajectory prediction module to generate predicted trajectories for each of one or more proximate vehicles near the host vehicle based on the proposed host vehicle trajectory, determining if the proposed trajectory for the host vehicle will conflict with any of the predicted trajectories of the proximate vehicles, and modifying the proposed trajectory for the host vehicle until conflicts are eliminated.

Abstract: Improved battery separators, base films or membranes, batteries, cells, devices, systems, vehicles, and/or methods of making and/or using such separators, films or membranes, batteries, cells, devices, systems, vehicles, and/or methods of enhancing battery or cell charge rates, charge capacity, and/or discharge rates, and/or methods of improving batteries, systems including such batteries, vehicles including such batteries and/or systems, and/or the like; biaxially oriented porous membranes, composites including biaxially oriented porous membranes, biaxially oriented microporous membranes, biaxially oriented macroporous membranes, battery separators with improved charge capacities and the related methods and methods of manufacture, methods of use, and the like; flat sheet membranes, liquid retention media; dry process separators; biaxially stretched separators; dry process biaxially stretched separators having a thickness range between about 5 ?m and 50 ?m, preferably between about 10 ?m and 25 ?m, having imp

Abstract: In a grain sampling and imaging device, a grain bin (1) is located under a sampling body (5), a grain feed connector (4) is fixed to a top of the sampling body (5), an observation window (2) is installed on the sampling body (5), a camera (3) is installed above the observation window (2); grains fall to a grain feed connector (4), and then into the sampling body (5), and then are sieved by multiple passages of the sampling body (5), a part of the grains randomly enter the observation window (2) and photographed by the camera (3), and finally all of the grains enter the grain bin (1) through a discharge outlet (5.1) provided at a bottom of the sampling body (5).