Patents by Inventor Xiaoxu Li

Xiaoxu Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variable optical power splitter
    Patent number: 9164242
    Abstract: An apparatus and method for splitting and controlling optical powers provided by an input fiber and received by a plurality of output fibers comprises: (a) providing a first collimated beam from the input fiber using a first lens; (b) splitting the first collimated beam into a plurality of separated collimated beams having different directions using a collimated beam splitting device; (c) controlling area of each separated collimated beam by moving the collimated beam splitting device on a plane perpendicular to the first collimated beam; and (d) focusing the plurality of separated collimated beams using a second lens and coupling the focused beams into the plurality of output fibers, respectively.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: October 20, 2015
    Assignee: Alliance Fiber Optic Products, Inc.
    Inventors: Yao Li, Xiaoxu Li, Xinzhong Wang
  • Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
    Patent number: 9095601
    Abstract: A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2?-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: August 4, 2015
    Assignee: WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: Matthew L. Becker, Huafeng Fang, Xiaoxu Li, Dipanjan Pan, Raffaella Rossin, Xiankai Sun, John Stephen Taylor, Jeffrey L. Turner, Michael John Welch, Karen L. Wooley
  • UNIVERSAL METHYLATION PROFILING METHODS
    Publication number: 20150148240
    Abstract: This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns.
    Type: Application
    Filed: December 19, 2014
    Publication date: May 28, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Timothy H. Bestor, John R. Edwards, Jingyue Ju, Xiaoxu Li
  • FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS
    Publication number: 20140315191
    Abstract: This invention provides a process for sequencing single-stranded DNA employing modified nucleotides.
    Type: Application
    Filed: April 1, 2014
    Publication date: October 23, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li
  • CELL PERMEABLE NANOCONJUGATES OF SHELL-CROSSLINKED KNEDEL (SCK) AND PEPTIDE NUCLEIC ACIDS ("PNAs") WITH UNIQUELY EXPRESSED OR OVER-EXPRESSED mRNA TARGETING SEQUENCES FOR EARLY DIAGNOSIS AND THERAPY OF CANCER
    Publication number: 20130230452
    Abstract: A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2?-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
    Type: Application
    Filed: December 5, 2012
    Publication date: September 5, 2013
    Applicant: Washington University
    Inventors: Matthew L. Becker, Huafeng Fang, Xiaoxu Li, Dipanjan Pan, Raffaella Rossin, Xiankai Sun, John Stephen Taylor, Jeffrey L. Tumer, Michael John Welch, Karen L. Wooley
  • Electronic compensation of nonlinear effects of semiconductor optical amplifiers
    Patent number: 8452191
    Abstract: Systems and methods are disclosed for compensating for impairments caused by a semiconductor optical amplifier (SOA). One such method comprises receiving an optical signal which has been distorted in the physical domain by an SOA, and propagating the distorted optical signal backward in the electronic domain in a corresponding virtual SOA.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: May 28, 2013
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Guifang Li, Xiaoxu Li
  • Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
    Patent number: 8354093
    Abstract: A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2?-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: January 15, 2013
    Assignee: Washington University
    Inventors: Matthew L. Becker, Huafeng Fang, Xiaoxu Li, Dipanjan Pan, Raffaella Rossin, Xiankai Sun, John-Stephen Taylor, Jeffrey L. Turner, Michael John Welch, Karen L. Wooley
  • Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
    Patent number: 8298792
    Abstract: This invention provides a process for sequencing single-stranded DNA employing modified nucleotides.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: October 30, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li
  • Electronic post-compensation of optical transmission impairments using digital backward propagation
    Patent number: 8204389
    Abstract: Systems and method of compensating for transmission impairment are disclosed. One such method comprises: receiving an optical signal which has been distorted in the physical domain by an optical transmission channel; and propagating the distorted optical signal backward in the electronic domain in a corresponding virtual optical transmission channel.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: June 19, 2012
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Guifang Li, Eduardo Mateo, Likai Zhu, Xiaoxu Li, Gilad Goldfarb, Xin Chen, Inwoong Kim, Fatih Yaman
  • FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS
    Publication number: 20120021408
    Abstract: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.
    Type: Application
    Filed: February 8, 2011
    Publication date: January 26, 2012
    Inventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li
  • UNIVERSAL METHYLATION PROFILING METHODS
    Publication number: 20110177508
    Abstract: This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. This invention also provides neobases and methods of sequencing for methylation patterns using neobases.
    Type: Application
    Filed: July 22, 2009
    Publication date: July 21, 2011
    Inventors: Timothy H. Bestor, John R. Edwards, Jingyue Ju, Xiaoxu Li
  • Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
    Patent number: 7883869
    Abstract: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: February 8, 2011
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li
  • Electronic Compensation of Nonlinear Effects of Semiconductor Optical Amplifiers
    Publication number: 20100239270
    Abstract: Systems and methods are disclosed for compensating for impairments caused by a semiconductor optical amplifier (SOA). One such method comprises receiving an optical signal which has been distorted in the physical domain by an SOA, and propagating the distorted optical signal backward in the electronic domain in a corresponding virtual SOA.
    Type: Application
    Filed: March 22, 2010
    Publication date: September 23, 2010
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Guifang Li, Xiaoxu Li
  • FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS
    Publication number: 20100092952
    Abstract: This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.
    Type: Application
    Filed: November 30, 2007
    Publication date: April 15, 2010
    Inventors: Jingyue Ju, Dae Hyun Kim, Lanrong Bi, Qinglin Meng, Xiaoxu Li
  • Electronic Post-Compensation of Optical Transmission Impairments Using Digital Backward Propagation
    Publication number: 20090214215
    Abstract: Systems and method of compensating for transmission impairment are disclosed. One such method comprises: receiving an optical signal which has been distorted in the physical domain by an optical transmission channel; and propagating the distorted optical signal backward in the electronic domain in a corresponding virtual optical transmission channel.
    Type: Application
    Filed: January 9, 2009
    Publication date: August 27, 2009
    Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Guifang Li, Eduardo Mateo, Likai Zhu, Xiaoxu Li, Gilad Goldfarb, Xin Chen, Inwoong Kim, Fatih Yaman
  • Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids ("PNAs") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
    Publication number: 20060159619
    Abstract: A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2?-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
    Type: Application
    Filed: October 14, 2005
    Publication date: July 20, 2006
    Inventors: Matthew Becker, Huafeng Fang, Xiaoxu Li, Dipanjan Pan, Raffaella Rossin, Xiankai Sun, John-Stephen Taylor, Jeffrey Turner, Michael Welch, Karen Wooley