Patents by Inventor Xiaoyuan Chen

Xiaoyuan Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160129138
    Abstract: Disclosed are nanoparticles comprising octapod iron oxide having eight trigonal bipyramidal arms and a method of preparing the same. The nanoparticles are prepared by heating a mixture of a ferric carboxylate, a carboxylic acid, a chloride salt, water, and a non-polar solvent, to a temperature above about 300° C. Also disclosed is a method of magnetic resonance imaging a tissue in a mammal, comprising use of the aforesaid nanoparticles.
    Type: Application
    Filed: June 3, 2013
    Publication date: May 12, 2016
    Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV, XIAMEN UNIVERSITY
    Inventors: Jinhao Gao, Xiaoyuan Chen, Zenghuan Zhao
  • Publication number: 20160104615
    Abstract: Provided is a preparation method of a crystalline silicon film. The method includes: 1) forming a mask for making a periodic silicon rod array on a monocrystalline silicon wafer substrate, and forming the periodic silicon rod array on the monocrystalline silicon substrate by a wet chemical etching or dry etching process; 2) forming barrier layers on the surface of the monocrystalline silicon substrate and the surface of the silicon rod array for next selectively epitaxial growth of silicon; 3) exposing silicon cores on the heads of the rod array by a selective etching process to form a silicon seed array; 4) growing a continuous silicon film at the top of the rod array by a chemical vapor deposition method using the exposed silicon cores as seeds for selectively epitaxial growth of silicon; and 5) lifting off the silicon film and transferring the silicon film to a preset substrate, and the seeded substrate is reusable.
    Type: Application
    Filed: May 7, 2014
    Publication date: April 14, 2016
    Inventors: Dongfang LIU, Wei ZHANG, Xiaoyuan CHEN, Hui YANG, Cong WANG, Linfeng LU
  • Publication number: 20150330976
    Abstract: The invention provides a method for detecting the presence or absence of a biomarker in a biological sample at a very low concentration comprising the steps of (a) contacting the biological sample with a capture binding sequence immobilized on a surface, (b) providing a conjugate comprising a detection binding sequence-glucose oxidase, (c) contacting the surface with the detection binding sequence-glucose oxidase conjugate, (d) separating any unbound detection binding sequence-glucose oxidase conjugate from the surface, (e) incubating the resulting surface with a glucose solution and a mixture comprising gold nanoparticles and a gold salt, wherein the gold nanoparticles have an initial particle size of about 5 nm, and (f) observing any change in color of the mixture. The invention also provides a method for diagnosing the presence of a prostate cancer biomarker in a subject and a kit for detecting or quantifying a biomarker in a biological sample.
    Type: Application
    Filed: May 18, 2015
    Publication date: November 19, 2015
    Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Xiaoyuan Chen, Dingbin Liu
  • Patent number: 9109846
    Abstract: Sheets that are made up of oriented polymer chains are provided. Chains of polymer may be oriented or substantially aligned in one or more directions exhibiting enhanced thermal conductivity along the direction of orientation. Orientation of polymers within sheets may lead to a wide range of thermally relevant applications.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: August 18, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Gang Chen, Erik Skow, Xiaoyuan Chen
  • Publication number: 20150086515
    Abstract: Compositions and methods of use thereof encompass engineered mesenchymal stem cells as a vehicle to deliver secreted tissue necrosis factor-RGD4C fusion polypeptides for tumor treatment, thereby reducing side effects of TNF. A reporter gene can be included in vector constructs to monitor the localization and viability of engineered MSCs after administration into a recipient animal. The genetically modified mesenchymal stem cell can comprise an expression cassette comprising a nucleic acid sequence operably linked to a gene expression promoter and encoding the heterologous fusion polypeptide comprising a tissue necrotic factor region and an integrin-binding region.
    Type: Application
    Filed: April 19, 2013
    Publication date: March 26, 2015
    Inventors: Zhen Cheng, Kai Chen, Xiaoyuan Chen
  • Publication number: 20150068574
    Abstract: Thermoelectric materials with high figures of merit, ZT values, are disclosed. In many instances, such materials include nano-sized domains (e.g., nanocrystalline), which are hypothesized to help increase the ZT value of the material (e.g., by increasing phonon scattering due to interfaces at grain boundaries or grain/inclusion boundaries). The ZT value of such materials can be greater than about 1, 1.2, 1.4, 1.5, 1.8, 2 and even higher. Such materials can be manufactured from a thermoelectric starting material by generating nanoparticles therefrom, or mechanically alloyed nanoparticles from elements which can be subsequently consolidated (e.g., via direct current induced hot press) into a new bulk material. Non-limiting examples of starting materials include bismuth, lead, and/or silicon-based materials, which can be alloyed, elemental, and/or doped. Various compositions and methods relating to aspects of nanostructured theromoelectric materials (e.g., modulation doping) are further disclosed.
    Type: Application
    Filed: October 17, 2014
    Publication date: March 12, 2015
    Inventors: Zhifeng Ren, Bed Poudel, Gang Chen, Yucheng Lan, Dezhi Wang, Qing Hao, Mildred Dresselhaus, Yi Ma, Xiao Yan, Xiaoyuan Chen, Xiaowei Wang, Joshi R. Giri, Bo Yu
  • Patent number: 8865995
    Abstract: Thermoelectric materials with high figures of merit, ZT values, are disclosed. In many instances, such materials include nano-sized domains (e.g., nanocrystalline), which are hypothesized to help increase the ZT value of the material (e.g., by increasing phonon scattering due to interfaces at grain boundaries or grain/inclusion boundaries). The ZT value of such materials can be greater than about 1, 1.2, 1.4, 1.5, 1.8, 2 and even higher. Such materials can be manufactured from a thermoelectric starting material by generating nanoparticles therefrom, or mechanically alloyed nanoparticles from elements which can be subsequently consolidated (e.g., via direct current induced hot press) into a new bulk material. Non-limiting examples of starting materials include bismuth, lead, and/or silicon-based materials, which can be alloyed, elemental, and/or doped. Various compositions and methods relating to aspects of nanostructured thermoelectric materials (e.g., modulation doping) are further disclosed.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: October 21, 2014
    Assignees: Trustees of Boston College, Massachusetts Institute of Technology
    Inventors: Zhifeng Ren, Bed Poudel, Gang Chen, Yucheng Lan, Dezhi Wang, Qing Hao, Mildred Dresselhaus, Yi Ma, Xiao Yan, Xiaoyuan Chen, Xiaowei Wang, Joshi R. Giri, Bo Yu
  • Publication number: 20140249468
    Abstract: Disclosed are imaging agents having the following Formula I: (I); wherein F is a near infrared fluorophore, S is an enzymatically cleavable oligopeptide, Q is a fluorescence quencher molecule, and M is a moiety selected from the group consisting of PEG or derivative thereof and a targeting ligand, and wherein F, Q and M are linked to separate amino acids of the enzymatically cleavable oligopeptide. Compositions comprising such compounds, as well as methods of use, methods of identifying a cell or a population of cells in vivo expressing a protease of interest, and methods of treating a disease through imaging are also disclosed.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 4, 2014
    Applicant: The United States of America,as represented by the Secretary, Department of Health and Human Service
    Inventors: Xiaoyuan Chen, Seulki Lee, Lei Zhu
  • Publication number: 20140162966
    Abstract: Disclosed is a nanoparticulate complex comprising an artificial phosphate receptor of formula (I): P-[L-[-N(CH2-2-pyridyl)2]]p.pZN2+ (I) wherein P represents a nanoparticulate substrate, L represents a linking group, and p is an integer of ?1. Also disclosed are a method for silencing a gene in a cancer patient in need thereof, a method for treating or preventing cancer in a patient in need thereof, and a method for targeting a cell in cancer treatment comprising use of the nanoparticulate complex, for example, a DPA/Zn-functionalized nanoparticulate complex.
    Type: Application
    Filed: November 21, 2013
    Publication date: June 12, 2014
    Inventors: Xiaoyuan Chen, Seulki Lee, Ki Young Choi, Gang Liu
  • Publication number: 20120180840
    Abstract: Systems and methods utilizing solar-electrical generators are discussed. Solar-electrical generators are disclosed having a radiation-capture structure and one or more thermoelectric converters. Heat produced in a capture structure via impingement of solar radiation can maintain a portion of a thermoelectric converter at a high temperature, while the use of a low temperature at another portion allows electricity generation. Thus, unlike photovoltaic cells which are generally primarily concerned with optical radiation management, solar thermoelectrics converters are generally concerned with a variety of mechanisms for heat management. Generators can include any number of features including selective radiation surfaces, low emissivity surfaces, flat panel configurations, evacuated environments, and other concepts that can act to provide thermal concentration. Designs utilizing one or more optical concentrators are also disclosed.
    Type: Application
    Filed: March 27, 2012
    Publication date: July 19, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Gang Chen, Xiaoyuan Chen, Mildred Dresselhaus, Zhifeng Ren
  • Patent number: 8168879
    Abstract: Systems and methods utilizing solar-electrical generators are discussed. Solar-electrical generators are disclosed having a radiation-capture structure and one or more thermoelectric converters. Heat produced in a capture structure via impingement of solar radiation can maintain a portion of a thermoelectric converter at a high temperature, while the use of a low temperature at another portion allows electricity generation. Thus, unlike photovoltaic cells which are generally primarily concerned with optical radiation management, solar thermoelectrics converters are generally concerned with a variety of mechanisms for heat management. Generators can include any number of features including selective radiation surfaces, low emissivity surfaces, flat panel configurations, evacuated environments, and other concepts that can act to provide thermal concentration. Designs utilizing one or more optical concentrators are also disclosed.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: May 1, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Gang Chen, Xiaoyuan Chen, Mildred Dresselhaus, Zhifeng Ren
  • Publication number: 20100301258
    Abstract: that are made up of oriented polymer chains are provided. Chains of polymer may be oriented or substantially aligned in one or more directions exhibiting enhanced thermal conductivity along the direction of orientation. Orientation of polymers within sheets may lead to a wide range of thermally relevant applications.
    Type: Application
    Filed: April 17, 2008
    Publication date: December 2, 2010
    Applicant: Massachusetts Institute of Technolohy
    Inventors: Gang Chen, Erik Skow, Xiaoyuan Chen
  • Publication number: 20100280098
    Abstract: Disclosed herein are oligonucleotide conjugates that include ligands that target cell receptors that mediate endocytosis. The ligands can include peptides and small molecules. The conjugates can include carrier macromolecules to which the ligands and oligonucleotides are attached, or conjugates where an oligonucleotide is attached to a ligand in the absence of a carrier macromolecule. The oligonucleotides can include therapeutic oligonucleotides, such as siRNA, antisense RNA and miRNA. The ligand can be an RGD peptide. Also disclosed herein are methods of delivering the conjugates to cells in subjects.
    Type: Application
    Filed: October 6, 2008
    Publication date: November 4, 2010
    Inventors: Rudolph L. Juliano, Rowshon Alam, Vidula Dixit, Hyunmin Kang, Xiaoyuan Chen, Zi-Bo Li
  • Publication number: 20100260673
    Abstract: Rapid assessment of cancer response to a therapeutic regimen can determine efficacy early in the course of treatment. Briefly described, embodiments of this disclosure, among others, encompass a class of molecular imaging probes that can predict tumor early responses to anti-angiogenic therapies, such as that based on Bevacizumab (AVASTIN™). In particular, the present disclosure provides peptides that selectively bind to vascularized taget tissues such as, but not limited to solid tumors, responsive to anti-angiogenic therapies and which can, therefore, be useful to selectively concentrate moieties such as detectable labels, or therapeutic agents, in a tumor. The detectable labels, therefore, provide a way to selectively detect and monitor tissues, and most advantageously tumors, that respond to anti-angiogenic therapies.
    Type: Application
    Filed: April 6, 2010
    Publication date: October 14, 2010
    Inventors: QIZHEN CAO, XIAOYUAN CHEN
  • Publication number: 20100068151
    Abstract: Disclosed are pharmaceutical compounds comprising a cell-specific targeting moiety, an anti-cell proliferation moiety, and a chelator moiety. Also disclosed are methods for treating a subject with a hyperproliferative disease, methods for diagnosing presence of a hyperproliferative disease in a subject, and methods for detecting a therapeutic response in a subject that employ the pharmaceutical compounds of the present invention.
    Type: Application
    Filed: March 11, 2009
    Publication date: March 18, 2010
    Inventors: Michael G. Rosenblum, Xiaoyuan Chen
  • Publication number: 20100015058
    Abstract: The present disclosure encompasses heterodimeric compositions for delivering radiolabeled and other ligands to a cell or tissue, and particularly to compositions and methods of use thereof for targeting and imaging cells and tissues expressing both an integrin and gastrin-releasing peptide receptor, in particular prostate cancer cells. The disclosure, therefore, firstly encompasses compositions that can comprise a heterodimeric probe comprising a first peptide domain comprising a moiety capable of selectively binding to an integrin; a second peptide domain comprising a moiety capable of selectively binding to a gastrin-releasing peptide receptor; a linker connecting the first peptide domain and the second peptide domain; and a prosthetic group. The first peptide domain comprises at least one tripeptide comprising the amino acid sequence of arginine-glycine-aspartate, and the second domain can be the peptide bombesin(7-14).
    Type: Application
    Filed: June 25, 2009
    Publication date: January 21, 2010
    Applicant: STANFORD UNIVERSITY
    Inventors: ZIBO LI, XIAOYUAN CHEN
  • Publication number: 20090260667
    Abstract: Systems and methods utilizing solar-electrical generators are discussed. Solar-electrical generators are disclosed having a radiation-capture structure and one or more thermoelectric converters. Heat produced in a capture structure via impingement of solar radiation can maintain a portion of a thermoelectric converter at a high temperature, while the use of a low temperature at another portion allows electricity generation. Thus, unlike photovoltaic cells which are generally primarily concerned with optical radiation management, solar thermoelectrics converters are generally concerned with a variety of mechanisms for heat management. Generators can include any number of features including selective radiation surfaces, low emissivity surfaces, flat panel configurations, evacuated environments, and other concepts that can act to provide thermal concentration. Designs utilizing one or more optical concentrators are also disclosed.
    Type: Application
    Filed: April 28, 2009
    Publication date: October 22, 2009
    Applicant: Massachusetts Institute of Technology
    Inventors: Gang Chen, Xiaoyuan Chen, Mildred Dresselhaus, Zhifeng Ren
  • Patent number: 7471448
    Abstract: An optical device includes an input optical source that provides and optical signal to the optical device. A surface phonon polariton (SPP) nanostructure receives the optical signal that interacts with the SPP nanostructure to excite a Raman process and produce a Raman light signal. The Raman light signal comprises a broad spectral range from near infrared to far infrared.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: December 30, 2008
    Assignee: Massachusetts Institute of Technology
    Inventors: Gang Chen, Xiaoyuan Chen
  • Publication number: 20080267882
    Abstract: Embodiments of the present disclosure provide for RGD compounds that include a multimeric RGD (arginine-glycine-aspartic acid (Arg-Gly-Asp)) peptide, methods of making the RGD compound, pharmaceutical compositions including RGD compound, methods of using the RGD compositions or the pharmaceutical compositions including RGD compositions, methods of diagnosing and/or targeting angiogenesis related disease and related biological events, kits for diagnosing and/or targeting angiogenesis related disease and related biological events, and the like. In addition, the present disclosure includes compositions used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging) of the RGD compounds in vivo.
    Type: Application
    Filed: April 28, 2008
    Publication date: October 30, 2008
    Applicant: Stanford University
    Inventors: Xiaoyuan Chen, Zibo Li
  • Publication number: 20080264486
    Abstract: A photovoltaic device comprises: a first cladding material; a photosensitive material having an index of refraction larger than the first cladding material index of refraction, the photosensitive material disposed adjacent the first cladding material; and a second cladding material having an index of refraction smaller than the photosensitive material index of refraction, the photosensitive material disposed between the first cladding material and the second cladding material so as to form a waveguide for confining propagating photons; and first and second electrodes in electrical contact with the photosensitive material.
    Type: Application
    Filed: April 30, 2008
    Publication date: October 30, 2008
    Inventors: Xiaoyuan Chen, Gang Chen