Abstract: The present disclosure provides a wireless network system and a smart device management method using LED lighting devices. The wireless network system includes a wireless router and a plurality of LED lighting devices with WI-FI modules that have wireless access and network switch capabilities. Through the WI-FI modules, the LED lighting devices may access the wireless network provided by the wireless router or the WI-FI modules of any other LED lighting devices that have been wirelessly connected to the wireless router. The network address of the wireless router and the network addresses of the LED lighting devices are in the same network segment. The present disclosure provides a wireless switch cascade method. The WI-FI module of the LED lighting device has wireless switch capabilities, allowing the IP address of the accessed devices and the module itself to be in the same network segment, and enabling centralized control of the connected devices.

Abstract: A system for remote monitoring based on an LED lighting device is provided. The system includes a smart terminal configured to check regularly data and status of the LED lighting device stored in a cloud server and a wireless router configured to provide a wireless network. The LED lighting device includes a Wi-Fi module and a microwave sensor module, where the Wi-Fi module is configured to connect the LED lighting device to the wireless network, perform real-time data acquisition on the microwave sensor module, and upload the acquired data to the cloud server in real time; and the microwave sensor module is configured to detect object movement within an effective range. Further, the system includes the cloud server configured to receive information about an abnormal object moving within the effective range sent from the Wi-Fi module, and send the received information to the smart terminal.

Abstract: To compare sensitivities of the compounds, A549 human lung cancer cells were treated with increasing concentrations (0, 1, 5, 10, 25 ?M) of 2-(2-Nitro-fluoren-9-ylidenemethyl)-phenol (CYD-1-87) and derivatives for 48 h. The surviving cell fraction was determined using the sulforhodamine B (SRB) assay as described in (Vichai & Kirtikara, Nat Protoc 1, 1112-1116, 2006 hereby incorporated by reference). The sulforhodamine B (SRB) assay is used for cell density determination, based on the measurement of cellular protein content. The method described here has been optimized for the toxicity screening of compounds to adherent cells in a 96-well format. After an incubation period, cell monolayers are fixed with 10% (wt/vol) trichloroacetic acid and stained for 30 min, after which the excess dye is removed by washing repeatedly with 1% (vol/vol) acetic acid. The protein-bound dye is dissolved in 10 mM Tris base solution for OD determination at 510 nm using a microplate reader.

Abstract: The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

Abstract: This disclosure relates to methods of treating cancer comprising administering an effective amount of a STAT3 inhibitor, prodrugs, or derivatives thereof, in combinations with an EGFR tyrosine kinase inhibitors, prodrugs, or derivatives thereof, to a subject in need thereof. In certain embodiments, the STAT3 inhibitor is niclosamide or salt thereof. In certain embodiments, the EGFR tyrosine kinase inhibitor is erlotinib or salt thereof.

Abstract: The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.