Abstract: The invention relates to a method for preparing high-stability liquid blueberry anthocyanins, belonging to the field of food processing. A method for preparing high-stability liquid blueberry anthocyanins comprises the following process steps: adding graphene oxide and chitosan to an MES buffer solution at room temperature, mixing homogeneously and adding EDC and NHS sequentially, reacting to obtain a first solution; adding dry blueberry anthocyanin powder in the first solution, adjusting pH to 4.5 to 5.0 and mixing homogeneously to obtain a second solution, and treating the second solution at 350 to 420 MPa and 2 to 4° C. to obtain the product. The method for increasing the stability of blueberry anthocyanins provided by the present invention uses dry blueberry anthocyanin powder as a raw material and adds graphene oxide combined with chitosan compound as an anthocyanin stabilizer, thereby increasing the stability of blueberry anthocyanins during processing and production.

Abstract: The present invention provides a method and an apparatus for determining travel path bound, a vehicle, a storage medium and a terminal. The method includes: under a first coordinate system, according to contour point positions respectively corresponding to a vehicle and an obstacle in a path trajectory, determining a collision-anticipated overlap corner position; based on a trajectory normal of the vehicle and the overlap corner position, determining a contour corner overlap line and a decision corner reference line; if a first intersection position between the contour corner overlap line and the decision corner reference line is not located on the contour edge, based on the overlap corner position, the decision corner reference line and contour corner positions on the contour corner overlap line, determining a collision-avoiding distance of the vehicle; under a second coordinate system, based on the collision-avoiding distance, generating a travel path bound.

Abstract: The present disclosure provides a method and an apparatus for planning an automatic parking path, a medium and a device and belongs to the field of self driving technologies. The method includes: extracting perception information within a predetermined parking space including a target vehicle place, which is perceived by a vehicle; based on the perception information, identifying a ground sideline of the target parking place, a road sideline and an actual obstacle contour line; cropping the ground sideline and the road sideline intersecting with the ground sideline and taking remaining ground sideline and road sideline as corresponding boundaries of an available parking space of the target parking place; and, performing collision detection based on the corresponding boundaries of the available parking space and the actual obstacle contour line, and based on a result of the collision detection, performing vehicle trajectory planning to obtain an automatic parking planning path.

Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

Abstract: Provided are a method for generating a lane changing decision-making model and a method and an apparatus for lane changing decision-making of an unmanned vehicle. The method for generating a lane changing decision-making model includes: obtaining a training sample set of vehicular lane changing, wherein the training sample set includes a plurality of training sample groups, each of the training sample groups includes a training sample under each time step length in a process that the vehicle completes lane changing based on a planned lane changing trajectory, the training sample includes a group of state variables and corresponding control variables; obtaining the lane changing decision-making model by training a decision-making model based on deep reinforcement learning network by use of the training sample set, wherein the lane changing decision-making model enables the state variable of the target vehicle and the corresponding control variable to be correlated.

Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

Abstract: The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

Abstract: The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

Abstract: The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

Abstract: Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.