Abstract: Provided is a catenated VAR2CSA recombinant protein, a preparation therefor and a use thereof. The catenated VAR2CSA recombinant protein comprises a binding domain, SpyTag, a p53dim structural domain, and SpyCatcher, which are randomly arranged. The binding domain comprises a structural domain, in the VAR2CSA protein, binding to placenta-like chondroitin sulfate A. The catenated VAR2CSA recombinant protein has high stability and affinity to the tumor-specific antigen placenta-like chondroitin sulfate A, and can be effectively used in the field of tumor immunotherapy, such as immune cell therapy.

Abstract: The present disclosure relates to codon-optimized sequences coding for hGCDH polypeptide and recombinant adeno-associated virus (rAAV) vectors comprising one of said sequences under the control of a promoter component. Also provided herein are viral particles comprising the rAAV vector, a pharmaceutical composition comprising the rAAV vector or the viral particles, and uses thereof in treating Glutaric aciduria type I (GA-I).

Abstract: A combination of an anti-TROP-2 antibody-drug conjugate and anti-PD-L1 antibody or other chemotherapeutic drugs such as Carboplatin or Cisplatin, and an application of the combination in the preparation of drugs for preventing and/or treating tumor diseases, wherein the anti-TROP-2 antibody may be Sacituzumab.

Abstract: Provided are a chimeric antigen receptor and an application thereof; said chimeric antigen receptor contains a domain which identifies any one of, or a combination of at least two of, the malarial protein VAR2CSA, a protein tag on malarial protein VAR2CSA, or a compound capable of labeling the malarial protein VAR2CSA. The chimeric antigen receptor can identify the VAR2CSA protein or the recombinant protein (rVAR2) of any one of, or at least two of, the domains of the VAR2CSA protein which can bind to placental-like chondroitin sulfate A (pl-CSA). The VAR2CSA protein or rVAS2 protein is capable of targeting several different types of tumor cells by means of binding to the pl-CSA on the surface of the tumor cell.

Abstract: The invention relates to RO water purifier (100) with provision for dispensing hot or cold water. The device has a user-interface through which a user can choose how hot the purified water should be. The RO water purifier (100) comprises a compartment (9) for storage of pre-heated or pre-cooled purified water. The compartment comprises an inlet for return of any undispensed purified hot, cold, or ambient water to flow back from the user-interface. The compartment has an outlet for pre-heated or pre-cooled purified water to flow out into a device (8) for heating or cooling it further as desired by the user. The device for heating or cooling the purified ambient water is configured to heat the water to 80 to 95° C. or alternatively, is configured to cool it to 15 to 5° C., and wherein in said e compartment said pre-heated water is stored at 40 to 75° C. and when it is pre, cooled it is stored at 10 to 20° C., and wherein temperature of said purified ambient water is 25 to 40° C.

Abstract: A delivery device for delivering a pacing lead to a patient's heart includes an elongated sheath having a distal end, and a plurality of mapping electrodes positioned at the distal end. The distal end of the sheath may have a distal end face, and the mapping electrodes may include two electrodes that diametrically oppose one another at a position exposed on or spaced from the distal end face. The sheath includes a plurality of flexible sections spaced apart from one another, and a pull wire that causes the sheath to deflect from a substantially straight configuration to a dual hinged curved configuration that maneuvers and positions the electrodes in the vicinity of the bundle of His. The sheath may include a PTFE liner having axially oriented, platelet-like fibril features that enable the sheath to be split along its length from a proximal end to the distal end.

Abstract: A delivery device for delivering a pacing lead to the His bundle of a patient's heart includes an elongated sheath having a distal end, and a plurality of mapping electrodes positioned at the distal end. The distal end of the sheath may have a distal end face, and the mapping electrodes may include two electrodes that diametrically oppose one another at a position exposed on or spaced from the distal end face. The sheath includes a plurality of flexible sections spaced apart from one another, and a pull wire that causes the sheath to deflect from a substantially straight configuration to a dual hinged curved configuration that maneuvers and positions the electrodes in the vicinity of the bundle of His. The sheath may include a PTFE liner having axially oriented, platelet-like fibril features that enable the sheath to be split along its length from a proximal end to the distal end.

Abstract: The present disclosure relates generally to percutaneous heart pumps including a self-expandable and collapsible impeller housing fabricated from a mesh of a shape memory alloy, such as nitinol, and a base polymer coating and a top polymer coating. Specifically, the present disclosure relates to highly flexible and fluid-impermissible polymer coatings having improved adherence and performance properties on the metallic surfaces of the impeller housing mesh thus improving the overall performance of the percutaneous heart pumps.

Abstract: A gasket for a hemostasis valve includes an annular wall, a membrane, a central protrusion on the membrane, and a plurality of ligaments attached to the central protrusion extending radially to the annular wall. The membrane, central protrusion, and ligaments are divided by slits into a plurality of flaps, with each flap bounded along an outer circumferential edge by the annular wall, along an inner circumferential edge by the central protrusion, and along its radial edges by segments of the ligaments. Two such gaskets can be arranged, back-toback, in a hemostasis valve. To facilitate such assembly, each gasket can include a plurality of positioning protrusions extending axially and a plurality of positioning recesses set into a circumferential surface, with the protrusions and recesses having complementary shapes for proper interconnection and fit between gaskets.

Abstract: The present disclosure relates generally to percutaneous heart pumps including a self-expandable and collapsible impeller housing fabricated from a mesh of a shape memory alloy, such as nitinol, and a base polymer coating and a top polymer coating. Specifically, the present disclosure relates to highly flexible and fluid-impermissible polymer coatings having improved adherence and performance properties on the metallic surfaces of the impeller housing mesh thus improving the overall performance of the percutaneous heart pumps.

Abstract: An expandable cannula for a percutaneous heart pump includes a substantially open proximal end, a substantially open distal end and an elongate central portion disposed between the proximal end and the distal end. The elongate central portion has an inner surface and an opposing outer surface. The expandable cannula is made of a shape memory alloy having an austenite finish temperature Af that is at or below the body temperature of a human patient.

Abstract: A method of manufacturing a catheter shaft includes the steps of forming an inner layer of a first polymeric material, forming a plait matrix layer including a second polymeric material about the inner layer, and forming an outer layer of a third polymeric material about the plait matrix layer. The plait matrix layer includes a braided wire mesh partially or fully embedded within the second polymeric material, which is different from at least one of the first polymeric material forming the inner layer and the third polymeric material forming the outer layer. The second polymeric material has a higher yield strain and/or a lower hardness than at least the first polymeric material, and preferably both the first and the third polymeric materials. The first polymeric material and the third polymeric material may be different or the same. The catheter shaft may be formed by stepwise extrusion, co-extrusion, and/or reflow processes.

Abstract: A delivery device for delivering a pacing lead to the His bundle of a patient's heart includes an elongated sheath having a distal end, and a plurality of mapping electrodes positioned at the distal end. The distal end of the sheath may have a distal end face, and the mapping electrodes may include two electrodes that diametrically oppose one another at a position exposed on or spaced from the distal end face. The sheath includes a plurality of flexible sections spaced apart from one another, and a pull wire that causes the sheath to deflect from a substantially straight configuration to a dual hinged curved configuration that maneuvers and positions the electrodes in the vicinity of the bundle of His. The sheath may include a PTFE liner having axially oriented, platelet-like fibril features that enable the sheath to be split along its length from a proximal end to the distal end.

Abstract: An electronic cigarette includes a housing, wherein the housing is elongate and has a head end disposed toward the user and a tail end extending away from the user. The housing comprises a bottom cover and a shell section. A battery is retained within the housing. An atomizer tank cartridge fits to the housing. An electrical heating apparatus powered by the battery. A groove is formed between the bottom cover and the shell section. A trim piece is mounted between the bottom cover and shell section. The trim piece is a hot-melt material, and connected to the groove via a heating process. The trim piece passes around an external periphery of the housing. The trim piece is an epoxy resin material. The housing further comprises a removable mouthpiece cover attached at a head end.

Abstract: An intracardiac echocardiography catheter includes a shaft and an ultrasound transducer at a distal end of the shaft. The ultrasound transducer includes an outer polymeric encapsulant layer and a nanocoating applied to the outer polymeric encapsulant layer. The nanocoating is configured to provide increased surface lubricity and self-cleaning properties to the ultrasound transducer.

Abstract: A delivery device for delivering a pacing lead to the His bundle of a patient's heart includes an elongated sheath having a distal end, and a plurality of mapping electrodes positioned at the distal end. The distal end of the sheath may have a distal end face, and the mapping electrodes may include two electrodes that diametrically oppose one another at a position exposed on or spaced from the distal end face. The sheath includes a plurality of flexible sections spaced apart from one another, and a pull wire that causes the sheath to deflect from a substantially straight configuration to a dual hinged curved configuration that maneuvers and positions the electrodes in the vicinity of the bundle of His. The sheath may include a PTFE liner having axially oriented, platelet-like fibril features that enable the sheath to be split along its length from a proximal end to the distal end.

Abstract: In various embodiments of the present disclosure, a surgical catheter is provided. The present disclosure provides a catheter shaft that includes a distal portion and a proximal portion. The proximal portion comprises a handle operably connected to the distal portion of the elongated structure. The distal portion three radially positioned polymeric layers. At least two of the layers include chemically dissimilar polymers and at least one of the three layers includes functionalized polyvinylidene fluoride (PVDF).

Abstract: Aspects of the present disclosure are directed to intravascular electrophysiology catheters including a catheter handle with a steering-wire locking mechanism.

Abstract: Embodiments include a catheter comprising a proximal handle, a distal tip, and a shaft extending between the proximal handle and the distal tip. The shaft comprises an outer polymer layer, and an inner polymer layer disposed adjacent to the outer polymer layer and defining an internal lumen. The inner polymer layer includes a blend of two or more polymers, and the blend of two or more polymers includes PTFE and one or more copolymers.

Abstract: A method of manufacturing a catheter shaft includes the steps of forming an inner layer of a first polymeric material, forming a plait matrix layer including a second polymeric material about the inner layer, and forming an outer layer of a third polymeric material about the plait matrix layer. The plait matrix layer includes a braided wire mesh partially or fully embedded within the second polymeric material, which is different from at least one of the first polymeric material forming the inner layer and the third polymeric material forming the outer layer. The second polymeric material has a higher yield strain and/or a lower hardness than at least the first polymeric material, and preferably both the first and the third polymeric materials. The first polymeric material and the third polymeric material may be different or the same. The catheter shaft may be formed by stepwise extrusion, co-extrusion, and/or reflow processes.