Patents by Inventor Xiaoqin Wang

Xiaoqin Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9554989
    Abstract: The present invention is directed to silk-based drug delivery compositions for controlled, sustained delivery of therapeutic agent(s) as well as methods of making and using the same.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: January 31, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Tuna Yucel, Michael L. Lovett, Xiaoqin Wang
  • Patent number: 9381164
    Abstract: The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: July 5, 2016
    Assignee: Trustees of Tufts College
    Inventors: Xiaoqin Wang, David L. Kaplan
  • Publication number: 20160038637
    Abstract: The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be shaped into 3-dimentional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.
    Type: Application
    Filed: June 30, 2015
    Publication date: February 11, 2016
    Applicant: Trustees of Tufts College
    Inventors: Shenzhou Lu, Xiaoqin Wang, Fiorenzo Omenetto, David L. Kaplan
  • Patent number: 9254333
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 9, 2016
    Assignee: Trustees of Tufts College
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Publication number: 20150273021
    Abstract: The present invention is directed to silk-based drug delivery compositions or compositions for sustained delivery of therapeutic agent(s), such as glucagon-like peptide (GLP-1) receptor agonists, as well as methods of making and using the same.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 1, 2015
    Inventors: David L. Kaplan, Michael Lovett, Tuna Yucel, Xiaoqin Wang
  • Publication number: 20150258199
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Application
    Filed: January 23, 2015
    Publication date: September 17, 2015
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Publication number: 20150238617
    Abstract: The present invention on directed to silk-based drug delivery compositions for sustained delivery of drugs, e.g., for cancer therapy, and methods of their use for treatment.
    Type: Application
    Filed: October 11, 2013
    Publication date: August 27, 2015
    Inventors: David L. Kaplan, Tuna Yucel, Michael Lovett, Xiaoqin Wang
  • Publication number: 20150150993
    Abstract: Provided herein relates to compositions and methods for lubrication of a surface. The surface amenable to the compositions and methods described herein can be a non-biological surface, a biological surface, or a combination thereof. In some embodiments, the composition comprising a phospholipid-coated silk microsphere can be used for lubrication of a surface. In some embodiments, the composition comprising a phospholipid-coated silk microsphere can be used for joint lubrication, e.g., for treatment of joint disorders such as arthritis.
    Type: Application
    Filed: April 25, 2013
    Publication date: June 4, 2015
    Inventors: David L. Kaplan, Xiaoqin Wang, Vijay John, Noshir Pesika, Rubo Zheng
  • Publication number: 20150093363
    Abstract: The present invention relates to a method for inducing and/or promoting osteogenic differentiation using extracellular vesicles and the use thereof.
    Type: Application
    Filed: May 10, 2013
    Publication date: April 2, 2015
    Inventors: Karin Ekström, Peter Thomsen, Jukka Lausmaa, Omar Omar, Xiaoqin Wang
  • Publication number: 20150056293
    Abstract: The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 26, 2015
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Xiaoqin Wang, David L. Kaplan
  • Publication number: 20150056294
    Abstract: Provided herein relates to methods and compositions for preparing a silk microsphere and the resulting silk microsphere. In some embodiments, the methods and compositions described herein are all aqueous, which can be used for encapsulating an active agent in a silk microsphere, while maintaining activity of the active agent during processing. In some embodiments, the resulting silk microsphere can be used for sustained delivery of an active agent encapsulated therein.
    Type: Application
    Filed: April 12, 2013
    Publication date: February 26, 2015
    Inventors: David L. Kaplan, Tuna Yucel, Xiaoqin Wang, Michael Lovett
  • Publication number: 20150045764
    Abstract: The present invention is directed to silk-based drug delivery compositions for controlled, sustained delivery of therapeutic agent(s) as well as methods of making and using the same.
    Type: Application
    Filed: March 11, 2013
    Publication date: February 12, 2015
    Inventors: David L. Kaplan, Tuna Yucel, Michael L. Lovett, Xiaoqin Wang
  • Publication number: 20150037422
    Abstract: Embodiments of various aspects described herein are directed to silk-based compositions for ocular delivery of at least one active agent, e.g., at least one therapeutic agent and methods of using the same. In some embodiments, the silk-based compositions can provide sustained release of at least one therapeutic agent to at least a portion of an eye. Thus, some embodiments of the silk-based compositions can be used for treatment of an ocular condition, e.g., age-related macular degeneration.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 5, 2015
    Inventors: David L. Kaplan, Michael L. Lovett, Xiaoqin Wang, Tuna Yucel
  • Publication number: 20140343120
    Abstract: Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as NPRA and NPRC, or combinations of these therapies. Routes used for delivering polynucleotides encoding a natriuretic peptide, or, for example, siRNA that down regulates natriuretic peptide receptor include subcutaneous injection, oral gavage, transdermal and intranasal delivery routes. Compositions can include chitosan, chitosan derivatives, and chitosan derivative and a lipid. Transdermal delivery can use a transdermal cream. Intranasal delivery can use a dropper or an aspirator for delivery of a mist. Oral gavage delivers equivalent to oral delivery.
    Type: Application
    Filed: December 11, 2013
    Publication date: November 20, 2014
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: SHYAM S. MOHAPATRA, WEIDONG XU, XIAOYUAN KONG, XIAOQIN WANG, SUBHRA MOHAPATRA
  • Publication number: 20140303346
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Application
    Filed: April 7, 2014
    Publication date: October 9, 2014
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Patent number: 8722067
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: May 13, 2014
    Assignee: Trustees of Tufts College
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Patent number: 8715740
    Abstract: The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: May 6, 2014
    Assignee: Trustees of Tufts College
    Inventors: Xiaoqin Wang, David L. Kaplan
  • Publication number: 20140105978
    Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
    Type: Application
    Filed: October 17, 2013
    Publication date: April 17, 2014
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Xiaoqin Wang
  • Publication number: 20130243866
    Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
    Type: Application
    Filed: May 7, 2013
    Publication date: September 19, 2013
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. KAPLAN, Xiaoqin WANG
  • Patent number: 8483081
    Abstract: The present invention discloses a method for estimating quality of a link in a broad-band wireless communication system. The method includes: calculating quality indicators of sub-carriers in an input signal of a receiver of the system; clipping the quality indicators of the sub-carriers; and averaging the clipped quality indicators of the sub-carriers to obtain an average value as an estimation result of an effective quality indicator of the link. The present application also discloses an apparatus for estimating quality of a link in a broad-band wireless communication system, an adaption method and apparatus for a link in a broad-band wireless communication system. The methods and apparatus of the present invention can achieve relatively low calculation complexity and high accuracy.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: July 9, 2013
    Assignee: Fujitsu Limited
    Inventors: Xiaoqin Wang, Xin Wang, Masahiro Watanabe, Taiji Kondo