Abstract: An object of the present invention is to develop a shape memory and superelastic alloy that does not contain nickel, and has superelasticity and shape memory properties even if being subjected to heat treatment in spite of high biocompatibility, moreover having high cold workability. The Ti—Nb—Zr base alloy is comprising an alloy composition consisting of 40 to 60 wt % Ti, 18 to 30 wt % Nb, 18 to 30 wt % Zr, and 0.77 to 3.7 wt % at least one metal additional element selected from Al, Sn, In and Ga. The Ti—Nb—Zr base alloy is a practical alloy in which the principal components form a strong and dense oxidation film to exhibit high biocompatibility, and also the alloy has superelasticity and shape memory properties, high cold workability, and high low-temperature properties.

Abstract: Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.

Abstract: Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective imnunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.

Abstract: The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.

Abstract: Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.

Abstract: A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (? and ?) produced by alternative splicing has been identified in humans. A transgenic model was created that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Over-expressing C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. The C21 protein forms a complex with a class of molecules that plays a critical role in transcription, the co-repressors of nuclear hormone receptors.

Abstract: A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (? and ?) produced by alternative splicing has been identified in humans. A transgenic model was created that shows that over-expression of C21 in mouse hematopoietic cells alters myeloid development and suggests that members of this family are involved in regulating stem cell differentiation. Over-expressing C21 in 3T3 fibroblasts increases their resistance to apoptotic stimuli. The C21 protein forms a complex with a class of molecules that plays a critical role in transcription, the co-repressors of nuclear hormone receptors.

Abstract: Cell-mediated immune response to a papillomavirus infection can be induced by vaccination with DNA encoding papillomavirus E genes. E genes can both prevent the occurrence of papillomavirus disease, and treat disease states. Canine papillomavirus (COPV) E genes which are codon-optimized to enhance expression in host cells are also given.

Abstract: Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against papillomavirus infection through stimulation of neutralizing antibody and cell-mediated immunity.

Abstract: The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.

Abstract: The invention is a series of synthetic virus-like particles comprising a heterologous conformational epitope useful in the characterization of human papillomavirus infection, and useful to vaccinate individual for protection against HPV 6 and HPV 11 infections, and assays employing the synthetic virus-like particles.

Abstract: The present invention relates, in part, to newly developed assay for diagnosing cancers, particularly endometrial and mammary, endometriosis and endometrial fibroids along with methods for identifying therapeutic agents that modulate endometrial steroid binding protein II activity for the treatment of the above disorders.

Abstract: The presentinvention provides a new method for diagnosing and treating cancers, endometriosis and endometrial fibroids. Further provided are therapeutic agents and pharmaceutical compositions for treating cancers, endometriosis and endometrial fibroids.

Abstract: Provided are combined nucleic acid hybridization-detection assays for detecting, or determining the concentration of, a target nucleic acid in a sample of biological fluid; detecting, or determining the concentration of, each one of two or more target nucleic acids in a sample of biological fluid; determining the amount of a metabolite of a target nucleic acid in a biological fluid; determining the amounts of multiple metabolites of a target nucleic acid in a biological fluid; detecting a metabolite of a target nucleic acid in a biological fluid; detecting multiple metabolites of a target nucleic acid in a biological fluid; and for determining the concentration of a ribozyme in mammalian serum.