Abstract: Methods which make use of baculovirus vector (BV)-magnetic nanoparticle (BV-MNP) complexes to facilitate in vivo delivery of clustered regularly interspaced palindromic repeat (CRISPR) systems are provided. BV-MNP complexes carrying a CRISPR nuclease and a guide RNA having homology to an immune checkpoint gene can be administered to a subject to inhibit the immune checkpoint gene. Inhibition of the immune checkpoint gene can promote a desired immune response in the subject. Methods which leverage the contrast provided by MNPs in BV-MNP complexes in combination with magnetic resonance imaging (MRI) to detect in vivo delivery of CRISPR systems are also provided.

Abstract: Various embodiments of the present disclosure are directed to a magnetic resonance imaging (MRI) radio frequency (RF) coil comprising a current-control circuit. A conductive trace forms a coil inductor and comprises a first trace segment and a second trace segment separated by the current-control circuit, which comprises a first reactive element and a circuit branch. The first reactive element is electrically coupled from the first trace segment to the second trace segment, and the circuit branch is electrically coupled in parallel with the first reactive element. The circuit branch comprises a second reactive element and a sub-circuit branch electrically coupled in parallel. The sub-circuit branch comprises a third reactive element and an electronic switch (e.g., a PIN diode) electrically coupled in series. The first reactive element and the third reactive element are one of capacitive and inductive, and the second reactive element is another one of capacitive and inductive.

Abstract: The invention relates to stable formulations comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4), optionally further containing an anti-human programmed death receptor 1 (PD-1) antibody or antigen binding fragment thereof. Also provided are methods of treating various cancers and chronic infections with the formulations of the invention.

Abstract: The present disclosure provides a magnetic resonance imaging (MRI) radio frequency (RF) coil that has a discontinuous cylindrical-like shape and that has a decoupling ring enhanced to accommodate a discontinuity in the discontinuous cylindrical-like shape without use of electrical connectors. As seen hereafter, such enhancement allows the decoupling ring to extend in a closed path fully within the discontinuous cylindrical-like shape, which may, for example, be a U shape, a C shape, or some other suitable shape.

Abstract: A method for controlling an artificial intelligence (AI) device for implementing a digital avatar can include receiving an audio signal corresponding to a user query, converting, by a speech-to-text neural network model, the audio signal into a text query, inputting the text query into a large language gesture instruction model to generate high level movement instructions, inputting the text query and the high level movement instructions into an information retrieval model to generate a text response including at least one sentence and digital avatar control information, and inputting the text response into a text-to-speech neural network model to generate an audio response.

Abstract: The method for displaying a multimedia resource includes: displaying a first multimedia resource on a multimedia display page; in response to a scene selection instruction, displaying scene representation information respectively corresponding to at least one viewing scene on the multimedia display page in a process of displaying the first multimedia resource; in which the scene representation information is configured to represent a corresponding viewing scene, and enter the corresponding viewing scene to browse a multimedia resource under the corresponding viewing scene in response to the scene representation information being triggered.

Abstract: A magnetic resonance imaging (MRI) system can include a magnetic resonance imaging (MRI) radio frequency (RF) coil, which is or otherwise includes a degenerate birdcage coil (DBC) or a ladder coil. The MRI RF coil includes a row of meshes for operation in a half driving transmit mode. The meshes can include driving meshes and non-driving meshes, where each non-driving mesh is coupled between neighboring driving meshes. Driving meshes are electrically coupled to drivers, whereas non-driving meshes are not. The MRI RF coil may have enhanced transmit power efficiency and magnetic field uniformity with fewer drivers.

Abstract: A lamp includes a light source, a reflecting mirror, an internal lens and a wall element. The reflecting mirror is configured to reflect light rays emitted by the light source to the internal lens, the light rays sequentially pass through the internal lens and the wall element and exit. The internal lens includes a main body, a first protruding part and a second protruding part, and both of the first protruding part and the second protruding part abut the wall element, so that a gap is formed between the main body of the internal lens and the wall element.

Abstract: The invention relates to the technical field of intelligent construction and maintenance, and relates to a non-contact visual monitoring system and method for a flexible protective structure against rockfall disasters; it comprises a hardware system and a data analysis system, and the hardware system uses a multipoint distributed high-resolution high-speed camera to capture dynamic image sequences of a protective structure under the rockfall impact in a non-contact mode; the data analysis system comprises an impact deformation state full-field tracking module and a multipoint impact large deformation extraction module, and the impact deformation state full-field tracking module captures spatio-temporal changes of impact deformation of the protective system by adopting a full-field optical flow method, constructs a two-dimensional velocity amplitude distribution diagram and performs full-field spatio-temporal tracking of large deformation of the system.

Abstract: Various embodiments of the present disclosure are directed towards a magnetic resonance imaging (MRI) knee coil comprising a local shim coil. The local shim coil is disposed in a housing of the MRI knee coil. An electromagnetic coil is also disposed in the housing and spaced from the local shim coil. The local shim coil comprises one or more conductors. Each of the conductors of the local shim coil are disposed on a semi-cylindrical surface, and the semi-cylindrical surface extends laterally from a first side of the housing to a second side of the housing. The local shim coil is configured to generate a local shimming magnetic field that reduces a localized magnetic field inhomogeneity caused by a susceptibility artifact disposed in a knee of a patient.

Abstract: The disclosure provides a perovskite patterned film and a preparation method and application thereof. The preparation method comprises the following steps: coating a PbX2 precursor on a substrate, and annealing to obtain a PbX2 film substrate; coating AY salt on the nano stamp with the pattern, and annealing to obtain an AY film nano stamp; carrying out nanoimprinting to obtain an APb(X,Y)3 perovskite patterned film. According to the method, the perovskite pattern is accurately constructed on the PbX2 substrate in a mode of combining contact imprinting and ion diffusion, the PbX2/perovskite/PbX2 coplanar surface smooth thin film is obtained, the perovskite pattern serves as an active area, the rest PbX2 naturally serves as a wide-band-gap insulation/inert isolation material, the residual rate of the thin film is low, and the yield is greatly improved.

Abstract: The technology of this application relates to an encoding method, an encapsulation method, a display method, an apparatus, and an electronic device. The encoding method includes obtaining a to-be-encoded image, determining N encoding scales (N is an integer greater than 1) for the image, determining an encoding parameter corresponding to each of the N encoding scales, to obtain N groups of encoding parameters, and encoding the image N times by using a preset single-scale encoder based on the N groups of encoding parameters to obtain N groups of bitstream data. In this way, the image is encoded to obtain the bitstream data with a small data amount (namely, the bitstream data with a low encoding scale), so that when a network fluctuates, the bitstream data corresponding to the image can arrive at a decoder side with a higher probability, thereby ensuring smoothness of video playing.

Abstract: A non-volatile storage apparatus includes non-volatile memory cells, word lines connected to the non-volatile memory cells, and a control circuit connected to the word lines and the memory cells. The word lines include data word lines and dummy word lines. Memory cells connected to data word lines are configured to store host data. Memory cells connected to dummy word lines do not store host data. The control circuit is configured to erase, program and read the memory cells. Errors from threshold voltage up-shifting in the memory cells connected to dummy word lines is prevented by adjusting the voltage applied to dummy word lines.

Abstract: The present disclosure provides a method for manufacturing capacitor array, including: forming, on an upper surface of the substrate, a laminated structure including sacrificial layers and support layers; forming a patterned mask layer on an upper surface of the laminated structure; etching the laminated structure based on the patterned mask layer to form a through hole, wherein after the through hole is formed, the patterned mask layer is retained on the upper surface of the laminated structure, and the through hole penetrates through the patterned mask layer and the laminated structure; forming a first electrode on a sidewall and at a bottom of the through hole; forming, in the patterned mask layer and the laminated structure, and removing the sacrificial layer based on the opening; forming a capacitor dielectric layer on a surface of the first electrode; and forming a second electrode on a surface of the capacitor dielectric layer.

Abstract: A tumor radiotherapy planning design method and apparatus, an electronic device, and a computer storage medium are provided, including: obtaining a current optimization parameter vector set, and calculating a current cost function value; randomly correcting the current optimization parameter vector set to generate alternative optimization parameter vector sets; then performing planning parameter optimization, and calculating corresponding total cost function values; determining current optimal or suboptimal alternative optimization parameter vector sets according to the total cost function values, sampling to update the current optimization parameter vector set and the current cost function value according to the total cost function values of the current alternative optimization parameter vector sets, and then performing an iteration repeatedly until a convergence condition is satisfied; and outputting an optimal optimization parameter vector set after the iteration, determining planning parameters, and calcu

Abstract: The memory device includes a plurality of dies, and each die includes a plurality of blocks with a plurality of word lines. Some of the word lines are arranged in a plurality of exclusive OR (XOR) sets with each XOR set containing word lines in the same positions across the plurality of dies. The memory device further includes a controller that is configured to program the word lines of the blocks of at least one of the dies in a first programming direction. The controller is further configured to program the word lines of the blocks of at least one other die in a second programming direction that is opposite of the first programming direction.

Abstract: Disclosed are a target LED chip with a reflective layer and a manufacturing method. The method comprises providing a target substrate to a bottom of an initial LED chip, to obtain a first LED chip; depositing a first target liquid onto a top surface of the first LED chip to form a target protective layer, so as to obtain a second LED chip; etching the second LED chip from the target protective layer, to obtain a third LED chip; treating the third LED chip according to a first target method to form reflective layers, so as to obtain a fourth LED chip; and removing top reflective layers, second side wall reflective layers and first sub-protective layers of the plurality of second LED sub-units, to obtain the target LED chip comprising the plurality of target LED sub-units and the target substrate.

Abstract: The present disclosure is directed to a balun package comprising a set of inductive baluns for a magnetic resonance imaging (MRI) radio frequency (RF) coil. A first resonant circuit and a second resonant circuit each comprise an inductor. A first decoupling circuit leg is between and shared by the first and second resonant circuits and includes one or more decoupling inductors and/or one or more decoupling capacitors. A first cable bundle is wound to form the inductor of the first resonant circuit or is otherwise spaced from and inductively coupled to the inductor of the first resonant circuit.