Abstract: The present invention relates to a method of improving the efficacy of treatment of line 2+ metastatic castration-resistant prostate cancer (mCRPC) with biallelic DNA-repair anomalies in a male human, wherein said biallelic DNA-repair anomalies are selected from: i) BRCA (BRCA1, BRCA2, or a combination thereof), ii) non-BRCA (ATM, FANCA, PALB2, CHEK2, BRIP1, HDAC2, or any combination thereof): or iii) any combination thereof; wherein the male human has received prior taxane-based chemotherapy and androgen receptor (AR)-targeted therapy; said method of improving the efficacy of treatment comprising administering to said male human a once-daily oral dosing of 300 mg niraparib.

Abstract: In response to a request to park an ADV in a parking lot, a set of parking-trajectories associated with a set of predetermined locations near one or more parking spots in the parking lot may be obtained, where the set of parking-trajectories was previously generated based on prior collected planning and control data of the parking lot. Each parking-trajectory of the set of parking-trajectories may correspond to one parking spot of the one or more parking spots in the parking lot. A parking-trajectory may be selected from the set of parking-trajectories based on a current location of the ADV. The ADV may be controlled to park in a corresponding parking spot according to the selected parking-trajectory.

Abstract: The present disclosure relates to a transducer and a headphone. The transducer includes a magnetic circuit system, a coil, a first vibration transmitting plate, and a second vibration transmitting plate. The magnetic circuit system includes a magnet assembly. The coil is sleeved on an outside of the magnet assembly around an axis parallel to a vibration direction of the transducer. The first vibration transmitting plate and the second vibration transmitting plate elastically support the magnet assembly in the vibration direction from opposite sides of the magnet assembly, respectively. In the present disclosure, the magnet assembly is elastically supported by the first vibration transmitting plate and the second vibration transmitting plate in the vibration direction of the transducer from the opposite sides, respectively, to make it free of abnormal vibration, such as obvious shaking, which is conducive to increasing stability of vibration of the transducer.

Abstract: Disclosed is a phase measurement device, comprising: a first wave plate, a first polarization splitting prism, a fourth wave plate, a retroreflector, a third wave plate, a reflector, a second wave plate, a polarizer, a second polarization splitting prism, a third polarization splitting prism, a first photoelectric detector, a second photoelectric detector, and a base, wherein the first to third polarization splitting prisms and the first and second photoelectric detectors are fixed on the base; the first to fourth wave plates are respectively arranged around the periphery of the first polarization splitting prism; the polarizer is arranged on an emitting surface of the third polarization splitting prism; the retroreflector is arranged on an outer side of the fourth wave plate; and the reflector is arranged on an outer side of the third wave plate. An interferometric signal is resolved to obtain a measurement light beam phase.

Abstract: A computing device may receive trigger data defining a trigger event and logic to add an enriched event associated with the trigger event. A computing device may detect occurrence of the trigger event in execution of one or more digital services by an executable service platform in an online operational environment of a service provider system based on the trigger data. A computing device may generate event data describing the execution of the trigger event and the enriched event responsive to the detecting based on the logic of the trigger data. A computing device may store the event data within an offline simulation environment. A computing device may simulate operation of the executable service platform offline using the event data. A computing device may output a result of the simulating for display in a user interface.

Abstract: An unnatural amino acid may have a structure as shown in formula (1) or may be an enantiomer thereof: Such unnatural amino acid may be used, e.g., in recombinant proteins. A recombinant protein may contain such unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid can be simple and convenient to prepare, safe in nature, difficult to inactivate when inserted into a protein, and may have a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate.

Abstract: The present invention relates to an electronic device, a wireless communication method, and a computer readable medium. According to one embodiment, the electronic device used for wireless communication comprises a processing circuit. The processing circuit is configured to perform control to send data and information related to retransmission of the data to a target user equipment by means of a sidelink. The processing circuit is further configured to control operation for the retransmission of the data.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A 3D printing device and method for integrated manufacturing of functionally gradient materials and three-dimensional structures. The device includes an active and passive mixing and printing module and a constraining and sacrificial layer printing module. An input end of the active mixing module connects to multiple anti-settling feeding modules, and an output end of the active mixing module connects to the passive mixing and printing module. The passive mixing and printing module and the constraining and sacrificial layer printing module are mounted on one side of an XYZ three-axis module. The constraining and sacrificial layer printing module connects to a constraining and sacrificial layer feeding module and prints and forms a functionally gradient three-dimensional structure.

Abstract: Provided are a method and system for controlling interactive live streaming co-hosting, a device, and a medium. The method for controlling interactive live streaming co-hosting includes acquiring a first interactive image and receiving a mirror interactive image of a second terminal by a first terminal, where the first terminal and the second terminal are in a live streaming co-hosting state, and the mirror interactive image of the second terminal is obtained by performing mirror processing on a second interactive image of the second terminal; and combining the first interactive image and the mirror interactive image by the first terminal to obtain a target interactive image.

Abstract: A substrate module, a display apparatus, and a liquid crystal antenna are provided in the present disclosure. The substrate module includes a first substrate. The first substrate includes a first sub-region and a second sub-region; the second sub-region includes a binding region; and the binding region includes first pins. The first sub-region includes first loads, and a first sub-pin is electrically connected to the first load. The second sub-region includes at least one second load, and a second sub-pin is electrically connected to the second load. The second load includes a capacitor including a first capacitor. The first substrate includes a first base substrate, a first electrode layer, a first insulating layer and a second electrode layer. Along a direction perpendicular to a plane of the base substrate, an overlapping portion of a first electrode portion and a second electrode portion forms the first capacitor.

Abstract: An electronic device has a curved screen. An arc-shaped transition edge is disposed on both sides of a corner of the curved screen, and a black border is bent to a side surface of the electronic device, so that a full-screen effect without a black border is achieved, and the fringe of the curved screen is continuous and smooth as a whole.

Abstract: The present application provides a near field communication antenna structure, a housing with the same, and an electronic terminal, the near field communication antenna structure including a first conductive body, a second conductive body, a micro-slit structure, a first feed point and a second feed point, wherein the micro-slit structure is positioned between the first conductive body and the second conductive body to separate the first conductive body from the second conductive body, the first feed point is provided on the first conductive body, and the second feed point is provided on the second conductive body. The use of the above NFC antenna structure saves a separate NFC antenna structure, reduces cost and has a simple structure.

Abstract: A system and a method are disclosed for adjusting communication settings based on user segmentation. An activity-based communication management system retrieves behavioral and demographic data of at least one user. The system inputs the behavioral data and the demographic data into machine learning models. For each of the machine learning models, the system receives a respective activity parameter characterizing a predicted activity occurring within a time window. The system determines, based on the received activity parameters, a category to which the behavioral data and demographic data belong. The system subsequently adjusts a plurality of communication settings based on the determined category. The activity-based communication management system may provide user segmentation using both empirical activity parameters (e.g., historical behavioral data) and predicted activity parameters.

Abstract: The present disclosure relates to an electronic device, a wireless communication method and a computer-readable medium. According to one embodiment, an electronic device for wireless communication comprises a processing circuit, wherein the processing circuit is configured to conduct control so as to send a reference signal for a direct link to the other user equipment or to receive same from the other user equipment; the processing circuit is also configured to conduct control so as to carry out beamforming-based direct link communication with the other user equipment; and at least one of a sending beam and a receiving beam for direct link communication is determined based on the measurement of the reference signal.

Abstract: A silicone release coating dispersion has a polyorganosiloxane continuous phase and an aqueous discontinuous phase. The aqueous discontinuous phase includes water and an ionic liquid. The polyorganosiloxane continuous phase includes a hydrosily-N lation reaction curable silicone release coating composition. A method for preparation of the silicone release coating dispersion, and a method for use thereof to form a silicone release coating are provided.

Abstract: A network device may receive an indication to enable sub-band full duplex uplink transmission for a first user equipment (UE), and may determine whether the first UE and a second UE are associated with a separation that is more than a threshold separation. The network device may enable the sub-band full duplex uplink transmission for the first UE based on determining that the first UE and the second UE are associated with a separation that is more than the threshold separation. The network device may deny the sub-band full duplex uplink transmission for the first UE based on determining that the first UE and the second UE are associated with a separation that is less than the threshold separation.

Abstract: The present application provides a bottom layer metal interconnection line structure, at least including a test key and leads connected to the test key; the test key being composed of a plurality of metal lines connected end-to-end; the plurality of metal lines being arranged in the same plane in a winding manner, wherein at least one suspending via structure is provided at each winding point; and two leads are provided and respectively connected to ends of the metal lines located at a head end and a tail end in the test key. The present application increases a maximum root-mean-square current that the winding metal interconnection lines can withstand while improving a heat dissipation problem of the bottom layer metal interconnection lines.

Abstract: A display substrate is provided, including: a base substrate including at least pixel and hole areas; sub-pixels arranged on the base substrate and in the pixel area; a hole in the hole area; a first barrier dam between the sub-pixels and the hole and at least partially surrounding the hole; a functional film layer, an organic material layer and an encapsulating structure sequentially arranged on the display substrate in a direction away from the base substrate, an orthographic projection of the organic material layer on the base substrate falling within the pixel area, the organic material layer including at least one film layer; and a filling structure, at least a portion of which is arranged between the hole and the first barrier dam. The filling structure and the at least one film layer of the organic material layer are in the same layer and include the same material.

Abstract: Disclosed in the present invention is a method for preparing 2-iodo aryl ether under the action of alkali metal hydride: adding alkali metal hydride and phenol to a solvent, then adding 1,2-diiodoarene, and reacting at 0-100° C. to obtain a 2-iodo aryl ether product. The coupling process of the present invention does not require the addition of a transition metal catalyst, and does not cause metal contamination to the product; the method of the present invention can be performed at room temperature and has high functional group compatibility, and solves the problem that existing metal-catalysed coupling to aryl ether reactions need to be performed at a relatively high temperature.