Abstract: An improved method of treating cancers CD19 CAR T cells by administering the CD19 CAR T cells to the central nervous system, e.g., by intracerebroventricular administration, is described.

Abstract: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.

Abstract: Methods for treating AL amyloidosis using chimeric antigen receptors targeting CS1 are described.

Abstract: The present invention provides a carbon-lithium composite powder and a preparation method thereof. In the present invention, a carbon material is used as a skeleton to support metal lithium, which increases the specific surface area of the composite powder, and can effectively reduce the current density and stabilize the surface potential of an electrode, thereby effectively inhibit the growth of lithium dendrites during the process in which the metal lithium is used as an anode material. The present invention provides a method for preparing a lithium metal secondary battery electrode. In the present invention, a roller-press flaking process is adopted to prepare the electrode, such that it is easy to regulate the effective capacity of the metal lithium loaded on the current collector, thereby better matching the corresponding active cathode material to improve the effective utilization rate of the metal lithium.

Abstract: A novel carbon-based material (abbreviated N-FCN) composed of carbon, hydrogen, oxygen and nitrogen and application thereof. The raw materials of the novel carbon-based material are derived from natural or simple inorganic matter which provide the four elements of carbon, hydrogen, oxygen and nitrogen. A composite organic matter is formed at low voltage and low energy and comprises a carbon base in graphite structure, at least one or more composite organic functional groups and an organic small molecule, wherein at least two or more amino acids may be detected in the organic small molecule. The novel carbon-based material may induce an active response of an omanism. After a trace amount of the novel carbon-based material is released into a biological growth environment, the organism will actively respond to the novel carbon-based material.

Abstract: The present invention provides a method for constructing a next-generation sequencing library for detecting low-frequency mutations, and a kit thereof. The constructing method comprises steps of obtaining blunt-end DNA fragments, obtaining DNA fragments with A-tail at the 3? end, obtaining adapter-added DNA fragments using a specific nucleotide sequence and obtaining amplification products using a specific nucleotide sequence.

Abstract: An improved method for preparing T cell populations expressing a chimeric antigen receptor is described.

Abstract: A method of determining a condition within a wellbore. The method comprises introducing a tubular member in a wellbore extending through a subterranean formation, the tubular member comprising a downhole article including a deformable material disposed around a surface of the tubular member, electrically conductive elements dispersed within the deformable material. The method includes measuring at least one electrical property of the deformable material. At least one of water ingress into the wellbore or an amount of expansion of the deformable material is determined based on the at least one measured electrical property. Related downhole systems and other related methods are also disclosed.

Abstract: T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells.

Abstract: Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.

Abstract: A method of determining a condition within a wellbore. The method comprises introducing a tubular member in a wellbore extending through a subterranean formation, the tubular member comprising a downhole article including a deformable material disposed around a surface of the tubular member, electrically conductive elements dispersed within the deformable material. The method includes measuring at least one electrical property of the deformable material. At least one of water ingress into the wellbore or an amount of expansion of the deformable material is determined based on the at least one measured electrical property. Related downhole systems and other related methods are also disclosed.

Abstract: A method for treatment of saline-alkali land is provided, comprising at least one self-circulating process, the self-circulating process comprising: step 1, converting saline-alkali water deposited in the saline-alkali land into acidic water by an electrolysis system, whereby the salt content of the acidic water is lower than that of the saline-alkali water; and step 2, leaching the saline-alkali land with leaching water comprising the acidic water. A device for treatment of saline-alkali land according to the above-described method is also provided, comprising: an electrolysis system for converting saline-alkali water deposited in the saline-alkali land into acidic water, whereby the salt content of the acidic water is lower than that of the saline-alkali water; and a leaching system for leaching the saline-alkali land with leaching water comprising the acidic water.

Abstract: A method for identifying HB red-corolla germplasm resources of upland cotton by PCR, including: amplifying genomic DNAs of the upland cotton by PCR using a pair of primers; performing gel electrophoresis on amplified products; and determining whether PCR products is derived from upland HB red-corolla cotton based on results of the gel electrophoresis.

Abstract: A method for treatment of saline-alkali land is provided, comprising at least one self-circulating process, the self-circulating process comprising: step 1, converting saline-alkali water deposited in the saline-alkali land into acidic water by an electrolysis system, whereby the salt content of the acidic water is lower than that of the saline-alkali water; and step 2, leaching the saline-alkali land with leaching water comprising the acidic water. A device for treatment of saline-alkali land according to the above-described method is also provided, comprising: an electrolysis system for converting saline-alkali water deposited in the saline-alkali land into acidic water, whereby the salt content of the acidic water is lower than that of the saline-alkali water; and a leaching system for leaching the saline-alkali land with leaching water comprising the acidic water.

Abstract: The invention proposes a finger lever (1) for actuating a gas exchange valve (4) of an internal combustion engine, said finger lever (1) being composed of side walls (11), a valve contacting element (12), a roller axle (8)/roller (9) and a joint socket element (13). According to the invention, the side walls comprise through-openings (15, 16) that are aligned to each other in pairs and in which each of the valve contacting element and the joint socket element are retained after the manner of a pin and bore connection by respective axle ends or axle stubs (18, 19) pointing in a transverse direction of the side walls.