GPCR RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS FOR THEIR USE

Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.

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Description
CROSS-REFERENCES TO RELATED APPLICATIONS

This application is a U.S. Non-Provisional application, claiming the benefit of U.S. Provisional Application No. 63/274,893, filed on Nov. 2, 2021, U.S. Provisional Application No. 63/183,612, filed on May 3, 2021, U.S. Provisional Application No. 63/143,025, filed on Jan. 28, 2021, the entire contents of each of which are herein incorporated by reference.

FIELD

Provided herein are GLP-1 receptor modulator compounds; pharmaceutical compositions comprising the compounds; methods of producing the compounds; and methods of using the compounds, and compositions for therapy. The compounds, and compositions are useful, for instance, in methods of treatment, and prevention of metabolic diseases or conditions, methods of detection of metabolic diseases or conditions, and methods of diagnosis of metabolic diseases or conditions.

BACKGROUND

Diabetes is a serious chronic disease that occurs when the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces. Complications of diabetes include, damage to the heart, blood vessels, eyes, kidneys, and nerves. Diabetes can increase risk of heart disease, and stroke. The results include serious effects on quality of life, health, and mortality. WHO Global Report on Diabetes, 2016, World Health Organization. As of 2017, approximately 462 million individuals worldwide, about 6.28% of the population was affected by type 2 diabetes, and this prevalence was increasing measurably. Khan et al., 2020, J Epidemiol. Glob. Health 10(1):107-111. The global economic burden of diabetes in 2015 was estimated to be $1.3T, and estimated to increase to $2.1T by 2030. Bommer et al., 2018, Diabetes Care 41(5):963-970. Approximately 90-95% of all diabetes cases are type 2 diabetes. Tripathi & Srivastava, 2016, Med. Sci. Monit. 12(7):RA130-147.

The glucagon-like peptide-1 receptor (GLP-1 receptor, or GLP1R) has emerged as a potential target for treating type 2 diabetes. Its ligand, glucagon-like peptide-1 (GLP-1) enhances glucose-induced insulin secretion, and increases insulin synthesis among many other effects. Doyle and Egan, 2007, Pharmacol. Ther. 113(3):546-593. GLP-1 is known to delay gastric emptying, suppress food intake, increase satiety, and reduce weight in humans. Shah and Vella, 2014 Rev Endocr Metab Disord. 15(3): 181-187. Activating the GLP-1 receptor has been shown to have beneficial effects on insulin secretion and the maintenance of beta cell glucose sensing, transcription, synthesis, proliferation, and survival. Doyle and Egan, 2007, supra. While the GLP-1 receptor is a promising therapeutic target, only a handful of GLP-1 receptor drugs have been approved to date, and most, or all of these are peptide, or polypeptide drugs.

There is a need for additional therapies for treating metabolic diseases, and conditions, like type 2 diabetes. Small molecules targeting GLP-1 receptor should provide safe, stable, and easy to administer therapeutics for metabolic diseases, and conditions such as type 2 diabetes.

SUMMARY

Provided herein are GLP-1 receptor modulator compounds of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), and sub-formulas thereof, compositions comprising the compounds, methods of producing the compounds, and methods of using the compounds, and compositions in treatment, and diagnosis. The compounds of Formula (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), and sub-formulas and embodiments thereof, are useful for modulating the activity of GLP-1 receptor. In certain embodiments, the compounds can be used to agonize the activity of GLP-1 receptor. In certain embodiments, the compounds can be used for treating diseases, or conditions modulated by GLP-1 receptor.

In one aspect, provided is a compound of Formula (I), or a pharmaceutically acceptable salt, or stereoisomer thereof:

wherein, A is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, —NMe2, or —CF3;
Ring B is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted bicyclic;
Ring C is substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heterocycloalkenyl, each comprising at least one N, linked to L3 as depicted;
zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6;
W is N, CR14, or C; when W is CR4, the adjacent dashed line indicates a single bond; when
W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═;
L1 is selected from the group consisting of a bond, —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—;
L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, —CH(OH)—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—;
L4 is absent, or L4 together with L1 and Rings A and B form a fused tricycle, and L5 is absent;
L5 is absent, or L5 together with L2 and Rings B and C form a fused tricycle, and L4 is absent;
R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, unsubstituted heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene;
R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl;
each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—;
R11 is hydrogen, or alkyl;
R12 is hydrogen, or alkyl;
R13 is hydrogen, or alkyl;
R14 is hydrogen, cyano, halo, hydroxyl, alkyl, haloalklyl, methyl, CH2F, or CH2OH;
wherein when L1 is a —CH2O—, L4 is absent, and L5 is absent, then either L2 is —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, or

or L3 is —C(O)—, or both.

In one aspect, provided is a compound of Formula (Ia), or a pharmaceutically acceptable salt or stereoisomer thereof:

wherein, A is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, —NMe2, or —CF3;
Ring B is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
Ring C is further unsubstituted or further substituted, and/or bridged;
zero, one, or two of D1, D2, and D3 are N, and the rest are CH or CR6;
W is N, CH, or C; when W is CH the adjacent dashed lines indicate single bonds;

    • when W is C, one adjacent dashed line indicates a double bond, for instance L2 is —C(H)═;
      L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—;
      L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —CF2—, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—;
L4 is absent, or L4 together with L1 and Rings A and B form a fused tricycle, and L5 is absent;
L5 is absent, or L5 together with L2 and Rings B and C form a fused tricycle, and L4 is absent;
R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, unsubstituted heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene;
R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl;
each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—;
R11 is hydrogen or alkyl;
R12 is hydrogen or alkyl; and
R13 is hydrogen or alkyl;
wherein, when L1 is —CH2O—, L4 is absent, and L5 is absent, then either L2 is —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, or

or L3 is —C(O)—, or both.

In one aspect, provided is a compound of Formula (XXX), or a pharmaceutically acceptable salt, or stereoisomer thereof:

Wherein, W is N, CH, or C; when W is CH, the adjacent dashed lines indicate single bonds;
when W is C, one adjacent dashed line indicates a double bond, for instance L2 is —C(H)═;
zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH or CR1;
zero, one, or two of B1, B2, B3, and B4 are N, and the rest are CH or CR2;
zero, one, or two of D1, D2, and D3 are N, and the rest are CH or CR6;
L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—;
L2 is selected from the group consisting of a bond, —C(O)—, —CH2—. —C(H)═, —SO2—, —O—, —CF2—, —CHF—, —CH(OH)—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—;
each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—;
each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—;
each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—;
R4 is unsubstituted alkyl, substituted alkyl, unsubstituted heteroalkyl, substituted heteroalkyl, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene;
R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl;
each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—;
R11 is hydrogen, or alkyl;
R12 is hydrogen, or alkyl;
R13 is hydrogen, or alkyl; and
o is an integer from 0 to 4.

In one aspect provided herein is a compound of Formula XXXI, or a pharmaceutically acceptable salt, or stereoisomer thereof:

wherein W is N, CH, or C; when W is CH, the adjacent dashed lines indicate single; zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1;
zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6;
each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—;
L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—;
L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—, —CHF—, —CH(OH)—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—;
each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—;
R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene;
R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl;
each R6 is independently selected from the group consisting of F, and methyl;
R11 is hydrogen, or alkyl;
R12 is hydrogen, or alkyl; R13 is hydrogen, or alkyl; and
o is 1, 2, 3, or 4.

In certain aspects, the compounds are useful in methods of treatment and prevention of metabolic diseases, and conditions, methods of detection of metabolic diseases, and conditions, and methods of diagnosis of metabolic diseases, and conditions.

In another aspect, provided are compositions comprising a compound of Formula (I), (Ia), (XXX), or (XXXI). In some embodiments, the compositions are pharmaceutical compositions. Any suitable pharmaceutical composition may be used. In a further aspect, provided herein is a kit comprising the compound of Formula (I), (Ia), (XXX), or (XXXI), or embodiments thereof, or a pharmaceutical composition thereof.

In another aspect, provided herein are methods of using the compounds or the compositions described herein. In some embodiments, the methods are for treatment. In some embodiments, the methods are diagnostic methods. In some embodiments, the methods are analytical methods. In some embodiments, the compounds, or compositions described herein are used to treat a disease, or condition. In some aspects, the disease, or condition is selected from metabolic diseases, or conditions. In certain embodiments, the disease is type 2 diabetes.

Also provided herein is the use of compounds described herein, and compositions thereof, for the treatment of a metabolic disease, or condition. Also provided herein is the use of compounds described herein, and compositions thereof, for the treatment of type 2 diabetes.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 provides intravenous glucose tolerance test (IVGTT) in cynomolgus monkeys.

DESCRIPTION OF EXEMPLARY EMBODIMENTS

Described herein are GLP-1 receptor compounds useful for treating metabolic diseases or conditions, such as type 2 diabetes.

Definitions

Unless otherwise defined, all terms of art, notations and other scientific terminology used herein are intended to have the meanings commonly understood by those of skill in the art to which this disclosure pertains. In some cases, terms with commonly understood meanings are defined herein for clarity, and/or ready reference. The techniques and procedures described or referenced herein are generally well understood, and are commonly employed using conventional methodologies by those skilled in the art. As appropriate, procedures involving the use of commercially available kits, and reagents are generally carried out in accordance with manufacturer-defined protocols, and conditions unless otherwise noted.

As used herein, the singular forms “a,” “an,” and “the” include the plural referents unless the context clearly indicates otherwise.

The term “about” indicates and encompasses an indicated value, and a range above and below that value. In certain embodiments, the term “about” indicates the designated value±10%, ±5%, or ±1%. In certain embodiments, the term “about” indicates the designated value±one standard deviation of that value. In certain embodiments, for example, logarithmic scales (e.g., pH), the term “about” indicates the designated value±0.3, ±0.2, or ±0.1.

When referring to the compounds provided herein, the following terms have the following meanings unless indicated otherwise. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of ordinary skill in the art. In the event that there is a plurality of definitions for a term herein, those in this section prevail unless stated otherwise.

“Alkoxy” and “alkoxyl,” refer to the group —OR″ where R″ is alkyl or cycloalkyl. Alkoxy groups include, in certain embodiments, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, tert-butoxy, sec-butoxy, n-pentoxy, n-hexoxy, 1,2-dimethylbutoxy, and the like.

The term “alkoxyamine,” as used herein, refers to the group -alkylene-O—NH2, wherein alkylene is as defined herein. In some embodiments, alkoxyamine groups can react with aldehydes to form oxime residues. Examples of alkoxyamine groups include —CH2CH2—O—NH2 and —CH2—O—NH2.

The term “alkyl,” as used herein, unless otherwise specified, refers to a saturated straight, or branched hydrocarbon. In certain embodiments, the alkyl group is a primary, secondary, or tertiary hydrocarbon. In certain embodiments, the alkyl group includes one to ten carbon atoms (i.e., C1 to C10 alkyl). In certain embodiments, the alkyl is a lower alkyl, for example, C1-6 alkyl, and the like. In certain embodiments, the alkyl group is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, secbutyl, t-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, 3-methylpentyl, 2,2-dimethylbutyl, and 2,3-dimethylbutyl. In certain embodiments, “substituted alkyl” refers to an alkyl substituted with one, two, or three groups independently selected from a halogen (e.g., fluoro (F), chloro (Cl), bromo (Br), or iodo (I)), alkyl, haloalkyl, hydroxyl, amino, alkylamino, alkoxy, aryl, heteroaryl, cycloalkyl, cyano, oxo, alkyne, and heterocycloalkylalkylene. In some embodiments, alkyl is unsubstituted.

The term “alkylene,” as used herein, unless otherwise specified, refers to a divalent alkyl group, as defined herein. “Substituted alkylene” refers to an alkylene group substituted as described herein for alkyl. In some embodiments, alkylene is unsubstituted.

“Alkenyl” refers to an olefinically unsaturated hydrocarbon group, in certain embodiments, having up to about eleven carbon atoms, or from two to six carbon atoms (e.g., “lower alkenyl”), which can be straight-chained or branched, and having at least one, or from one to two sites of olefinic unsaturation. “Substituted alkenyl” refers to an alkenyl group substituted as described herein for alkyl.

“Alkenylene” refers to a divalent alkenyl as defined herein. Lower alkenylene is, for example, C2-C6-alkenylene.

“Alkynyl” refers to acetylenically unsaturated hydrocarbon groups, in certain embodiments, having up to about eleven carbon atoms, or from two to six carbon atoms (e.g., “lower alkynyl”), which can be straight-chained or branched, and having at least one, or from one to two sites of acetylenic unsaturation. Non-limiting examples of alkynyl groups include acetylene (—C≡CH), propargyl (—CH2C≡CH), and the like. “Substituted alkynyl” refers to an alkynyl group substituted as described herein for alkyl.

“Alkynylene” refers to a divalent alkynyl as defined herein. Lower alkynylene is, for example, C2-C6-alkynylene.

“Amino” refers to —NH2.

The term “alkylamino,” as used herein, and unless otherwise specified, refers to the group —NHR″ where R″ is, for example, C1-10alkyl, as defined herein. In certain embodiments, alkylamino is C1-6alkylamino.

The term “dialkylamino,” as used herein, and unless otherwise specified, refers to the group —NR″R″ where, each R″ is independently C1-10alkyl, as defined herein. In certain embodiments, dialkylamino is di-C1-6alkylamino.

The term “aryl,” as used herein, and unless otherwise specified, refers to phenyl, biphenyl, or naphthyl. The term includes both substituted and unsubstituted moieties. An aryl group can be substituted with any described moiety including, but not limited to, one or more moieties (e.g., in some embodiments one, two, or three moieties) selected from the group consisting of halogen (e.g., fluoro (F), chloro (Cl), bromo (Br), or iodo (I)), alkyl, haloalkyl, hydroxyl, amino, alkylamino, arylamino, alkoxy, aryloxy, nitro, cyano, sulfonic acid, sulfate, phosphonic acid, phosphate, and phosphonate, wherein each moiety is independently either unprotected, or protected as necessary, as would be appreciated by those skilled in the art (e.g., Greene, et al., Protective Groups in Organic Synthesis, John Wiley and Sons, Second Edition, 1991); and wherein the aryl in the arylamino and aryloxy substituents are not further substituted.

The term “arylamino,” as used herein, and unless otherwise specified, refers to an —NR′R″ group where R′ is hydrogen, or C1-C6-alkyl; and R″ is aryl, as defined herein.

The term “arylene,” as used herein, and unless otherwise specified, refers to a divalent aryl group, as defined herein.

The term “aryloxy,” as used herein, and unless otherwise specified, refers to an —OR group where R is aryl, as defined herein.

“Alkarylene” refers to an arylene group, as defined herein, wherein the aryl ring is substituted with one or two alkyl groups. “Substituted alkarylene” refers to an alkarylene, as defined herein, where the arylene group is further substituted, as defined herein for aryl.

“Aralkylene” refers to an -alkyl-arylene- or arylene-alkyl, for instance, a —C1-C2 alkyl-arylene-, -arylene-C1-C2 alkyl-, or —C1-C2 alkyl-arylene-C1-C2 alkyl- group, where arylene is as defined herein. “Substituted aralkylene” refers to an aralkylene, as defined herein, where the aralkylene group is substituted, as defined herein for aryl. “Substituted C1-C2 alkyl” refers to a C1-C2 alkyl group that is substituted as defined herein for an alkyl.

“Arylalkylene” refers to -alkyl-arylene- or arylene-alkyl, for instance, a —C1-C2 alkyl-arylene-, -arylene-C1-C2 alkyl-, or —C1-C2 alkyl-arylene-C1-C2 alkyl- group, where arylene is as defined herein. “Substituted arylalkylene” refers to an arylalkylene, as defined herein, where the arylalkylene group is substituted, as defined herein for aryl. “Substituted C1-C2 alkyl” refers to a C1-C2 alkyl group that is substituted as defined herein for an alkyl.

“Carboxyl” or “carboxy” refers to —C(O)OH or —COOH.

The term “cycloalkyl,” as used herein, unless otherwise specified, refers to a saturated cyclic hydrocarbon. In certain embodiments, the cycloalkyl group may be a saturated, and/or bridged, and/or non-bridged, and/or a fused bicyclic group. In certain embodiments, the cycloalkyl group includes three to ten carbon atoms (i.e., C3 to C10 cycloalkyl). In some embodiments, the cycloalkyl has from three to fifteen carbons (C3-15), from three to ten carbons (C3-10), from three to seven carbons (C3-7), or from three to six carbons (C3-C6) (i.e., “lower cycloalkyl”). In certain embodiments, the cycloalkyl group is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexylmethyl, cycloheptyl, bicyclo[2.1.1]hexyl, bicyclo[2.2.1]heptyl, decalinyl, or adamantyl.

The term “cycloalkylene,” as used herein refers to a divalent cycloalkyl group, as defined herein. In certain embodiments, the cycloalkylene group is cyclopropylene

cyclobutylene

cyclopentylene

cyclohexylene

cycloheptylene

and the like. Lower cycloalkylene refers to a C3-C6-cycloalkylene.

The term “cycloalkylalkyl,” as used herein, unless otherwise specified, refers to an alkyl group, as defined herein, substituted with one or two cycloalkyl, as defined herein.

The term “ester,” as used herein, refers to —C(O)OR, or —COOR, where R is alkyl, as defined herein.

The term “haloalkyl” refers to an alkyl group, as defined herein, substituted with one, or more halogen atoms (e.g., in some embodiments one, two, three, four, or five) which are independently selected.

The term “heteroalkyl” refers to an alkyl, as defined herein, in which one or more carbon atoms are replaced by heteroatoms. As used herein, “heteroalkenyl” refers to an alkenyl, as defined herein, in which one, or more carbon atoms are replaced by heteroatoms. As used herein, “heteroalkynyl” refers to an alkynyl, as defined herein, in which one, or more carbon atoms are replaced by heteroatoms. Suitable heteroatoms include, but are not limited to, nitrogen (N), oxygen (O), and sulfur (S) atoms. Heteroalkyl, heteroalkenyl, and heteroalkynyl are optionally substituted. Examples of heteroalkyl moieties include, but are not limited to, aminoalkyl, sulfonylalkyl, and sulfinylalkyl. Examples of heteroalkyl moieties also include, but are not limited to, methylamino, methylsulfonyl, and methylsulfinyl. “Substituted heteroalkyl” refers to heteroalkyl substituted with one, two, or three groups independently selected from halogen (e.g., fluoro (F), chloro (Cl), bromo (Br), or iodo (I)), alkyl, haloalkyl, hydroxyl, amino, alkylamino, and alkoxy. In some embodiments, a heteroalkyl group may comprise one, two, three, or four heteroatoms. Those of skill in the art will recognize that a 4-membered heteroalkyl may generally comprise one, or two heteroatoms, a 5- or 6-membered heteroalkyl may generally comprise one, two, or three heteroatoms, and a 7- to 10-membered heteroalkyl may generally comprise one, two, three, or four heteroatoms.

The term “heteroalkylene,” as used herein, refers to a divalent heteroalkyl, as defined herein. “Substituted heteroalkylene” refers to a divalent heteroalkyl, as defined herein, substituted as described for heteroalkyl.

The term “heterocycloalkyl” refers to a monovalent, monocyclic, or multicyclic non-aromatic ring system, wherein one, or more of the ring atoms are heteroatoms independently selected from oxygen (O), sulfur (S), and nitrogen (N) (e.g., where the nitrogen, or sulfur atoms may be optionally oxidized, and the nitrogen atoms may be optionally quaternized) and the remaining ring atoms of the non-aromatic ring are carbon atoms. In certain embodiments, heterocycloalkyl is a monovalent, monocyclic, or multicyclic fully-saturated ring system. In certain embodiments, the heterocycloalkyl group has from three to twenty, from three to fifteen, from three to ten, from three to eight, from four to seven, from four to eleven, or from five to six ring atoms. The heterocycloalkyl may be attached to a core structure at any heteroatom or carbon atom which results in the creation of a stable compound. In certain embodiments, the heterocycloalkyl is a monocyclic, bicyclic, tricyclic, or tetracyclic ring system, which may include a fused or bridged ring system and in which the nitrogen or sulfur atoms may be optionally oxidized, and/or the nitrogen atoms may be optionally quaternized. In some embodiments, heterocycloalkyl radicals include, but are not limited to, 2,5-diazabicyclo[2.2.2]octanyl, decahydroisoquinolinyl, dihydrobenzisoxazinyl, dihydrofuryl, dihydroisoindolyl, dihydropyranyl, dihydropyrazolyl, dihydropyrazinyl, dihydropyridinyl, dihydropyrimidinyl, dihydropyrrolyl, dioxolanyl, 1,4-dithianyl, furanonyl, imidazolidinyl, imidazolinyl, indolinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, oxazolidinonyl, oxazolidinyl, oxiranyl, piperazinyl, piperidinyl, 4-piperidonyl, pyrazolidinyl, pyrazolinyl, pyrrolidinyl, pyrrolinyl, quinuclidinyl, tetrahydrofuryl, tetrahydroisoquinolinyl, tetrahydropyranyl, tetrahydrothienyl, thiamorpholinyl, thiazolidinyl, tetrahydroquinolinyl, and 1,3,5-trithianyl. In certain embodiments, heterocycloalkyl may also be optionally substituted as described herein. In certain embodiments, heterocycloalkyl is substituted with one, two, or three groups independently selected from halogen (e.g., fluoro (F), chloro (Cl), bromo (Br), or iodo (I)), alkyl, haloalkyl, hydroxyl, amino, alkylamino, oxo, cyano, and alkoxy. In some embodiments, a heterocycloalkyl group may comprise one, two, three, or four heteroatoms. Those of skill in the art will recognize that a 4-membered heterocycloalkyl may generally comprise one or two heteroatoms, a 5 or 6-membered heterocycloalkyl may generally comprise one, two, or three heteroatoms, and a 7- to 10-membered heterocycloalkyl may generally comprise one, two, three, or four heteroatoms.

“Heterocycloalkylene” refers to a divalent heterocycloalkyl as defined herein.

The term “heteroaryl” refers to a monovalent monocyclic aromatic group, and/or multicyclic aromatic group, wherein at least one aromatic ring contains one, or more heteroatoms independently selected from oxygen, sulfur, and nitrogen in the ring. Each ring of a heteroaryl group can contain one, or two oxygen atoms, one, or two sulfur atoms, and/or one to four nitrogen atoms, provided that the total number of heteroatoms in each ring is four, or less and each ring contains at least one carbon atom. In certain embodiments, the heteroaryl has from five to twenty, from five to fifteen, or from five to ten ring atoms. A heteroaryl may be attached to the rest of the molecule via a nitrogen or a carbon atom. In some embodiments, monocyclic heteroaryl groups include, but are not limited to, furanyl, imidazolyl, isothiazolyl, isoxazolyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, triazolyl, thiadiazolyl, thiazolyl, thienyl, tetrazolyl, and triazinyl. Examples of bicyclic heteroaryl groups include, but are not limited to, benzofuranyl, benzimidazolyl, benzoisoxazolyl, benzopyranyl, benzothiadiazolyl, benzothiazolyl, benzothienyl, benzotriazolyl, benzoxazolyl, furopyridyl, imidazopyridinyl, imidazothiazolyl, indolizinyl, indolyl, indazolyl, isobenzofuranyl, isobenzothienyl, isoindolyl, isoquinolinyl, naphthyridinyl, oxazolopyridinyl, phthalazinyl, pteridinyl, purinyl, pyridopyridyl, pyrrolopyridyl, quinolinyl, quinoxalinyl, quinazolinyl, thiadiazolopyrimidyl, and thienopyridyl. Examples of tricyclic heteroaryl groups include, but are not limited to, acridinyl, benzindolyl, carbazolyl, dibenzofuranyl, perimidinyl, phenanthrolinyl, phenanthridinyl, phenarsazinyl, phenazinyl, phenothiazinyl, phenoxazinyl, and xanthenyl. In certain embodiments, heteroaryl may also be optionally substituted as described herein. “Substituted heteroaryl” is a heteroaryl substituted as defined for aryl.

The term “heteroarylene” refers to a divalent heteroaryl group, as defined herein. “Substituted heteroarylene” is a heteroarylene substituted as defined for aryl.

The term “heteroarylalkylene” refers to -alkyl-heteroarylene- or -heteroarylene-alkyl, for instance, a —C1-C2 alkyl-heteroarylene-, -heteroarylene-C1-C2 alkyl-, or —C1-C2 alkyl-heteroarylene-C1-C2 alkyl- group, where heteroarylene is as defined herein. “Substituted heteroarylalkylene” refers to a heteroarylalkylene, as defined herein, where the heteroarylalkylene group is substituted, as defined herein for aryl. “Substituted C1-C2 alkyl” refers to a C1-C2 alkyl group that is substituted as defined herein for an alkyl.

As used herein, an “oxo” refers to ═O.

The term “protecting group,” as used herein, and unless otherwise specified, refers to a group that is added to an oxygen, nitrogen, or phosphorus atom to prevent its further reaction, or for other purposes. A wide variety of oxygen, and nitrogen protecting groups are known to those skilled in the art of organic synthesis. (See, e.g., Greene, et al., Protective Groups in Organic Synthesis, John Wiley and Sons, Fourth Edition, 2006, which is incorporated herein by reference).

“Pharmaceutically acceptable salt” refers to any salt of a compound provided herein which retains its biological properties, and which is not toxic or otherwise undesirable for pharmaceutical use. Such salts may be derived from a variety of organic, and inorganic counter-ions well known in the art. Such salts include, but are not limited to (1) acid addition salts formed with organic, or inorganic acids such as hydrochloric, hydrobromic, sulfuric, nitric, phosphoric, sulfamic, acetic, trifluoroacetic, trichloroacetic, propionic, hexanoic, cyclopentylpropionic, glycolic, glutaric, pyruvic, lactic, malonic, succinic, sorbic, ascorbic, malic, maleic, fumaric, tartaric, citric, benzoic, 3-(4-hydroxybenzoyl)benzoic, picric, cinnamic, mandelic, phthalic, lauric, methanesulfonic, ethanesulfonic, 1,2-ethane-disulfonic, 2-hydroxyethanesulfonic, benzenesulfonic, 4-chlorobenzenesulfonic, 2-naphthalenesulfonic, 4-toluenesulfonic, camphoric, camphorsulfonic, 4-methylbicyclo[2.2.2]-oct-2-ene-1-carboxylic, glucoheptonic, 3-phenylpropionic, trimethylacetic, tert-butylacetic, lauryl sulfuric, gluconic, glutamic, hydroxynaphthoic, salicylic, stearic, cyclohexylsulfamic, quinic, muconic acid, and the like; or (2) salts formed when an acidic proton present in the parent compound either (a) is replaced by a metal ion, for example, an alkali metal ion, an alkaline earth ion, or an aluminum ion, or alkali metal, or alkaline earth metal hydroxides, such as sodium, potassium, calcium, magnesium, aluminum, lithium, zinc, and barium hydroxide, or ammonia; or (b) coordinates with an organic base, such as aliphatic, alicyclic, or aromatic organic amines, including, without limitation, ammonia, methylamine, dimethylamine, diethylamine, picoline, ethanolamine, diethanolamine, triethanolamine, ethylenediamine, lysine, arginine, ornithine, choline, N,N′-dibenzylethylene-diamine, chloroprocaine, procaine, N-benzylphenethylamine, N-methylglucamine piperazine, tris(hydroxymethyl)-aminomethane, tetramethylammonium hydroxide, and the like.

Pharmaceutically acceptable salts further include, by way of example and without limitation, sodium, potassium, calcium, magnesium, ammonium, and tetraalkylammonium salts, and the like, and when the compound contains a basic functionality, salts of non-toxic organic, or inorganic acids, such as hydrohalides, for example, hydrochloride and hydrobromide, sulfate, phosphate, sulfamate, nitrate, acetate, trifluoroacetate, trichloroacetate, propionate, hexanoate, cyclopentylpropionate, glycolate, glutarate, pyruvate, lactate, malonate, succinate, sorbate, ascorbate, malate, maleate, fumarate, tartarate, citrate, benzoate, 3-(4-hydroxybenzoyl)benzoate, picrate, cinnamate, mandelate, phthalate, laurate, methanesulfonate (mesylate), ethanesulfonate, 1,2-ethane-disulfonate, 2-hydroxyethanesulfonate, benzenesulfonate (besylate), 4-chlorobenzenesulfonate, 2-naphthalenesulfonate, 4-toluenesulfonate, camphorate, camphorsulfonate, 4-methylbicyclo[2.2.2]-oct-2-ene-1-carboxylate, glucoheptonate, 3-phenylpropionate, trimethylacetate, tert-butylacetate, lauryl sulfate, gluconate, glutamate, hydroxynaphthoate, salicylate, stearate, cyclohexylsulfamate, quinate, muconate, and the like.

The term “substantially free of” or “substantially in the absence of” with respect to a composition refers to a composition that includes at least 85%, or 90% by weight, in certain embodiments 95%, 98%, 99%, or 100% by weight; or in certain embodiments, 95%, 98%, 99%, or 100% of the designated enantiomer or diastereomer of a compound. In certain embodiments, in the methods and compounds provided herein, the compounds are substantially free of one of two enantiomers. In certain embodiments, in the methods and compounds provided herein, the compounds are substantially free of one of two diastereomers. In certain embodiments, in the methods, and compounds provided herein, the compounds are substantially free of enantiomers (i.e., a racemic, or 50:50 mixture of compounds).

Similarly, the term “isolated” with respect to a composition refers to a composition that includes at least 85%, 90%, 95%, 98%, or 99% to 100% by weight, of the compound, the remainder comprising other chemical species, enantiomers or diastereomers.

“Solvate” refers to a compound provided herein, or a salt thereof, that further includes a stoichiometric, or non-stoichiometric amount of solvent bound by non-covalent intermolecular forces. Where the solvent is water, the solvate is a hydrate.

“Isotopic composition” refers to the amount of each isotope present for a given atom, and “natural isotopic composition” refers to the naturally occurring isotopic composition, or abundance for a given atom. Atoms containing their natural isotopic composition may also be referred to herein as “non-enriched” atoms. Unless otherwise designated, the atoms of the compounds recited herein are meant to represent any stable isotope of that atom. For example, unless otherwise stated, when a position is designated specifically as hydrogen (H), the position is understood to have hydrogen at its natural isotopic composition.

“Isotopic enrichment” refers to the percentage of incorporation of an amount of a specific isotope at a given atom in a molecule in the place of that atom's natural isotopic abundance. For example, deuterium (D) enrichment of 1% at a given position means that 1% of the molecules in a given sample contain deuterium at the specified position. Because the naturally occurring distribution of deuterium is about 0.0156%, deuterium enrichment at any position in a compound synthesized using non-enriched starting materials is about 0.0156%. The isotopic enrichment of the compounds provided herein can be determined using conventional analytical methods known to one of ordinary skill in the art, including mass spectrometry and nuclear magnetic resonance spectroscopy.

“Isotopically enriched” refers to an atom having an isotopic composition other than the natural isotopic composition of that atom. “Isotopically enriched” may also refer to a compound containing at least one atom having an isotopic composition other than the natural isotopic composition of that atom.

As used herein, “alkyl,” “alkylene,” “alkylamino,” “dialkylamino,” “cycloalkyl,” “aryl,” “arylene,” “alkoxy,” “amino,” “carboxyl,” “heterocycloalkyl,” “heteroaryl,” “heteroarylene,” “carboxyl,” and “amino acid” groups optionally comprise deuterium (D) at one, or more positions where hydrogen (H) atoms are present, and wherein the deuterium composition of the atom or atoms is other than the natural isotopic composition.

Also as used herein, “alkyl,” “alkylene,” “alkylamino,” “dialkylamino,” “cycloalkyl,” “aryl,” “arylene,” “alkoxy,” “amino,” “carboxyl,” “heterocycloalkyl,” “heteroaryl,” “heteroarylene,” “carboxyl,” and “amino acid” groups optionally comprise carbon-13 (13C) at an amount other than the natural isotopic composition.

As used herein, term “EC50” refers to a dosage, concentration, or amount of a particular test compound that elicits a dose-dependent response at 50% of maximal expression of a particular response that is induced, provoked, or potentiated by the particular test compound.

As used herein, and unless otherwise specified, the term “IC50” refers to an amount, concentration, or dosage of a particular test compound that achieves a 50% inhibition of a maximal response in an assay that measures such response.

As used herein, the terms “subject”, and “patient” are used interchangeably. The terms “subject”, and “subjects” refer to an animal, such as a mammal including a non-primate (e.g., a cow, pig, horse, cat, dog, rat, and mouse), and a primate (e.g., a monkey, such as a cynomolgous monkey, a chimpanzee, and a human), and in certain embodiments, a human. In certain embodiments, the subject is a farm animal (e.g., a horse, a cow, a pig, etc.), or a pet (e.g., a dog or a cat). In certain embodiments, the subject is a human.

As used herein, the terms “therapeutic agent”, and “therapeutic agents” refer to any agent(s) which can be used in the treatment, or prevention of a disorder, or one or more symptoms thereof. In certain embodiments, the term “therapeutic agent” includes a compound provided herein. In certain embodiments, a therapeutic agent is an agent which is known to be useful for, or has been, or is currently being used for the treatment, or prevention of a disorder, or one, or more symptoms thereof.

“Therapeutically effective amount” refers to an amount of a compound, or composition that, when administered to a subject for treating a condition, is sufficient to effect such treatment for the condition. A “therapeutically effective amount” can vary depending on, inter alia, the compound, the disease or disorder, and its severity, and the age, weight, etc., of the subject to be treated.

“Treating” or “treatment” of any disease, or disorder refers, in certain embodiments, to ameliorating a disease, or disorder that exists in a subject. In another embodiment, “treating”, or “treatment” includes ameliorating at least one physical parameter, which may be indiscernible by the subject. In yet another embodiment, “treating”, or “treatment” includes modulating the disease, or disorder, either physically (e.g., stabilization of a discernible symptom), or physiologically (e.g., stabilization of a physical parameter), or both. In yet another embodiment, “treating”, or “treatment” includes delaying, or preventing the onset of the disease, or disorder, or delaying, or preventing recurrence of the disease, or disorder. In yet another embodiment, “treating”, or “treatment” includes the reduction or elimination of either the disease, or disorder, or retarding the progression of the disease, or disorder, or of one, or more symptoms of the disease, or disorder, or reducing the severity of the disease, or disorder, or of one, or more symptoms of the disease, or disorder.

As used herein, the terms “prophylactic agent”, and “prophylactic agents” as used refer to any agent(s) which can be used in the prevention of a disorder, or one or more symptoms thereof. In certain embodiments, the term “prophylactic agent” includes a compound provided herein. In certain other embodiments, the term “prophylactic agent” does not refer a compound provided herein. For example, a prophylactic agent is an agent which is known to be useful for, or has been or is currently being used to prevent, or impede the onset, development, progression, and/or severity of a disorder.

As used herein, the phrase “prophylactically effective amount” refers to the amount of a therapy (e.g., prophylactic agent) which is sufficient to result in the prevention, or reduction of the development, recurrence, or onset of one or more symptoms associated with a disorder, or to enhance or improve the prophylactic effect(s) of another therapy (e.g., another prophylactic agent).

Compounds of Formulae (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII)

Provided herein are GLP-1 receptor compounds useful for modulating one, or more properties of GLP-1 receptor. The compounds can be prepared as described herein and used for therapy, or diagnosis. In certain embodiments, the therapy is the treatment of a metabolic disease or condition. In certain embodiments, the therapy is the treatment of type 2 diabetes.

The embodiments described herein include the recited compounds as well as pharmaceutically acceptable salts, hydrates, solvates, stereoisomers, tautomers, and/or mixtures thereof.

In certain embodiments, provided is a compound of Formula (I), or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof; wherein A is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, —NMe2, or —CF3; Ring B is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ring C is further unsubstituted or further substituted, and/or bridged; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; L1 is selected from the group consisting of a bond, —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —CF2—, —SO2—, —O—, —CF2—. —CHF—, —CH(OH)—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; L4 is absent, or L4 together with L1 and Rings A and B form a fused tricycle, and L5 is absent; L5 is absent, or L5 together with L2 and Rings B and C form a fused tricycle, and L4 is absent; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, unsubstituted heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—; R11 is hydrogen, or alkyl; R12 is hydrogen, or alkyl; and R13 is hydrogen, or alkyl. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —CF2—, —SO2—, —O—, —CF2—. —CHF—, —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-.

In certain embodiments of Formula (I), when L1 is —CH2O—, L4 is absent, and L5 is absent, then either L2 is —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—, CHF—, —CHOH—, —NH—, —N(Me)-, or

or L3 is —C(O)—, or both. In certain embodiments, when L1 is —CH2O—, L4 is absent, and L5 is absent, then L2 is —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, or

In certain embodiments, when L1 is —CH2O—, L4 is absent, and L5 is absent, then L3 is —C(O)—. In certain embodiments, when L1 is —CH2O—, L4 together with L1 and Rings A and B form a fused tricycle. In certain embodiments, when L1 is —CH2O—, L5 together with L2 and Rings B and C form a fused tricycle. In certain embodiments, when L1 is —CH2O—, Ring C is substituted or unsubstituted azetidinyl, substituted or unsubstituted pyrrolidinyl, or substituted or unsubstituted piperidinyl.

In certain embodiments, A is a ring selected from phenyl and cyclohexyl. In certain embodiments, Ring C is selected from piperidine and piperazine. In certain embodiments, Ring B is selected from phenyl, furan, pyridine, pyrimidine, thiophene, oxazole, and benzofuran. In certain embodiments, A is phenyl and Ring C is piperazine. In certain embodiments, A is phenyl, and Ring C is piperidine. In certain embodiments, A is phenyl, and Ring C is piperazine, and Ring B is phenyl. In certain embodiments, A is phenyl, and Ring C is piperazine, and Ring B is furan. In certain embodiments, A is phenyl, and Ring C is piperidine, and Ring B is phenyl. In certain embodiments, A is phenyl, and Ring C is piperidine, and Ring B is furan.

In certain embodiments, A is a ring selected from phenyl and cyclohexyl. In certain embodiments, Ring C is selected from substituted piperidine, azetidine, and pyrrolidine. In certain embodiments, Ring B is selected from phenyl, furan, pyridine, pyrimidine, thiophene, oxazole, and benzofuran. In certain embodiments, A is phenyl and Ring C is piperazine. In certain embodiments, A is phenyl, and Ring C is piperidine. In certain embodiments, A is phenyl, and Ring C is substituted piperidine. In certain embodiments, A is phenyl, and Ring C is azetidine. In certain embodiments, A is phenyl, and Ring C is pyrrolidine. In certain embodiments, A is phenyl, Ring C is piperazine, and Ring B is phenyl. In certain embodiments, A is phenyl, Ring C is piperazine, and Ring B is furan. In certain embodiments, A is phenyl, Ring C is piperidine, and Ring B is phenyl. In certain embodiments, A is phenyl, Ring C is piperidine, and Ring B is furan. In certain embodiments, A is phenyl, Ring C is substituted piperidine, and Ring B is phenyl. In certain embodiments, A is phenyl, Ring C is substituted piperidine, and Ring B is furan. In certain embodiments, A is phenyl, Ring C is azetidine, and Ring B is phenyl. In certain embodiments, A is phenyl, Ring C is azetidine, and Ring B is furan. In certain embodiments, A is phenyl, Ring C is pyrrolidine, and Ring B is phenyl. In certain embodiments, A is phenyl, Ring C is pyrrolidine, and Ring B is furan.

In certain embodiments, provided is a compound of Formula (Ta), or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof; wherein A is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, —NMe2, or —CF3; Ring B is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ring C is further unsubstituted or further substituted, and/or bridged; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; W is N, CH, or C; when W is CH, the adjacent dashed lines indicate single bonds; when W is C, one adjacent dashed line indicates a double bond, for instance L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; L4 is absent, or L4 together with L1 and Rings A and B form a fused tricycle, and L5 is absent; L5 is absent, or L5 together with L2 and Rings B and C form a fused tricycle, and L4 is absent; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, unsubstituted heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—; R11 is hydrogen, or alkyl; R12 is hydrogen, or alkyl; and R13 is hydrogen, or alkyl. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —CF2—, —SO2—, —O—, —CF2—. —CHF—, —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-.

In certain embodiments of Formula (Ia), when L1 is —CH2O—, L4 is absent, and L5 is absent, then either L2 is —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, or

or L3 is —C(O)—, or both. In certain embodiments, when L1 is —CH2O—, L4 is absent, and L5 is absent, then L2 is —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, or

In certain embodiments, when L1 is —CH2O—, L4 is absent, and L5 is absent, then L2 is —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, or

In certain embodiments, when L is —CH2O—, L4 is absent, and L5 is absent, then L3 is —C(O)—. In certain embodiments, when L is —CH2O—, L4 together with L1 and Rings A and B form a fused tricycle. In certain embodiments, when L1 is —CH2O—, L5 together with L2 and Rings B and C form a fused tricycle.

In certain embodiments, A is a ring selected from phenyl, and cyclohexyl. In certain embodiments, Ring C is selected from piperidine, and piperazine. In certain embodiments, Ring B is selected from phenyl, furan, pyridine, pyrimidine, thiophene, oxazole, and benzofuran. In certain embodiments, A is phenyl and Ring C is piperazine. In certain embodiments, A is phenyl, and Ring C is piperidine. In certain embodiments, A is phenyl, and Ring C is piperazine, and Ring B is phenyl. In certain embodiments, A is phenyl, and Ring C is piperazine, and Ring B is furan. In certain embodiments, A is phenyl, and Ring C is piperidine, and Ring B is phenyl. In certain embodiments, A is phenyl, and Ring C is piperidine, and Ring B is furan.

In certain embodiments, provided is a compound of Formula (XXX), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof; wherein W is N, CH, or C; when W is CH, the adjacent dashed lines indicate single bonds; when W is C, one adjacent dashed line indicates a double bond, for instance L2 is —C(H)═; zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1; zero, one, or two of B1, B2, B3, and B4 are N, and the rest are CH, or CR2; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—. —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted heteroalkyl, substituted heteroalkyl, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—; R11 is hydrogen or alkyl; R12 is hydrogen, or alkyl; R13 is hydrogen, or alkyl; and o is an integer from 0 to 4. In certain embodiments, the compound of Formula (XXX) is selected from compounds 82, 83, 91, 92, and 110, in Table 1.

In certain embodiments, provided is a compound of Formula (XXXI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof; wherein W is N, CH, or C; when W is CH, the adjacent dashed lines indicate single; zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1;

zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6;
each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—;
L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—;
L2 is selected from the group consisting of a bond, —C(O)—, —CH2—. —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—;
each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—;
R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene;
R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl;
each R6 is independently selected from the group consisting of F, and methyl;
R11 is hydrogen, or alkyl;
R12 is hydrogen, or alkyl;
R13 is hydrogen, or alkyl; and
o is 1, 2, 3, or 4. In certain embodiments, the compound of Formula (XXXI) is selected from compounds 97 and 107 in Table 1.

In certain embodiments, the compound of Formula (I) is according to Formula (IIa), or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1; zero, one, or two of B1, B2, B3, and B4 are N, and the rest are CH, or CR2, wherein, in Formula IIa B4 is absent; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of F, and methyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; and o is 1, 2, 3, or 4.

In certain embodiments, the compound of Formula (I) is according to Formula (IIb), or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1; zero, one, or two of B1, B2, B3, and B4 are N, and the rest are CH or CR2, wherein, in Formula IIb, B4 is absent; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of F, and methyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; and o is 1, 2, 3, or 4.

In certain embodiments, the compound of Formula (I) is according to Formula (IIc), or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1; zero, one, or two of B1, B2, B3, and B4 are N, and the rest are CH or CR2, wherein, in Formula IIc B4 is absent; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of F, and methyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; R4 is hydrogen, cyano, halo, hydroxyl, or methyl; and o is 1, 2, 3, or 4.

In certain embodiments, the compound of Formula (I) is according to Formula (IId), or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1; zero, one, or two of B1, B2, B3, and B4 are N, and the rest are CH or CR2, wherein, in Formula IId B4 is absent; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of F, and methyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; R14 is hydrogen, cyano, halo, hydroxyl, or methyl; and o is 1, 2, 3, or 4.

In certain embodiments, the compound of Formula (I) is according to Formula (IIg), or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1; zero, one, or two of B1, B2, B3, and B4 are N, and the rest are CH or CR2, wherein, in Formula IIg, B4 is absent; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of F, and methyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl.

In certain embodiments, the compound of Formula (I) is according to Formula (IIh), or a pharmaceutically acceptable salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein zero, one, or two of A1, A2, A3, A4, and A5 are N, and the rest are CH, or CR1; zero, one, or two of B1, B2, B3, and B4 are N, and the rest are CH or CR2, wherein, in Formula IIg, B4 is absent; zero, one, or two of D1, D2, and D3 are N, and the rest are CH, or CR6; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is unsubstituted alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of F, and methyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl.

In certain embodiments, provided is a compound of Formula (III), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —CF2—, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, L2 is O. In certain embodiments, the compound of Formula (III) is selected from compounds 2, 3, 5-7, 10-18, 21-23, 25, 29, 32, 33, 35, 45, 46, 48, 50-52, 54, 56-58, 64-70, 75-80, 86, 89, 93, 95, 98, 100, 103-105, 111, 112, 115, 116, 122, 126, 130-133, 135, 137, 148, 149, 151, 157-159, 161, 162, 165, 166, 174, 187, 188, 202-208, 215-217, 221, 231, 232, 242, 243, 254, 255, 260, 263, 288, 294, 301, 318, 319, and 321 in Table 1.

In certain embodiments, provided is a compound of Formula (IIIa), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, L2 is O. In certain embodiments, the compound of Formula (IIIa) is selected from compounds 103, 104, 111, 116, 126, 130-133, 135, 137, 148, 149, 151, 157-159, 161, 162, 165, 166, 174, 187, 188, 202-208, 215-217, 221, 231, 232, 242, 243, 254, 255, 260, 263, 288, 294, 301, 318, 319, and 321 in Table 1.

In certain embodiments, provided is a compound of Formula (IV), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (IV) is selected from compounds 8, 9, 19, 20, 24, 26, 30, 31, 36-43, 47, 49, 55, 59, 63, 72-74, 81, 84, 94, 96, 108, and 109 in Table 1.

In certain embodiments, provided is a compound of Formula (V), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)— each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (V) is selected from compound 71 in Table 1.

In certain embodiments, provided is a compound of Formula (VI) or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (VI) is selected from compounds 34, 62, and 331 in Table 1.

In certain embodiments, provided is a compound of Formula (VII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (VII) is selected from compounds 60, 102, 113, 124, 136, 138, 141, 144, 154, 156, 160, 186, 214, 256, 278, and 279 in Table 1.

In certain embodiments, provided is a compound of Formula (VIII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (VIII) is selected from compound 44 in Table 1.

In certain embodiments, provided is a compound of Formula (IX), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (IX) is selected from compounds 27 and 28 in Table 1.

In certain embodiments, provided is a compound of Formula (X), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)— each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (X) is selected from compound 4, 272, and 284 in Table 1.

In certain embodiments, provided is a compound of Formula (XI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (XI) is selected from compounds 53, 90, 121, 142, and 143 in Table 1.

In certain embodiments, provided is a compound of Formula (XII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)— each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (XII) is compound 108 in Table 1.

In certain embodiments, provided is a compound of Formula (XIII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)— each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (XIII) is selected from compounds 88, 178, and 179 in Table 1.

In certain embodiments, provided is a compound of Formula (XIV), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (XIV) is selected from compounds 85, 139, and 220 in Table 1.

In certain embodiments, provided is a compound of Formula (XV), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, L2 is O. In certain embodiments, the compound of Formula (XV) is selected from compounds 101, 114, 118, 120, 123, 140, 146, 152, 153, 198-200, 246-249, 251-253, 264, 268-271, 285, 290, 291, 330, and 347 in Table 1.

In certain embodiments, provided is a compound of Formula (XVI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R3 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, L2 is O. In certain embodiments R14 is CH2F or CH2OH. In certain embodiments, the compound of Formula (XVI) is selected from compounds 99, 128, 145, 150, 155, 163, 164, 168-171, 182, 183, 189, 227, 230, 239-241, 250, 257-259, 265-267, 274-277, 280, 283, 287, 292, 295, 297, 299, 308, 316, 321, 322, 333, 335, 337, 345, 346, 352, 354, 356-358, 362-364, 366-368, 378, and 380 in Table 1.

In certain embodiments, provided is a compound of Formula (XVIa), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; R4 is hydrogen, cyano, halo, hydroxyl, or methyl; n is an integer from 0 to 5; m is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —CF2—, —SO2—, —O—, —CF2—. —CHF—, —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, L2 is O. In certain embodiments, the compound of Formula (XVI) is selected from compounds 128, 145, 168-171, 182, 183, 227, 230, 239-241, 250, 257-259, 265-267, 274-277, 280, 283, 287, 292, 295, 297, 299, 302, 308, 316, 321, 322, 333, 335-337, 344-346, 352, 354, 356-359, 362-368, 378, and 380 in Table 1.

In certain embodiments, provided is a compound of Formula (XVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (XVII) is selected from compound 106 in Table 1.

In certain embodiments, provided is a compound of Formula (XVIII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R3 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (XVIII) is compound 87 in Table 1.

In certain embodiments, provided is a compound of Formula (XXV), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; R4 is hydrogen, cyano, halo, hydroxyl, or methyl; n is an integer from 0 to 5; m is an integer from 0 to 4; o is an integer from 0 to 4; p is an integer from 0 or 1; q is an integer from 0 or 1. In certain embodiments, p is 0; and q is 0. In certain embodiments, p is 1; and q is 0. In certain embodiments, p is 0; and q is 1. In certain embodiments, p is 1; and q is 1. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —CF2—, —SO2—, —O—, —CF2—. —CHF—, —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, the compound of Formula (XXV) is compound 286 in Table 1.

In certain embodiments, provided is a compound of Formula (XXVI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein W is N, CR14, or C; when W is CR4, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is selected from the group consisting of —NH— and —N(Me)-. In certain embodiments, L2 is O. In certain embodiments, the compound of Formula (XXVI) is selected from compounds 261, 262, 296, 304, 306, 307, 311, 313, 315, 325, 326, 331, 338, 340, 342, 343, 348, 353, 354, 355, 369, 374-, 376, 475-481, 483, 485, 489, 490, 492, 493, 495, 498, 504, 510, 512, 514, and 515 in Table 1.

In certain embodiments, provided is a compound of Formula (XXVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein A is —NMe2 or —N(CH3)cylcohexane; L1 is absent; W is N, CR14, or C; when W is CR14, the adjacent dashed line indicates a single bond; when W is C, the adjacent dashed line indicates a double bond or L2 is —C(H)═; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, the compound of Formula (XXVII) is selected from compounds 1 and 62 in Table 1.

In certain embodiments, provided is a compound of Formula (XXXIX), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; o is an integer from 0 to 4; and r is an integer from 0 to 3. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, each R6 is independently selected from the group consisting of F, and methyl. In certain embodiments, each R6 is F. In certain embodiments, the compound of Formula (XXXIX) is selected from compounds 224, 300, 303, 309, 310, 317, and 320 in Table 1.

In certain embodiments, provided is a compound of Formula (XL), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; o is an integer from 0 to 4; and r is an integer from 0 to 3. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, each R6 is independently selected from the group consisting of F, and methyl. In certain embodiments, each R6 is F. In certain embodiments, the compound of Formula (XL) is selected from compounds 302, 325, 336, 344, 359, and 365 in Table 1.

In certain embodiments, provided is a compound of Formula (XLI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; o is an integer from 0 to 4; and r is an integer from 0 to 3. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, each R6 is independently selected from the group consisting of F, and methyl. In certain embodiments, each R6 is F. In certain embodiments, each R6 is methyl. In certain embodiments, the compound of Formula (XLI) is selected from compounds 302, 325, 336, 344, 359, 365, 478, 482, 484, 494, 496, 500-503, 505, 508, 509, and 511 in Table 1.

In certain embodiments, provided is a compound of Formula (XLII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is —O—. In certain embodiments, the compound of Formula (XLII) is selected from compounds 370, 371, 373, 375, 377, 378, 486, and 513 in Table 1.

In certain embodiments, provided is a compound of Formula (XLIII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2—, or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkylalkylene, or substituted heterocycloalkylalkylene; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—; each R11 is hydrogen or alkyl; each R12 is hydrogen or alkyl; each R13 is hydrogen or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; o is an integer from 0 to 4; r is an integer from 0 to 3. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is —O—. In certain embodiments, each R6 is independently selected from the group consisting of F, and methyl. In certain embodiments, each R6 is F. In certain embodiments, each R6 is methyl. In certain embodiments, the compound of Formula (XLIII) is c selected from compounds 487 and 488 in Table 1.

In certain embodiments, provided is a compound of Formula (XLII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is —O—. In certain embodiments, the compound of Formula (XLIV) is compound 372 in Table 1.

In certain embodiments, provided is a compound of Formula (XLV), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is —O—. In certain embodiments, the compound of Formula (XLV) is compound 379 in Table 1.

In certain embodiments, provided is a compound of Formula (XLVI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; and o is an integer from 0 to 4. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, L2 is —O—. In certain embodiments, the compound of Formula (XLVI) is selected from compounds 125 and 129 in Table 1.

In certain embodiments, provided is a compound of Formula (XLI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof:

wherein L1 is selected from the group consisting of —O—, —CH2—, —NH—, —N(Me)-, —N(Et)-, —OCH2—, —OC(H,Me)-, —CH2O—, —NHCH2—, —N(Me)CH2—, and —SO2NH—; L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —NH—, —N(Me)-, and

L3 is —CH2— or —C(O)—; each R1 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R2 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; each R3 is independently selected from the group consisting of alkyl, substituted alkyl, halo, cyano, azido, alkoxy, haloalkoxy, and R11R12NCO—; R4 is alkyl, substituted alkyl, unsubstituted arylalkylene, substituted arylalkylene, heteroalkyl, substituted heteroalkyl, unsubstituted heteroarylalkylene, substituted heteroarylalkylene, unsubstituted heterocycloalkyl, or substituted heterocycloalkyl; R5 is selected from the group consisting of —COOH, —COCF3, —C(OH)CF3, —CONHCN, —CONHOH, CONHOMe, —CONHSO2N(Me)2, —PO3H2, —PO(Me)(OH), —SO3H, —SO2NH2, —SO2NHMe, —B(OH)2,

and tetrazolyl; each R6 is independently selected from the group consisting of alkyl, substituted alkyl, halo, hydroxyl, alkoxyl, R11R12NCO—, and R11R12N—; each R11 is hydrogen, or alkyl; each R12 is hydrogen, or alkyl; each R13 is hydrogen, or alkyl; n is an integer from 0 to 5; m is an integer from 0 to 4; o is an integer from 0 to 4; and r is an integer from 0 to 3. In certain embodiments, L2 is selected from the group consisting of a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—, and

In certain embodiments, each R6 is independently selected from the group consisting of F, and methyl. In certain embodiments, each R6 is F. In certain embodiments, each R6 is methyl. In certain embodiments, the compound of Formula (XLVII) is compound 491 in Table 1.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein each R2 and R3 is H, or F.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein m is 0; and o is 0.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein W is N, or CH.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein W is C.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein W is CH.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein W is N.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein W is CR14.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is selected from the group consisting of oxetan-2-yl-methyl, (1-ethyl-1H-imidazol-5-yl)-methyl, oxelan-3-yl-methyl and 1,3-oxazol-2-yl-methyl.

In certain embodiments, provided is a compound of any of Formulas (XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is selected from the group consisting of oxetan-2-yl-methyl, and (1-ethyl-1H-imidazol-5-yl)-methyl.

In certain embodiments, provided is a compound of any of Formulas (XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is oxetan-2-yl-methyl.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is (2S)-oxetan-2-yl-methyl.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is (1-ethyl-1H-imidazol-5-yl)-methyl.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is selected from the group consisting of (S)-buta-4-yl-1,3-diol, butan-1-yl-one, 1-(cyanomethyl)-cycloprop-1-yl-methyl, 1-(Fluoromethyl)-cycloprop-1-yl-methyl, 1-hydroxyl-cycloprop-1-yl-methyl, isoxazol-5-yl-methyl, (1-methyl-1H-imidazol-5-yl)-methyl, 1-methoxy-cycloprop-1yl-methyl, methoxyethan-2-yl, 1-(2-methoxyethyl)-cycloprop-1-yl-methyl, and 2-oxabicyclo[2.1.1]hexa-1-yl-methyl.

In certain embodiments, provided is a compound of Formula (XXX), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is H.

In certain embodiments, provided is a compound of Formula (XXX), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is selected from the group consisting of oxelan-3-yl-methyl and 1,3-oxazol-2-yl-methyl.

In certain embodiments, provided is a compound of Formula (XXX) and (XXXI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is (3R)-oxelan-3-yl-methyl.

In certain embodiments, provided is a compound of Formula (XXX) and (XXXI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R4 is 1,3-oxazol-2-yl-methyl.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R5 is —COOH, or —COOMe.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R5 is —COOH

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R5 is tetrazolyl.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein R5 is 1H-1,2,3,4-tetrazol-5-yl.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —CH2—, —C(O)—, or —SO2—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is a bond, —C(O)—, —CH2—, —C(H)═, —SO2—, —O—, —CF2—. —CHF—, or —CH(OH)—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —CH═ or —O—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —CF2—, —CHF—, or —CH(OH)—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH— or —N(Me)-.

In certain embodiments, provided is a compound of Formula (XXX), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is a bond.

In certain embodiments, provided is a compound of Formula (XXXI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —CH2—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L3 is —CH2—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L3 is —C(O)—.

In certain embodiments, provided is a compound of Formulas (XXX), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —CH2O—, or —OCH2—.

In certain embodiments, provided is a compound of Formula (XXXI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —CH2O—, or —OCH2.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —CH2O—; and L2 is —CH2— or —CO—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —CH2O—; and L3 is —C(O)—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —O—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —CH2—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —NH—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —N(Me)-.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —N(Et)-.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L is —OCH2—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —OC(H,Me)-.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —CH2O—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L is —NHCH2—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —N(Me)CH2—.

In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L1 is —SO2NH—.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), a (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLICI), L1 is —O—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIIV), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —CH2O—; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —OCH2—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, -OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH— and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH— and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —NH—; and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —NH—; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)- and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)- and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)- and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIVI), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2— and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —C(O)-L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —N(Me)CH2—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)- and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), a (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —OC(H,Me)-; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —C(O)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —C(H)═. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —SO2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XVII), L1 is —SO2NH—; L2 is —C(H)═; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —SO2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —C(O)-L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(O)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —C(O)-L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(O)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —C(O)-L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(O)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —C(H)═; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —SO2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XVII), L1 is —O—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLIII), L1 is —O—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), vR4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —CH2O—; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —CHF-L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —OCH2—; and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —OCH2—; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH— and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH— and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —NH—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI) (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), o(XXXIX), and (XL-XLVII), r a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)- and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —N(Me)- and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)- and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)- and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)- and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)- and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —N(Et)-; and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —N(Et)-; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(ME)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —NHCH2—; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH— and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. n certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. n certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2s)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2s)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI) (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2-L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I(XXXIX), and (XL-XLVII)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)- and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)- and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)- and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —O—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —CF2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —CHF—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —CH(OH)—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —NH—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; and L2 is —N(Me)-. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CF2—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CHF—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; and L3 is —CH2—. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CHF—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; and R2 and R3 are each H. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (2S)-oxetan-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH-L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is (1-ethyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2s)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (2S)-oxetan-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is (1-ethyl-1H-imidazol-5-yl)-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), L is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —CH2O—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —OCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI) R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Et)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —NHCH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —NHCH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2-L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2-L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —N(Me)CH2—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —N(Me)CH2—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —OC(H,Me)-; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is oxelan-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; and R4 is 1,3-oxazol-2-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is —COOH. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is oxelan-3-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —O—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CF2—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CHF—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —CH(OH)—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —NH—; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), L1 is —SO2NH—; L2 is —N(Me)-; L3 is —CH2—; R2 and R3 are each H; R4 is 1,3-oxazol-2-yl-methyl; and R5 is tetrazolyl, for instance 1H-1,2,3,4-tetrazol-5-yl. In any embodiment according to this paragraph, R1 can be selected from H, Cl, F, Me, —CF3, —OMe, —CN, —C(O)NMe2, alkyl, propyl, isopropyl, and cyclopropyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3R)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (3S)-azetidine-3-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (S)-buta-4-yl-1,3-diol. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is butan-1-yl-one. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(cyanomethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), R4 is 1-(Fluoromethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (XXXIX), and (XL-XLIII), (I)-(XVIII), (XXV)-(XXVII), (XXX), and (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-hydroxyl-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is isoxazol-5-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is (1-methyl-1H-imidazol-5-yl)-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-methoxy-cycloprop-1yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is methoxyethan-2-yl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 1-(2-methoxyethyl)-cycloprop-1-yl-methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2R)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl}. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is {[(2S)-1-(1,2-oxazole-3-carbonyl)azetidin-2-yl]methyl. In certain embodiments of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), R4 is 2-oxabicyclo[2.1.1]hexa-1-yl-methyl. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —NH—. In certain embodiments, provided is a compound of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof, wherein L2 is —N(Me)-.

In certain embodiments, provided is a compound of Table 1 below, or a pharmaceutically salt, tautomer, stereoisomer, and/or mixture of stereoisomers thereof.

Com- pound Structure IUPAC 1 2-({4-[6-dimethylamino)pyrimidine-4- carbonyl]piperazin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 2 2-[(4-{3-[2-chloro-4- (trifluoromethyl)phenoxy]benzoyl}piperazin- 1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 3 2-[(4-{3-[(4- fluorophenyl)methyl]benzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 4 2-({4-[2-(2- cyanophenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 5 2-({4-[3-(4- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 6 2-({4-[3-(4- methoxyphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 7 2-({4-[3-(4- chlorophenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 8 2-{[4-({5-[(3-chloro-2- methylphenoxy)methyl]furan-2- yl}methyl)piperzin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 9 2-{[4-({5-[(2,4- dichlorophenoxy)methyl]furan-2- yl}methyl)piperzin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 10 2-({4-[3-(4-cyano-2- fluorophenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 11 2-({4-[3-(2,5- dichlorophenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 12 2-({4-[3-(5-chloro-2- fluorophenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 13 2-({4-[3-(4- fluorophenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 14 2-({4-[3-(2- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 15 2-({4-[3-(2-chloro-4- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 16 2-({4-[3-(2-fluoro-4- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 17 2-({4-[3-(3- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 18 2-({4-[3-(2,4- dimethylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 19 2-[(4-{5-[(3-chloro-2- methylphenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 20 1-{[(2S)-oxetan-2-yl]methyl}-2-[(4-{[5- (phenoxymethyl)furan-2- yl]methyl}piperazin-1-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 21 2-({4-[4-(3- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 22 2-({4-[4-(4- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 23 methyl 2-({4-[3-(2-chloro-4- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylate 24 methyl 2-[(4-{5-[(3-chloro-2- methylphenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylate 25 2-[(4-{3-[(4- methylphenyl)amino]benzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 26 2-[(4-{5-[(2,4- dichlorophenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 27 2-[(4-{[6-(2,4-dichlorophenyl)-1- benzofuran-2-yl]methyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 28 2-[(4-{[6-(4-chloro-2-fluorophenyl)-1- benzofuran-2-yl]methyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 29 2-[(4-{3-[methyl(4- methylphenyl)amino]benzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 30 1-{[(2S)-oxetan-2-yl]methyl}-2-({4-[5- (phenoxymethyl)furan-2- carbonyl]piperazin-1-yl}methyl)-1H-1,3- benzodiazole-6-carboxylic acid 31 2-[(4-{5-[(4-chlorophenoxy)methyl]furan- 2-carbonyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 32 2-[(4-{3-[(2-chloro-4- methylphenyl)methyl]benzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 33 2-[(4-{3-[(4- methylphenyl)methyl]benzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 34 2-({4-[6-(4-methylphenoxy)pyrimidine-4- carbonyl]piperazin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 35 2-[(4-{[3-(4- methylphenoxy)phenyl]methyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 36 2-[(4-{5-[(4-chloro-2- fluorophenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 37 2-[(4-{5-[(4-cyano-2- fluorophenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 38 2-[(4-{5-[(2-chloro-4- methylphenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 39 2-[(4-{5-[(2-chlorophenoxy)methyl]furan- 2-carbonyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 40 2-[(4-{5-[(3-chlorophenoxy)methyl]furan- 2-carbonyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 41 2-[(4-{5-[(2,4- dimethylphenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 42 2-[(4-{5-[(4-methylphenoxy)methyl]furan- 2-carbonyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 43 2-[(4-{5-[(2-methylphenoxy)methyl]furan- 2-carbonyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 44 2-{[4-(7-methyl-9-oxo-9H-xanthene-3- carbonyl)piperazin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 45 2-[(4-{3-[(2,4- dimethylphenyl)(methyl)amino]benzoyl} piperazin-1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 46 1-[(1-ethyl-1H-imidazol-5-yl)methyl]-2-[(4- {3-[methyl(4- methylphenyl)amino]benzoyl}piperazin-1- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 47 2-[(4-{5-[(2,4- dichlorophenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 48 2-[(4-{3-[(2,4- dichlorophenyl)methyl]benzoyl}piperazin- 1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 49 2-{[4-(5-{[4-(dimethylcarbamoyl)-2- fluorophenoxy]methyl}furan-2- carbonyl)piperazin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 50 2-[(4-{3-[(2-chloro-4- methylphenyl)amino]benzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 51 2-[(4-{3-[(2-chloro-4- methylphenyl)(methyl)amino]benzoyl} piperazin-1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 52 2-[(4-{3-[(2-chloro-4- methylphenyl)(ethyl)amino]benzoyl} piperazin-1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 53 1-{[(2S)-oxetan-2-yl]methyl}-2-{[8- (trifluoromethoxy)-1H,2H,3H,4H,5H- pyrido[4,3-b]indol-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 54 2-[(4-{3-[(2-chloro-4- methylphenyl)(methyl)amino]benzoyl} piperazin-1-yl)methyl]-1-[(1-ethyl-1H- imidazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 55 2-[(4-{5-[(2,4- dimethylphenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 56 2-[(4-{3-[(2-chloro-4- methylphenyl)methyl]benzoyl}piperazin-1- yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 57 2-({4-[3-(2-chloro-4- methylphenoxy)benzoyl]piperazin-1- yl}methyl)-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 58 2-[(4-{3-[(2-chloro-4- methylphenyl)amino]benzoyl}piperazin-1- yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 59 2-[(4-{5-[(2,4- dichlorophenyl)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 60 2-{[4-({2-[(2,4-dichlorophenoxy)methyl]- 1,3-oxazol-5-yl}methyl)piperidin-1- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 61 2-[(4-{6- [cyclohexyl(methyl)amino]pyrimidine-4- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 62 2-[(4-{6-[methyl(phenyl)amino]pyrimidine- 4-carbonyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 63 2-{[4-({5-[(2,4- dichlorophenoxy)methyl]furan-2- yl}methyl)piperazin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 64 2-[(4-{3-[(2-chloro-4- methylphenoxy)methyl]benzoyl}piperazin- 1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 65 2-[(4-{3-[(2-chloro-4- methylphenoxy)methyl]benzoyl}piperazin- 1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 66 2-[(4-{3-[(4-cyano-2- fluorophenyl)methoxy]benzoyl}piperazin- 1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 67 2-[(4-{3-[(4-cyano-2- fluorophenyl)methoxy]benzoyl}piperazin- 1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 68 2-[(4-{3-[(4-cyano-2- fluorophenoxy)methyl]benzoyl}piperazin- 1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 69 2-[(4-{3-[(4-cyano-2- fluorophenoxy)methyl]benzoyl}piperazin- 1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 70 2-({4-[3-(4- methylbenzenesulfonamido)benzoyl] piperazin-1-yl}methyl)-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 71 2-[(4-{5-[(2,4- dichlorophenoxy)methyl]thiophene-2- carbonyl}piperazin-1-yl)methyl]-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 72 2-{[4-({5-[(2,4- dichlorophenoxy)methyl]furan-2- yl}methyl)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 73 2-[(4-{5-[(2,4- dichlorophenyl)methoxy]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 74 2-{[4-({5-[(2,4- dichlorophenyl)methoxy]furan-2- yl}methyl)piperazin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 75 2-[(4-{5-[(2-chloro-4- methylphenyl)(methyl)amino]-2- methylbenzoyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 76 2-[(4-{5-[(2-chloro-4- methylphenyl)(methyl)amino]-2- methylbenzoyl}piperazin-1-yl)methyl]-1- [(1-ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 77 2-{[4-(3-{[(2-chloro-4- methylphenyl)(methyl)amino]methyl}benzoyl) piperazin-1-yl]methyl}-1-[(1-ethyl-1H- imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 78 2-{[4-(3-{[(2-chloro-4- methylphenyl)(methyl)amino]methyl}benzoyl) piperazin-1-yl]methyl}-1-{[(2S)-oxetan- 2-yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 79 2-{[4-(3-{[(2-chloro-4- methylphenyl)amino]methyl}benzoyl) piperazin-1-yl]methyl}-1-[(1-ethyl-1H-imidazol- 5-yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 80 2-{[4-(3-{[(2-chloro-4- methylphenyl)amino]methyl}benzoyl) piperazin-1-yl]methyl}-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 81 2-[(4-{5-[(2-chloro-4- cyclopropylphenoxy)methyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 82 3-fluoro-4-{[(6-{1-[5-(1H-1,2,3,4-tetrazol- 5-yl)pyridine-2-carbonyl]piperidin-4- yl}pyridin-2-yl)oxy]methyl}benzonitrile 83 3-fluoro-4-{[(6-{1-[6-(1H-1,2,3,4-tetrazol- 5-yl)pyridine-3-carbonyl]piperidin-4- yl}pyridin-2-yl)oxy]methyl}benzonitrile 84 2-{[4-({5-[(2,4- dichlorophenoxy)methyl]furan-2- yl}methyl)-1,2,3,6-tetrahydropyridin-1- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 85 2-[(4-{5-[(2-chloro-4- methylphenyl)(methyl)amino]pyridine-3- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 86 2-[(4-{3-[(2-chloro-4- methylphenyl)(methyl)amino]benzenesulfonyl} piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 87 2-[(3-{3-[(2-chloro-4- methylphenyl)(methyl)amino]benzoyl}-3,8- diazabicyclo[3,2.1]octan-8-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 88 2-[(4-{4-[(2-chloro-4- methylphenyl)(methyl)amino]pyridine-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 89 2-[(4-{3-[2-methyl-4-(propan-2- yl)phenoxy]benzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 90 2-({6-[(4-chloro-2-fluorophenyl)methoxy]- 1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 91 5-(4-{6-[(4-cyano-2- fluorophenyl)methoxy]pyridin-2- yl}piperidine-1-carbonyl)pyridine-2- carboxylic acid 92 3-fluoro-4-{[(6-{4-[6-(1H-1,2,3,4-tetrazol- 5-yl)pyridine-3-carbonyl]piperazin-1- yl}pyridin-2-yl)oxy]methyl}benzonitrile 93 2-[(4-{5-[(2-chloro-4- methylphenyl)(methyl)amino]-2- cyclopropylbenzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 94 2-[(4-{5-[(1R*)-1-(2,4- dichlorophenoxy)ethyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 95 2-[(4-{3-[(2-chloro-4- methylphenyl)(methyl)amino]-4- fluorobenzoyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 96 2-[(4-{5-[(1S)-1-(2,4- dichlorophenoxy)ethyl]furan-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 97 1-({5-[(2,4-dichlorophenoxy)methyl]furan- 2-yl}methyl)-4-[6-(1H-1,2,3,4-tetrazol-5- yl)pyridine-3-carbonyl]piperazine 98 2-[(4-{5-[(2-chloro-4- methylphenyl)(methyl)amino]-2- fluorobenzoyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 99 2-[(4-{2-[(2-chloro-4- methylphenyl)(methyl)amino]pyridine-4- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 100 2-[(4-{3-[(2-chloro-4- methylphenyl)(methyl)amino]-5- fluorobenzoyl}piperazin-1-yl)methyl]-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 101 2-[(4-{6-[(2-chloro-4- methylphenyl)(methyl)amino]pyridine-2- carbonyl}piperazin-1-yl)methyl]-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 102 2-[(4-{2-[(2,4-dichlorophenoxy)methyl]- 1,3-oxazole-5-carbonyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 103 2-{[4-({3-[(2,4- dichlorophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 104 2-{[4-({3-[(2,4- dichlorophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-[(1-ethyl-1H- imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 105 2-{[4-(1-{3-[(2-chloro-4- methylphenyl)(methyl)amino]phenyl} cyclopropyl)piperazin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 106 2-{[4-({3-[(2-chloro-4- methylphenyl)(methyl)amino]phenyl} methylidene)pyridin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 107 5-[4-({5-[(2,4- dichlorophenoxy)methyl]furan-2- yl}methyl)piperidine-1-carbonyl]-2-(1H- 1,2,3,4-tetrazol-5-yl)pyridine 108 2-{[4-({5-[(2,4- dichlorophenoxy)methyl]furan-2- yl}methyl)piperidin-1-yl]methyl}-3-[(1- ethyl-1H-imidazol-5-yl)methyl]-3H- imidazo[4,5-b]pyridine-5-carboxylic acid 109 2-{[4-({5-[(2,4- dichlorophenoxy)methyl]furan-2- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 110 6-[(2,4-dichlorophenyl)methoxy]-1′-{[6- (2H-1,2,3,4-tetrazol-5-yl)pyridin-3- yl]methyl}-1′,2′,3′,6′-tetrahydro-2,4′- bipyridine 111 2-[(4-{3-[(2-chloro-4- methylphenyl)(methyl)amino]phenoxy} piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 112 2-[(4-{3-[1-(2-chloro-4- methylphenyl)ethyl]benzoyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 113 2-[(4-{5-[(2,4-dichlorophenoxy)methyl]- 1,3-oxazole-2-carbonyl}piperazin-1- yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 114 2-{[4-({6-[(2-cyano-4- methylphenoxy)methyl]pyridin-2- yl}methyl)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 115 2-[(4-{3-[(4-cyclopropyl-2- methylphenyl)(methyl)amino]benzoyl} piperazin-1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 116 2-{[4-({3-[(2-chloro-4- methylphenyl)(methyl)amino]phenyl}methyl) piperidin-1-yl]methyl}-1-{[(2S)-oxetan- 2-yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 117 2-{[4-({3-[(2-chloro-4- methylphenyl)(methyl)amino]phenyl}methyl)- 1,2,3,6-tetrahydropyridin-1-yl]methyl}- 1-{[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 118 2-{[4-({6-[(2-chloro-4- methylphenoxy)methyl]pyridin-2- yl}methyl)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 120 2-{[4-({6-[(2-chloro-4- methylphenoxy)methyl]pyridin-2- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 121 2-({8-[(4-chloro-2-fluorophenyl)methoxy]- 1H,2H,3H,4H,9H-pyrido[3,4-b]indol-2- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 122 2-[(4-{3-[(2-chloro-4- cyclopropylphenyl)(methyl)amino]benzoyl} piperazin-1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 123 2-{[4-({6-[(2-chloro-4- methylphenoxy)methyl]-3-fluoropyridin-2- yl}methyl)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 124 2-{[4-({2-[(2,4-dichlorophenoxy)methyl]- 1,3-oxazol-5-yl}methyl)piperidin-1- yl]methyl}-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 125 2-{[4-({2-[(2,4-dichlorophenoxy)methyl]- 1,3-oxazol-5-yl}methyl)piperidin-1- yl]methyl}-3-[(1-ethyl-1H-imidazol-5- yl)methyl]-3H-imidazol[4,5-b]pyridine-5- carboxylic acid 126 2-{[4-({3-[(2,4-dichlorophenoxy)methyl]-5- fluorophenyl}methyl)piperidin-1- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 128 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 129 2-{[4-({2-[(2,4-dichlorophenoxy)methyl]- 1,3-oxazol-5-yl}methyl)piperidin-1- yl]methyl}-3-{[(2S)-oxetan-2-yl]methyl}- 3H-imidazo[4,5-b]pyridine-5-carboxylic acid 130 2-{[4-({3-[(2-chloro-4- methylphenoxy)methyl]phenyl}(hydroxy) methyl)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 131 2-{[4-({3-[(2-chloro-4- methylphenoxy)methyl]phenyl}(fluoro) methyl)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 132 2-{[4-({3-[(2-chloro-4- methylphenoxy)methyl]phenyl} difluoromethyl)piperidin-1-yl]methyl}-1- [(1-ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 133 2-{[4-({3-[(2,4-dichlorophenoxy)methyl]-5- fluorophenyl}methyl)piperidin-1- yl]methyl}-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 135 2-{[4-({3-[(2,4-dichlorophenoxy)methyl]-2- fluorophenyl}methyl)piperidin-1- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 136 2-({4-[(2-{[(3-chloro-5-cyclopropylpyridin- 2-yl)oxy]methyl}-1,3-oxazol-5- yl)methyl]piperidin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 137 2-{[4-({5-[(2,4-dichlorophenoxy)methyl]-2- fluorophenyl}methyl)piperidin-1- yl]methyl}-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 138 2-{[4-({2-[(4-chloro-2- cyanophenoxy)methyl]-1,3-oxazol-5- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 139 2-{[4-({5-[(2,4- dichlorophenoxy)methyl]pyridin-3- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 140 2-{[4-({6-[(2,4- dichlorophenoxy)methyl]pyridin-2- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 141 2-{[4-({2-[(4-chloro-2- methylphenoxy)methyl]-1,3-oxazol-5- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 142 2-({8-[(2,4-dichlorophenyl)methoxy]- 1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2- yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 143 2-({8-[(2,4-dichlorophenyl)methoxy]- 1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2- yl}methyl)-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 144 2-({4-[(2-{[(3-chloro-5-cyclopropylpyridin- 2-yl)oxy]methyl}-1,3-oxazol-5- yl)methyl]piperidin-1-yl}methyl)-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 145 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 146 2-({4-[(6-{[2-(hydroxymethyl)-4- methylphenoxy]methyl}pyridin-2- yl)methyl]piperidin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 148 2-{[4-({3-[(2,4- dichlorophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-{[(3R)-oxolan-3- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 149 2-{[4-({3-[(2,4- dichlorophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-[(1,3-oxazol-2- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 150 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}methyl)-4-(hydroxymethyl)piperidin-1- yl]methyl}-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 151 2-{[4-({3-[(2,4- dichlorophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-{[(2S)-oxolan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 152 2-{[4-({6-[(2-chloro-4- cyclopropylphenoxy)methyl]pyridin-2- yl}methyl)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 153 2-{[4-({6-[(2-chloro-4- cyclopropylphenoxy)methyl]pyridin-2- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 154 2-({4-[(2-{[(4-chloro-6-cyclopropylpyridin- 3-yl)oxy]methyl}-1,3-oxazol-5- yl)methyl]piperidin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 155 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}methylidene)piperidin-1-yl]methyl}-1- [(1-ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 156 2-[(4-{2-[(2,4-dichlorophenoxy)methyl]- 1,3-oxazole-5-carbonyl}piperazin-1- yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 157 2-[(4-{3-[(2,4- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 158 2-{[4-({3-[(4-chloro-2- cyanophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-{[(3R)-oxolan-3- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 159 2-{[4-({3-[(4-chloro-2- cyanophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-[(1,3-oxazol-2- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 160 2-[(4-{2-[(2-chloro-4- cyclopropylphenoxy)methyl]-1,3-oxazole- 5-carbonyl}piperazin-1-yl)methyl]-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 161 2-{[4-({3-[(2,4- dichlorophenoxy)methyl]phenyl}difluoro methyl)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 162 2-{[4-({3-[(2,4-dichlorophenoxy)methyl]-4- fluorophenyl}methyl)piperidin-1- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 163 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}methyl)-4-methylpiperidin-1-yl]methyl}- 1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H- 1,3-benzodiazole-6-carboxylic acid 164 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}methyl)-4-(fluoromethyl)piperidin-1- yl]methyl}-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 165 2-{[4-({3-[(4-chloro-2- cyanophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-[(1-ethyl-1H- imidazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 166 2-{[4-({3-[(4-chloro-2- cyanophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 168 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 169 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(3R)- oxolan-3-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 170 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1,3- oxazol-2-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 171 2-{[4-({2-[(4-chloro-2- cyanophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 174 2-[(4-{3-[(2,4- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 178 2-{[4-({4-[(2,4- dichlorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 179 2-{[4-({4-[(2,4- dichlorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 182 2-{[4-({2-[(4-chloro-2- cyanophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 183 2-{[4-({2-[(2-cyano-4- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 186 2-{[(2S)-4-{2-[(2,4- dichlorophenoxy)methyl]-1,3-oxazole-5- carbonyl}-2-methylpiperazin-1-yl]methyl}- 1-{[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 187 2-{[4-({3-[(2-cyano-4- fluorophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 188 2-{[4-({3-[(2-cyano-4- fluorophenoxy)methyl]phenyl}methyl) piperidin-1-yl]methyl}-1-[(1-ethyl-1H- imidazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 189 2-{[4-cyano-4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}methyl)piperidin-1-yl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 198 (S)-2-((4-((6-((2,4- Dichlorophenoxy)methyl)pyridin-2- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 199 2-{[4-({6-[(2,4- dichlorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 200 2-{[4-({6-[(2,4- dichlorophenyl)methoxy]pyridin-2- yl}methyl)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 202 2-({4-[(S)-{3-[(2,4- dichlorophenoxy)methyl]phenyl}(fluoro) methyl]piperidin-1-yl}methyl)-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 203 2-({4-[(R)-{3-[(2,4- dichlorophenoxy)methyl]phenyl}(fluoro) methyl]piperidin-1-yl}methyl)-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 204 (R)-2-((4-((3-((2,4- dichlorophenoxy)methyl)phenyl)(methoxy) methyl)piperidin-1-yl)methyl)-1-((1-ethyl- 1H-imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 205 (S)-2-((4-((3-((2,4- dichlorophenoxy)methyl)phenyl)(methoxy) methyl)piperidin-1-yl)methyl)-1-((1-ethyl- 1H-imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 206 (S)-2-((4-(3-((2-Cyano-4- fluorophenoxy)methyl)phenoxy)piperidin- 1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H- benzo[d]imidazole-6-carboxylic acid 207 2-[(4-{3-[(2,4- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-[(1,2-oxazol-5-yl)methyl]- 1H-1,3-benzodiazole-6-carboxylic acid 208 2-((4-(3-((2,4- Dichlorophenoxy)methyl)phenoxy)piperidin- 1-yl)methyl)-1-(isoxazol-5-ylmethyl)-1H- benzo[d]imidazole-6-carboxylic acid 214 2-{[4-({2-[(2,4-dichlorophenoxy)methyl]- 1,3-oxazol-5-yl}oxy)piperidin-1- yl]methyl}-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 215 2-[(4-{3-[(4-chloro-2- cyanophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 216 2-((4-(3-((2,4- Dichlorophenoxy)methyl)phenoxy)piperidin- 1-yl)methyl)-1-(oxazol-5-ylmethyl)-1H- benzo[d]imidazole-6-carboxylic acid 217 2-[(4-{3-[(2,4- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-[(1,3-oxazol-2-yl)methyl]- 1H-1,3-benzodiazole-6-carboxylic acid 220 (S)-2-((4-((2-((2-Chloro-4- fluorophenoxy)methyl)pyridin-4- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 221 2-[(4-{3-[(4-chloro-2- fluorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 224 2-[(4-{3-[(2,4- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-7-fluoro-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 227 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(2S)-2,4- dihydroxybutyl]-1H-1,3-benzodiazole-6- carboxylic acid 230 2-((4-((2-((4-Chloro-2- fluorophenoxy)methyl)pyridin-4- yl)oxy)piperidin-1-yl)methyl)-1-((1-ethyl- 1H-imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 231 2-[(4-{3-[(4-chloro-2- fluorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 232 2-[(4-{3-[(4-chloro-2- cyanophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-[(1,3-oxazol-2-yl)methyl]- 1H-1,3-benzodiazole-6-carboxylic acid 239 2-((4-((2-((4-Chloro-2- isocyanophenoxy)methyl)pyridin-4- yl)oxy)piperidin-1-yl)methyl)-1-(oxazol-2- ylmethyl)-1H-benzo[d]imidazol-6- carboxylic acid 240 2-{[4-({2-[(4-chloro-2- cyanophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1,3- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 241 2-{[4-({2-[(4-chloro-2- cyanophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1,2- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 242 2-[(4-{3-[(3,5- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 243 2-[(4-{3-[(2,3- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 246 2-{[4-({6-[(4-chloro-2- cyanophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 247 2-{[4-({6-[(4-chloro-2- fluorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 248 2-{[4-({6-[(4-chloro-2- cyanophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 249 2-{[4-({6-[(4-chloro-2- fluorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 250 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 251 2-{[4-({6-[(4-chloro- cyanophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1,3- oxazol-2-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 252 2-{[4-({6-[(4-chloro-2- cyanophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1,3- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 253 2-{[4-({6-[(4-chloro-2- cyanophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1,2- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 254 2-{[(2S,4R)-4-{3-[(2,4- dichlorophenoxy)methyl]phenoxy}-2- methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 255 2-[(4-{3-[(2,4- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-[(1-methyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 256 2-{[(2S)-4-{2-[(2,4- dichlorophenoxy)methyl]-1,3-oxazole-5- carbonyl}-2-methylpiperazin-1-yl]methyl}- 1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H- 1,3-benzodiazole-6-carboxylic acid 257 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1,2- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 258 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1,3- oxazol-2-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 259 2-{[4-({2-[(4-chloro-2- cyanophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1- methyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 260 )-2-((4-((3-((4-Chloro-2- cyanophenoxy)methyl)phenyl)fluoromethyl) piperidin-1-yl)methyl)-1-((1-ethyl-1H- imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 261 2-((4-((2-((4-Cyano-2- fluorophenoxy)methyl)pyrimidin-4- yl)oxy)piperidin-1-yl)methyl)-1-((1-ethyl- 1H-imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 262 (S)-2-((4-((2-((4-Cyano-2- fluorophenoxy)methyl)pyrimidin-4- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 263 (S)-2-((4-((3-((4-chloro-2- cyanophenoxy)methyl)phenyl)fluoromethyl) piperidin-1-yl)methyl)-1-((1-ethyl-1H- imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 264 2-{[4-({6-[(4-chloro-2- fluorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1- methyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 265 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1,3- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 266 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1,2- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 267 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1- methyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 268 2-{[4-({6-[(4-chloro-2- fluorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1,3- oxazol-2-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 269 2-{[4-({6-[(4-chloro-2- fluorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1,3- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 270 2-{[4-({6-[(4-chloro-2- fluorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-[(1,2- oxazol-5-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 271 2-((4-((2-((2,4- Dichlorophenoxy)methyl)pyridin-3- yl)oxy)piperidin-1-yl)methyl)-1-((1-ethyl- 1H-imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 272 2-[(4-{2-[(2,4- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 274 2-(((2S,4S)-4-((2-((2,4- Dichlorophenoxy)methyl)pyridin-4-yl)oxy)- 2-methylpiperidin-1-yl)methyl)-1-((1-ethyl- 1H-imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 275 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1-ethyl- 1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 276 2-((4-((2-((4-Chloro-2- cyanophenoxy)methyl)pyridin-4-yl)oxy)- 2,2-dimethylpiperidin-1-yl)methyl)-1-((1- ethyl-1H-imidazol-5-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 277 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 278 2-{[(2S,4R)-4-({2-[(2,4- dichlorophenoxy)methyl]-1,3-oxazol-5- yl}methyl)-2-methylpiperidin-1-yl]methyl}- 1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H- 1,3-benzodiazole-6-carboxylic acid 279 2-{[(2S,4S)-4-({2-[(2,4- dichlorophenoxy)methyl]-1,3-oxazol-5- yl}methyl)-2-methylpiperidin-1-yl]methyl}- 1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H- 1,3-benzodiazole-6-carboxylic acid 280 1-[(azetidin-3-yl)methyl]-2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 283 2-{[(2S,4S)-4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4-yl}oxy)- 2-methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 284 2-[(4-{2-[(2,4- dichlorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 285 (S)-2-((4-((6-((4-Cyano-2- fluorophenoxy)methyl)pyridin-2- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 286 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-3- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 287 2-({4-[(2-{[4-chloro-2- (hydroxymethyl)phenoxy]methyl}pyridin- 4-yl)oxy]piperidin-1-yl}methyl)-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 288 2-{[4-(3-{[(5-chloro-3-fluoropyridin-2- yl)oxy]methyl}phenoxy)piperidin-1- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 290 2-{[(2S,4R)-4-({6-[(4-chloro-2- fluorophenoxy)methyl]pyridin-2-yl}oxy)-2- methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 291 2-{[(2S,4S)-4-({6-[(4-chloro-2- fluorophenoxy)methyl]pyridin-2-yl}oxy)-2- methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 292 2-({4-[(2-{[4-chloro-2- (hydroxymethyl)phenoxy]methyl}pyridin- 4-yl)oxy]piperidin-1-yl}methyl)-1-[(oxetan- 2-yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 294 2-{[4-(3-{[(5-chloro-3-fluoropyridin-2- yl)oxy]methyl}phenoxy)piperidin-1- yl]methyl}-1-(1-ethyl-1H-imidazol-5- yl)methyl]-1H-1,3-benzodiazole-6- carboxylic acid 295 2-{[(2S,4R)-4-({2-[(2,4- dichlorophenoxy)methyl]pyridin-4-yl}oxy)- 2-methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 296 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 297 (S)-2-((4-((2-((4-(Difluoromethyl)-2- fluorophenoxy)methyl)pyridin-4- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 299 (S)-2-((4-((2-((4-Chloro-2- (fluoromethyl)phenoxy)methyl)pyridin-4- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 300 2-((4-(3-((4-Cyano-2- fluorophenoxy)methyl)phenoxy)piperidin- 1-yl)methyl)-4-fluoro-1-((1- (fluoromethyl)cyclopropyl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 301 2-[(4-{3-[(4-cyano-2- fluorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-4-fluoro-1-{[1- (fluoromethyl)cyclopropyl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 302 2-{[4-(3-{[4-(difluoromethyl)-2- fluorophenoxy]methyl}phenoxy)piperidin- 1-yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 303 2-({4-[(2-{[4-(difluoromethyl)-2- fluorophenoxy]methyl}pyridin-4- yl)oxy]piperidin-1-yl}methyl)-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 304 (S)-2-((4-((2-((2,4- Dichlorophenoxy)methyl)pyrimidin-4- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 305 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 306 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 307 2-{[4-({2-[(2-cyano-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 308 2-{[4-({2-[(2-cyano-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 309 2-({4-[(2-{[(5-chloro-3-fluoropyridin-2- yl)oxy]methyl}pyridin-4-yl)oxy]piperidin- 1-yl}methyl)-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 310 2-[(4-{3-[(4-cyano-2- fluorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-4-fluoro-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 311 2-{[4-(3-{[4-(difluoromethyl)-2- fluorophenoxy]methyl}phenoxy)piperidin- 1-yl]methyl}-4-fluoro-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 312 2-({4-[(2-{[4-(difluoromethyl)-2- fluorophenoxy]methyl}pyrimidin-4- yl)oxy]piperidin;-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 313 2-(((2S,4S)-4-((2-((4-Cyano-2- fluorophenoxy)methyl)pyrimidin-4-yl)oxy)- 2-methylpiperidin-1-yl)methyl)-1-(((S)- oxetan-2-yl)methyl)-1H-benzo[d]imidazole- 6-carboxylic acid 314 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 315 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[1-(fluoromethyl)cyclopropyl]methyl}-1H- 1,3-benzodiazole-6-carboxylic acid 316 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 317 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(4-ethyl- 4H-1,2,4-triazol-3-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 318 2-[(4-{3-[(2-cyano-4- fluorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-4-fluoro-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 319 2-[(4-{3-[(4-cyano-2- fluorophenoxy)methyl]phenoxy}piperidin- 1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 320 2-{[(2S,4S)-4-{3-[(4-cyano-2- fluorophenoxy)methyl]phenoxy}-2- methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 321 2-{[(2S,4S)-4-{3-[(4-cyano-2- fluorophenoxy)methyl]phenoxy}-2- methylpiperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 322 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[1- (fluoromethyl)cyclopropyl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 323 2-({4-[(2-{[4-fluoro-2- (trifluoromethyl)phenoxy]methyl}pyridin- 4-yl)oxy]piperidin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 324 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-4- fluoro-1-{[(2S)-oxetan-2-yl]methyl}-1H- 1,3-benzodiazole-6-carboxylic acid 325 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[1-(fluoromethyl)cyclopropyl]methyl}-1H- 1,3-benzodiazole-6-carboxylic acid 326 2-{[4-({2-[(2-chloro-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[1- (cyanomethyl)cyclopropyl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 327 2-{[4-({2-[(2-chloro-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 328 2-{[4-({2-[(2-chloro-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[1-(fluoromethyl)cyclopropyl]methyl}-1H- 1,3-benzodiazole-6-carboxylic acid 329 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 330 (S)-2-((4-((6-((4-Cyano-2- fluorophenoxy)methyl)-3-fluoropyridin-2- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 331 2-{[4-({6-[(4-cyano-2- fluorophenoxy)methyl]-3-fluoropyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 333 2-{[(3S)-3-{3-[(4-cyano-2- fluorophenoxy)methyl]phenoxy}pyrrolidin- 1-yl]methyl}-4-fluoro-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 335 2-{[(3S)-3-{3-[(4-chloro-2- fluorophenoxy)methyl]phenoxy}pyrrolidin- 1-yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 336 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 337 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-5-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 338 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[1- (cyanomethyl)cyclopropyl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 339 2-({4-[(2-{[2-fluoro-4- (trifluoromethyl)phenoxy]methyl}pyrimidin- 4-yl)oxy]piperidin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 340 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[1- (cyanomethyl)cyclopropyl]methyl}-4- fluoro-1H-1,3-benzodiazole-6-carboxylic acid 341 1-{[1-(cyanomethyl)cyclopropyl]methyl}- 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 342 1-{[1-(cyanomethyl)cyclopropyl]methyl}- 2-{[4-({2-[(2,4- dichlorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1H- 1,3-benzodiazole-6-carboxylic acid 343 2-({4-[(2-{[4-fluoro-2- (trifluoromethyl)phenoxy]methyl}pyrimidin- 4-yl)oxy]piperidin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 344 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[1- (fluoromethyl)cyclopropyl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 345 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- (2-methoxyethyl)-1H-1,3-benzodiazole-6- carboxylic acid 346 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1- hydroxycyclopropyl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 347 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-(2- oxobutyl)-1H-1,3-benzodiazole-6- carboxylic acid 348 2-{[4-({6-[(4-cyano-2- fluorophenoxy)methyl]-5-fluoropyridin-2- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 349 2-{[4-({2-[(2-cyano-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[1- (cyanomethyl)cyclopropyl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 352 2-{[(3S)-3-{3-[(4-chloro-2- fluorophenoxy)methyl]phenoxy}pyrrolidin- 1-yl]methyl}-4-fluoro-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 353 2-{[4-({2-[(4- chlorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 354 2-{[(2S,4S)-4-({2-[(2-cyano-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[1-(cyanomethyl)cyclopropyl]methyl}-1H- 1,3-benzodiazole-6-carboxylic acid 355 2-(((2S,4S)-4-((2-((2-cyano-4- fluorophenoxy)methyl)pyrimidin-4-yl)oxy)- 2-methylpiperidin-1-yl)methyl)-1-(((S)- oxetan-2-yl)methyl)-1H-benzo[d]imidazole- 6-carboxylic acid 356 2-{[(2S,4S)-4-({2-[(2-cyano-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 357 2-({4-[(2-{[2-fluoro-4- (trifluoromethyl)phenoxy]methyl}pyridin- 4-yl)oxy]piperidin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 358 2-({4-[(2-{[2-(difluoromethyl)-4- fluorophenoxy]methyl}pyridin-4- yl)oxy]piperidin-1-yl}methyl)-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 359 2-{[4-({2-[(2-chloro-4- cyanophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 362 2-{[(3S)-3-({2-[(4-chloro-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)pyrrolidin-1-yl]methyl}-4-fluoro-1- [(oxetan-2-yl)methyl]-1H-1,3-benzodiazole- 6-carboxylic acid 363 1-{[1-(cyanomethyl)cyclopropyl]methyl}- 2-({4-[(2-{[4-(difluoromethyl)-2- fluorophenoxy]methyl}pyridin-4- yl)oxy]piperidin-1-yl}methyl)-1H-1,3- benzodiazole-6-carboxylic acid 364 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyridin-4-yl}oxy)-2- methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 365 2-{[(2S,4S)-4-[(2-{[4-(difluoromethyl)-2- fluorophenoxy]methyl}pyridin-4-yl)oxy]-2- methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 366 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 367 (S)-2-((4-((2-((4-Cyano-2- fluorophenoxy)methyl)-5-fluoropyridin-4- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 368 2-((4-((2-((4-Chloro-2- fluorophenoxy)methyl)pyridin-4- yl)oxy)piperidin-1-yl)methyl)-1-((1- methoxycyclopropyl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 369 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-1-[(1- methoxycyclopropyl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 370 2-{[4-({2-[(2-chloro-4- cyanophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 371 2-{[4-({2-[(2-chloro-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-3-{[(2S)- oxetan-2-yl]methyl}-3H-imidazo[4,5- b]pyridine-5-carboxylic acid 372 (S)-2-((4-((6-((4-Cyano-2- fluorophenoxy)methyl)pyridin-2- yl)oxy)piperidin-1-yl)methyl)-3-(oxetan-2- ylmethyl)-3H-imidazo[4,5-b]pyridine-5- carboxylic acid 373 2-{[4-({6-[(4-cyano-2- fluorophenoxy)methyl]pyridin-2- yl}oxy)piperidin-1-yl]methyl}-3-{[(2S)- oxetan-2-yl]methyl}-3H-imidazo[4,5- b]pyridine-5-carboxylic acid 374 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-3-{[(2S)- oxetan-2-yl]methyl}-3H-imidazo[4,5- b]pyridine-5-carboxylic acid 375 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]-5-fluoropyrimidin- 4-yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 376 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-3- {[(2S)-oxetan-2-yl]methyl}-3H- imidazo[4,5-b]pyridine-5-carboxylic acid 377 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-fluorophenyl]methyl}-1-[(1- ethyl-1H-imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 378 2-{[4-({6-[(4-cyano-2- fluorophenoxy)methyl]pyridin-2-yl}oxy)-2- fluorophenyl]methyl}-1-[(1-ethyl-1H- imidazol-5-yl)methyl]-1H-1,3- benzodiazole-6-carboxylic acid 379 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)-2-fluorophenyl]methyl}-1- [(1-ethyl-1H-imidazol-5-yl)methyl]- 1H-1,3-benzodiazole-6-carboxylic acid 380 (S)-2-((4-((2-((4-chloro-2- fluorophenoxy)methyl)-5-fluoropyridin-4- yl)oxy)piperidin-1-yl)methyl)-1-(oxetan-2- ylmethyl)-1H-benzo[d]imidazole-6- carboxylic acid 381 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyrimidin-4- yl}amino)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 382 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyrimidin-4- yl}(methyl)amino)piperidin-1-yl]methyl}- 1-{[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 475 2-{[4-({2-[(4-cyclopropyl-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 476 2-{[4-({2-[(2-cyano-4- cyclopropylphenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 477 2-{[(2S,4S)-4-({2-[(2-chloro-4- cyanophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 478 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]-5-fluoropyridin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 479 2-{[4-({2-[(2,4- difluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 480 2-{[4-({2-[1-(4-cyano-2- fluorophenoxy)ethyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 481 2-{[4-({2-[(4-chloro-2- cyanophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 482 2-{[4-({2-[(2,4- difluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 483 2-{[4-({2-[(2-chloro-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2R)-1- (1,2-oxazole-3-carbonyl)azetidin-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 484 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-methyl-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 485 2-{[(2S,4S)-4-({2-[(2,4- difluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 486 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl)methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-imidazo[4,5- b]pyridine-6-carboxylic acid 487 2-{[(1R,3S,5S)-3-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-8-azabicyclo[3.2.1]octan-8- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 488 2-{[(1R,3R,5S)-3-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-8-azabicyclo[3.2.1]octan-8- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 489 2-{[(2S,4S)-4-({2-[(4-chloro-2- cyanophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 490 2-{[(2R,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-(fluoromethyl)piperidin-1- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 491 2-{[4-({6-[(4-cyano-2- fluorophenoxy)methyl]pyridazin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 492 2-{[(2S,4S)-4-({2-[(2-cyano-4- fluorophenoxy)methyl]-5-fluoropyrimidin- 4-yl}oxy)-2-methylpiperidin-1-yl]methyl}- 1-{[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 493 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]-5-fluoropyrimidin- 4-yl}oxy)-2-methylpiperidin-1-yl]methyl}- 1-{[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 494 4-fluoro-1-{[(2S)-oxetan-2-yl]methyl}-2- {[4-({2-[(2,4,5- trifluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 495 1-{[(2S)-oxetan-2-yl]methyl}-2-{[4-({2- [(2,4,5-trifluorophenoxy)methyl]pyrimidin- 4-yl}oxy)piperidin-1-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 496 2-{[4-({2-[(2,4- difluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 497 2-{[(2S,4S)-4-({2-[(2,4- difluorophenoxy)methyl]pyridin-4-yl}oxy)- 2-methylpiperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 498 2-{[4-({2-[(4-cyano-2,5- difluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 499 2-{[4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyridin-4- yl}oxy)piperidin-1-yl]methyl}-4-methyl-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 500 2-{[4-({2-[(2-cyano-4- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-methyl-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 501 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyridin-4-yl}oxy)-2- methylpiperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 502 2-{[4-({2-[(4-cyano-2,5- difluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 503 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyridin-4-yl}oxy)-2- methylpiperidin-1-yl]methyl}-4-methyl-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 504 2-{[4-({2-[(2-cyano-4,5- difluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 505 2-{[4-({2-[(2-cyano-4,5- difluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-4-fluoro-1- {[(2S)-oxetan-2-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid 506 2-{[(1S,4S,5R)-5-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-azabicyclo[2.2.1]heptan-2- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 507 2-{[(1R,4R,5S)-5-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-azabicyclo[2.2.1]heptan-2- yl]methyl}-1-{[(2S)-oxetan-2-yl]methyl}- 1H-1,3-benzodiazole-6-carboxylic acid 508 (S)-2-((4-((2-((2-cyano-4- cyclopropylphenoxy)methyl)pyrimidin-4- yl)oxy)piperidin-1-yl)methyl)-4-fluoro-1- (oxetan-2-ylmethyl)-1H-benzo[d]imidazole- 6-carboxylic acid 509 2-(((2S,4S)-4-((2-((2-cyano-4- cyclopropylphenoxy)methyl)pyrimidin-4- yl)oxy)-2-methylpiperidin-1-yl)methyl)-4- fluoro-1-(((S)-oxetan-2-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 510 2-(((2S,4S)-4-((2-((2-cyano-4- cyclopropylphenoxy)methyl)pyrimidin-4- yl)oxy)-2-methylpiperidin-1-yl)methyl)-1- (((S)-oxetan-2-yl)methyl)-1H- benzo[d]imidazole-6-carboxylic acid 511 2-{[4-({2-[(4-chloro-2- fluorophenoxy)methyl]pyrimidin-4- yl}(cyclopropylmethyl)amino)piperidin-1- yl]methyl}-4-fluoro-1-{[(2S)-oxetan-2- yl]methyl}-1H-1,3-benzodiazole-6- carboxylic acid 512 2-{[(2S,4S)-4-({2-[(2,4- difluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[(2S)-oxetan-2-yl]methyl}-1H- imidazo[4,5-b]pyridine-6-carboxylic acid 513 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[(2S)-oxetan-2-yl]methyl}-1H- imidazo[4,5-b]pyridine-6-carboxylic acid 514 2-{[(2S,4S)-2-methyl-4-({2-[(2,4,5- trifluorophenoxy)methyl]pyrimidin-4- yl}oxy)piperidin-1-yl]methyl}-1-{[(2S)- oxetan-2-yl]methyl}-1H-1,3-benzodiazole- 6-carboxylic acid 515 2-{[(2S,4S)-4-({2-[(4-cyano-2- fluorophenoxy)methyl]pyrimidin-4- yl}oxy)-2-methylpiperidin-1-yl]methyl}-1- {[(3R)-oxolan-3-yl]methyl}-1H-1,3- benzodiazole-6-carboxylic acid

Optically Active Compounds

In certain embodiments, compounds provided herein may have several chiral centers and may exist in and be isolated in optically active and racemic forms. In certain embodiments, some compounds may exhibit polymorphism. A person of skill in the art will appreciate that compounds provided herein can exist in any racemic, optically-active, diastereomeric, polymorphic, or stereoisomeric form, and/or mixtures thereof. A person of skill in the art will also appreciate that such compounds described herein that possess the useful properties also described herein is within the scope of this disclosure. A person of skill in the art will further appreciate how to prepare optically active forms of the compounds described herein, for example, by resolution of racemic forms via recrystallization techniques, by synthesis from optically-active starting materials, by chiral synthesis, or by chromatographic separation using a chiral stationary phase. In addition, most amino acids are chiral (i.e., designated as L- or D-, wherein the L-enantiomer is the naturally occurring configuration) and can exist as separate enantiomers.

Examples of methods to obtain optically active materials are known in the art, and include at least the following:

    • i) physical separation of crystals—a technique whereby macroscopic crystals of the individual enantiomers are manually separated. This technique can be used if crystals of the separate enantiomers exist (i.e., the material is a conglomerate, and the crystals are visually distinct);
    • ii) simultaneous crystallization—a technique whereby the individual enantiomers are separately crystallized from a solution of the racemate, only if the latter is a conglomerate in the solid state;
    • iii) enzymatic resolutions—a technique wherein partial, or complete separation of a racemate is accomplished by virtue of different rates of reaction of the enantiomers in the presence of an enzyme;
    • iv) enzymatic asymmetric synthesis—a synthetic technique wherein at least one step of the synthesis uses an enzymatic reaction to obtain an enantiomerically pure, or enriched synthetic precursor of the desired enantiomer;
    • v) chemical asymmetric synthesis—a synthetic technique wherein the desired enantiomer is synthesized from an achiral precursor using chiral catalysts, or chiral auxiliaries to produce asymmetry (i.e., chirality) in the product;
    • vi) diastereomer separations—a technique wherein a racemic compound is treated with an enantiomerically pure reagent (a chiral auxiliary) that converts the individual enantiomers to diastereomers. The resulting diastereomers are then separated by chromatography, or crystallization by virtue of their now more distinct diastereomeric differences, and then the chiral auxiliary is removed to obtain each enantiomer;
    • vii) first- and second-order asymmetric transformations—a technique wherein diastereomers of the racemate equilibrate in solution to yield a preponderance of a diastereomer of the desired enantiomer, or where kinetic, or thermodynamic crystallization of the diastereomer of the desired enantiomer perturbs the equilibrium such that eventually in principle all the material is converted to the crystalline diastereomer of the desired enantiomer. The desired enantiomer is then derived from the diastereomer;
    • viii) kinetic resolutions—this technique refers to the achievement of partial or complete resolution of a racemate (or of a further resolution of a partially resolved compound) by virtue of unequal reaction rates of the enantiomers with a chiral, or non-racemic reagent, or catalyst under kinetic conditions;
    • ix) enantiospecific synthesis from non-racemic precursors—a synthetic technique wherein the desired enantiomer is obtained from chiral starting materials, and where the stereochemical integrity is not or is only minimally compromised over the course of the synthesis;
    • x) chiral liquid chromatography—a technique wherein the enantiomers of a racemate are separated in a liquid mobile phase by virtue of their different interactions with a stationary phase. The stationary phase can be made of chiral material, or the mobile phase can contain an additional chiral material to provoke the different interactions;
    • xi) chiral gas chromatography—a technique wherein the racemate is volatilized and enantiomers are separated by virtue of their different interactions in the gaseous mobile phase with a column containing a fixed non-racemic adsorbent phase;
    • xii) extraction with chiral solvents—a technique wherein the enantiomers are separated by virtue of kinetic or thermodynamic dissolution of one enantiomer into a particular chiral solvent;
    • xiii) transport across chiral membranes—a technique wherein a racemate is placed in contact with a thin membrane barrier. The barrier typically separates two miscible fluids, one containing the racemate, and a driving force such as a concentration, or pressure differential causes preferential transport across the membrane barrier. Separation occurs as a result of the non-racemic nature of the membrane which allows only one enantiomer of the racemate to pass through.

In some embodiments, provided herein are compositions of compounds of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII), that are substantially free of a designated stereoisomer of that compound. In certain embodiments, in the methods and compounds of this disclosure, the compounds are substantially free of other stereoisomers. In some embodiments, the composition includes a compound that is at least 85%, 90%, 95%, 98%, or 99% to 100% by weight of the compound, the remainder comprising other chemical species, or enantiomers. In some embodiments, provided herein are compositions of compounds of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII).

that are substantially free of a designated enantiomer of that compound. In certain embodiments, in the methods and compounds of this disclosure, the compounds are substantially free of other enantiomers. In some embodiments, the composition includes a compound that is at least 85%, 90%, 95%, 98%, or 99% to 100% by weight of the compound, the remainder comprising other chemical species or enantiomers.

Isotopically Enriched Compounds

Also provided herein are isotopically enriched compounds including, but not limited to, isotopically enriched compounds of any of Formulas (I)-(XVIII), (XXV)-(XXVII), (XXX), (XXXI), (XXXIX), and (XL-XLVII).

Isotopic enrichment (for example, deuteration) of pharmaceuticals to improve pharmacokinetics (“PK”), pharmacodynamics (“PD”), and/or toxicity profiles, has been previously demonstrated within some classes of drugs. See, for example, Lijinsky et al., Food Cosmet. Toxicol., 20: 393 (1982); Lijinsky et al., J. Nat. Cancer Inst., 69: 1127 (1982); Mangold et al., Mutation Res. 308: 33 (1994); Gordon et al., Drug Metab. Dispos., 15: 589 (1987); Zello et al., Metabolism, 43: 487 (1994); Gately et al., J. Nucl. Med., 27: 388 (1986); Wade D, Chem. Biol. Interact. 117: 191 (1999).

Isotopic enrichment of a drug can be used, for example, to (1) reduce or eliminate unwanted metabolites; (2) increase the half-life of the parent drug; (3) decrease the number of doses needed to achieve a desired effect; (4) decrease the amount of a dose necessary to achieve a desired effect; (5) increase the formation of active metabolites if any are formed; and/or (6) decrease the production of deleterious metabolites in specific tissues. Isotopic enrichment of a drug can also be used to create a more effective and/or safer drug for combination therapy, whether the combination therapy is intentional or not.

Replacement of an atom for one of its isotopes often will result in a change in the reaction rate of a chemical reaction. This phenomenon is known as the Kinetic Isotope Effect (“KIE”). For example, if a C—H bond is broken during a rate-determining step in a chemical reaction (i.e., the step with the highest transition state energy), substitution of a (heavier) isotope for that reactive hydrogen will cause a decrease in the reaction rate. The Deuterium Kinetic Isotope Effect (“DKIE”) is the most common form of KIE. (See, e.g., Foster et al., Adv. Drug Res., vol. 14, pp. 1-36 (1985); Kushner et al., Can. J. Physiol. Pharmacol., vol. 77, pp. 79-88 (1999)).

The magnitude of the DKIE can be expressed as the ratio between the rates of a given reaction in which a C—H bond is broken, and the same reaction where deuterium is substituted for hydrogen and the C-D bond is broken. The DKIE can range from about one (no isotope effect) to very large numbers, such as 50, or more, meaning that the reaction can be fifty, or more, times slower when deuterium has been substituted for hydrogen.

Substitution of tritium (“T”) for hydrogen results in yet a stronger bond than deuterium and gives numerically larger isotope effects. Similarly, substitution of isotopes for other elements including, but not limited to, 13C, or 14C for carbon; 33S, 34S, or 36S for sulfur; 15N for nitrogen; and 17O, or 18O for oxygen may lead to a similar kinetic isotope effect.

The animal body expresses a variety of enzymes for the purpose of eliminating foreign substances, such as therapeutic agents, from its circulation system. Examples of such enzymes include the cytochrome P450 enzymes (“CYPs”), esterases, proteases, reductases, dehydrogenases, and monoamine oxidases to react with and convert these foreign substances to more polar intermediates, or metabolites for renal excretion. Some of the most common metabolic reactions of pharmaceutical compounds involve the oxidation of a carbon-hydrogen (C—H) bond to either a carbon-oxygen (C—O), or carbon-carbon (C═C) pi-bond. The resultant metabolites may be stable, or unstable under physiological conditions, and can have substantially different PK/PD, and acute, and long-term toxicity profiles relative to the parent compounds. For many drugs, such oxidations are rapid. Therefore, these drugs often require the administration of multiple or high daily doses.

Therefore, isotopic enrichment at certain positions of a compound provided herein will produce a detectable KIE that will affect the pharmacologic, PK, PD, and/or toxicological profiles of a compound provided herein in comparison with a similar compound having a natural isotopic composition.

Compositions and Uses Pharmaceutical Compositions and Methods of Administration

The compounds provided herein can be formulated into pharmaceutical compositions using methods available in the art and those disclosed herein. Any of the compounds provided herein can be provided in the appropriate pharmaceutical composition and be administered by a suitable route of administration.

The methods provided herein encompass administering pharmaceutical compositions comprising at least one compound provided herein and one or more compatible and pharmaceutically acceptable carriers. In this context, the term “pharmaceutically acceptable” means approved by a regulatory agency of the Federal, or state government, or listed in the U.S. Pharmacopeia, or other generally recognized pharmacopeia for use in animals, and in certain embodiments in humans. The term “carrier” includes a diluent, adjuvant (e.g., Freund's adjuvant (complete and incomplete)), excipient, or vehicle with which the therapeutic is administered. Such pharmaceutical carriers can be sterile liquids, such as water and oils including petroleum, animal, vegetable, or oils of synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil, and the like. Water can be used as a carrier when the pharmaceutical composition is administered intravenously. Saline solutions, and aqueous dextrose, and glycerol solutions can also be employed as liquid carriers, particularly for injectable solutions. Examples of suitable pharmaceutical carriers are described in Martin, E.W., Remington's Pharmaceutical Sciences.

In clinical practice the pharmaceutical compositions, or compounds provided herein may be administered by any route known in the art. Exemplary routes of administration include, but are not limited to, inhalation, intraarterial, intradermal, intramuscular, intraperitoneal, intravenous, nasal, parenteral, pulmonary, and subcutaneous routes. In some embodiments, a pharmaceutical composition or compound provided herein is administered parenterally.

The compositions for parenteral administration can be emulsions or sterile solutions. Parenteral compositions may include, for example, propylene glycol, polyethylene glycol, vegetable oils, and injectable organic esters (e.g., ethyl oleate). These compositions can also contain wetting, isotonizing, emulsifying, dispersing, and stabilizing agents. Sterilization can be carried out in several ways, for example, using a bacteriological filter, via radiation, or via heating. Parenteral compositions can also be prepared in the form of sterile solid compositions which can be dissolved at the time of use in sterile water, or any other injectable sterile medium.

In some embodiments, a composition provided herein is a pharmaceutical composition, or a single unit dosage form. Pharmaceutical compositions, and single unit dosage forms provided herein comprise a prophylactically, or therapeutically effective amount of one, or more prophylactic, or therapeutic compounds.

The pharmaceutical composition may comprise one, or more pharmaceutical excipients. Any suitable pharmaceutical excipient may be used, wherein a person of ordinary skill in the art is capable of selecting suitable pharmaceutical excipients. Non-limiting examples of suitable excipients include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene glycol, water, ethanol, and the like. Whether a particular excipient is suitable for incorporation into a pharmaceutical composition, or dosage form depends on a variety of factors well known in the art including, but not limited to, the way in which the dosage form will be administered to a subject and the specific compound in the dosage form. The composition, or single unit dosage form, if desired, can also contain minor amounts of wetting, or emulsifying agents, or pH buffering agents. Accordingly, the pharmaceutical excipients provided below are intended to be illustrative, and not limiting. Additional pharmaceutical excipients include, for example, those described in the Handbook of Pharmaceutical Excipients, Rowe et al. (Eds.) 6th Ed. (2009), incorporated by reference herein in its entirety.

In some embodiments, the pharmaceutical composition comprises an anti-foaming agent. Any suitable anti-foaming agent may be used. In some aspects, the anti-foaming agent is selected from an alcohol, an ether, an oil, a wax, a silicone, a surfactant, and combinations thereof. In some aspects, the anti-foaming agent is selected from a mineral oil, a vegetable oil, ethylene bis stearamide, a paraffin wax, an ester wax, a fatty alcohol wax, a long-chain fatty alcohol, a fatty acid soap, a fatty acid ester, a silicon glycol, a fluorosilicone, a polyethylene glycol-polypropylene glycol copolymer, polydimethylsiloxane-silicon dioxide, ether, octyl alcohol, capryl alcohol, sorbitan trioleate, ethyl alcohol, 2-ethyl-hexanol, dimethicone, oleyl alcohol, simethicone, and combinations thereof.

In some embodiments, the pharmaceutical composition comprises a co-solvent. Illustrative examples of co-solvents include, ethanol, poly(ethylene) glycol, butylene glycol, dimethylacetamide, glycerin, and propylene glycol.

In some embodiments, the pharmaceutical composition comprises a buffer. Illustrative examples of buffers include, acetate, borate, carbonate, lactate, malate, phosphate, citrate, hydroxide, diethanolamine, monoethanolamine, glycine, methionine, guar gum, and monosodium glutamate.

In some embodiments, the pharmaceutical composition comprises a carrier, or filler. Illustrative examples of carriers, or fillers include, lactose, maltodextrin, mannitol, sorbitol, chitosan, stearic acid, xanthan gum, and guar gum.

In some embodiments, the pharmaceutical composition comprises a surfactant. Illustrative examples of surfactants, include d-alpha tocopherol, benzalkonium chloride, benzethonium chloride, cetrimide, cetylpyridinium chloride, docusate sodium, glyceryl behenate, glyceryl monooleate, lauric acid, macrogol 15 hydroxystearate, myristyl alcohol, phospholipids, polyoxyethylene alkyl ethers, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, polyoxylglycerides, sodium lauryl sulfate, sorbitan esters, and vitamin E polyethylene(glycol) succinate.

In some embodiments, the pharmaceutical composition comprises an anti-caking agent. Illustrative examples of anti-caking agents include, calcium phosphate (tribasic), hydroxymethyl cellulose, hydroxypropyl cellulose, and magnesium oxide.

Other excipients that may be used with the pharmaceutical compositions include, for example, albumin, antioxidants, antibacterial agents, antifungal agents, bioabsorbable polymers, chelating agents, controlled release agents, diluents, dispersing agents, dissolution enhancers, emulsifying agents, gelling agents, ointment bases, penetration enhancers, preservatives, solubilizing agents, solvents, stabilizing agents, and sugars. Specific examples of each of these agents are described, for example, in the Handbook of Pharmaceutical Excipients, Rowe et al. (Eds.) 6th Ed. (2009), The Pharmaceutical Press, incorporated by reference herein in its entirety.

In some embodiments, the pharmaceutical composition comprises a solvent. In some aspects, the solvent is saline solution, such as a sterile isotonic saline solution, or dextrose solution. In some aspects, the solvent is water for injection.

In some embodiments, the pharmaceutical compositions are in a particulate form, such as a microparticle or a nanoparticle. Microparticles, and nanoparticles may be formed from any suitable material, such as a polymer, or a lipid. In some aspects, the microparticles, or nanoparticles are micelles, liposomes, or polymersomes.

Further provided herein are anhydrous pharmaceutical compositions, and dosage forms comprising a compound, since, in some embodiments, water can facilitate the degradation of some compounds.

Anhydrous pharmaceutical compositions, and dosage forms provided herein can be prepared using anhydrous, or low moisture containing ingredients, and low moisture, or low humidity conditions. Pharmaceutical compositions, and dosage forms that comprise lactose, and at least one active ingredient that comprises a primary, or secondary amine can be anhydrous if substantial contact with moisture, and/or humidity during manufacturing, packaging, and/or storage is expected.

An anhydrous pharmaceutical composition can be prepared and stored such that its anhydrous nature is maintained. Accordingly, anhydrous compositions can be packaged using materials known to prevent exposure to water such that they can be included in suitable formulary kits. Examples of suitable packaging include, but are not limited to, hermetically sealed foils, plastics, unit dose containers (e.g., vials), blister packs, and strip packs.

Lactose-free compositions provided herein can comprise excipients that are well known in the art and are listed, for example, in the U.S. Pharmocopeia (USP) SP (XXI)/NF (XVI). In general, lactose-free compositions comprise an active ingredient, a binder/filler, and a lubricant in pharmaceutically compatible, and pharmaceutically acceptable amounts. Exemplary lactose-free dosage forms comprise an active ingredient, microcrystalline cellulose, pre gelatinized starch, and magnesium stearate.

Also provided are pharmaceutical compositions, and dosage forms that comprise one, or more excipients that reduce the rate by which a compound will decompose. Such excipients, which are referred to herein as “stabilizers,” include, but are not limited to, antioxidants such as ascorbic acid, pH buffers, or salt buffers.

Parenteral Dosage Forms

In certain embodiments, provided are parenteral dosage forms. Parenteral dosage forms can be administered to subjects by various routes including, but not limited to, subcutaneous, intravenous (including bolus injection), intramuscular, and intraarterial. Because their administration typically bypasses subjects' natural defenses against contaminants, parenteral dosage forms are typically sterile, or capable of being sterilized prior to administration to a subject. Examples of parenteral dosage forms include, but are not limited to, solutions ready for injection, dry products ready to be dissolved or suspended in a pharmaceutically acceptable vehicle for injection, suspensions ready for injection, and emulsions.

Suitable vehicles that can be used to provide parenteral dosage forms are well known to those skilled in the art. Examples include, but are not limited to Water for Injection USP; aqueous vehicles such as, but not limited to, Sodium Chloride Injection, Ringer's Injection, Dextrose Injection, Dextrose, and Sodium Chloride Injection, and Lactated Ringer's Injection; water miscible vehicles such as, but not limited to, ethyl alcohol, polyethylene glycol, and polypropylene glycol; and non-aqueous vehicles such as, but not limited to, corn oil, cottonseed oil, peanut oil, sesame oil, ethyl oleate, isopropyl myristate, and benzyl benzoate.

Excipients that increase the solubility of one, or more of the antibodies disclosed herein can also be incorporated into the parenteral dosage forms.

Dosage and Unit Dosage Forms

In human therapeutics, the doctor will determine the posology which he considers most appropriate according to a preventive, or curative treatment, and according to the age, weight, condition, and other factors specific to the subject to be treated.

In certain embodiments, a composition provided herein is a pharmaceutical composition, or a single unit dosage form. Pharmaceutical compositions, and single unit dosage forms provided herein comprise a prophylactically, or therapeutically effective amount of one, or more prophylactic, or therapeutic antibodies, or antigen binding fragments thereof.

The amount of the compound, or composition which will be effective in the prevention, or treatment of a disorder, or one, or more symptoms thereof will vary with the nature, and severity of the disease, or condition, and the route by which the compound is administered. The frequency and dosage will also vary according to factors specific for each subject depending on the specific therapy (e.g., therapeutic or prophylactic agents) administered, the severity of the disorder, disease, or condition, the route of administration, as well as age, body, weight, response, and the past medical history of the subject. Effective doses may be extrapolated from dose-response curves derived from in vitro, or animal model test systems.

In certain embodiments, exemplary doses of a composition include milligram, or microgram amounts of the compound per kilogram of subject, or sample weight (e.g., about 10 micrograms per kilogram to about 50 milligrams per kilogram, about 100 micrograms per kilogram to about 25 milligrams per kilogram, or about 100 microgram per kilogram to about 10 milligrams per kilogram). In certain embodiments, the dosage of the compound provided herein, based on weight of the compound, administered to prevent, treat, manage, or ameliorate a disorder, or one, or more symptoms thereof in a subject is 0.1 mg/kg, 1 mg/kg, 2 mg/kg, 3 mg/kg, 4 mg/kg, 5 mg/kg, 6 mg/kg, 10 mg/kg, or 15 mg/kg or more of a subject's body weight. In another embodiment, the dosage of the composition, or a composition provided herein administered to prevent, treat, manage, or ameliorate a disorder, or one, or more symptoms thereof in a subject is 0.1 mg to 200 mg, 0.1 mg to 100 mg, 0.1 mg to 50 mg, 0.1 mg to 25 mg, 0.1 mg to 20 mg, 0.1 mg to 15 mg, 0.1 mg to 10 mg, 0.1 mg to 7.5 mg, 0.1 mg to 5 mg, 0.1 to 2.5 mg, 0.25 mg to 20 mg, 0.25 to 15 mg, 0.25 to 12 mg, 0.25 to 10 mg, 0.25 mg to 7.5 mg, 0.25 mg to 5 mg, 0.25 mg to 2.5 mg, 0.5 mg to 20 mg, 0.5 to 15 mg, 0.5 to 12 mg, 0.5 to 10 mg, 0.5 mg to 7.5 mg, 0.5 mg to 5 mg, 0.5 mg to 2.5 mg, 1 mg to 20 mg, 1 mg to 15 mg, 1 mg to 12 mg, 1 mg to 10 mg, 1 mg to 7.5 mg, 1 mg to 5 mg, or 1 mg to 2.5 mg.

The dose can be administered according to a suitable schedule, for example, once, two times, three times, or four times weekly. It may be necessary to use dosages of the compound outside the ranges disclosed herein in some cases, as will be apparent to those of ordinary skill in the art. Furthermore, it is noted that the clinician, or treating physician will know how, and when to interrupt, adjust, or terminate therapy in conjunction with subject response.

Different therapeutically effective amounts may be applicable for different diseases, and conditions, as will be readily known by those of ordinary skill in the art. Similarly, amounts sufficient to prevent, manage, treat, or ameliorate such disorders, but insufficient to cause, or sufficient to reduce, adverse effects associated with the antibodies, or antigen binding fragments thereof provided herein are also encompassed by the described dosage amounts, and dose frequency schedules herein. Further, when a subject is administered multiple dosages of a composition provided herein, not all of the dosages need be the same. For example, the dosage administered to the subject may be increased to improve the prophylactic, or therapeutic effect of the composition, or it may be decreased to reduce one, or more side effects that a particular subject is experiencing.

In certain embodiments, treatment, or prevention can be initiated with one, or more loading doses of a compound, or composition provided herein followed by one, or more maintenance doses.

In certain embodiments, a dose of a compound, or composition provided herein can be administered to achieve a steady-state concentration of the compound in blood, or serum of the subject. The steady-state concentration can be determined by measurement according to techniques available to those of skill or can be based on the physical characteristics of the subject such as height, weight, and age.

In certain embodiments, administration of the same composition may be repeated and the administrations may be separated by at least one day, two days, three days, five days, ten days, fifteen days, thirty days, forty-five days, two months, seventy-five days, three months, or six months. In other embodiments, administration of the same prophylactic, or therapeutic agent may be repeated, and the administration may be separated by at least one day, two days, three days, five days, ten days, fifteen days, thirty days, forty-five days, two months, seventy-five days, three months, or six months.

Therapeutic Applications

For therapeutic applications, the compounds are administered to a mammal, in certain embodiments, a human, in a pharmaceutically acceptable dosage suitable for administration form such as those known in the art, and those discussed herein, intravenously as a bolus or by continuous infusion over a period of time, by intramuscular, intraperitoneal, intra-cerebrospinal, subcutaneous, intra-articular, intrasynovial, intrathecal, or intratumoral routes. The compounds also are suitably administered by peritumoral, in