Abstract: Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment of bacterial infections, such as pneumonia.

Abstract: It discloses a sustained release grouting material, a preparation method and an application thereof; the sustained release grouting material comprises a water swelling core and a water-soluble sustained release coating, the water swelling core is composed of bentonite, SAP and xanthan gum, which is granulated by disc granulator relying on the cohesiveness of xanthan gum; the water-soluble sustained-release coating is prepared by mixing water-soluble starch, polyvinyl alcohol, poloxamer, lubricant and plasticizer with deionized water to obtain a film-forming solution, and the film-forming solution is coated on a coating machine; the invention uses a coating machine to coat a layer of slow-release coating on the surface of the water-absorbing expansion core, and adjusts the coating thickness by controlling the mass ratio of the coating film-forming liquid to the water-absorbing expansion core particles, so as to realize the controllable water absorption onset time of the expansion core.

Abstract: An aeronautical aluminum alloy minimum-quantity-lubrication milling machining device includes a machine tool worktable and spindle connected with a machine tool power system. The spindle is connected with a tool holder that is fixed with a cutting tool. The machine tool worktable is provided with a machine tool fixture, the tool holder is connected with a minimum-quantity-lubrication mechanism, the machine tool fixture includes a fixture body that is fixedly provided with a limit block for contact with two adjacent side surfaces of a workpiece, the fixture body is provided with a plurality of clamping elements capable of pressing the workpiece against an upper surface of the fixture body, and a top of the clamping element is provided with a detection member for detecting a relative position between the clamping element and the spindle. The device can avoid interference and contact between a nozzle and the clamping element.

Abstract: The present invention relates to a carbide tool cleaning and coating production line and a method, including a cleaning device including a support frame, a cleaning mechanism and a drying mechanism are sequentially disposed under the support frame connected to a moving mechanism, the moving mechanism is connected to a lifting mechanism being capable of being connected to a tool fixture bracket being configured to accommodate the tool fixture; a coating device including a coating chamber which a plane target mechanism and a turntable assembly disposed in, the turntable assembly is capable of being connected to a plurality of tool fixtures being capable of rotating around an axial line of the coating chamber under the driving of the turntable assembly and rotating around an axial line thereof at the same time; and, a manipulator being disposed between the cleaning device and the coating device.

Abstract: The present disclosure provides a risk assessment method of water inrush in tunnels constructed in water-rich grounds. The method includes the following steps: simulating a tunnel excavation process by finite element software MIDAS GTS NX and fluid-structure interaction; according to a research method of control variables, analyzing effects of a groundwater level, an elastic modulus and advanced pipe shed grouting on the stability of surrounding rock, and improving an algorithm of a radial basis function (RBF) neural network using a Grey Relation Analysis (GRA)-based Partitioning Around Medoid (PAM) clustering algorithm to assess risks of water inrush occurring in Qingdao area.

Abstract: The present invention provides a high-efficient magnesium ion removal system for salt lake brine based on in situ alkali production using bipolar membrane electrochemical process, it is constructed with cathode, cathode cell, anode, anode cell, and anion exchange membranes, bipolar membranes, acid cells, alkali cells, mesh materials for precipitate aggregation, acid-washing cells.

Abstract: The embodiment of the present disclosure provides a display panel and a display apparatus. The display panel includes a long side, a short side, a display pixel, a scan driving circuit, a drive circuit board, and chips on film. one end of each chip on film is coupled to the short side, and another end is coupled to the drive circuit board. The drive circuit board and the scan driving circuit of the embodiment of the present disclosure are respectively located on the short side and the long side of the display panel to improve the problem that the font is easily deformed during display.

Abstract: The present invention belongs to the field of pharmaceutical manufacturing technology. The present invention provides a pharmaceutical composition of a conjugate and a preparation method thereof. The pharmaceutical composition is preferably administered by injection. The docetaxel conjugate has a structural formula as shown in the following formula: (I).

Abstract: An electrochemical apparatus includes a housing and an electrode assembly accommodated in the housing. The electrode assembly includes a first electrode plate, a second electrode plate, and a separator wound together. The first electrode plate includes a first current collector having a first region and a second region; and a first active material layer disposed in the first region. The second region is provided at an end of the first current collector in a first direction to form a first tab. The second electrode plate includes a second current collector; at least two second tabs; and a second active material layer disposed on the second current collector. The at least two second tabs are connected to an end of the second current collector, the at least two second tabs being facing away from the second region in a first direction; the at least two second tabs are spaced apart in a winding direction of the electrode assembly and are integrally formed with the second current collector.

Abstract: The present disclosure is related to systems and methods for medical imaging. The method includes determining a sequence of scan states of a medical device for a sequence of regions of interest (ROIs) of a subject. Each of the sequence of scan states corresponds to an ROI in the sequence of ROIs. When the medical device is in a scan state of the sequence of scan states, an isocenter of the medical device is aligned with a center of the corresponding ROI. The method includes generating a set of controlling information of the medical device based on the sequence of scan states. Each of the set of controlling information is configured to switch the medical device to a corresponding scan state in the sequence of scan states. The method includes controlling the medical device to scan the sequence of ROIs. Before scanning each of the sequence of ROIs, the medical device is positioned to the corresponding scan state according to the corresponding controlling information.

Abstract: A server cluster determines a first memory requirement of a first distributed application, where the first memory requirement indicates a memory size. The server cluster determines N first server nodes in the server cluster based on the first memory requirement and an available memory resource of each server node in the server cluster, and constructs a first memory pool based on the N first server nodes. The server cluster provides a service for the first distributed application based on the first memory pool.

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

Abstract: A low-heat-loss operation method of a line-focusing heat collection system and the line-focusing heat collection system are provided. The method includes the following steps. Solar energy is utilized to preheat a collector tube in an empty tube state, so that the collector tube is in a preheating mode. After a set preheating temperature is reached, a heat transfer working medium is injected into the collector tube. In the injection process of the heat transfer working medium, an injection section of the collector tube is converted into a focusing mode from a preheating mode. After heat collection is finished, the circulation of the heat transfer working medium is stopped, and the focusing mode of the collector tube is kept. In the drainage process of the heat transfer working medium, an emptying section of the collector tube is converted into a light heat-tracing mode from a focusing mode.

Abstract: A method for selection of a core network. The method which can be performed by a first network node comprises receiving a message for a terminal device from a second network node. The message can enable the first network node to determine a category of the terminal device. The method further comprises selecting a core network for the terminal device based at least in part on the category of the terminal device. The terminal device can be served by a dedicated core network selected for the terminal device adaptively, so that network configuration and resource efficiency can be improved.

Abstract: The present invention discloses a same-cavity integrated vertical high-speed multistage superfine pulverizing device and method for walnut shells. The same-cavity integrated vertical high-speed multistage superfine pulverizing device for walnut shells includes a double-channel sliding type feeding device and a same-cavity integrated vertical pulverizing device. The same-cavity integrated vertical pulverizing device includes a material lifting disc and a same-cavity integrated vertical pulverizing barrel. A first-stage coarse crushing region, a second-stage fine crushing region, a third-stage pneumatic impact micro pulverizing region and a fourth-stage airflow mill superfine pulverizing region are disposed in the same-cavity integrated vertical pulverizing barrel.

Abstract: The present disclosure provides a multi-factor quantitative analysis method for deformation of a neighborhood tunnel. The method includes the following steps: analyzing monitoring data generated at a tunnel site; simulating collapse occurring at a shallow buried section of a tunnel; determining the degree of influence of each factor on the tunnel and a stratum; and determining quantitative influence of each factor on tunnel deformation. The present disclosure can not only provide an accurate theoretical basis for the construction of the shallow buried section of the small-distance tunnel, but also guarantee safety and cost saving during tunnel construction.

Abstract: The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

Abstract: The present invention belongs to the field of alkaline polymer electrolyte membranes, and relates to a comb-shaped structure polybenzimidazole anion exchange membrane with high conductivity and preparation method thereof. In the invention, firstly, polybenzimidazole is grafted with the non-cationic side chains to the max grafting rate to synthesize the de-protonated comb-shaped polybenzimidazole material, avoiding the N—H in benzimidazole forms ionic binding with cationic functional groups, which will reduce the reactivity and mobility of cationic groups; then react de-protonated comb-shaped polybenzimidazole with quaternization reagent to attach the pendent side chain with cationic functional groups, making it easy to aggregate to form ion clusters and hydrophilic/hydrophobic microphase separation. The anion exchange membrane prepared in this invention has excellent conductivity, mechanical properties and alkaline stability.

Abstract: An automobile hub fixture includes a fixture body and a positioning apparatus. The fixture body includes a fixed platform and a plurality of clamping claws arranged at intervals in a circumferential direction of the fixed platform. The clamping claws are configured to clamp an outer rim of a hub. The plurality of clamping claws are connected to a driving member by using a linkage, and the driving member drives the clamping claws to radially move along the fixed platform. The positioning apparatus includes a movable platform slidably connected to the clamping claws. A positioning module configured to position an inner rim or the outer rim of the hub is mounted to the movable platform. The machining device includes a fixture, a machine tool, and a minimal quantity lubrication apparatus. The production line includes a machining device, a loading system, a loading and unloading manipulator, and a catching table.

Abstract: The present invention relates to a powder dry-pressing molding device and method.