Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Abstract: The present disclosure provides a display apparatus, a timing controller and a control method thereof. The control method of the timing controller includes: receiving and storing a video stream, where the video stream includes n initial display frames arranged in sequence, n is greater than or equal to 2, and a frame frequency of each initial display frame sequentially increases or decreases from a first initial display frame to an n-th initial display frame; generating a luminance control signal and n modified display frames according to the n initial display frames, where the n modified display frames respectively correspond to the n initial display frames; the luminance control signal is a pulse signal and includes n control segments, and the n control segments respectively correspond to the n modified display frames; and sending the luminance control signal and the n modified display frames to a display panel, so that the display panel displays according to the modified display frames.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Abstract: A method and system for correcting misalignment of, or of aligning, images of one or more portions of a subject, the images obtained by a two- or three-dimensional medical imaging modality. The method comprises: in consecutive first and second two- or three-dimensional sub-volume scans, (a) identifying at least one first portion and at least one second portion respectively of a common anatomical feature or structure, and/or (b) determining first and second axes of objects (such as anatomical features or structures, or portions thereof) in the first and second sub-volume scans, respectively; determining, based on those portions, or based on the axes, a transformation that aligns or brings into registration the portions; aligning the first and second sub-volume scans by applying the transformation and forming aligned first and second sub-volume scans; generating an aligned image from the aligned first and second sub-volume scans; and outputting the aligned image.

Abstract: A method utilizing optical path difference in two-phase flow for analytical calculation of particle size gradation and solid content comprises: changing a width of measurement area of a laser particle size analyzer, and collecting extinction values at two different optical path lengths and a scattered light intensity signal on each detector during monitoring; utilizing the scattered light intensity signal with a long optical path to subtract the scattered light intensity signal with a short optical path on each detector to obtain a set of new scattered light intensity signals with background subtracted; processing particle size distribution inversion calculations for the set of scattered light intensity signals with background subtracted to obtain gradation data of solid particles; processing subtraction of the logarithm of the extinction value of the short optical path from the logarithm of the extinction value of the long optical path to obtain new extinction value; calculating the solid content based on th

Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Abstract: A fiber-metal laminate having a honeycomb sandwich structure and a preparation method thereof are provided. Firstly, based on material reduction processing technology, a recessed polygonal structure is obtained according to a design trajectory, and an upper layer and a lower layer are closed to form a recessed honeycomb sandwich structure. Then, processed surfaces of the upper layer and the lower layer are chemically treated to passivate the processed surfaces, with the aim of increasing the adhesion between a fiber layer and the metal layers. Then, a viscous mixture is filled into the recessed structures of the metal layers to ensure the multifunctional characteristics and impact resistance of the fiber-metal laminate. Then, a fiber prepreg is laid between the upper layer and the lower layer to obtain a prefabricated fiber-metal laminate. Finally, the prefabricated fiber-metal laminate undergoes thermal curing treatment under pressure in a hot-pressing tank, thereby obtaining the fiber-metal laminate.

Abstract: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.

Abstract: Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.

Abstract: A headset includes multiple pairs of acoustic sensors for capturing audio of a local area surrounding the headset. Each pair of acoustic sensors includes an acoustic sensor on a side of the headset and an additional acoustic sensor on an opposite side of the headset. One pair of acoustic sensors is positioned closer to the ears of a user than other pairs of acoustic sensors. The headset determines a filter for each pair of acoustic sensors that modifies audio captured by the acoustic sensors of a pair. Application of the filter causes audio captured by the pair of acoustic sensors to have sound similar to audio captured at the user's ears. In some embodiments, audio from multiple pairs of acoustic sensors is filtered by corresponding filters then combined.

Abstract: An auxiliary sputum excretion method for a non-invasive ventilator and the invasive ventilator, solving the technical problem of how to help a patient with non-invasive ventilation to excrete sputum. In the auxiliary sputum excretion method, a sputum excretion operation is initiated in each respiratory cycle of a patient after the non-invasive ventilator determines that the patient needs sputum excretion during a normal mechanical ventilation of the non-invasive ventilator for the patient, and the sputum excretion operation is stopped in response to determining that the patient needs to stop the sputum excretion.

Abstract: Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

Abstract: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.

Abstract: A method and system for training a machine learning model for reducing or removing a foreign material or artefacts due to a foreign material from an image of a subject, the method comprising: generating one or more first simulated images from one or more real or simulated images of the foreign material (and optionally artefacts due to the foreign material), and from one or more real images of one or more subjects that are free of the foreign material and of artefacts due to the foreign material, such that the generated simulated images include the foreign material and artefacts due to the foreign material; generating one or more predicted images employing at least the first simulated images with a machine learning network that implements a machine learning model; and training or updating the machine learning model with the machine learning network by reducing or minimizing a difference between the one or more predicted images and ground truth data comprising one or more real or simulated images.

Abstract: This invention provides methods for detecting viruses, viral antigens, viral antibodies, and other antigens and antibodies using single molecule electronic nanopores and polymer tags.

Abstract: This invention relates to the use of nucleoside, nucleotide and other compounds which are inhibitors or terminators of viral RNA dependent RNA polymerases or inhibitors of exonucleases as antiviral agents. These antiviral agents can be used alone or in combination with other polymerase or exonuclease inhibitors, helicase inhibitors, HCV NS5A inhibitors, HIV integrase inhibitors and HCV NS3-4A and other protease inhibitors to treat viral infections such as SARS-CoV-2, the causative agent of the COVID-19 infection.