Abstract: Disclosed is a method and compounds for treating AMPK, cGAS, or ?F508-CFTR mediated diseases, the method including administering one or more AMPK, cGAS, or CFTR DUBTACs to a subject who has an AMPK, cGAS, or ?F508-CFTR-mediated disease, the AMPK, cGAS, or CFTR DUBTACs being heterobifunctional small-molecule compounds (or bivalent compounds in short) including an AMPK, cGAS, or CFTR ligand conjugated to a de-ubiquitination tag (such as a small-molecule ligand of USP7) via a linker, which would stabilize AMPK, cGAS, or CFTR. The AMPK, cGAS, or ?F508-CFTR-mediated disease can be a disease resulting from AMPK, cGAS, or CFTR destabilization. The AMPK, cGAS, or ?F508-CFTR-mediated disease can have reduced AMPK, cGAS, or CFTR expression relative to a wild-type tissue of the same species and tissue type. The disclosed bivalent compounds stabilize AMPK, cGAS, or CFTR by recruiting USP7.

Abstract: A solar energy utilization device, comprising a cover (300), two double-sided light energy utilization units (100, 200), and a concentrating mirror structure (400). A first light energy utilization portion (110) of the first double-sided light energy utilization unit (100) faces the cover (300); the second double-sided light energy utilization unit (200) is arranged perpendicular to the first double-sided light energy utilization unit (100); at least part of the concentrating mirror structure (400) is located on the side of the first double-sided light energy utilization unit (100) facing away from the cover (300), and is used for enabling light to converge to a second light energy utilization portion (120) of the first double-sided light energy utilization unit (100) and enabling light to converge to at least one light energy utilization portion (210, 220) of the second double-sided light energy utilization unit (200).

Abstract: The present invention discloses a hot-rolled strip steel and manufacturing method therefor. The hot-rolled strip steel comprises the following components in mass percentage: C: 0.04-0.09%, Si?0.50%, Mn: 0.10-1.50%, P?0.03%, S?0.01%, Al?0.60%, Cr: 1.5-4.5%, Cu: 0.10-0.60%, Ti: 0.05-0.18%, Ni?0.30%, Nb?0.06%, N?0.008%, and the balance being Fe and inevitable impurities, and the hot-rolled strip steel further satisfies: 2Mn+Cr?6%, with element symbols being substituted with mass percentages of corresponding chemical elements in the hot-rolled strip steel for calculation. The present invention shows excellent resistance to atmospheric corrosion and mechanical properties.

Abstract: Disclosed are small molecule ubiquitin carboxyl-terminal hydrolase 2 (USP2) inhibitors which display great potency in inhibiting cancer cell proliferation by elevating wild type P53 levels, reducing cyclin D levels or blocking ACE2 dependent virus from entering host cells by reducing ACE2 levels. The results indicate that these USP2 inhibitors have potential to be used in treating various diseases, including cancer and virus infection depending on ACE2.

Abstract: A solar energy utilization device, comprising a light energy utilization device (200) and a convex light concentrating device (100). The convex light concentrating device (100) is filled with a transparent liquid (130). The convex light concentrating device (100) has a light-transmissive convex sidewall (110) provided obliquely, and sunlight can be transmitted to the transparent liquid (130) from the light-transmissive convex sidewall (110). A first light energy utilization part (210) is provided at the bottom of an accommodating cavity, and sunlight transmitted from the transparent liquid (130) to the light-transmissive convex sidewall (110) forms a total internal reflection phenomenon, so that the convex light concentrating device (100) more conveniently concentrates the sunlight onto the first light energy utilization part (210).

Abstract: A solar energy utilization device, comprising a light energy utilization device and at least one liquid light condensing device. The liquid light condensing device is filled with a transparent liquid. The liquid light condensing device has at least one photoreceptor capable of transmitting sunlight into the transparent liquid and a reflector that reflects incident sunlight. In the liquid light condensing device, the sunlight that is reflected by the reflector and then transmitted to the photoreceptor from the transparent liquid forms a total reflection phenomenon, such that the sunlight is prevented from being refracted from the photoreceptor after being reflected by the reflector into the transparent liquid. Thus more sunlight is condensed onto a light energy utilization part of the light energy utilization device, thereby improving the light condensing efficiency.

Abstract: A steel for high-strength aluminum clad substrate, comprising the following chemical elements by mass percent: C: 0.008-0.02%, 0<Si?0.005%, Mn: 0.25-0.5%, P: 0.018-0.03%, Al?0.005%, N: 0.0040-0.010%, Ti: 0.02-0.04%, O: 0.02-0.050%, and the balance being Fe and other inevitable impurities. The manufacturing method therefor comprises the steps of: (1) smelting and casting; (2) reheating: reheating a casting blank to 1180° C.-1250° C.; (3) rough rolling; (4) finish rolling; (5) coiling; and (6) cooling to room temperature. The steel for high-strength aluminum clad substrate has good strength and good plasticity.

Abstract: Disclosed is a solar energy utilization apparatus, comprising a liquid light-condensing unit (100), a light energy utilization unit (200) and a reflection groove (300), wherein the light energy utilization unit (200) has a first light energy utilization part (210) and a second light energy utilization part (220), and the liquid light-condensing unit (100) has a light-receiving surface larger than the width of the first light energy utilization part (210) and/or the second light energy utilization part (220), and can receive more sunlight. The liquid light-condensing unit (100) is filled with a transparent liquid (130), and sunlight can be transmitted through a transparent wall of the liquid light-condensing unit (100) and into the transparent liquid (130), and then form a total reflection phenomenon.

Abstract: Disclosed are a solar energy utilization apparatus and a combined structure thereof. The solar energy utilization apparatus comprises a transparent top cover, a reflection groove and a light energy utilization unit. The transparent top cover is provided with a first transparent part recessed inward and a second transparent part protruding upward from the recess of the first transparent part; and based on such structure, sunlight reflected and refracted to the outer side of the transparent top cover can be re-refracted from other regions to the inner side of the transparent top cover, thereby improving the quantity of light refracted into the transparent top cover.

Abstract: A battery material containment device comprises a lid; a housing case that is constructed and arranged to hold a battery material during a thermal analysis operation, the housing case including a threaded region for receiving and removably coupling with the lid to form a gas-tight seal and securing the battery material in the housing case; at least one vent for providing a gas flow path for the release of gasses generated by the battery material in the housing case during the thermal analysis operation; and a heat flow pathway between the battery material and a sensor that is maintained during the thermal analysis operation.

Abstract: The present invention provides a hot-rolled strip steel and manufacturing method therefor. The hot-rolled strip steel comprises the following components in mass percentage: C: 0.04 to 0.15%, Si?0.50%, Mn: 0.30 to 2.00%, Cr: 1.5 to 4.5%, Cu: 0.10 to 0.60%, P?0.03%, S?0.01%, and Al: 0.01 to 0.60%, with the balance being Fe and unavoidable impurities; and further satisfies: 2.5%?2Mn+Cr?6.0%, with elemental symbols being substituted with mass percentages of corresponding elements in the hot-rolled strip steel for calculation. The hot-rolled strip steel of the present invention exhibits excellent resistance to atmospheric corrosion and mechanical properties, and can be directly used for supporting bracket structural parts such as guardrails, mast towers and photovoltaics without coating on the surface.

Abstract: A solar energy utilization unit, comprising a light energy utilization device, a liquid light concentration device and a reflecting structure. The reflecting structure can reflect sunlight to the light energy utilization device located at middle part of the liquid light concentration device. In the liquid light concentration device, a transmission or total reflection phenomenon is formed by sunlight emitted from a transparent liquid to a light-transmitting sidewall or light-transmitting top wall. The reflecting structure can reflect some of sunlight, which is outside a receiving range of the liquid light concentration device, to the first light energy utilization portion and the second light energy utilization portion of the light energy utilization device, so as to improve the light concentration efficiency of the solar energy utilization unit.

Abstract: An integrated machine for automatic cutting, polishing, stacking, and unloading of substrates, including a laser cutting machine, a mechanical laser arm, a polishing machine, a polishing device, a first finished product placement rack, a second finished product placement rack, and an automatic stacking device. The mechanical laser arm is fixed on the frame of the laser cutting machine, the polishing device is fixed on the polishing machine, and the first finished product placement rack and the second finished product placement rack are arranged on both sides of the automatic stacking device. The present disclosure can achieve cutting the substrates of any size, and can automatically polish the edges of the cut substrates. The present disclosure has the characteristics of automation, integration, and multi-functionality, effectively reducing the number of supporting equipment and occupying space.

Abstract: An integrated machine for automatic cutting, polishing, stacking, and unloading of substrates, including a laser cutting machine, a mechanical laser arm, a polishing machine, a polishing device, a first finished product placement rack, a second finished product placement rack, and an automatic stacking device. The mechanical laser arm is fixed on the frame of the laser cutting machine, the polishing device is fixed on the polishing machine, and the first finished product placement rack and the second finished product placement rack are arranged on both sides of the automatic stacking device. The present disclosure can achieve cutting the substrates of any size, and can automatically polish the edges of the cut substrates. The present disclosure has the characteristics of automation, integration, and multi-functionality, effectively reducing the number of supporting equipment and occupying space.

Abstract: A computer implemented method analyzes a domain name. A number of processor units identifies the domain name for analysis. The number of processor units splits the domain name into tokens. The number of processor units combines the tokens into different arrangements to form permutated domain names. The number of processor units identifies features for the permutated domain names using a set of domain name databases. The number of processor units analyze the permutated domain names with the features to determine a maliciousness of the domain name.

Abstract: A device for unsealing a sample pan for a thermal analysis instrument includes a sample pan holder, an actuator element and a punch element. The sample pan holder is configured to secure the sample pan in a fixed position with respect to the sample pan holder. The actuator element is secured to the sample pan holder and is formed of a thermally sensitive material that changes the shape of the actuator element in response to a change in an external temperature to a transition temperature. The punch element is attached to the actuator element and is positioned with respect to the sample pan such that the change in the shape of the actuator element in response to the change in the external temperature moves the punch element to puncture the sealing element to thereby expose the internal volume of the sample pan to an external environment.

Abstract: Disclosed is a solar energy utilization unit and a combined structure thereof. The solar energy utilization unit comprises a light energy utilization means, a convex liquid light-concentrating means, a first reflection formation and a second reflection formation. The first reflection formation can reflect sunlight to the convex liquid light-concentrating means. The sunlight emitted, in the convex liquid light-concentrating means, from a transparent liquid to a transparent convex sidewall produces the phenomenon of total reflection, such that more sunlight can be concentrated onto the first light energy utilization part of the light energy utilization means.

Abstract: REPLACEMENT A solar energy utilization unit and a combined formation thereof. The solar energy utilization unit comprises a light energy utilization device (100), a liquid light concentration device (200) and a reflection structure (300). The liquid light concentration device (200) has an accommodating chamber filled with a transparent liquid (201). The liquid light concentration device (200) forms a structure capable of transmitting and/or totally reflecting sunlight to a first light energy utilization portion (110) of the light energy utilization device (100). A light reflection chamber (310) is formed between the reflection structure (300), a second light energy utilization portion (120) and the liquid light concentration device (200). The reflection structure (300) is capable of reflecting sunlight entering the light reflection chamber (310) to the second light energy utilization portion (120).

Abstract: Disclosed are a solar energy utilization apparatus and a combined structure thereof. The solar energy utilization apparatus comprises a transparent top cover, a reflection groove and a light energy utilization unit. The transparent top cover is provided with a first transparent part recessed inward and a second transparent part protruding upward from the recess of the first transparent part; and based on such structure, sunlight reflected and refracted to the outer side of the transparent top cover can be re-refracted from other regions to the inner side of the transparent top cover, thereby improving the quantity of light refracted into the transparent top cover.

Abstract: Disclosed is a solar energy utilization apparatus, comprising a liquid light-condensing unit (100), a light energy utilization unit (200) and a reflection groove (300), wherein the light energy utilization unit (200) has a first light energy utilization part (210) and a second light energy utilization part (220), and the liquid light-condensing unit (100) has a light-receiving surface larger than the width of the first light energy utilization part (210) and/or the second light energy utilization part (220), and can receive more sunlight. The liquid light-condensing unit (100) is filled with a transparent liquid (130), and sunlight can be transmitted through a transparent wall of the liquid light-condensing unit (100) and into the transparent liquid (130), and then form a total reflection phenomenon.