Abstract: In certain embodiments, this disclosure relates to KRAS agonists, pharmaceutical composition, and uses in managing cancer. In certain embodiments, the KRAS agonist is 4-(4-(2-bromoacetamido)butyl)benzoic acid, salt, prodrug, or derivative thereof. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of a compound of Formula I, salt, prodrug, or derivative thereof, to a subject in need thereof, wherein, substituents are reported herein.

Abstract: In certain embodiments, this disclosure relates to KRAS agonists, pharmaceutical composition, and uses in managing cancer. In certain embodiments, the KRAS agonist is 4-(4-(2-bromoacetamido)butyl)benzoic acid, salt, prodrug, or derivative thereof. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of a compound of Formula I, salt, prodrug, or derivative thereof, to a subject in need thereof, wherein, substituents are reported herein.

Abstract: This disclosure relates to inhibitors of Mcl-1 stimulated homologous recombination (HR) DNA repair and uses for treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an inhibitor of Mcl-1 in combination with other anti-cancer agents, e.g., that induce DNA replication stress. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering compounds disclosed herein in combination with hydroxyurea, olaparib, or combinations thereof.

Abstract: This disclosure relates to inhibitors of Mcl-1 stimulated homologous recombination (HR) DNA repair and uses for treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an inhibitor of Mcl-1 in combination with other anti-cancer agents, e.g., that induce DNA replication stress. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering compounds disclosed herein in combination with hydroxyurea, olaparib, or combinations thereof.

Abstract: This disclosure relates to inhibitors of Mcl-1 and Akt binding, pharmaceutical compositions, and uses in treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of an inhibitor of Mcl-1 and Akt binding to a subject in need thereof. In certain embodiments, the inhibitor prevents the PEST domain of Mcl-1 from directly interacting with the pleckstrin homology (PH) domain of Akt.

Abstract: In certain embodiments, this disclosure relates to KRAS agonists, pharmaceutical composition, and uses in managing cancer. In certain embodiments, the KRAS agonist is 4-(4-(2-bromoacetamido)butyl)benzoic acid, salt, prodrug, or derivative thereof. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of a compound of Formula I, salt, prodrug, or derivative thereof, to a subject in need thereof, wherein, substituents are reported herein.

Abstract: This disclosure relates to inhibitors of Mcl-1 stimulated homologous recombination (HR) DNA repair and uses for treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an inhibitor of Mcl-1 in combination with other anti-cancer agents, e.g., that induce DNA replication stress. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering compounds disclosed herein in combination with hydroxyurea, olaparib, or combinations thereof.

Abstract: In accordance with various embodiments of the disclosed subject matter, a wireless voice transparent transmission apparatus and a related control terminal are provided. The wireless voice transparent transmission apparatus includes an input unit configured for collecting a voice command; a control unit connected to the input unit configured for acquiring an audio signal corresponding to the voice command collected by the input unit in real time; and a wireless transmission unit including a software access application programming interface (API) and a radio frequency (RF) module. The RF module is connected to the control unit, the software access API is configured for establishing a wireless network connection between the RF module and at least one wireless terminal, the RF module is configured for transmitting the audio signal acquired by the control unit to the at least one wireless terminal.

Abstract: In accordance with various embodiments of the disclosed subject matter, a speech detection method and a related apparatus are provided. The speech detection method includes the steps of switching a speech acquisition system from a non-trigger mode into a trigger mode according to a the first preset condition, recording a trigger mode operating reference time starting from zero, and setting a non-trigger mode operating reference time to zero; acquiring speech signals by using the speech acquisition system in the trigger mode to obtain first pulse-code modulation data; extracting the first pulse-code modulation data during the trigger mode operating reference time according to a second preset condition; and matching the first pulse-code modulation data during the trigger mode operating reference time with a speech model to obtain speech data.

Abstract: The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

Abstract: A light emitting diode (LED) lighting device is provided. The device includes an LED light source assembly installed on the top of a heat sink body, and an LED driving and power supply unit configured to drive the LED light source assembly and provide electrical power for the LED lighting device. The device also includes a heat sink including the heat sink body and a heat sink covering, where the heat sink covering has an opening; and a plane including the highest point of the top of the heat sink body is higher than a plane including the opening of the heat sink covering. Further, the device includes a radio frequency (RF) antenna installed on periphery of the heat sink body. A plane that includes the highest point of the RF antenna is at the same level or lower than the plane that includes the highest point of the top of the heat sink body.

Abstract: The present invention provides a network self-healing method and system using lighting devices each including a WI-FI module with a wireless access point (AP) function. The lighting devices are wirelessly connected to a wireless router. The lighting devices scan a service set identifier (SSID) of the wireless router to confirm that the wireless router is not able to be connected to and to switch to a self-healing networking mode. The wireless AP function of each lighting device is activated according to a self-healing networking rule. One lighting device is selected from the lighting devices and is used as a first lighting device router. The wireless AP function of each of other non-selected lighting devices remaining in the plurality of lighting devices is deactivated, and wirelessly connected to the first lighting device router respectively.

Abstract: An LED lighting device, and a smart home control system and method are provided. A smart terminal is configured to send a control instruction to an LED lighting device and to receive at least one sound pulse signal from the LED lighting device to remotely control one or more household electrical appliances that have an infrared remote control function. The LED lighting device includes a Wi-Fi module, an infrared remote control module and a sound pulse detection module. The Wi-Fi module receives the control instruction and transmits the control instruction to the infrared remote control module. The infrared remote control module converts the control instruction to an infrared control signal. The sound pulse detection module detects a prompt tone when the one or more household electrical appliances are turned on remotely, converts the prompt tone to a sound pulse signal, and sends the sound pulse signal to the smart terminal.

Abstract: A system for remote monitoring based on an LED lighting device is provided. The system includes a smart terminal configured to check regularly data and status of the LED lighting device stored in a cloud server and a wireless router configured to provide a wireless network. The LED lighting device includes a Wi-Fi module and a microwave sensor module, where the Wi-Fi module is configured to connect the LED lighting device to the wireless network, perform real-time data acquisition on the microwave sensor module, and upload the acquired data to the cloud server in real time; and the microwave sensor module is configured to detect object movement within an effective range. Further, the system includes the cloud server configured to receive information about an abnormal object moving within the effective range sent from the Wi-Fi module, and send the received information to the smart terminal.

Abstract: The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

Abstract: The present disclosure provides a wireless network system and a smart device management method using LED lighting devices. The wireless network system includes a wireless router and a plurality of LED lighting devices with WI-FI modules that have wireless access and network switch capabilities. Through the WI-FI modules, the LED lighting devices may access the wireless network provided by the wireless router or the WI-FI modules of any other LED lighting devices that have been wirelessly connected to the wireless router. The network address of the wireless router and the network addresses of the LED lighting devices are in the same network segment. The present disclosure provides a wireless switch cascade method. The WI-FI module of the LED lighting device has wireless switch capabilities, allowing the IP address of the accessed devices and the module itself to be in the same network segment, and enabling centralized control of the connected devices.

Abstract: A light emitting diode (LED) lighting device is provided. The device includes an LED light source assembly installed on the top of a heat sink body, and an LED driving and power supply unit configured to drive the LED light source assembly and provide electrical power for the LED lighting device. The device also includes a heat sink including the heat sink body and a heat sink covering, where the heat sink covering has an opening; and a plane including the highest point of the top of the heat sink body is higher than a plane including the opening of the heat sink covering. Further, the device includes a radio frequency (RF) antenna installed on periphery of the heat sink body. A plane that includes the highest point of the RF antenna is at the same level or lower than the plane that includes the highest point of the top of the heat sink body.

Abstract: The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

Abstract: The present invention provides a network self-healing method and system using lighting devices each including a WI-FI module with a wireless access point (AP) function. The lighting devices are wirelessly connected to a wireless router. The lighting devices scan a service set identifier (SSID) of the wireless router to confirm that the wireless router is not able to be connected to and to switch to a self-healing networking mode. The wireless AP function of each lighting device is activated according to a self-healing networking rule. One lighting device is selected from the lighting devices and is used as a first lighting device router. The wireless AP function of each of other non-selected lighting devices remaining in the plurality of lighting devices is deactivated, and wirelessly connected to the first lighting device router respectively.

Abstract: An LED lighting device, and a smart home control system and method are provided. A smart terminal is configured to send a control instruction to an LED lighting device and to receive at least one sound pulse signal from the LED lighting device to remotely control one or more household electrical appliances that have an infrared remote control function. The LED lighting device includes a Wi-Fi module, an infrared remote control module and a sound pulse detection module. The Wi-Fi module receives the control instruction and transmits the control instruction to the infrared remote control module. The infrared remote control module converts the control instruction to an infrared control signal. The sound pulse detection module detects a prompt tone when the one or more household electrical appliances are turned on remotely, converts the prompt tone to a sound pulse signal, and sends the sound pulse signal to the smart terminal.