Abstract: Single-domain antibodies binding to the CLL1 protein and their uses are provided. Specifically, a single-domain antibody with the amino acid sequence of SEQ ID NO: 1 is provided. This single-domain antibody exhibits high affinity and can effectively and specifically target CLL1-positive cells. It can efficiently promote the secretion of IFN? by NK cells, activate the effector functions of NK cells, and significantly induce the cytotoxic effects of NK cells, thereby demonstrating a strong capacity for specifically killing CLL1-positive cells. The single-domain antibody can be formulated into drugs for the clinical prevention or treatment of diseases related to the CLL1 target. It can also be used for the preparation of CAR cells targeting CLL1 or detection kits for the CLL1 protein. The single-domain antibody drug features stable structure, small molecular size, ease of recombinant expression, and low production costs.

Abstract: The present disclosure provides a fusion training method for a risk control model, including: receiving label data, and refining expert knowledge; separately performing multi-order feature crossing on the label data and the expert knowledge, to obtain a data representation and a rule representation; purifying the data representation based on the rule representation; and training and outputting the risk control model based on the purified data representation.

Abstract: Symmetric spiral configurations of portions of a negative trace and a positive trace with opposite orientations provide for a field cancellation effect in a Wilkinson power divider (or combiner), wherein magnetic fields produced by the positive trace are substantially cancelled out by magnetic fields produced by the negative trace. The geometries of the positive trace and the negative trace effectively produce isolation inductors. Some implementations utilize a transformer, which includes a first positive input port and a first negative input port, an amplifier, and a transformer, which include an input shunt inductor of the differential power divider as part of the transformer.

Abstract: A system and method for determining improved target speeds for accelerated cruise control systems of vehicles. Data is obtained by human-operated ego vehicles, the data including ego-vehicle speeds, lead-vehicle speeds, follow distances, and location tuples of the ego vehicles, such as GNSS coordinates. The location tuples are mapped to lane centerpoints of a high-definition map. A machine-learning model is trained to determine target speeds of a future vehicle based on the ego-vehicle speeds, lead-vehicle speeds, follow distances, and lane centerpoints. The trained model can be implemented as part of an accelerated cruise control system in a vehicle.

Abstract: An autonomous mobile device (AMD) moves within in a physical space. The AMD may encounter features in the physical space, such as flooring transitions, or obstacles that may impede movement. Sensors such as an ultrasonic sensor, optical time of flight sensors, inertial measurement unit (IMU), wheel speed sensors, and motor torque sensors acquire sensor data. Based on the sensor data, a location of an obstacle, and characterize whether that obstacle is traversable or non-traversable, is determined. If traversable, the AMD may continue moving past the obstacle. If non-traversable, the location of the obstacle may be added to a map used for route planning. Based on the location of the non-traversable obstacle, the AMD may move to a recovery location away from the obstacle, and resume moving.

Abstract: A fusion protein with the amino acid sequence of SEQ ID NO: 1 and the nucleic acid molecule (SEQ ID NO: 3) including an encoding gene of a chimeric antigen receptor and an encoding gene of a chimeric switch receptor are provided. By designing fusion gene containing the encoding gene of the chimeric antigen receptor and the encoding gene of the chimeric switch receptor, PD-L1 activated inhibition of anti-tumor T cell responses is converted into a CD27-mediated activation signal, thereby endowing CAR-T cells with the capability of resisting an immunosuppressive tumor microenvironment, thereby enhancing its in vivo persistence. In addition, the micro-environment near a tumor is regulated by promoting secretion of cytokines IFN-? and IFN-?2 to relieve the immunosuppression thereof, thereby mobilizing the organism autoimmunity to participate in the killing effect on tumor cells, and improving the anti-tumor effect of the CAR-T cells.

Abstract: Disclosed is an antibody capable of binding to the interleukin 4 (IL-4) receptor (IL-4). Also disclosed are a nucleic acid sequence encoding the antibody, a vector including the nucleic acid sequence, and a host cell transformed or transfected with the vector. Provided are a method for producing the antibody, a medical use of the antibody, and a kit including the antibody.

Abstract: An autonomous mobile device (AMD) moves within in a physical space. The AMD may encounter features in the physical space, such as flooring transitions, or obstacles that may impede movement. Sensors such as an ultrasonic sensor, optical time of flight sensors, inertial measurement unit (IMU), wheel speed sensors, and motor torque sensors acquire sensor data. Based on the sensor data, a location of an obstacle, and characterize whether that obstacle is traversable or non-traversable, is determined. If traversable, the AMD may continue moving past the obstacle. If non-traversable, the location of the obstacle may be added to a map used for route planning. Based on the location of the non-traversable obstacle, the AMD may move to a recovery location away from the obstacle, and resume moving.

Abstract: A method and apparatus for protecting data, and a device and a medium are provided. The method comprises acquiring, by a first device, a feature representation generated by a second device on the basis of sample data and according to a second model, wherein the first device has label information for the sample data; and the first device and the second device are used for jointly training a first model at the first device and the second model at the second device. The method further comprises generating, by the first device, a prediction label for the sample data on the basis of the feature representation and according to the first model. The method further comprises determining, by the first device and on the basis of the feature representation, the label information and the predicted label, a total loss value used for training the first model and the second model.

Abstract: An electric vehicle charging control device includes a charging station and an electronic dynamic charging schedule generator. The charging station has at least a first charging port and a second charging port. The electronic dynamic charging schedule generator has an electronic controller is configured to determine when a first electric vehicle user accesses the first charging port. The electronic controller is further configured to determine when a second electric vehicle user accesses the second charging port. The second electric user accesses the second charging port after the first user accesses the first charging port. The electronic controller is programmed to generate a first charging schedule for the first electric vehicle. The electronic controller is programmed to generate a second charging schedule for the second electric vehicle. The electronic controller is programmed to update the first charging schedule based on the second charging schedule.

Abstract: Disclosed is a power supply assembly comprising a first printed circuit board (PCB), a second PCB that is vertically spaced apart from the first PCB, and a switch supported on the second PCB. The power supply assembly further comprises a conductive pillar that couples the first PCB to the second PCB, wherein current output by the switch flows from the switch to the first PCB via the conductive pillar.

Abstract: The present disclosure describes techniques of performing machine unlearning in a recommendation model. An unlearning process of the recommendation model may be initiated in response to receiving a request for deleting a fraction of user data from any particular user. The recommendation model may be pre-trained to recommend content to users based at least in part on user data. Values of entries in a matrix corresponding to the fraction of user data may be configured as zero. The matrix may comprise entries denoting preferences of users with respect to content items. Confidence values associated with the fraction of user data may be configured as zero to block influence of the fraction of user data on performance of the recommendation model. The unlearning process may be implemented by performing a number of iterations until the recommendation model has converged.

Abstract: The present disclosure provides a method for diagnosing structural in-service performance based on high dam risk mode and failure path. The method includes: constructing a high dam risk incident case database and extracting risk feature parameters; applying multi-scale hierarchical adaptive correspondence analysis, and resolving the problem of imbalance feature weights through feature weight calculation, hierarchical weighting of risk modes, establishment of physical similarity indices, and structural difference compensation, generating a weighted similar-project ranking list; constructing a time-series adaptive network model with multiple failure modes coupled to address the imperfect time-series evolution mechanism of failure paths, and outputting a time-series failure path prediction model; combining the similar-project ranking list and the time-series failure path prediction model to conduct engineering analogy analysis and generate a high dam safety status assessment report.

Abstract: The present disclosure discloses a staple cartridge, a staple cartridge assembly, and an anastomosis device. A feeding groove of a staple cartridge provided in the present disclosure is arranged to extend in the first predetermined direction. Multiple staple slot groups are distributed on both sides of the feeding groove along the slot-width direction of the feeding groove, and the number of staple slot groups on both sides of the feeding groove is different.

Abstract: A circuit includes a digital attenuator part with first and second attenuator terminals, a first inductor, a first switched arrangement, and a second switched arrangement. The first inductor has a first terminal coupled to the first attenuator terminal and a second terminal coupled to the second attenuator terminal. The first switched arrangement has a first switch with a first switch-terminal and a second switch-terminal. The first switch-terminal is coupled to the first terminal of the first inductor. A first resistor and a first capacitor are arranged in parallel, coupled between the second switch-terminal and a reference voltage. The second switched arrangement has a second switch with a first switch-terminal and a second switch-terminal. The first switch-terminal is coupled to the second terminal of the first inductor. A second resistor and a second capacitor are arranged in parallel and coupled between the second switch-terminal and the reference voltage.

Abstract: A method for assessing quality of an echocardiogram image based on fusion of image and text features is provided, which relates to the field of medical imaging technologies. The method includes performing feature extraction and classification by using a target detection model, aligning image features with quality control text features by using a visual-language feature alignment module, and performing sentence template selection, linear projection, and merging by using a large language model.

Abstract: Substantially equal mutual inductances between a primary coil and respective secondary windings of a secondary coil of a transformer with an integrated differential Wilkinson power divider or combiner help to ensure balanced outputs for the transformer. The primary coil and the secondary coil are substantially symmetric to provide a high coupling between the coils, and the secondary windings of the secondary coil are substantially symmetric to help provide the substantially equal mutual inductances. The secondary windings of the secondary coil cross over each other an equal number of times to further ensure balanced outputs for the transformer.

Abstract: Various embodiments include a printed circuit board cover assembly comprising a cover layer that attaches to at least a portion of a printed circuit board layer, and a retention hook that extends from the cover layer and physically interfaces with at least a portion of a connection port. In various embodiments, a printed circuit board package comprises a printed circuit board layer, a cover layer that attaches to at least a portion of the printed circuit board layer, and a retention hook extending from the cover layer, the retention hook configured to physically interface with at least a portion of a connection port.

Abstract: The disclosure relates to a power amplifier apparatus. A power amplifier apparatus includes a power amplifier circuit configured to receive an RF input signal at an RF input and to generate an RF output signal at an RF output; an adaptive bias circuit comprising a biasing transistor, the biasing transistor having a common terminal coupled to the RF input and to a tail current source, and the biasing transistor further having an input terminal coupled to a DC bias voltage source; and a rectification booster comprising a current mirror device, wherein a first side of the current mirror device is coupled to an output terminal of the biasing transistor and wherein a second side of the current mirror device is coupled to the RF input.

Abstract: Described herein are new solid oxide fuel cell interconnects and methods for making same that may comprise a novel bilayer construct on an anode substrate to provide a dense microstructure, low area specific resistance, and negligible oxygen permeability to form a bilayer ceramic interconnect that is a strong candidate for next-generation, durable, and low-cost tubular solid oxide fuel cells.