Patents by Inventor Xiaoqin Wang

Xiaoqin Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130171260
    Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
    Type: Application
    Filed: February 27, 2013
    Publication date: July 4, 2013
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Xiaoqin Wang
  • Publication number: 20130060008
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Application
    Filed: April 27, 2012
    Publication date: March 7, 2013
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Patent number: 8293486
    Abstract: The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: October 23, 2012
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Xiaoqin Wang, Monica A. Serban
  • Publication number: 20120187591
    Abstract: The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped.
    Type: Application
    Filed: September 29, 2010
    Publication date: July 26, 2012
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Xiaoqin Wang, David L. Kaplan
  • Patent number: 8187616
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: May 29, 2012
    Assignee: Trustees of Tufts College
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Publication number: 20120129255
    Abstract: The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.
    Type: Application
    Filed: July 20, 2010
    Publication date: May 24, 2012
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Xiaoqin Wang, Monica A. Serban
  • Patent number: 8071560
    Abstract: This invention pertains to inhibitors of atrial natriuretic peptide receptor A (NPRA) function, such as small interfering RNA (siRNA), useful for reducing the inflammation associated with many human diseases, such as asthma, respiratory syncytial virus (RSV) infection, and cancers (such as melanoma, lung cancer, and/or ovarian cancer) by interfering with NPRA gene expression or otherwise reducing NPRA function within a subject; and methods for treating a subject suffering from, or at risk of developing, an inflammatory disease, respiratory allergy (such as allergic rhinitis and asthma), viral infection, and/or cancer by administering such NPRA inhibitors to the subject.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: December 6, 2011
    Assignee: University of South Florida
    Inventors: Shyam S. Mohapatra, Weidong Xu, Xiaoyuan Kong, Xiaoqin Wang
  • Publication number: 20110223153
    Abstract: The present invention provides for compositions and methods for preparing aqueous insoluble, ductile, flexible silk fibroin films. The silk films comprise silk fibroin and about 10% to about 50% (w/w) glycerol, and are prepared by entirely aqueous processes. The ductile silk film may be further treated by extracting the glycerol from and re-drying the silk film. Active agents may be embedded in or deposited on the glycerol modified silk film for a variety of medical applications. The films may be into 3-dimentional structures, or placed on support surfaces as labels or coatings. The glycerol modified silk films of the present invention are useful in variety of applications such as tissue engineering, medical devices or implants, drug delivery, and edible pharmaceutical or food labels.
    Type: Application
    Filed: October 9, 2009
    Publication date: September 15, 2011
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Shenzhou Lu, Xiaoqin Wang, Fiorenzo Omenetto, David Kaplan
  • Publication number: 20110122787
    Abstract: The present invention discloses a method for estimating quality of a link in a broad-band wireless communication system. The method includes: calculating quality indicators of sub-carriers in an input signal of a receiver of the system; clipping the quality indicators of the sub-carriers; and averaging the clipped quality indicators of the sub-carriers to obtain an average value as an estimation result of an effective quality indicator of the link. The present application also discloses an apparatus for estimating quality of a link in a broad-band wireless communication system, an adaption method and apparatus for a link in a broad-band wireless communication system. The methods and apparatus of the present invention can achieve relatively low calculation complexity and high accuracy.
    Type: Application
    Filed: October 20, 2010
    Publication date: May 26, 2011
    Applicant: FUJITSU LIMITED
    Inventors: Xiaoqin Wang, Xin Wang, Masahiro Watanabe, Taiji Kondo
  • Publication number: 20100178304
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Application
    Filed: May 29, 2008
    Publication date: July 15, 2010
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Publication number: 20100028451
    Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
    Type: Application
    Filed: September 26, 2007
    Publication date: February 4, 2010
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Xiaoqin Wang
  • Publication number: 20080214437
    Abstract: Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as NPRA and NPRC, or combinations of these therapies. Routes used for delivering polynucleotides encoding a natriuretic peptide, or, for example, siRNA that down regulates natriuretic peptide receptor include subcutaneous injection, oral gavage, transdermal and intranasal delivery routes. Compositions can include chitosan, chitosan derivatives, and chitosan derivative and a lipid. Transdermal delivery can use a transdermal cream. Intranasal delivery can use a dropper or an aspirator for delivery of a mist. Oral gavage delivers equivalent to oral delivery.
    Type: Application
    Filed: November 30, 2007
    Publication date: September 4, 2008
    Inventors: Shyam S. Mohapatra, Weidong Xu, Xiaoyuan Kong, Xiaoqin Wang, Subhra Mohapatra
  • Publication number: 20070265204
    Abstract: This invention pertains to inhibitors of atrial natriuretic peptide receptor A (NPRA) function, such as small interfering RNA (siRNA), useful for reducing the inflammation associated with many human diseases, such as asthma, respiratory syncytial virus (RSV) infection, and cancers (such as melanoma, lung cancer, and/or ovarian cancer) by interfering with NPRA gene expression or otherwise reducing NPRA function within a subject; and methods for treating a subject suffering from, or at risk of developing, an inflammatory disease, respiratory allergy (such as allergic rhinitis and asthma), viral infection, and/or cancer by administering such NPRA inhibitors to the subject.
    Type: Application
    Filed: April 30, 2007
    Publication date: November 15, 2007
    Applicant: University of South Florida
    Inventors: Shyam Mohapatra, Weidong Xu, Xiaoyuan Kong, Xiaoqin Wang