Abstract: The present invention discloses a compound represented by Formula I shown below, a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein R1 is preferably pyridyl; R2 is preferably halogen, halogenated C1-4 alkoxyl; R3 and R4 are preferably methyl; ring A is preferably phenyl ring or thiazole ring. The compound of the invention can strongly and specifically bind to ?-synuclein aggregates and so be used as a tracer for optical imaging of ?-synuclein aggregates in biological samples or in vivo (such as brain). As radio-labeled the compound of the invention, it can be used as a radio imaging tracer for PET, SPECT, and other imaging techniques to realize the detection of ?-synuclein lesions by non-invasive visualization in vivo (such as the brain). The compound of the invention is also used for preparing the radio-labeled tracer or its composition thereof.

Abstract: An array substrate, a display panel and a manufacturing method thereof are provided. The array substrate includes data lines, gate lines, a gate driving structure electrically connected with the gate lines and the gate driving signal lines, gate driving signal lines and a data fanout wiring region. The array substrate further includes a dummy fanout wiring region, a dummy pad region and a bended line, the data fanout wiring region and the dummy fanout wiring region are located at both sides of the display region, the data lines are electrically connected with pads in the dummy pad region through the wires in the dummy fanout wiring region; the gate driving signal lines are electrically connected with pads in the dummy pad region; a transmission line is disposed at one side of the gate driving structure away from the display region and electrically connected with the bended line.

Abstract: Disclosed are a small molecule binding ligand of a ?-synuclein aggregate, and a preparation method therefor and a use thereof. The small molecule binding ligand of a ?-synuclein aggregate is a compound shown in the following general formula (I). The compound can specifically and strongly bind to a ?-synuclein aggregate and can be used for detecting/dyeing the ?-synuclein aggregate and Lewy body in the brain of a patient, and a radioactive marker of the compound can be used as an imaging tracer probe required in image examination technologies such as PET and SPECT for clinical disease diagnosis. The compound is further used for preparing the radioactively marked imaging tracer probe or a composition thereof. Diseases associated with ?-synuclein misfolding and abnormal aggregation comprise Parkinson's disease, Parkinson's disease dementia, Alzheimer's disease, multiple system atrophy, Lewy body dementia, etc.

Abstract: An array substrate, a method for manufacturing the array substrate, and a display apparatus; the array substrate includes a base substrate, including multiple sub-pixel areas arranged in an array; multiple data lines, disposed at column gaps of the multiple sub-pixel areas, where at least part of the data lines include a widened portion for supporting a photo spacer; and multiple gate lines and multiple common electrode lines, disposed at row gaps of the plurality of sub-pixel areas; where the multiple gate lines and the multiple common electrode lines are disposed on a different layer from the multiple data lines, and one of part of the multiple gate lines and at least part of the multiple common electrode lines includes an avoidance portion wrapped around the widened portion.

Abstract: An integrated circuit is disclosed which includes a stacked P+ substrate, n-type epitaxial layer, and one or more p-type epitaxial layers, with a buried layer located in the one or more p-type epitaxial layers to be adjacent to the n-type epitaxial layer, a central isolated region located in the one or more p-type epitaxial layers to be positioned over the buried layer, one or more concentric shallow isolation ring structures positioned to surround the central isolated region and to extend down through the buried layer and into the n-type epitaxial layer, and a concentric deep poly isolation structure positioned to surround the central isolated region and the one or more concentric shallow isolation ring structures and to extend down through the n-type epitaxial layer and into the P+ substrate, wherein the concentric deep poly isolation structure include one or more polysilicon layers that are shorted to the P+ substrate.

Abstract: A schlieren system for in-situ/online monitoring of spatter in a large-area melt pool is provided, including a parallel light generation part, a parallel light deflection part, and an image acquisition part. The system can monitor spatter and other physical phenomena in the melt pool in a process of multi-layer printing and adjust a monitored area during an experiment to expand a monitored range. A reflector group composed of a plurality of plane mirrors is arranged, such that an optical path can be kept away from powder and dust areas, avoiding interference between the schlieren system and inherent devices inside a build chamber. Communication between a laser path controller and an optical path deflecting mirror galvanometer motor controller is established to automatically control the plane mirrors to change the monitored area, automatically track the melt pool, and realize online monitoring.

Abstract: The present disclosure relates to the technical field of electrical device state monitoring, and particularly discloses an open-phase fault monitoring system, in which a relay communication unit is configured with an MCU as a central control processing unit, and an external ADC realizes high-speed A/D conversion for a plurality of signals; a timing function is realized by a GNSS&RTC of the relay communication unit, a data interaction function is realized by a LORA module, and data is sent to a background industrial personal computer based on a designed sampling frequency. The system of the present disclosure has the advantages of small volume, high precision, low cost, easy installation and the like, and realizes real-time monitoring and accurate identification of a line open-phase fault of an auxiliary power supply system in a nuclear power plant.

Abstract: Provided is an antibody or an antigen-binding fragment thereof, a T cell antigen receptor, an immune cell expressing the T cell antigen receptor (TCR), and a preparation method therefor and the use thereof. The TCR can specifically recognize corresponding pMHC complexes, activate TCR T cells, and produce high-level cytokines IFN?, IL2, TNF?, significantly kill target cells and prolong the life of tumor-bearing mice.

Abstract: A schlieren system for in-situ/online monitoring of spatter in a large-area melt pool is provided, including a parallel light generation part, a parallel light deflection part, and an image acquisition part. The system can monitor spatter and other physical phenomena in the melt pool in a process of multi-layer printing and adjust a monitored area during an experiment to expand a monitored range. A reflector group composed of a plurality of plane mirrors is arranged, such that an optical path can be kept away from powder and dust areas, avoiding interference between the schlieren system and inherent devices inside a build chamber. Communication between a laser path controller and an optical path deflecting mirror galvanometer motor controller is established to automatically control the plane mirrors to change the monitored area, automatically track the melt pool, and realize online monitoring.

Abstract: An array substrate includes a driving circuit arranged on the base substrate, and the driving circuit includes a pull-up node control circuit, a first pull-down node control circuit, and an output circuit; the pull-up node control circuit controls a potential of the pull-up node; the first pull-down node control circuit controls to write a first control voltage provided by the first control voltage line into the first pull-down node; the output circuit controls the driving signal output terminal to output a driving signal under the control of the potential of the pull-up node; the array substrate also includes a first conductive portion arranged on the base substrate; the first conductive portion is electrically connected to the first control voltage line.

Abstract: The present invention relates to a method for constructing a digital twin system for an additive manufacturing process with lifecycle data management. The digital twin system for an additive manufacturing process constructed by the method includes a data acquisition and supervisory control system, a data management and storage system, a manufacturing executing system, a configuration model, a simulation system, and a multi-physics simulation system. The present invention can fully and accurately characterize the molding quality of parts, thereby saving a lot of time required for offline data processing, and achieving real-time acquisition and updating of data.

Abstract: A display may include an array of pixels. Each pixel in the array may include a drive transistor, emission transistors, a data loading transistor, a gate voltage setting transistor, an initialization transistor, an anode reset transistor, a storage capacitor, and an optional current boosting capacitor coupled in series with an isolation transistor. A data refresh may include a initialization phase, a threshold voltage sampling phase, and a data programming phase. The threshold voltage sampling phase can be substantially longer than the data programming phase to decrease a current sampling level during the threshold voltage sampling phase, which helps reduce the display luminance sensitivity to temperature variations. During a data refresh, the isolation transistor can be turned on to provide current boosting. During emission periods, the isolation transistor is turned off to prevent cathode noise from potentially coupling through to one or more direct-current voltage nodes in the pixel.

Abstract: A reusable protective clothing includes a one-piece protective suit which includes integrated top and trousers attached with gloves and shoe covers, and a protective headpiece having a face shield. A front side of the protective headpiece is provided with a full-vision goggle with 180-degree field of view, the full-vision goggle is integrated with the face shield, a back side of the protective headpiece is provided with a protective hood made of a material of the one-piece protective suit, the protective hood is integrated with the top, the front side of the protective headpiece is provided with an air vent for a mouth and a nose configured according to facial features of a wearer, and an outer side of the protective headpiece is provided with ear-shaped hooks. The protective clothing is designed according to application environment and medical requirements to prevent exposure to pathogenic microorganisms.

Abstract: Provided is an apparatus for driving a display having a display unit, an image data storage, a lookup storage, a waveform generation unit, and a processing unit. The display unit may operate a microcapsule. The image data storage may store current and next grayscale data of the microcapsule. The lookup storage may look up a first waveform dataset corresponding to the current and next grayscale data. The waveform generation unit may generate a second waveform dataset from the first waveform dataset. The processing unit may drive the display unit to apply voltage to the microcapsule according to the second waveform dataset. Also provided is a method for driving a display, which includes providing the apparatus for driving the display, and having the display unit to operate the microcapsule according to the current grayscale data. Further provided is a computer program product adapted to perform the method.

Abstract: The present disclosure provides an array substrate and a touch display device. The array substrate includes: a plurality of pixels arranged in an array, each pixel includes N sub-pixels of different colors arranged along a first direction, and N?3; a plurality of touch sensor units arranged in an array, each touch sensor unit corresponds to m*N sub-pixels in the first direction, and m is a positive integer; a plurality of touch signal lines, each touch sensor unit is connected with at least one touch signal line. Along the first direction, each touch sensor unit in a same row is connected with a same number of touch signal lines, each touch signal line is connected with a corresponding touch sensor unit through an access point, and the access points of the touch signal lines connected to a same row of touch sensor units are in a same sub-pixel color environment.

Abstract: The present disclosure relates to the technical field of electrical device state monitoring, and particularly discloses an open-phase fault monitoring system, in which a relay communication unit is configured with an MCU as a central control processing unit, and an external ADC realizes high-speed A/D conversion for a plurality of signals; a timing function is realized by a GNSS&RTC of the relay communication unit, a data interaction function is realized by a LORA module, and data is sent to a background industrial personal computer based on a designed sampling frequency. The system of the present disclosure has the advantages of small volume, high precision, low cost, easy installation and the like, and realizes real-time monitoring and accurate identification of a line open-phase fault of an auxiliary power supply system in a nuclear power plant.

Abstract: A display may include an array of pixels. Each pixel in the array may include a drive transistor, emission transistors, a data loading transistor, a gate voltage setting transistor, an initialization transistor, an anode reset transistor, a storage capacitor, and an optional current boosting capacitor coupled in series with an isolation transistor. A data refresh may include a initialization phase, a threshold voltage sampling phase, and a data programming phase. The threshold voltage sampling phase can be substantially longer than the data programming phase to decrease a current sampling level during the threshold voltage sampling phase, which helps reduce the display luminance sensitivity to temperature variations. During a data refresh, the isolation transistor can be turned on to provide current boosting. During emission periods, the isolation transistor is turned off to prevent cathode noise from potentially coupling through to one or more direct-current voltage nodes in the pixel.

Abstract: In one embodiment, a semiconductor die includes a polycrystalline semiconductor resistor structure (poly resistor structure). The poly resistor structure includes a resistive path between a first terminal and a second terminal. The poly resistor structure includes a first region having a net first conductivity type dopant concentration located in the resistance path and a second region having a net second conductivity type dopant concentration located in the resistance path. A silicide structure is located on both a first portion of the first region and a first portion of the second region to electrically connect the first portion of the first region and the first portion of the second region. In some embodiments, poly resistor structures with different conductivity type regions can be connected together.

Abstract: Disclosed are a method for improving a surface quality of an alloy micro-area via a supersaturated film and use thereof. The method includes: adding nickel chloride to a sodium chloride-ethylene glycol electrolyte until the electrolyte is saturated, and conducting electrochemical machining.

Abstract: An array substrate, a display panel and a manufacturing method thereof are provided. The array substrate includes data lines, gate lines, a gate driving structure electrically connected with the gate lines and the gate driving signal lines, gate driving signal lines and a data fanout wiring region. The array substrate further includes a dummy fanout wiring region, a dummy pad region and a bended line, the data fanout wiring region and the dummy fanout wiring region are located at both sides of the display region, the data lines are electrically connected with pads in the dummy pad region through the wires in the dummy fanout wiring region; the gate driving signal lines are electrically connected with pads in the dummy pad region; a transmission line is disposed at one side of the gate driving structure away from the display region and electrically connected with the bended line.