Abstract: A method for treating a patient comprising: (a) providing a composition comprising a population of T cells expressing both a chimeric antigen receptor (CAR) and a T cell receptor specific for a cytomegalovirus (CMV) antigen; (b) administering the composition to the patient; and (c) administering to the patient a viral vector encoding: (i) CMV pp65 and (ii) a fusion protein comprising exon 4 of CMV protein IE1 (e4) and exon 5 of CMV protein IE2 (e5) either prior to or subsequent to administering the composition comprising a population of T cells to the patient is described.

Abstract: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.

Abstract: In an intelligent multi-rotor rescue thrower, a throwing projectile head is located at a foremost end of the thrower, a parachute storage bin is mounted at a center of a front end of the throwing projectile head, a rear end of the throwing projectile head is connected to a projectile body shell through threads, and a first splitter plate, a second splitter plate, and a third splitter plate are directly connected to the projectile body shell through slide grooves built in the projectile body shell to equally divide a space in a cavity of the projectile body shell; connecting flanges tightly connect the projectile body shell to motors, a rotor is connected to an upper end of each of the motors, and three rotors are provided in the space in the cavity of the projectile body shell.

Abstract: Methods for treating AL amyloidosis using chimeric antigen receptors targeting CS1 are described.

Abstract: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.

Abstract: A copolyester, comprising structural units represented by [I], [II], [III] and [IV]. The number of structural units represented by [III] is 1-99% of the number of structural units represented by [I], and the number of structural units represented by [IV] is 0-99% of the number of structural units represented by [I]. Also provided are a preparation method therefor and an application thereof. Because an introduced high-temperature self-crosslinking group and an ion group can improve the melt viscosity and the melt intensity during burning of a copolyester, and effectively enhance the char-forming capability of the copolyester, the copolyester exhibits excellent flame retardance and anti-dripping performance. The preparation process for the copolyester is mature, convenient to operate, and easy to control and apply to industrial production.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: In an intelligent multi-rotor rescue thrower, a throwing projectile head is located at a foremost end of the thrower, a parachute storage bin is mounted at a center of a front end of the throwing projectile head, a rear end of the throwing projectile head is connected to a projectile body shell through threads, and a first splitter plate, a second splitter plate, and a third splitter plate are directly connected to the projectile body shell through slide grooves built in the projectile body shell to equally divide a space in a cavity of the projectile body shell; connecting flanges tightly connect the projectile body shell to motors, a rotor is connected to an upper end of each of the motors, and three rotors are provided in the space in the cavity of the projectile body shell.

Abstract: Methods of treatment for HIV employing T cells expressing both a chimeric antigen receptors targeted to HIV and a CMV-specific T cell receptor.

Abstract: The present invention provides a method for constructing a next-generation sequencing library for detecting low-frequency mutations, and a kit thereof. The constructing method comprises steps of obtaining blunt-end DNA fragments, obtaining DNA fragments with A-tail at the 3? end, obtaining adapter-added DNA fragments using a specific nucleotide sequence and obtaining amplification products using a specific nucleotide sequence.

Abstract: Chimeric antigen receptors targeting both BAFF-R and CD19 are described as are methods for their use.

Abstract: The present invention provides a method for constructing a next-generation sequencing library for detecting low-frequency mutations, and a kit thereof. The constructing method comprises steps of obtaining blunt-end DNA fragments, obtaining DNA fragments with A-tail at the 3? end, obtaining adapter-added DNA fragments using a specific nucleotide sequence and obtaining amplification products using a specific nucleotide sequence.

Abstract: T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells.

Abstract: The present invention provides a method of enhancing the function of CAR T cells comprising administering to the CAR T cells a PP2A inhibitor and optionally one or more anti-cancer therapies.

Abstract: Provided is a carbon-based functional material (simply as FCN or FCN material) and applications thereof. The carbon-based functional material consists of three elements, namely carbon, nitrogen, and oxygen, having sp2 carbons as the backbone and functional groups R formed on the surface and/or periphery of a carbon backbone substrate, the R functional groups being a combination of groups such as a hydroxyl, carboxyl, ether bond, epoxy, carbonyl, aldehyde, ester, and alkyl.

Abstract: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.

Abstract: An improved method for preparing T cell populations expressing a chimeric antigen receptor is described.

Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: An improved method of treating cancers CD19 CAR T cells by administering the CD19 CAR T cells to the central nervous system, e.g., by intracerebroventricular administration, is described.

Abstract: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.