Abstract: The present invention relates to peptide ligands of the melanocortin receptors, in particular the melanocortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.

Abstract: A continuum arm robot system comprising at least a first continuum arm robot and a second continuum arm robot, each continuum arm robot being controlled by its own actuator pack, and each actuator pack being coupled to a single control computer, wherein at least the second continuum arm robot comprises a releasable connection mechanism to engage in gripping the first continuum arm robot in a workspace, so as to link the at least two continuum arm robots into a single redundant robotic system with at least the second continuum arm robot providing support for the first continuum arm robot.

Abstract: Embodiments of the invention are directed to data replication in an active-active databases having a source site and a target site. Aspects include creating a subscription activation message in a capture address space, the subscription activation message having a timestamp after a latest committed timestamp of the active-active databases and transmitting the subscription activation message to a subscription activation module of the target site of the active-active databases. Based on a determination that one or more tables associated with the subscription activation message are inactive, aspects also include repairing the one or more tables. Based on a determination that all tables associated with the subscription activation message are active, aspects include initiate replication of the capture address space from the source site to the target site with a timestamp of the latest committed timestamp.

Abstract: Embodiments of the present disclosure relate to a vehicle lighting system with modular lights. The vehicle lighting system may include a control hub and one or more modular lights. A modular light may include one or more light cores assembled on an assemble frame module. Each light core may include a light source module and an optic module. The light core may be an illuminating light core or a signal light core. The module light may further include a decorative frame module.

Abstract: A vehicle light is disclosed. The vehicle light includes a first optical device and a second optical device. The first optical device and a light source are sealed in a housing. The second optical device is removably attached to the housing. The first optical device transmits the light rays from the light source into an intermediate pattern. The second optical device transmits the intermediate pattern to a target pattern. The second optical device may be switched to obtain a different target beam pattern or a different color.

Abstract: The present disclosure provides a light bulb for use in a lamp housing of a vehicle. The light bulb includes a bulb body assembly having one or more light sources fixedly attached thereto, and a mounting assembly configured to mount on the lamp housing. The bulb body assembly and the mounting assembly are connected by a rotatable joint such that positions of the one or more light sources can be adjusted after the mounting assembly is mounted on the lamp housing. In some embodiments, a key portion is attached to the bulb body assembly to rotate the bulb body assembly relative to the mounting assembly.

Abstract: A locking system for a continuum arm robot system, the robot system includes: a continuum arm robot having a manipulatable tip, a passive robot section through which controls for the manipulatable tip, and at least one ferromagnetic collar, and at least one external controllable electromagnetic device which can be activated so that the ferromagnetic section on the continuum arm robot is attracted to the electromagnetic device.

Abstract: Embodiments of the present disclosure relate to a vehicle head lamp with customized and/or variable lighting patterns. The vehicle lamp assembly may include an optical assembly, a first LED light source positioned to project light beams to the optical assembly a second LED light source positioned to project light beams to the optical assembly, and a control circuit configured to selectively operating the first LED light source and the second light source.

Abstract: A sensing system for a continuum arm robot, the sensing system comprising at least one camera ring system mounted to the continuum robot, the camera ring system having at least two forward-facing cameras that face along the axis of the robot towards the tip.

Abstract: The present disclosure provides a light bulb for use in a lamp housing of a vehicle. The light bulb includes a bulb body assembly having one or more light sources fixedly attached thereto, and a mounting assembly configured to mount on the lamp housing. The bulb body assembly and the mounting assembly are connected by a rotatable joint such that positions of the one or more light sources can be adjusted after the mounting assembly is mounted on the lamp housing. In some embodiments, a key portion is attached to the bulb body assembly to rotate the bulb body assembly relative to the mounting assembly.

Abstract: Embodiments of the invention are directed to data replication in an active-active databases having a source site and a target site. Aspects include creating a subscription activation message in a capture address space, the subscription activation message having a timestamp after a latest committed timestamp of the active-active databases and transmitting the subscription activation message to a subscription activation module of the target site of the active-active databases. Based on a determination that one or more tables associated with the subscription activation message are inactive, aspects also include repairing the one or more tables. Based on a determination that all tables associated with the subscription activation message are active, aspects include initiate replication of the capture address space from the source site to the target site with a timestamp of the latest committed timestamp.

Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

Abstract: Disclosed herein are anti-TIM-3 antibodies and antigen-binding fragments, polynucleotides encoding the antibodies and antigen-binding fragments, and pharmaceutical compositions comprising the antibodies and antigen-binding fragments. Uses of the anti-TIM-3 antibodies and antigen-binding fragments described herein in cancer treatment are also disclosed.

Abstract: Embodiments of the present disclosure relate to a vehicle head lamp with customized and/or variable lighting patterns. The vehicle lamp assembly may include an optical assembly, a first LED light source positioned to project light beams to the optical assembly a second LED light source positioned to project light beams to the optical assembly, and a control circuit configured to selectively operating the first LED light source and the second light source.

Abstract: Disclosed herein are anti-PD-L1 antibodies and antigen-binding fragments thereof, fusion proteins comprising a first domain comprising an anti-PD-L1 antibodies or an antigen-binding fragment thereof and a second domain comprising a fragment of TGF?RII that binds TGF? or a variant thereof, as well as polynucleotides that encode such antibodies or fusion proteins. Disclosed herein are also their uses in treatment of diseases such as cancers.

Abstract: The present invention provides a method for determining endometrial receptivity and an application thereof. Specifically, the present invention provides a method for determining endometrial receptivity and markers for determining an endometrial receptivity status. The markers of the present invention could greatly reduce the error rate during the determination of the endometrial receptivity.

Abstract: The present disclosure generally relates to apparatus and methods for controlling ventilation and temperature around a light source. A ventilation and temperature control assembly configured to selectively facilitate air circulation in an enclosure around a light source is disclosed. In some embodiments, a temperature sensor may be disposed near the light source. The air circulation may be switched on and off according to temperature measurement of the temperature sensor. In some embodiments, the ventilation and temperature control assembly includes a valve to selectively open and close a flow path in the ventilation and temperature control assembly.

Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

Abstract: Aspects include monitoring, by a controller, an operational status of a tracker system that is configured to track and record a current status of a job being executed and to report completion of the job to the controller. The recording includes storing two copies of the current status, where a first copy is stored in a shared memory location accessible by the controller. In response to determining, based on the monitoring, that the tracker system is operational, waiting to receive a job completion message for the job from the tracker system and performing a job completion action based on receiving the job completion message. In response to determining that the tracker system is not operational, obtaining the current status of the job from the shared memory location and performing the job completion action based on the current status indicating that the job has completed.

Abstract: A rigid link for a flexible robot, the rigid link including a rigid link body having a hollow core, the rigid link with at least two arms having proximal and distal ends, the arms are connected to the rigid link body, and wherein the arms being deployable between a closed configuration in which the proximal and distal ends of the arms are positioned proximate to the rigid link body and open configuration in which the arms are moved so that the distal ends of the arms are positioned away from the body of the rigid link.