Abstract: The present invention relates to an agomelatine hydrochloride hydrate of formula I, preparation and use thereof, and to pharmaceutical composition containing it. The agomelatine hydrohalide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps. wherein X is Cl.

Abstract: A non-contact monitoring system can include an electrode configured to detect electrical signals from a surface of a subject's body without directly contacting the surface of the subject's body (e.g., via capacitive coupling). The electrode can be positioned at a spaced apart distance from the subject's body (e.g., ranging up to about 30 cm). The signals from the electrodes can be processed in the analog and digital domain to determine one or more physiological conditions of a subject, such as drowsiness.

Abstract: The present application discloses crystals of 2-acetoxy-5-(?-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrobromate, crystal compositions and pharmaceutical compositions comprising them and their use. The crystals of prasugrel hydrobromate of the present application possess excellent stability and solubility.

Abstract: The invention provides a new crystalline form of agomelatine, preparation and use thereof. The X-ray powder diffraction diagram of the agomelatine crystalline form shows main peaks at the diffraction angles 2? 11.13°, 11.82°, 17.49°, 18.29°, 19.48°, 19.72°, 20.50°, 21.76°, 22.54°, 22.97°, 24.56°, 25.36°, 27.16° and 31.93°. Said new crystalline form is characterized by high purity, stability and good reproducibility, and thus is advantageous for the pharmaceutical formulation. In addition, the stability and solubility of said crystalline form are also superior over the several existing crystalline forms.

Abstract: The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble, more stable, and of higher purity than agomelatine itself, making it more suitable to be used in pharmaceutical preparation. Using this method, product of high purity can be obtained through a simple process, without having to incur further complicated steps.

Abstract: A sensor probe for time domain reflectometry may include a plurality of flexible elongated strips of an electrically conductive material extending from a proximal end portion of the probe to a distal end portion thereof. Each of the elongated strips can be substantially coplanar relative to each other along a path that is transverse to a longitudinal axis of the probe, and the plurality of elongated strips also being in a substantially parallel arrangement along the length of the probe. A flexible substrate of an insulating material can be attached to the sheets to maintain the sheets in the substantially parallel and coplanar arrangement. A connector is electrically coupled to the strips for providing communication of electrical signals relative to the strips.

Abstract: A system and method for receiving and tracking a plurality of transactions and distributing the transactions to at least two replication queues over a network. The system and method comprise a global queue for storing a number of the received transactions in a first predetermined order. The system and method also comprise a sequencer coupled to the global queue for creating a copy of each of the transactions for each of said at least two replication queues and for distributing in a second predetermined order each said copy to each of said at least two replication queues respectively, said copy containing one or more of the received transactions.

Abstract: A system and method for receiving and tracking a plurality of transactions and distributing the transactions to at least two replication queues over a network. The system and method comprise a global queue for storing a number of the received transactions in a first predetermined order. The system and method also comprise a sequencer coupled to the global queue for creating a copy of each of the transactions for each of said at least two replication queues and for distributing in a second predetermined order each said copy to each of said at least two replication queues respectively, said copy containing one or more of the received transactions.

Abstract: Methods and apparatus using time domain reflectometry to determine electrical properties of concrete for calculating physical and mechanical properties of the concrete that are indicative of concrete quality and durability. The dielectric constant of a concrete is determined to calculate the gravimetric water content of the concrete for use in finding the water-cement ratio of the concrete. Electrical conductivity of curing concrete is determined to calculate compressive strength of the concrete for use in predicting strength development in the concrete.

Abstract: A system and method for receiving and tracking a plurality of transactions and distributing the transactions to at least two replication queues over a network. The system and method comprise a global queue for storing a number of the received transactions in a first predetermined order. The system and method also comprise a sequencer coupled to the global queue for creating a copy of each of the transactions for each of said at least two replication queues and for distributing in a second predetermined order each said copy to each of said at least two replication queues respectively, said copy containing one or more of the received transactions.

Abstract: A method and apparatus for measuring dry density and gravimetric water content of soil includes the steps of providing a plurality of spikes adapted to be driven into the soil and driving the spikes into the soil in spaced relationship. An electrical signal is applied to the spikes and a reflected signal is analyzed using time domain reflectometry to determine an apparent dielectric constant and the bulk electrical conductivity of the soil. With these parameters, the dry density and gravimetric water content of the soil can be calculated using a predetermined relationship between apparent dielectric constant, bulk electrical conductivity, dry density and gravimetric water content. The predetermined relationship includes experimentally determined soil specific calibration constants. The calculated value of the bulk electrical conductivity as determined by time domain reflectometry is adjusted to correspond to a value for which values of the constants are known.

Abstract: Methods and apparatus using time domain reflectometry to determine electrical properties of concrete for calculating physical and mechanical properties of the concrete that are indicative of concrete quality and durability. The dielectric constant of a concrete is determined to calculate the gravimetric water content of the concrete for use in finding the water-cement ratio of the concrete. Electrical conductivity of curing concrete is determined to calculate compressive strength of the concrete for use in predicting strength development in the concrete.

Abstract: A method and apparatus for measuring dry density and gravimetric water content of soil includes the steps of providing a plurality of spikes adapted to be driven into the soil and driving the spikes into the soil in spaced relationship. An electrical signal is applied to the spikes and a reflected signal is analyzed using time domain reflectometry to determine an apparent dielectric constant and the bulk electrical conductivity of the soil. With these parameters, the dry density and gravimetric water content of the soil can be calculated using a predetermined relationship between apparent dielectric constant, bulk electrical conductivity, dry density and gravimetric water content. The predetermined relationship includes experimentally determined soil specific calibration constants. The calculated value of the bulk electrical conductivity as determined by time domain reflectometry is adjusted to correspond to a value for which values of the constants are known.