Abstract: Disclosed are an additive raw material composition and an additive for superhard material product, a composite binding agent, a superhard material product, a self-sharpening diamond grinding wheel and a method for manufacturing the same. The raw material composition consisting of components in following mass percentage: Bi2O3 25%˜40%, B2O3 25%˜40%, ZnO 5%˜25%, SiO2 2%˜10%, Al2O3 2%˜10%, Na2CO3 1%˜5%, Li2CO3 1%-5%, MgCO3 0%˜5%, and CaF2 1%˜5%. The composite binding agent is prepared from the additive and a metal composite binding agent. The self-sharpening diamond grinding wheel prepared from the composite binding agent has high self-sharpness, high strength, and fine texture, is uniformly consumed during the grinding process, does not need to be trimmed during the process of being used, and maintains good grinding force all the time, fundamentally solving the problems of long trimming time and high trimming cost of the diamond grinding wheel (FIG. 1).

Abstract: Disclosed are an additive raw material composition and an additive for superhard material product, a method for preparing the additive, a composite binding agent, a superhard material product, a self-sharpening diamond grinding wheel and a method for manufacturing the same. The raw material composition consisting of components in following mass percentage: Bi2O3 25%˜40%, B2O3 25%˜40%, ZnO 5%˜25%, SiO2 2%˜10%, Al2O3 2%˜10%, Na2CO3 1%˜5%, Li2CO3 1%˜5%, MgCO3 0%˜5%, and CaF2 1%˜5%. The composite binding agent is prepared from the additive and a metal composite binding agent. The self-sharpening diamond grinding wheel prepared from the composite binding agent has high self-sharpness, high strength, and fine texture, is uniformly consumed during the grinding process, does not need to be trimmed during the process of being used, and maintains good grinding force all the time, fundamentally solving the problems of long trimming time and high trimming cost of the diamond grinding wheel.

Abstract: The present disclosure provides compounds represented by Formula I-A: A1-L1-B1 I-A and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein A1, B1, and L1 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a condition or disorder responsive to degradation of MDM2 protein such as cancer.

Abstract: The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.

Abstract: Techniques described herein include an event notification processing platform configured to process large-scale event notifications in relative real time. The platform may receive event notifications from multiple sources and publish them to an event stream, or log. The platform may subsequently process each notification at a processing module according to one or more sets of rules and the processed information may be made available via a data store. Rule sets may be selected based on the type of event received by the platform. A backup data store may record event notifications as they are received or at periodic intervals. Event notification data may also be stored at multiple levels of the platform, so that in the case of a failure of one or more components of the platform, data may continue to be processed.

Abstract: The CRISPR-Cas nuclease system represents an efficient tool for genome editing and gene function analysis. It consists of two components: single-guide RNA (sgRNA) and the enzyme Cas9. The present invention introduces and optimizes a microfluidic membrane deformation method to deliver sgRNA and Cas9 into different cell types and achieve successful genome editing. This approach uses rapid cell mechanical deformation to generate transient membrane holes to enable delivery of biomaterials in the medium. The present invention has achieved high delivery efficiency of different macromolecules into different cell types, including hard-to-transfect lymphoma cells and embryonic stem cells, while maintaining high cell viability.

Abstract: Disclosed are an additive raw material composition and an additive for superhard material product, a method for preparing the additive, a composite binding agent, a superhard material product, a self-sharpening diamond grinding wheel and a method for manufacturing the same. The raw material composition consisting of components in following mass percentage: Bi2O3 25%˜40%, B2O3 25%˜40%, ZnO 5%˜25%, SiO2 2%˜10%, Al2O3 2%˜10%, Na2CO3 1%˜5%, Li2CO3 1%˜5%, MgCO3 0%˜5%, and CaF2 1%˜5%. The composite binding agent is prepared from the additive and a metal composite binding agent. The self-sharpening diamond grinding wheel prepared from the composite binding agent has high self-sharpness, high strength, and fine texture, is uniformly consumed during the grinding process, does not need to be trimmed during the process of being used, and maintains good grinding force all the time, fundamentally solving the problems of long trimming time and high trimming cost of the diamond grinding wheel.

Abstract: Techniques described herein include an event notification processing platform configured to process large-scale event notifications in relative real time. The platform may receive event notifications from multiple sources and publish them to an event stream, or log. The platform may subsequently process each notification at a processing module according to one or more sets of rules and the processed information may be made available via a data store. Rule sets may be selected based on the type of event received by the platform. A backup data store may record event notifications as they are received or at periodic intervals. Event notification data may also be stored at multiple levels of the platform, so that in the case of a failure of one or more components of the platform, data may continue to be processed.

Abstract: A method for estimating blur degree of image and a method for evaluating image quality are revealed. First, an input image is transmitted to an image processing device for producing a synthesized blur image including a nonlinear image sensing function according to a pixel intensity distribution parameter of the input image. Next, the image processing device matches the pixel intensity distribution according to the input image and the synthesized blur image for producing a blur degree parameter; By the way, the image processing device further estimating an estimated blur result according to the blur degree parameter. The method for estimating blur degree of image can be further applied to estimate blur distribution for a plurality of regions of interest of a plurality of input images. Thereby, the blur distribution of the input images can be estimated, and thus further evaluating the image quality of the plurality of input images.

Abstract: A method for estimating blur degree of image and a method for evaluating image quality are revealed. First, an input image is transmitted to an image processing device for producing a synthesized blur image including a nonlinear image sensing function according to a pixel intensity distribution parameter of the input image. Next, the image processing device matches the pixel intensity distribution according to the input image and the synthesized blur image for producing a blur degree parameter; By the way, the image processing device further estimating an estimated blur result according to the blur degree parameter. The method for estimating blur degree of image can be further applied to estimate blur distribution for a plurality of regions of interest of a plurality of input images. Thereby, the blur distribution of the input images can be estimated, and thus further evaluating the image quality of the plurality of input images.

Abstract: A method and device for retransmitting data is provided. A receiving end receives a data unit, and checks whether a Negative Acknowledgement NACK->Acknowledgement, ACK, error occurs. If the NACK->ACK error occurs, the receiving end transmits an Automatic Repeat Request ARQ request message to a transmitting end, for requesting the transmitting end to perform an ARQ retransmission. Therefore, by adopting the technical solutions of the embodiment of the invention, Hybrid Automatic Repeat Request HARQ NACK->ACK errors are avoided from being missed, the complexity of ARQ operation is lowered, and the ARQ retransmission feedback time is reduced.

Abstract: A method and device for retransmitting data is provided. A receiving end receives a data unit, and checks whether a Negative Acknowledgement NACK->Acknowledgement, ACK, error occurs. If the NACK->ACK error occurs, the receiving end transmits an Automatic Repeat Request ARQ request message to a transmitting end, for requesting the transmitting end to perform an ARQ retransmission. Therefore, by adopting the technical solutions of the embodiment of the invention, Hybrid Automatic Repeat Request HARQ NACK->ACK errors are avoided from being missed, the complexity of ARQ operation is lowered, and the ARQ retransmission feedback time is reduced.