Patents by Inventor Xiaowu Chen

Xiaowu Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pre-organized tricyclic integrase inhibitor compounds
    Publication number: 20090029939
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl, Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
    Type: Application
    Filed: May 25, 2007
    Publication date: January 29, 2009
    Inventors: James M. Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung U. Kim, Laura N. Schacherer
  • Phosphonate compounds having immuno-modulatory activity
    Patent number: 7470724
    Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: December 30, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Alan X. Huang, Thorsten Kirschberg, Christopher P. Lee, Richard L. Mackman, Peter H. Nelson, Hyung-Jung Pyun, Adrian S. Ray, William J. Watkins, Jennifer R. Zhang, Sundaramoorthi Swaminathan
  • Non nucleoside reverse transcriptase inhibitors
    Patent number: 7462608
    Abstract: Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: December 9, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: James M. Chen, Xiaowu Chen, Choung U. Kim, William A. Lee, Christopher P. Lee, Peter H. Nelson, James D. Tario, Lianhong Xu
  • Anti-cancer phosphonate analogs
    Patent number: 7452901
    Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: November 18, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher P. Lee, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Peter H. Nelson, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang, Lijun Zhang
  • Anti-inflammatory phosphonate compounds
    Patent number: 7432261
    Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: October 7, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Craig Gibbs, Ralph F. Hirschmann, Thorsten Kirschberg, Christopher P. Lee, Kuei-Ying Lin, Richard L. Mackman, Peter H. Nelson, David A. Oare, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang
  • Antiviral phosphonate analogs
    Patent number: 7429565
    Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 30, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Haolun Jin, Ralph F. Hirschmann, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Christopher P. Lee, William A. Lee, Richard L. Mackman, David Y. Markevitch, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang
  • Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
    Patent number: 7427636
    Abstract: The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 23, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Thorsten Kirschberg, Hyung-Jung Pyun, William J. Watkins, Jennifer R. Zhang
  • Purine nucleoside phosphorylase inhibitory phosphonate compounds
    Patent number: 7427624
    Abstract: The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: September 23, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Thorsten Kirschberg, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins
  • Kinase inhibitory phosphonate analogs
    Patent number: 7417055
    Abstract: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: August 26, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Thorsten Kirschberg, Richard L. Mackman, Sundaramoorthi Swaminathan, William J. Watkins
  • Phosphonate analogs for treating metabolic diseases
    Patent number: 7407965
    Abstract: The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: August 5, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Thorsten Kirschberg, Steven Krawczyk, Hyung-Jung Pyun, William J. Watkins
  • Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds
    Publication number: 20080076738
    Abstract: Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
    Type: Application
    Filed: April 11, 2005
    Publication date: March 27, 2008
    Inventors: Zhenhong Cai, Xiaowu Chen, Maria Fardis, Salman Jabri, Haolun Jin, Choung Kim, Samuel Metobo, Michael Mish, Richard Pastor
  • Method and compositions for identifying anti-hiv therapeutic compounds
    Publication number: 20070190523
    Abstract: The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).
    Type: Application
    Filed: November 6, 2003
    Publication date: August 16, 2007
    Inventors: Gabriel Birkus, James Chen, Xiaowu Chen, Tomas Cihlar, Eugene Eisenberg, Marcos Hatada, Gong-Xin He, Choung Kim, William Lee, Martin McDermott, Sundaramoorthi Swaminathan
  • Pre-organized tricyclic integrase inhibitor compounds
    Patent number: 7253180
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: August 7, 2007
    Assignee: Gilead Sciences, Inc.
    Inventors: James M. Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung U. Kim, Laura N. Schacherer
  • Purine nucleoside phosphorylase inhibitory phosphonate compounds
    Publication number: 20070027113
    Abstract: The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: February 1, 2007
    Inventors: James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Thorsten Kirschberg, Adrian Ray, Sundaramoorthi Swaminathan, William Watkins
  • Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
    Publication number: 20070010489
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Application
    Filed: April 25, 2003
    Publication date: January 11, 2007
    Inventors: Murty Arimilli, Mark Becker, Clifford Bryant, James Chen, Xiaowu Chen, Azar Dastgah, Maria Fardis, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard Mackman, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Wiliams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Therapeutic phosphonate compounds
    Publication number: 20060264404
    Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
    Type: Application
    Filed: October 25, 2005
    Publication date: November 23, 2006
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Alan Huang, Haolun Jin, Choung Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher Lee, William Lee, Kuei-Ying Lin, Richard Mackman, David Markevitch, Peter Nelson, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang, Lijun Zhang
  • Pre-organized tricyclic integrase inhibitor compounds
    Publication number: 20060217410
    Abstract: Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. Formula (I). A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
    Type: Application
    Filed: October 16, 2003
    Publication date: September 28, 2006
    Inventors: James Chen, Xiaowu Chen, Maria Fardis, Haolun Jin, Choung Kim, Laura Schacherer
  • Anti-inflammatory phosphonate compounds
    Publication number: 20060199788
    Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 7, 2006
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Thorsten Kirschberg, Christopher Lee, Kuei-Ying Lin, Richard Mackman, Peter Nelson, David Oare, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang
  • Non nucleoside reverse transcriptase inhibitors
    Publication number: 20060128692
    Abstract: Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
    Type: Application
    Filed: April 25, 2003
    Publication date: June 15, 2006
    Applicant: Gilead Sciences, INC
    Inventors: James Chen, Xiaowu Chen, Choung Kim, William Lee, Christopher Lee, Peter Nelson, James Tario, Lianhong Xu
  • Method and compositions for identifying anti-hiv therapeutic compounds
    Publication number: 20060115815
    Abstract: Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
    Type: Application
    Filed: April 25, 2003
    Publication date: June 1, 2006
    Inventors: Gabriel Birkus, James Chen, Xiaowu Chen, Tomas Cihlar, Eugene Eisenberg, Marcos Hatada, Gong-Xi He, Choung Kim, William Lee, Martin McDermott, Sundaramoorthi Swaminathan