Abstract: The disclosure generally relates to binding proteins that comprise antigen binding sites, a T cell receptor binding site, and a T cell co-stimulatory molecule binding site. The disclosure also relates to pharmaceutical compositions comprising such binding proteins, nucleic acid molecules encoding such binding proteins, and vectors comprising such nucleic acid molecules. The disclosure further relates to methods of treating a disorder or condition using such binding proteins and pharmaceutical compositions, binding proteins and pharmaceutical compositions for use in the treatment of a disorder or condition, and the use of such binding proteins and pharmaceutical compositions for the manufacture of a medicament for treating a disorder or condition.

Abstract: A light emitting module includes: a light emitting element array provided on a first substrate, including a plurality of light emitting elements arranged in an array in a row direction and a column direction, each of which includes a first electrode and a second electrode, wherein a driving current of the light emitting element is greater than or equal to 1 mA; and a plurality of row driving chips and a plurality of column driving chips provided on the first substrate. At least one row driving chip and at least one column driving chip are spaced apart in the row direction and the column direction. At least one row driving chip and at least one column driving chip are respectively electrically connected to the first electrodes of at least one row of light emitting elements and the second electrodes of at least one column of light emitting elements.

Abstract: This application discloses a vehicle power distribution integration architecture, a vehicle management system, and a vehicle. The vehicle power distribution integration architecture includes a low-voltage battery, a battery management module, and a low-voltage power distribution module. The low-voltage battery is electrically connected to the low-voltage power distribution module. The low-voltage power distribution module is provided with a low-voltage load access terminal for connecting to a low-voltage load. The battery management module and the low-voltage power distribution module share one controller. The controller is integrated with a function of managing the low-voltage battery and a function of controlling power distribution of the low-voltage load, so that control modules in a battery management solution and a low-voltage power distribution solution are creatively integrated into one controller. This simplifies the control wiring and has the characteristics such as low costs and simple structure.

Abstract: Embodiments of the present disclosure provide an electronic device and a display driving method. The electronic device includes a plurality of device groups and a plurality of driving elements; a first terminal of at least one device group among the plurality of device groups is coupled with a positive signal line, a second terminal of at least one device group among the plurality of device groups is coupled with an output terminal of any one of the plurality of driving elements, and a reference voltage terminal of any one of the plurality of driving elements is configured to be coupled with a reference signal line.

Abstract: A thin-film transistor (TFT), includes: a substrate (202); an organic semiconductor (OSC) layer (210) positioned on the substrate; a dielectric layer (214) positioned on the OSC layer; and a polymeric interlayer (212) disposed in-between the OSC layer and the dielectric layer, such that the dielectric layer is configured to exhibit a double layer capacitance effect. A method of forming a thin-film transistor, includes: providing a substrate; providing a bottom gate layer atop the substrate; disposing consecutively from the substrate, an organic semiconductor (OSC) layer, a dielectric layer, and a top gate layer; and patterning the OSC layer, the dielectric layer, and the top gate layer using a single mask.

Abstract: The present disclosure relates to antibodies or fragments thereof comprising an antigen binding domain capable of binding to a CD3 protein or a fragment thereof. The present disclosure also relates to such antibodies that bind to CD3 having optimized affinity to induce T cell activation, but without being associated with excessive cytokine release and reduced tolerability. The disclosure also relates to methods of producing these antibodies and their therapeutic uses.

Abstract: Provided herein are multispecific antibodies containing a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.

Abstract: Provided herein is a multispecific antibody containing two antigen binding arms capable of binding to a first target and at least one antigen binding arm capable of binding to a second target. The multispecific antibody includes a lambda charge pair introduced into the interface of a heavy chain and a light chain to reduce chain mispairing.

Abstract: Provided herein are trispecific antibodies containing three antigen binding arms each capable of binding to a different target, wherein each antigen binding arm contains a different lambda or kappa charge pair introduced into the interface of the respective heavy and light chains to reduce chain mispairing.

Abstract: Disclosed are a display panel and a display apparatus, wherein the display panel includes a plurality of first signal lines extending along a first direction and a plurality of pixel units arranged in an array in the first direction and a second direction; at least one pixel unit among the plurality of pixel units includes a component group and a drive chip configured to drive the component group to emit light; the component group includes K light emitting elements, and the drive chip includes K signal channel terminals, K is a positive integer greater than or equal to 2; for a pixel unit in a j-th row and an i-th column, cathodes of the K light emitting elements are electrically connected with an i-th first signal line, and an anode of an s-th light emitting element is electrically connected with an s-th signal channel terminal of the drive chip.

Abstract: Disclosed herein is an article including a multilayer sheet configured to be present in a compressive and/or tensile stress, wherein the multilayer sheet is rolled-up to form a curved article, and wherein the multilayer sheet comprises a piezoelectric film configured to tune a radius of curvature of the curved article upon application of an electrical field across the piezoelectric film. Also disclosed are curved, tunable articles configured as L, R, and/or C circuit components. Additionally disclosed are methods of making and using the same.

Abstract: An array substrate and a driving method therefor, and a display apparatus are disclosed. The array substrate includes: a base substrate; and a plurality of pixels located on the base substrate, where the plurality of pixels are arranged in an array in a first direction and a second direction. At least one pixel of the plurality of pixels includes: sub-pixels, and a pixel driving chip for driving each sub-pixel in the pixel. The array substrate further includes: a plurality of addressing signal lines located on the base substrate, where the addressing signal lines are coupled to addressing signal ends of pixel driving chips of a row of the pixels arranged in the first direction; and a plurality of data lines located on the base substrate, where the data lines are coupled to data signal ends of pixel driving chips of a column of the pixels arranged in the second direction.

Abstract: Embodiments of the present disclosure provide an electronic device and a display driving method. The electronic device includes a plurality of device groups and a plurality of driving elements; a first terminal of at least one device group among the plurality of device groups is coupled with a positive signal line, a second terminal of at least one device group among the plurality of device groups is coupled with an output terminal of any one of the plurality of driving elements, and a reference voltage terminal of any one of the plurality of driving elements is configured to be coupled with a reference signal line.

Abstract: A pixel unit includes N light-emitting devices and a pixel driving chip. The pixel driving chip includes: a data signal terminal used to receive a data signal; a power supply signal terminal used to receive a power supply signal; and N signal channel terminals being in one-to-one correspondence with the N light-emitting devices. A first electrode of a first light-emitting device in the N light-emitting devices is configured to be coupled to the power supply signal terminal, a second electrode of an n-th light-emitting device in the N light-emitting devices is coupled to a first electrode of an (n+1)-th light-emitting device and an n-th signal channel terminal in the N signal channel terminals; N is a positive integer greater than 1, and n is a positive integer greater than or equal to 1 and less than or equal to N.

Abstract: An array substrate and a driving method therefor, and a display apparatus are disclosed. The array substrate includes: a base substrate; and a plurality of pixels located on the base substrate, where the plurality of pixels are arranged in an array in a first direction and a second direction. At least one pixel of the plurality of pixels includes: sub-pixels, and a pixel driving chip for driving each sub-pixel in the pixel. The array substrate further includes: a plurality of addressing signal lines located on the base substrate, where the addressing signal lines are coupled to addressing signal ends of pixel driving chips of a row of the pixels arranged in the first direction; and a plurality of data lines located on the base substrate, where the data lines are coupled to data signal ends of pixel driving chips of a column of the pixels arranged in the second direction.

Abstract: The present disclosure provides a display apparatus, a display panel, and a method of driving a display panel. The display panel includes: a base substrate; a pixel array disposed on the base substrate, and including one or more pixel groups each of which includes a plurality of pixels; and a plurality of pixel driving chips disposed on the base substrate and configured to drive the pixel array to display, each of the pixel driving chips including a data signal terminal for receiving data signals and a control signal terminal, where for each of the pixel groups, the plurality of pixels in the pixel group are connected to a common pixel driving chip. A display frame of the display panel includes an address assignment stage and a data signal transmission stage.

Abstract: A pixel unit includes N light-emitting devices and a pixel driving chip. The pixel driving chip includes: a data signal terminal used to receive a data signal; a power supply signal terminal used to receive a power supply signal; and N signal channel terminals being in one-to-one correspondence with the N light-emitting devices. A first electrode of a first light-emitting device in the N light-emitting devices is configured to be coupled to the power supply signal terminal, a second electrode of an n-th light-emitting device in the N light-emitting devices is coupled to a first electrode of an (n+1)-th light-emitting device and an n-th signal channel terminal in the N signal channel terminals; N is a positive integer greater than 1, and n is a positive integer greater than or equal to 1 and less than or equal to N.

Abstract: An air conditioning unit includes: a first refrigeration system including a first evaporator, a first compressor, a first condenser, a first one-way valve, and a first throttling element connected in sequence in a loop as well as a second one-way valve connected in parallel with the first compressor, and a first fluorine pump connected in parallel with the first one-way valve; and a second refrigeration system including a second evaporator, a second compressor, a second condenser, a third one-way valve, and a second throttling element connected in sequence in a loop as well as a fourth one-way valve connected in parallel with the second compressor, and a second fluorine pump connected in parallel with the third one-way valve, where the first evaporator and the second evaporator are arranged front and rear in sequence along a return air cooling duct.

Abstract: Disclosed are a display panel and a display apparatus, wherein the display panel includes a plurality of first signal lines extending along a first direction and a plurality of pixel units arranged in an array in the first direction and a second direction; at least one pixel unit among the plurality of pixel units includes a component group and a drive chip configured to drive the component group to emit light; the component group includes K light emitting elements, and the drive chip includes K signal channel terminals, K is a positive integer greater than or equal to 2; for a pixel unit in a j-th row and an i-th column, cathodes of the K light emitting elements are electrically connected with an i-th first signal line, and an anode of an s-th light emitting element is electrically connected with an s-th signal channel terminal of the drive chip.

Abstract: The present disclosure provides systems and methods that can provide portable, real-time accessible DNA memories. An example DNA-based data storage system includes a loading region configured to receive a plurality of DNA-based data storage elements in a suspension fluid and a plurality of microtubes disposed in a capture/release region. The microtubes are configured to capture and release the DNA-based data storage elements. The DNA-based data storage system also includes a linearization region configured to linearize the DNA-based data storage elements and a readout region with a readout device configured to provide information indicative of the respective DNA-based data storage elements.