Abstract: Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a psoralen derivative and UVA irradiation.

Abstract: A baseline processing device and method are provided for analyzing signals with uneven distributions of pulses and slow varying baselines. In one embodiment, the device includes an A/D sampling unit for sampling a digital counting signal to obtain sampled data, and a baseline extracting unit for sorting the N sampled data in the sampling sequence by magnitude and for outputting, among the N sample data, one sample data A with a value equal to the mid-value in the N sample data. A phase compensating unit with a width of M, to which a digital signal is input, outputs a sampled data B according to a FIFO sequence, wherein M=N/2. A first subtractor subtracts the sample data A from the sample data B and outputs the result as baseline removed data.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo.

Abstract: A method for forming a contact insert subassembly (34) for a modular jack connector (200), includes the following steps: stamping a contact strip (10) to form a group of contacts (20) which are interconnected by an end carrier (11) and a middle carrier (13), the middle carrier dividing the contacts into first and second portions (21, 22); bending the first portion into a soldering tail portion for the contacts; subjecting the contact strip to an insert molding to form an insulative block (30) around the middle carrier (13); cutting the end carrier and the middle carrier from the contacts; and bending the second portion to form a contacting portion for the contacts.

Abstract: A modular jack connector comprises a housing (10), a plurality of terminals (20) received in the housing and a shield (30) enclosing the housing. The housing has a pair of sidewalls (101, 102), a bottom wall (103), a top wall (104) and a rear wall (105) together defining a receiving space (15) therebetween. The top wall defines an opening (12) in a front face thereof. The shield comprises a pair of side plates (301, 302), a top plate (304) and a rear plate (305) corresponding to the walls of the housing. The top plate defines a window (31) in a front edge thereof in communication with the opening and has a pair of opposite stoppers (32) extending into the window for engaging a latch (41) of a plug connector (40).

Abstract: A card edge connector (1) comprises an insulative housing (10) having opposite top and bottom walls (12, 14) defining a central slot (142) therebetween for receiving the electronic card, a row of upper contacts (15) and a row of lower contacts (16) retained in the top and bottom walls, respectively. A supporting embossment (1461) is formed in each of the lower passageways. Each of the upper and lower contacts forms a retaining portion (150, 160), a mating beam (152, 162) and a soldering portion (154, 164) extending from opposite ends of the retaining portion, respectively. The mating beam of the lower contact is shorter than the mating beam of the upper contact and is apart from and above the supporting means with a distance which is within the spring limitation amount of the mating beam of a corresponding lower contact retained in the housing.

Abstract: A socket connector (1) includes an insulating housing (3), a plurality of terminals (5) received in the housing, and a ring (4) which has a color different from that of the housing. The housing has a mating portion (310) at a front thereof, and a sleeve (30) projecting from the mating portion for insertion of a plug (21) of a mating connector (2) thereinto. An inner side (42) of the ring has ribs (420) formed thereon. The ribs securely engage with an outer surface (302) of the sleeve. A pair of latches (41) extends from the ring and engages with barbs (312) formed by the mating portion of the housing and located in holes (311) of the housing to secure the ring on the outer surface of the sleeve (30).

Abstract: An audio jack includes an insulative casing (6) inside which conductive terminals (1, 2, 3, 4) and a side mount grounding terminal (5) are disposed. The casing has a front face (60), a rear face (64), a pair of opposite side faces (62, 63), and a bottom wall (67) defining a recess (610) in an inner side thereof. An interior space (601) is defined in the casing. One side face of the casing defines a window (609) communicated with the interior space via the recess and a slit (608) communicated with the window. The grounding terminal includes a horizontal plate portion (53) received in the slit, an upwardly extending contact portion (51) extending through the window and projecting into the interior space through the recess, and a solder pad (52).

Abstract: A receptacle connector assembly (1) comprises an insulative housing (18) with a number of contacts (31, 41) retained therein and a pair of keying devices (50). The housing defines a first large-dimensioned receiving cavity (11) and a second small-dimensioned receiving cavity (21). The first receiving cavity has a channel (17). Each keying device comprises an engaging portion (511; 521) received in the first receiving cavity for being pushed outward by the mating plug connector, a resilient portion (513; 523) extending from the engaging portion, and a tongue (512; 522) extending from the resilient portion and projecting into the channel.

Abstract: An electrical connector assembly comprising: a pair of electrical connectors each including an insulative housing, a front shell having a pair of side walls, a rear shell and a plurality of terminals for soldering to a printed circuit board. An ear portion extends from one of the side walls of each front shell and has a through hole. The through holes are aligned with each other. An insulative board is formed between the insulative housings and extends forward. A hole is formed on a front face of the insulative board and aligned with the through holes for receiving a fastener extending through an electrical device shell.

Abstract: A method for forming a contact insert subassembly (34) for a modular jack connector (200), includes the following steps:

Abstract: A modular jack connector (100) includes a housing (1) defining a cavity (15) in a front wall (14) thereof, a plurality of terminals (2) received in the cavity, a dustproof cover (3), and a shield (4). A pair of slots (142) is defined in the front wall and a pair of block portions (122) is formed on a top wall (11) of the housing. The dustproof cover comprises a main body (32) defining a channel (34) in its upper edge, a resilient fastener (36) extending from the main body (32), and a pair of pivots (38). The pivots are received in the slots and are retained in place by a front face (42) of the shield. An abutting portion (364) of the resilient fastener abuts the block portions in a closed position. A spring end portion (366) extending through the channel is depressed to open the closed dustproof cover.