Patents by Inventor Xiaoqin Wang
Xiaoqin Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150037422Abstract: Embodiments of various aspects described herein are directed to silk-based compositions for ocular delivery of at least one active agent, e.g., at least one therapeutic agent and methods of using the same. In some embodiments, the silk-based compositions can provide sustained release of at least one therapeutic agent to at least a portion of an eye. Thus, some embodiments of the silk-based compositions can be used for treatment of an ocular condition, e.g., age-related macular degeneration.Type: ApplicationFiled: February 22, 2013Publication date: February 5, 2015Inventors: David L. Kaplan, Michael L. Lovett, Xiaoqin Wang, Tuna Yucel
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Publication number: 20140343120Abstract: Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as NPRA and NPRC, or combinations of these therapies. Routes used for delivering polynucleotides encoding a natriuretic peptide, or, for example, siRNA that down regulates natriuretic peptide receptor include subcutaneous injection, oral gavage, transdermal and intranasal delivery routes. Compositions can include chitosan, chitosan derivatives, and chitosan derivative and a lipid. Transdermal delivery can use a transdermal cream. Intranasal delivery can use a dropper or an aspirator for delivery of a mist. Oral gavage delivers equivalent to oral delivery.Type: ApplicationFiled: December 11, 2013Publication date: November 20, 2014Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: SHYAM S. MOHAPATRA, WEIDONG XU, XIAOYUAN KONG, XIAOQIN WANG, SUBHRA MOHAPATRA
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Publication number: 20140303346Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.Type: ApplicationFiled: April 7, 2014Publication date: October 9, 2014Applicant: TRUSTEES OF TUFTS COLLEGEInventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
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Patent number: 8722067Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.Type: GrantFiled: April 27, 2012Date of Patent: May 13, 2014Assignee: Trustees of Tufts CollegeInventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
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Patent number: 8715740Abstract: The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles.Type: GrantFiled: September 29, 2010Date of Patent: May 6, 2014Assignee: Trustees of Tufts CollegeInventors: Xiaoqin Wang, David L. Kaplan
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Publication number: 20140105978Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.Type: ApplicationFiled: October 17, 2013Publication date: April 17, 2014Applicant: TRUSTEES OF TUFTS COLLEGEInventors: David L. Kaplan, Xiaoqin Wang
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Publication number: 20130243866Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.Type: ApplicationFiled: May 7, 2013Publication date: September 19, 2013Applicant: TRUSTEES OF TUFTS COLLEGEInventors: David L. KAPLAN, Xiaoqin WANG
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Patent number: 8483081Abstract: The present invention discloses a method for estimating quality of a link in a broad-band wireless communication system. The method includes: calculating quality indicators of sub-carriers in an input signal of a receiver of the system; clipping the quality indicators of the sub-carriers; and averaging the clipped quality indicators of the sub-carriers to obtain an average value as an estimation result of an effective quality indicator of the link. The present application also discloses an apparatus for estimating quality of a link in a broad-band wireless communication system, an adaption method and apparatus for a link in a broad-band wireless communication system. The methods and apparatus of the present invention can achieve relatively low calculation complexity and high accuracy.Type: GrantFiled: October 20, 2010Date of Patent: July 9, 2013Assignee: Fujitsu LimitedInventors: Xiaoqin Wang, Xin Wang, Masahiro Watanabe, Taiji Kondo
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Publication number: 20130171260Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.Type: ApplicationFiled: February 27, 2013Publication date: July 4, 2013Applicant: TRUSTEES OF TUFTS COLLEGEInventors: David L. Kaplan, Xiaoqin Wang
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Publication number: 20130060008Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.Type: ApplicationFiled: April 27, 2012Publication date: March 7, 2013Applicant: TRUSTEES OF TUFTS COLLEGEInventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
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Patent number: 8293486Abstract: The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.Type: GrantFiled: July 20, 2010Date of Patent: October 23, 2012Assignee: Trustees of Tufts CollegeInventors: David L. Kaplan, Xiaoqin Wang, Monica A. Serban
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Publication number: 20120187591Abstract: The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped.Type: ApplicationFiled: September 29, 2010Publication date: July 26, 2012Applicant: TRUSTEES OF TUFTS COLLEGEInventors: Xiaoqin Wang, David L. Kaplan
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Patent number: 8187616Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.Type: GrantFiled: May 29, 2008Date of Patent: May 29, 2012Assignee: Trustees of Tufts CollegeInventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
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Publication number: 20120129255Abstract: The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.Type: ApplicationFiled: July 20, 2010Publication date: May 24, 2012Applicant: TRUSTEES OF TUFTS COLLEGEInventors: David L. Kaplan, Xiaoqin Wang, Monica A. Serban
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Patent number: 8071560Abstract: This invention pertains to inhibitors of atrial natriuretic peptide receptor A (NPRA) function, such as small interfering RNA (siRNA), useful for reducing the inflammation associated with many human diseases, such as asthma, respiratory syncytial virus (RSV) infection, and cancers (such as melanoma, lung cancer, and/or ovarian cancer) by interfering with NPRA gene expression or otherwise reducing NPRA function within a subject; and methods for treating a subject suffering from, or at risk of developing, an inflammatory disease, respiratory allergy (such as allergic rhinitis and asthma), viral infection, and/or cancer by administering such NPRA inhibitors to the subject.Type: GrantFiled: April 30, 2007Date of Patent: December 6, 2011Assignee: University of South FloridaInventors: Shyam S. Mohapatra, Weidong Xu, Xiaoyuan Kong, Xiaoqin Wang
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Publication number: 20110223153Abstract: The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be into 3-dimentional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.Type: ApplicationFiled: October 9, 2009Publication date: September 15, 2011Applicant: TRUSTEES OF TUFTS COLLEGEInventors: Shenzhou Lu, Xiaoqin Wang, Fiorenzo Omenetto, David Kaplan
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Publication number: 20110122787Abstract: The present invention discloses a method for estimating quality of a link in a broad-band wireless communication system. The method includes: calculating quality indicators of sub-carriers in an input signal of a receiver of the system; clipping the quality indicators of the sub-carriers; and averaging the clipped quality indicators of the sub-carriers to obtain an average value as an estimation result of an effective quality indicator of the link. The present application also discloses an apparatus for estimating quality of a link in a broad-band wireless communication system, an adaption method and apparatus for a link in a broad-band wireless communication system. The methods and apparatus of the present invention can achieve relatively low calculation complexity and high accuracy.Type: ApplicationFiled: October 20, 2010Publication date: May 26, 2011Applicant: FUJITSU LIMITEDInventors: Xiaoqin Wang, Xin Wang, Masahiro Watanabe, Taiji Kondo
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Publication number: 20100178304Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.Type: ApplicationFiled: May 29, 2008Publication date: July 15, 2010Applicant: TRUSTEES OF TUFTS COLLEGEInventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
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Publication number: 20100028451Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.Type: ApplicationFiled: September 26, 2007Publication date: February 4, 2010Applicant: TRUSTEES OF TUFTS COLLEGEInventors: David L. Kaplan, Xiaoqin Wang
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Publication number: 20080214437Abstract: Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as NPRA and NPRC, or combinations of these therapies. Routes used for delivering polynucleotides encoding a natriuretic peptide, or, for example, siRNA that down regulates natriuretic peptide receptor include subcutaneous injection, oral gavage, transdermal and intranasal delivery routes. Compositions can include chitosan, chitosan derivatives, and chitosan derivative and a lipid. Transdermal delivery can use a transdermal cream. Intranasal delivery can use a dropper or an aspirator for delivery of a mist. Oral gavage delivers equivalent to oral delivery.Type: ApplicationFiled: November 30, 2007Publication date: September 4, 2008Inventors: Shyam S. Mohapatra, Weidong Xu, Xiaoyuan Kong, Xiaoqin Wang, Subhra Mohapatra