Abstract: A method and apparatus is disclosed relating to food processing and preparation in commercial kitchens. The disclosed extreme vacuum cooling (EVC) technology and apparatus can work in ultra low pressure conditions with adaptive pressure control to avoid potential liquid splash inside the vacuum chamber caused by un-controlled low pressure conditions. Clean air or inert gas is added into the vacuum chamber so that the chamber pressure can track a setpoint trajectory that may have ramp up periods in order to avoid liquid splash events. The inventive apparatus allows the user to automatically cool various kinds of foods based on a recipe with minimal human interaction and meet food safety regulations. Different cooling recipes can be created based on the type and volume of the foods and a related vacuum pressure setpoint trajectory. High-volume food service kitchens can achieve less labor intensive, more time efficient, and higher throughput food preparation operations.

Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Abstract: A system and computer software mechanism is disclosed that can automatically detect smoking conditions for industrial flares. In an online mode, the software mechanism can analyze live video images to identify smoking conditions and generate a “Smoke Level” value to represent the seriousness of the smoking events. In an off-line mode, the software mechanism can load saved video files and analyze video images to identify smoking conditions and generate a “Smoke Level” value to represent the seriousness of the smoking events. In the online mode, the Smoke Level data can be sent to the plant distributed control system (DCS) or other control devices so alarms can be generated and automatic or manual control actions can be taken quickly to stop the flare from smoking. In both online and off-line modes, Smoke Level data can also be saved in historical files for reporting and smoke event tracking purposes.

Abstract: wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: Provided is a composition for detecting multiple encephalitis/meningitis/respiratory pathogens. The composition includes primer sequences for the pathogens as shown in SEQ ID NOs: 1-7, 9-23 and 25-32, in which SEQ ID NOs: 1-7 and 9-16 carry fluorescent reporter groups. In addition, the present invention further provides a use of the foregoing composition in the preparation of a kit, and a related kit and a method for using the same.

Abstract: The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy.

Abstract: A method and system is disclosed that can automatically detect smoking conditions for industrial flares. It can analyze live or historical video images to identify smoking conditions and generate a “Smoke Level” value in the range of 0 to 10 to represent the seriousness of the smoking events. The Smoke Level data can be sent to the plant distributed control system (DCS) or other control devices so alarms can be generated and automatic or manual control actions can be taken to stop the flare from smoking quickly. The Smoke Level data can also be saved in historical files for reporting and smoke event tracking purposes. Using the described method and system, industrial plants can comply with EPA regulations at all times, improve flare control and monitoring, be better prepared for EPA reporting and auditing, and save energy and manpower.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: Provided herein are tetracyclic oxazepinyl compounds useful in the treatment on cancers.

Abstract: Compounds of Formula (00A) and salts thereof, wherein R1, R2 R3, R4 and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: A method and apparatus is disclosed relating to smart Microgrids or off-grid solar systems with grid power integration supported by AC assisted off-grid power inverters that can (1) intelligently and selectively pull power from one or multiple DC sources including solar panels, wind generators, and batteries based on certain criteria; (2) invert DC power to AC power as generated AC power; (3) intelligently pull power from a connected AC source including grid AC, a gas generator, or a wind generator as input AC power; (4) combine the generated AC power with the input AC power; (5) supply the combined AC power, or the generated AC power, or the input AC power to an off-grid circuit to power various types of AC loads; (6) send no power to the connected AC source; (7) maximize DC power production; (8) minimize the consumption of input AC power; and (9) achieve good system performance under DC and AC power variations and load changes.

Abstract: Provided are a metasurface primary mirror, a metasurface secondary mirror, a method for manufacturing a metasurface primary mirror, a method for manufacturing a metasurface secondary mirror, and an optical system. The metasurface primary mirror, manufactured by using the method for manufacturing a metasurface primary mirror, includes a transparent substrate which includes a primary mirror metasurface pattern on the transparent substrate. The primary mirror metasurface is configured to satisfy a primary mirror phase distribution such that incident light reflected by a metasurface secondary mirror onto the metasurface primary mirror is reflected and focused.

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Abstract: Compounds of Formula (IA), or a pharmaceutically acceptable salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: The present application discloses a method for preparing optical metasurfaces, wherein the method is performed based on nano-imprinting, and the template used in the method is an imprinting template with patterns of meta-atoms. The method for preparing optical metasurfaces provided by the present application can replace the electron beam lithography method used in fabricating meta-atoms, greatly reducing the costs, and greatly reducing the production time. The method provided by the present application significantly improves the production cost and the production time, achieving a low-cost, large-scale fabrication of metasurface-based optical elements within a short time, and having good industrialization prospects.

Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: A microfluidic chip for circulating tumor cell separation, comprising a first shell layer, a second shell layer, and a filter membrane between the first shell layer and the second shell layer. A first channel is formed between the filter membrane and the first shell layer; a second channel is formed between the filter membrane and the second shell layer; the first shell layer is provided with m input interfaces and n output interfaces, wherein m is greater than or equal to 1 and n is greater than or equal to 1; the second shell layer is provided with x input interfaces and y output interfaces, wherein x is greater than or equal to 1 and y is greater than or equal to 1. The chip is used for circulating tumor cell separation to achieve high flux, high efficiency, and a simple method, and facilitate promotion.

Abstract: Disclosed are a system and method for micro-nano machining by femtosecond laser two-photon polymerization. The system includes: a femtosecond laser, an external light path modulation unit, an image capture apparatus, a focusing lens, a displacement platform, a computer and a monitoring apparatus, where the image capture apparatus is configured to capture cross-section graphs of a three-dimensional micro-nano device layer by layer, so that modulated femtosecond lasers form parallel beams arranged according to all layers of the cross-section graphs.

Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.