Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.

Abstract: The disclosure provides an earphone and a fabrication method thereof. The earphone includes: an earphone wire, wherein the earphone wire includes flexible wire parts and hard wire parts which are arranged alternately. The technical scheme provided in the disclosure solves the problem existing in the related technologies that earphone wires entwine easily and cannot be untangled readily and therefore effectively avoids the entwining of earphone wires and improves user experience.

Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.

Abstract: The present invention is related to novel 20-sulfonylamidine derivatives of camptothecin (1), method of synthesizing the same, and use thereof as an antitumor agent, for examples an antitumor agent for treating nasopharyngeal, lung, breast or prostate cancer.

Abstract: Disclosed in the present disclosure are substances having tyrosine kinase inhibitory activity and a preparation method and use thereof, wherein the substances are the compounds having the structure of general formula (I) or the geometric isomers or pharmaceutical salts thereof. Through evaluation on tyrosine kinase inhibitory activity and related experiments, the present disclosure demonstrates that these compounds have a good tyrosine kinase inhibitory activity, and may inhibit a variety of tumor cells, and thus may be developed into drugs for preventing and treating tumor diseases, especially liver cancer, lung cancer and neuroblastoma.

Abstract: A three-dimensional scaffold microstructure comprising a plurality of collapsed polymer columns for use in cell culture or nematode studies.

Abstract: The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.

Abstract: The disclosure provides an earphone and a fabrication method thereof. The earphone includes: an earphone wire, wherein the earphone wire includes flexible wire parts and hard wire parts which are arranged alternately. The technical scheme provided in the disclosure solves the problem existing in the related technologies that earphone wires entwine easily and cannot be untangled readily and therefore effectively avoids the entwining of earphone wires and improves user experience.

Abstract: The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose ratio in the cell culture media formulation.

Abstract: A LED lamp with omnidirectional beam angle, comprises a lamp bulb shell and a light emitting unit. The lamp bulb shell covers the light emitting unit. The LED lamp with omnidirectional beam angle also comprises a reflecting unit. The reflecting unit comprises a reflecting member, and the reflecting member is fixed on the lamp bulb shell. The reflecting member is provided with an annular reflecting surface, and the annular reflecting surface of the reflecting member is arranged corresponding to the light emitting unit in order to reflect the light emitted from the light emitting unit to the bottom of the lamp bulb shell. The LED lamp with omnidirectional beam angle has the advantage of simple structure.

Abstract: The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.

Abstract: This application discloses silicon solar cells manifesting enhanced light induced degradation characteristics. The application also discloses silicon solar cells with a silicon-based substrate comprising boron, oxygen and carbon, and an antireflective coating (ARC) containing at least one carbon-containing layer adjacent to the substrate. Also disclosed are methods for preparing solar cells.

Abstract: A one-piece core-making technique used in producing railway truck bolsters and side frames, which includes the following steps: 1. After scraping the top of a core box, applying a shaped top mould (11), which is precisely located, from top to bottom. 2. Press or slightly hit the top mould (11) to make sure the top mould covers/caps the scraping surface. 3. Keep pressing to make sure that the flat scraping surface was pressed to a required curved shape, like the shape of the top mould (11). 4. Last, it will become a one-piece core with a partially integrated inner cavity section. The one-piece core made by this technique has a smooth surface. This technique also can improve the internal quality of the product and ease work intensity.

Abstract: The present invention provides compounds of Formula I: compositions containing the same, and methods of use thereof such as for the treatment of cancer.

Abstract: A simple, effective and scalable method for fabricating carbon nanotubes. The method has two simple steps: (a) producing the carbon precursors (i.e., nanotubes of conducting polymer) in water solution via a soft template method involving a fibrillar complex and (b) carbonizing the carbon precursors (i.e. the nanotubes of the conducting polymer) at a temperature between 900-2200° C. in a nitrogen atmosphere or under a vacuum condition.

Abstract: Herein is disclosed a magnetic resonance imaging probe, having a probe shaft including a magnetic resonance antenna, and a spring tip attached to a distal end of the antenna.

Abstract: An integer cored craftwork of lorry with swing bolster and sideframe includes: a baroque top mold (11) being located exactly from above to below as sand on the surface of core box being finished to blow. The top mold (11) is pressed for being buckled on the surface of blowing sand, then a definite journey of pressure quantity is finished downwards, so that the locally even surface of blowing sand is extruded to be a curved shape up to the mustard according to the shape of the baroque top mold (11). Finally the integer core forming a integrate lumen section of a cast is finished. It provides a slick surface of integer core while improving the inherent quality of cast and easing the work intension.

Abstract: Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering or delivering therapeutic agents including genes and/or drugs to the tissues of the vessel. Such a method includes positioning a thermal energy delivery device proximal a target site with the vessel of a body and activating the thermal energy delivery device so as to heat the target site thereby locally increasing a temperature of tissue at the target site. In further embodiments, the method includes introducing a therapeutic medium to the target site over a predetermined time period, and wherein said activating occurs at least one of before, during or after said step of introducing.

Abstract: Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel. More particularly featured are such devices, systems and methods for use when administering or delivering therapeutic agents including genes and/or drugs to the tissues of the vessel. Such a method includes positioning a thermal energy delivery device proximal a target site within the vessel of a body and activating the thermal energy delivery device so as to heat the target site thereby locally increasing a temperature of tissue at the target site. In further embodiments, the method includes introducing a therapeutic medium to the target site over a predetermined time period, and wherein said activating occurs at least one of before, during or after said step of introducing.

Abstract: The present invention provides a vaccine production strain of Bordetella bronchiseptica that produces a pertussis toxin in high yield. The present invention provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin comprising the steps of introducing a plasmid containing a DNA encoding antibiotic resistance into a Bordetella bronchiseptica strain, selecting for isolates in which the DNA encoding antibiotic resistance is recombinantly incorporated into the chromosome in place of the Bordetella bronchiseptica toxin gene, introducing a plasmid containing DNA encoding subunits of the Bordetella pertussis toxins into the Bordetella bronchiseptica isolates; and, selecting for isolates in which DNA encoding Bordetella pertussis toxin subunit is recombinantly incorporated into the chromosome, the resulting cells producing the Bordetella pertussis toxin.