Abstract: Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein X, R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: A material composition, which is used as a liquid resist, includes a first component comprising a monomer portion and at least one cationically polymerizable functional group, and a crosslinker reactive with the first component and comprising at least three cationically polymerizable functional groups. The material composition also includes a cationic photoinitiator. Upon exposure to UV light, the material composition crosslinks via cure to form a cured resist film that is the reaction product of the first component, the crosslinker, and the cationic photoinitiator. An article includes a substrate layer and a resist layer formed on the substrate layer from the material composition.

Abstract: The present invention relates to a method for imprinting a micro-/nano-structure on a substrate, the method comprising (a) providing a mold containing a desired pattern or relief for a microstructure; (b) applying a polymer coating to the mold; and (c) transferring the polymer coating from the mold to a substrate under suitable temperature and pressure conditions to form an imprinted substrate having a desired micro-/nano-structure thereon.

Abstract: A method of forming nanofluidic enclosed channels includes providing a first substrate having a layer of a first material disposed thereon. A plurality of nanoscale slots is formed along a second substrate using nanolithography, etching, or other disclosed techniques. The first substrate is then bonded to the second substrate such that the layer of the first material on the first substrate is adjacent the plurality of slots on the second substrate to define a plurality of enclosed nanofluidic channels therethrough.

Abstract: An apparatus and method is disclosed for automatically controlling single-input-multi-output (SIMO) systems or processes. The control output signals of a plurality of single-input-single-output (SISO) automatic controllers are combined by a combined output setter so that these SISO controllers are converted to a multi-input-single-output (MISO) automatic controller based on certain criteria; and its resulting controller output signal is able to manipulate only one actuator to control a plurality of continuous process variables or attempt to minimize a plurality of error signals between the setpoints and their corresponding process variables.

Abstract: An apparatus and method is disclosed for automatically controlling multi-input-single-output (MISO) systems or processes. The control output signal of a single-input-single-output (SISO) automatic controller is converted by a reverse, sequential or combined split-range setter into a plurality of ranges of signals so that the SISO controller is converted to a single-input-multi-output (SIMO) automatic controller based on certain criteria; and the resulting controller output signals are able to manipulate a plurality of actuators to control one continuous process variable in different operating conditions. Without the need of building process mathematical models, this inventive apparatus and method is useful for automatically controlling unevenly paired multivariable systems or processes where there are more system inputs than outputs including but not limited to pH processes, chemical reactors, and air handling units.

Abstract: A method of fabricating a device including imprinting a mold having a protrusion against a substrate having a resist layer such that the protrusion engages the resist layer. The mold further has a mask member positioned generally adjacent the resist layer. Radiation energy is then transmitted through the mold and into the resist layer; however, the mask member substantially prevents transmission of the radiation energy therethrough, thereby defining an unexposed area in the resist layer. Once the mold is removed from the substrate, which consequently forms a first feature from nanoimprinting, the unexposed area of resist layer is removed through dissolving in a developer solution.

Abstract: Compounds of general formula I are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

Abstract: Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain

Abstract: A Model-Free Adaptive Quality Variable control system is disclosed for effectively controlling quality variables on-line in closed-loop fashion. It is able to automatically control quality variables under the conditions where there are significant varying time delays and disturbances in the process. Because of its unique capability, the control system is useful for building flexible and adaptive production systems, achieving Six Sigma quality control goals, and fulfilling the on demand manufacturing needs in the new e-commerce environment.

Abstract: Compounds of formula (I) or (II) wherein R1, R2, R3, R4, W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.

Abstract: The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount of a compound having the formula I or a pharmaceutically acceptable salt thereof.

Abstract: The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

Abstract: The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount of a compound having the formula I or a pharmaceutically acceptable salt thereof.

Abstract: Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

Abstract: A Model-Free Adaptive Quality Variable control system is disclosed for effectively controlling quality variables on-line in closed-loop fashion. It is able to automatically control quality variables under the conditions where there are significant varying time delays and disturbances in the process. Because of its unique capability, the control system is useful for building flexible and adaptive production systems, achieving Six Sigma quality control goals, and fulfilling the on demand manufacturing needs in the new e-commerce environment.

Abstract: A Robust Model-Free Adaptive controller is disclosed for effectively controlling simple to complex systems including industrial processes, equipment, facilities, devices, engines, robots, vehicles, and appliances. Without the need of re-designing a controller or re-tuning the controller parameters, the inventive controller is able to provide a wide robust range and keep the system under automatic control during normal and extreme operating conditions when there are significant disturbances or changes in system dynamics. Because of its simplicity and capability, the control system is useful for building flexible and adaptive production systems to fulfill the on demand manufacturing needs of the new e-commerce environment.

Abstract: A method of forming nanofluidic enclosed channels includes providing a first substrate having a layer of a first material disposed thereon. A plurality of nanoscale slots is formed along a second substrate using nanolithography, etching, or other disclosed techniques. The first substrate is then bonded to the second substrate such that the layer of the first material on the first substrate is adjacent the plurality of slots on the second substrate to define a plurality of enclosed nanofluidic channels therethrough.

Abstract: An enhanced model-free adaptive controller is disclosed, which consists of a linear dynamic neural network that can be easily configured and put in automatic mode to control simple to complex processes. Two multivariable model-free adaptive controller designs are disclosed. An enhanced anti-delay model-free adaptive controller is introduced to control processes with large time delays. A feedforward/feedback model-free adaptive control system with two designs is introduced to compensate for measurable disturbances.