Abstract: The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.

Abstract: The invention relates to pharmaceutical compositions comprising benzopyranone derivatives for the treatment of Severe Acute Respiratory Syndrome (SARS).

Abstract: The present invention provides a method and apparatus which assists a student in their approach and understanding to solving algebraic word problems. The invention includes a predetermined set of word problems. The student solves the word problem by selecting appropriate rate bars which are responsive to a selected word problem and placing the selected rate bars in proper placement with respect to a measurement line. The student also selects the proper equation, which also includes pre-solved solutions for the selected word problem. The student thus solves the problem through the use of the rate bars alone or in conjunction with a parallel solution provided in the pre-solved equation.

Abstract: The present invention provides an apparatus that assists a student with learning how to solve word problems, including cash flow type problems, by using the sense of touch to establish a greater pattern of formula recognition and usage. The word problems include a finite set of constant values for a predetermined number of variables. The apparatus includes a preliminary equation that is presolved for a particular set of values. A final equation is also presolved for the particular set of values. The preliminary equation and final equation are movably placed onto a work area which preferably includes a measurement line.

Abstract: The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.