Abstract: A Robust Model-Free Adaptive controller is disclosed for effectively controlling simple to complex systems including industrial processes, equipment, facilities, devices, engines, robots, vehicles, and appliances. Without the need of re-designing a controller or re-tuning the controller parameters, the inventive controller is able to provide a wide robust range and keep the system under automatic control during normal and extreme operating conditions when there are significant disturbances or changes in system dynamics. Because of its simplicity and capability, the control system is useful for building flexible and adaptive production systems to fulfill the on demand manufacturing needs of the new e-commerce environment.

Abstract: A method of forming nanofluidic enclosed channels includes providing a first substrate having a layer of a first material disposed thereon. A plurality of nanoscale slots is formed along a second substrate using nanolithography, etching, or other disclosed techniques. The first substrate is then bonded to the second substrate such that the layer of the first material on the first substrate is adjacent the plurality of slots on the second substrate to define a plurality of enclosed nanofluidic channels therethrough.

Abstract: An enhanced model-free adaptive controller is disclosed, which consists of a linear dynamic neural network that can be easily configured and put in automatic mode to control simple to complex processes. Two multivariable model-free adaptive controller designs are disclosed. An enhanced anti-delay model-free adaptive controller is introduced to control processes with large time delays. A feedforward/feedback model-free adaptive control system with two designs is introduced to compensate for measurable disturbances.

Abstract: A flexible multifunction model-free adaptive controller capable of controlling a very broad range of processes uses storage and selective use of multiple controller parameter sets, measurement filtering, transient prediction and use of extra controllers to dynamically set constraints for the output of the process controller in order to deal with transients resulting from sudden input changes, yet allow the process to run close to its physical limitations under dynamically varying operating conditions and periodic large processing parameter changes.

Abstract: The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount of a compound having the formula I or a pharmaceutically acceptable salt thereof.

Abstract: A model-free adaptive controller is disclosed, which uses a dynamic artificial neural network with a learning algorithm to control any single-variable or multivariable open-loop stable, controllable, and consistently direct-acting or reverse-acting industrial process without requiring any manual tuning, quantitative knowledge of the process, or process identifiers. The need for process knowledge is avoided by substituting 1 for the actual sensitivity function .differential.y(t)/.differential.u(t) of the process.