Abstract: The present application provides a method for preparing a drug-linker conjugate. Specifically, the present application provides a method for preparing compound IM2, which comprises the following steps: adding compound SM1 to a mixed solution of triphosgene and 4-dimethylaminopyridine to obtain an intermediate solution; adding compound SM2 to the intermediate solution, stirring the mixture, thereby obtaining compound IM2. The stability, practicality and scalability of the process are improved by optimizing the preparation process of IM2 and using a normal chromatography purification method that is easily scalable.

Abstract: Disclosed herein are approaches for forming an air grid of an image sensor. One method may include depositing a first fill material within a first plurality of trenches to form a plurality of grid structures, wherein the first plurality of trenches is formed through an oxide layer formed over a substrate, wherein the fill material is formed along a sidewall and a bottom surface of each trench of the plurality of trenches, and wherein a void is formed within the fill material. The method may further include forming a second plurality of trenches through the oxide layer and the first fill material.

Abstract: A computer-implemented method executed by one or more processors includes receiving interconnection data for a proposed interconnection to a power grid; accessing a power grid model including a topological representation of the power grid, electrical specifications of grid components, and empirical operation characteristics; and generating, using the interconnection data for the proposed interconnection to the power grid, and the power grid model, simulated power grid data. The simulated power grid data is based on simulating operation of the power grid with the proposed interconnection coupled to a location of the power grid identified by the interconnection data during a simulated time period. The simulated power grid data includes a plurality of different temporal and spatially dependent characteristics of the power grid. The method includes evaluating, using one or more metrics, the simulated power grid data; and outputting evaluation results of the one or more metrics.

Abstract: A computer-implemented method executed by one or more processors includes receiving interconnection data for a proposed interconnection to a power grid; accessing a power grid model including a topological representation of the power grid, electrical specifications of grid components, and empirical operation characteristics; and generating, using the interconnection data for the proposed interconnection to the power grid, and the power grid model, simulated power grid data. The simulated power grid data is based on simulating operation of the power grid with the proposed interconnection coupled to a location of the power grid identified by the interconnection data during a simulated time period. The simulated power grid data includes a plurality of different temporal and spatially dependent characteristics of the power grid. The method includes evaluating, using one or more metrics, the simulated power grid data; and outputting evaluation results of the one or more metrics.

Abstract: A scheduler. In some embodiments, a method includes: scheduling a first task, of a first job, on a first processing element, the scheduling including: calculating a slack in the first processing element, for the first task, based on an expected occupancy time, in the first processing element, of a second task, of the first job, and based on an expected occupancy time, in the first processing element, of a third task, of a second job.

Abstract: The present disclosure relates to the field of brake discs. Provided are a brake disc having a surface ultra-high-speed laser cladded wear-resistant and corrosion-resistant coating and a preparation method thereof, and a vehicle. The preparation method includes: performing pretreatment on a brake disc to obtain a brake disc to be cladded; adjusting an angle of the brake disc to be cladded, such that an included angle ?1 between a surface to be cladded and an axis of a cladding head and an included angle ?2 between an edge of the cladding head and the axis of the cladding head satisfy: ?1+0.5?2<90°; and sequentially performing ultra-high-speed laser cladding of a bottom layer and ultra-high-speed laser cladding of a hard surface layer on the brake disc to be cladded to obtain the brake disc having the surface ultra-high-speed laser cladded wear-resistant and corrosion-resistant coating.

Abstract: A curiosity-driven Android app automatic testing method includes the following steps:1) a left part represents a pre-processing assembly which achieves abstraction of an Android app state based on an Android interface structure; 2) a right part is curiosity-driven reinforcement learning module which maintains a historical access state set and optimizes an exploration policy constantly to guide a test to find more new states under the guidance of a reward function based on a curiosity thought; and 3) a middle part represents an advanced guidance module of a deterministic finite automaton (DFA), where the DFA is constructed during operation to record all access states and frequencies thereof; and if the new states are not explored within a given time budget, an AndroidExplore selects the most curious state as a starting point of a next exploration according to global information of the DFA.

Abstract: The present invention belongs to the technical field of membranes, and in particular relates to a polyamide composite reverse osmosis membrane and to a preparation method thereof. The polyamide composite reverse osmosis membrane provided by the present invention comprises: a nascent membrane and a temperature-responsive polypeptide grafted to a surface of the nascent membrane; the nascent membrane comprises a support layer and a polyamide separation layer joined to the support layer; the temperature-responsive polypeptide is a homopolymeric (L-glutamate) containing oligo(ethylene glycol). The polyamide composite reverse osmosis membrane provided in the present invention has excellent pollution resistance and oxidation resistance capabilities, has a low difficulty of cleaning, and has extremely broad market prospects.

Abstract: A pyrimidine-2,4-diamine compound and a preparation method and application thereof are provided. The pyrimidine-2,4-diamine compound of the present disclosure can be used in the research of biological or pharmacological phenomena and cathepsin C-involved signal pathway transduction and the evaluation of novel cathepsin C inhibitors. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-cathepsin C activity in vitro and in vivo and proved to have strong inhibitory activity on cathepsin C. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-NSP activity in vivo and proved to have strong inhibitory activity on NSP. The pyrimidine-2,4-diamine compound is subjected to the screening of anti-inflammatory activity in vivo and proved to have an effective therapeutic effect on inflammatory disease models. Meanwhile, the pyrimidine-2,4-diamine compound shows low toxicity and exhibits good application prospect.

Abstract: A charging and discharging circuit and method, and a computing device and a storage medium. Two energy storage elements in the charging and discharging circuit are connected by means of a first adjustment switch module, after a switch is turned on, heating control is performed, and self-heating of a battery is realized by means of an alternating current generated by a charging and discharging loop between a dual-driving electric motor and the battery.

Abstract: A space electric propulsion system and a xenon filling method therefor are provided, suitable for a filling process of an electric propulsion system using high-purity xenon as a working medium. By reasonably designing a filling process, the precision of a xenon filling amount is ensured, and xenon filling can be performed without weighing the whole spacecraft. This method features a simple and efficient filling device, short preparation time, precise and controllable filling process, as well as safety and convenience, which can effectively meet the requirements for a high-purity xenon rapid filling task of a satellite.

Abstract: A charge and discharge control method comprises: when a battery heating condition is satisfied, turning on a connecting circuit between a neutral point of a first electric motor and a neutral point of a second electric motor, wherein a first electric motor controller connected to the first electric motor and a second electric motor controller connected to the second electric motor are both connected between a positive electrode and a negative electrode of a battery; and controlling the turning-on/turning-off of bridge arms in the first electric motor controller and the second electric motor controller, and forming, in a circuit in which the battery is located, a charging loop and a discharging loop which are alternately switched.

Abstract: A charge-discharge circuit, a method, a computing device, and a control apparatus thereof, where a regulation switch module is connected between a first energy storage element and a second switch module, utilizing an alternating current generated by a charge-discharge loop between a drive motor and a battery to achieve battery self-heating.

Abstract: A charging and discharging circuit, a battery control circuit and an electrical device. The charging and discharging circuit includes: a power supply module, a first driving assembly, a second driving assembly and a first switch; the power supply module includes a battery, the first driving assembly includes a first motor, and the second driving assembly includes a second motor; the first driving assembly and the second driving assembly are connected in parallel between a positive electrode end and a negative electrode end of the power supply module; and one end of the first switch is connected to a neutral point of the first motor, and the other end of the first switch is connected to a neutral point of the second motor.

Abstract: A sexual health capacity measurement and analysis system, method, and device are provided. The method includes: acquiring a relative acceleration of waist movements of a male and a female; acquiring a start time and an end time of sexual activity to obtain a duration; acquiring a thrust count, a thrust distance, and a thrust frequency of the male, and/or a thrust count, a thrust distance, and a thrust frequency of the female; obtaining position data based on the relative acceleration of the waist movements of the male and the female; and inputting the relative acceleration of the waist movements of the male and the female, the duration, the thrust count, thrust distance, and thrust frequency of the male, and/or the thrust count, thrust distance, and thrust frequency of the female, and the position data into a hierarchical analysis model to obtain a sexual health capacity measurement and analysis result.

Abstract: Provided are a pharmaceutical composition of a PVRIG/TIGIT bispecific antibody and use thereof. Specifically, provided is a pharmaceutical composition, comprising a PVRIG/TIGIT bispecific antibody and a buffer solution. The pharmaceutical composition further comprises a sugar and a surfactant. Also provided is a pharmaceutical composition for treating cancer or infectious diseases.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a wireless communication device may identify, for removal from a hybrid automatic repeat request (HARQ) buffer of the wireless communication device, a HARQ process from a plurality of HARQ processes maintained in the HARQ buffer by the wireless communication device, wherein the HARQ process is identified based at least in part on one or more HARQ buffer management parameters. The wireless communication device may remove the HARQ process from the HARQ buffer. Numerous other aspects are described.

Abstract: The present application relates to the technical field of water quality monitoring for water supply systems, and provides a water quality monitoring method for a water supply system, a water supply system, and a refrigeration apparatus. The water quality monitoring method for a water supply system includes: controlling to convey water to a water outlet pipe of the water supply system; obtaining a water quality parameter in the water outlet pipe; judging whether the water quality parameter meets a standard; if the water quality parameter meets the standard, ending the monitoring; if the water quality parameter does not meet the standard, proceeding to a next operation; controlling to drain the water in the water supply system; and repeating the above obtaining operation, judging operation, and draining operation, until the water quality parameter meets the standard.

Abstract: In one aspect, a device for wireless communication is disclosed. The device includes at least one processor and a memory coupled to the at least one processor. The at least one processor is configured to cause the device to: receive reassembly timer configuration information. The at least one processor is also configured to receive one or more radio link control (RLC) segments, each RLC segment associated with a sequence number (SN), wherein the one or more RLC segments are associated with a reassembly timer expiration time based on the reassembly timer configuration information. The at least one processor is further configured to: release, prior to the reassembly timer expiration time, the one or more RLC segments based on an adjusted reassembly timer expiration time. The adjusted reassembly timer expiration time is determined based on an output from a learning model of the device. Other aspects are described and claimed.