Abstract: The present disclosure provides a display panel and display apparatus. The display panel includes an array substrate, including a first surface and a second surface arranged opposite to each other along a direction perpendicular to a light-exiting surface of the display panel, and a plurality of side surfaces connecting the first surface and the second surface, where the plurality of side surfaces includes a first side surface and a second side surface; a plurality of first soldering pads and a plurality of second soldering pads; a plurality of connecting wires at least at the first side, where the plurality of connecting wires is configured to connect the plurality of first soldering pads and the plurality of second soldering pads, and no connecting wire is disposed on the second side; and further includes a plurality of encapsulation structures, at least covering the plurality of side surfaces of the array substrate.

Abstract: A method for treating a patient comprising: (a) providing a composition comprising a population of T cells expressing both a chimeric antigen receptor (CAR) and a T cell receptor specific for a cytomegalovirus (CMV) antigen; (b) administering the composition to the patient; and (c) administering to the patient a viral vector encoding: (i) CMV pp65 and (ii) a fusion protein comprising exon 4 of CMV protein IE1 (e4) and exon 5 of CMV protein IE2 (e5) either prior to or subsequent to administering the composition comprising a population of T cells to the patient is described.

Abstract: A copolyester, comprising structural units represented by [I], [II], [III] and [IV]. The number of structural units represented by [III] is 1-99% of the number of structural units represented by [I], and the number of structural units represented by [IV] is 0-99% of the number of structural units represented by [I]. Also provided are a preparation method therefor and an application thereof. Because an introduced high-temperature self-crosslinking group and an ion group can improve the melt viscosity and the melt intensity during burning of a copolyester, and effectively enhance the char-forming capability of the copolyester, the copolyester exhibits excellent flame retardance and anti-dripping performance. The preparation process for the copolyester is mature, convenient to operate, and easy to control and apply to industrial production.

Abstract: Methods of treatment for HIV employing T cells expressing both a chimeric antigen receptors targeted to HIV and a CMV-specific T cell receptor.

Abstract: Chimeric antigen receptors targeting both BAFF-R and CD19 are described as are methods for their use.

Abstract: T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells.

Abstract: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.

Abstract: Methods of treatment for HIV employing T cells expressing both a chimeric antigen receptors targeted to HIV and a CMV-specific T cell receptor.

Abstract: A method for treating a patient comprising: (a) providing a composition comprising a population of T cells expressing both a chimeric antigen receptor (CAR) and a T cell receptor specific for a cytomegalovirus (CMV) antigen; (b) administering the composition to the patient; and (c) administering to the patient a viral vector encoding: (i) CMV pp65 and (ii) a fusion protein comprising exon 4 of CMV protein IE1 (e4) and exon 5 of CMV protein IE2 (e5) either prior to or subsequent to administering the composition comprising a population of T cells to the patient is described.

Abstract: CD19 scFv, methods for using such scFv, CAR that include such scFv, methods for making and using such CD19 targeted CAR T cells and CD19 targeted CAR natural killer (NK) cells are described as a methods to treat a variety of cancers.

Abstract: This disclosure relates, inter alia, to compositions comprising and methods making and using T cells expressing both a chimeric antigen receptor (CAR) targeted to HIV and a T cell receptor targeted to cytomegalovirus (CMV).

Abstract: An improved method for preparing T cell populations expressing a chimeric antigen receptor is described.

Abstract: Provided herein are, inter alia, antibody compounds comprising an anti-immune cell antibody (e.g., anti-CD3 antibody) covalently bound to a CS-1-binding antibody; immune cells bound to compounds comprising an anti-immune cell antibody (e.g., anti-CD3 antibody) covalently bound to a CS-1-binding antibody; humanized OKT3 antibodies; pharmaceutical compositions; and methods for treating cancer, such as multiple myeloma.

Abstract: A display panel, a display device, and a splicing display device are provided. The display panel includes pixels including subpixels, the subpixel includes a pixel circuit and a light-emitting element that are electrically connected to each other. In a pixel, light-emitting elements of the subpixels are arranged along a first direction, and pixel circuits of the subpixels are arranged along the first direction. In at least one pixel, an arrangement order of the light-emitting elements is different from an arrangement order of the pixel circuits; or arrangement orders of the pixel circuits in at least two pixels are different from each other, or arrangement orders of the light-emitting elements in at least two pixels are different from each other.

Abstract: Provided herein are, inter alia, methods and compositions including T cells expressing (i) a recombinant CAR protein which includes a peptide binding site and is capable of specifically binding cancer-specific antigens and (ii) a T cell receptor specific for a viral antigen (e.g., a CMV pp65 protein). The engineered T cells provided herein may be used in combination with a viral vaccine (e.g. cytomegalovirus (CMV) Triplex Vaccine) to treat a variety of cancers. The methods described herein also permit in vivo expansion of CMV-specific CAR T cells, instead of or in addition to ex vivo expansion, avoiding excessive T cell exhaustion that results in some cases from ex vivo manufacturing.

Abstract: T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: A method for treating a patient comprising: (a) providing a composition comprising a population of T cells expressing both a chimeric antigen receptor (CAR) and a T cell receptor specific for a cytomegalovirus (CMV) antigen; (b) administering the composition to the patient; and (c) administering to the patient a viral vector encoding: (i) CMV pp65 and (ii) a fusion protein comprising exon 4 of CMV protein IE1 (e4) and exon 5 of CMV protein IE2 (e5) either prior to or subsequent to administering the composition comprising a population of T cells to the patient is described.

Abstract: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.

Abstract: In an intelligent multi-rotor rescue thrower, a throwing projectile head is located at a foremost end of the thrower, a parachute storage bin is mounted at a center of a front end of the throwing projectile head, a rear end of the throwing projectile head is connected to a projectile body shell through threads, and a first splitter plate, a second splitter plate, and a third splitter plate are directly connected to the projectile body shell through slide grooves built in the projectile body shell to equally divide a space in a cavity of the projectile body shell; connecting flanges tightly connect the projectile body shell to motors, a rotor is connected to an upper end of each of the motors, and three rotors are provided in the space in the cavity of the projectile body shell.