Patents by Inventor Xuefei Tan

Xuefei Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIDINONE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230295109
    Abstract: The present invention relates to compounds of formula (I), (I), wherein R1, R2, R3, R4 and A are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 2, 2021
    Publication date: September 21, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Fabian DEY, Xin HONG, Xuefei TAN, Jiasu XU, Wei ZHU, Ge ZOU
  • IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230279001
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5 and A are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 2, 2021
    Publication date: September 7, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Jianguo CHEN, Fabian DEY, Xin HONG, Xuefei TAN, Jiasu XU, Weixing ZHANG, Wei ZHU, Ge ZOU
  • CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20220402897
    Abstract: The present invention provides novel compounds having the general formula (I) wherein R1 to R6, and m are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 17, 2019
    Publication date: December 22, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Chungen LIANG, Yongfu LIU, Xuefei TAN, Jun WU, Jianping WANG
  • SUBSTITUTED PYRIMIDINE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20220396567
    Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R4, L1, L2 and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 28, 2020
    Publication date: December 15, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Xingchun HAN, Chungen LIANG, Kun MIAO, Hong SHEN, Xuefei TAN, Jianping WANG, Li WANG
  • SUBSTITUTED 3,4-DIHYDROQUINAZOLINE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20220388969
    Abstract: The present invention provides novel compounds having the general formula (I) wherein R1 to R6 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 28, 2020
    Publication date: December 8, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Wenming CHEN, Song FENG, Chao LI, Zongxing QIU, Xuefei TAN, Guolong WU
  • CHROMAN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20220388972
    Abstract: The present invention provides compounds having the general formula (I) wherein R1 to R10, Gi, G2, X and m are as described herein, compositions including the compounds and methods of using the compounds for treating hepatitis B.
    Type: Application
    Filed: December 12, 2019
    Publication date: December 8, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Song FENG, Yongfu LIU, Xuefei TAN, Jiamin ZHENG
  • FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20220363657
    Abstract: The present invention provides flavone derivatives having the general formula (I) which are useful for the treatment of Hepatitis B Virus infection (HBV). The compounds act as cccDNA (covalently closed circular DMA) inhibitors.
    Type: Application
    Filed: September 11, 2019
    Publication date: November 17, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Chungen LIANG, Yongfu LIU, Hong SHEN, Xuefei TAN, Jun WU, Dongdong CHEN, Chao LI, Li WANG
  • QUINAZOLINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20220348549
    Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R6 and A are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 26, 2020
    Publication date: November 3, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Song FENG, Chungen LIANG, Chao LI, Zongxing QIU, Xuefei TAN, Guolong WU
  • SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20220213049
    Abstract: The present invention provides novel compounds having the general formula: (I) wherein R1 to R10, Gi, G2 and m are as described herein, compositions including the impounds and methods of using the compounds for the treatment of hepatitis B.
    Type: Application
    Filed: January 16, 2020
    Publication date: July 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Song FENG, Chungen LIANG, Kun MIAO, Xuefei TAN, Hong SHEN
  • N-CONTAINING CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
    Publication number: 20220169639
    Abstract: The present invention provides the compounds having the general formula: (I) wherein R1 to R8, and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: December 11, 2019
    Publication date: June 2, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Jiamin ZHENG, Yongfu LIU, Dongdong CHEN, Hong SHEN, Xuefei TAN
  • TRICYCLIC COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE
    Publication number: 20210387996
    Abstract: The present application provides compounds having the general formula: formula (I), wherein R1, R2, A, X and m are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful as inhibitors of cccDNA for treating Hepatitis B Virus (HBV) infections.
    Type: Application
    Filed: October 22, 2019
    Publication date: December 16, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Song FENG, Min JIANG, Xuefei TAN, Jun WU
  • FREE AMINO COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210323981
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 20, 2021
    Publication date: October 21, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Hong SHEN, Xuefei TAN, Chengang ZHOU, Mingwei ZHOU, Yimin HU, Houguang SHI, Fabian DEY, Yongqiang LIU, Xiao DING
  • OXOPYRIDO[1,2-A]PYRIMIDINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210317141
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1 to R7 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 17, 2021
    Publication date: October 14, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Xiao DING, Yimin HU, Yongqiang LIU, Hong SHEN, Honguang SHI, Xuefei TAN, Chengang ZHOU, Mingwei ZHOU
  • ARYL COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210309658
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 26, 2021
    Publication date: October 7, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Yimin HU, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Shixiang YAN, Weixing ZHANG, Zhiwei ZHANG, Chengang ZHOU, Mingwei ZHOU, Wei ZHU
  • TRICYCLIC COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210309657
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: May 26, 2021
    Publication date: October 7, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Yimin HU, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Shixiang YAN, Weixing ZHANG, Zhiwei ZHANG, Chengang ZHOU, Mingwei ZHOU, Wei ZHU
  • NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210238197
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 25, 2020
    Publication date: August 5, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian Dey, Xiao Ding, Yimin Hu, Yongqiang Liu, Hong Shen, Houguang Shi, Xuefei Tan, Chengang Zhou, Mingwei Zhou
  • SUBSTITUTED PYRIDOINDOLES FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION
    Publication number: 20210221832
    Abstract: The present invention relates to novel compounds of formula (I) or (II), wherein R1 to R6, R11 to R17 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 22, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Xiao DING, Yongqiang LIU, Hong SHEN, Houguang SHI, Xuefei TAN, Chengang ZHOU, Mingwei ZHOU
  • Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
    Publication number: 20200339603
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 29, 2020
    Publication date: October 29, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Yimin Hu, Chengang Zhou, Mingwei Zhou, Houguang Shi, Yongqiang Liu, Hong Shen, Maarten Vercruysse, Shixiang Yan, Xuefei Tan, Xianfeng Lin, Fabian Dey
  • Pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
    Patent number: 10662203
    Abstract: The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 26, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yimin Hu, Chengang Zhou, Mingwei Zhou, Houguang Shi, Yongqiang Liu, Hong Shen, Maarten Vercruysse, Shixiang Yan, Xuefei Tan, Xianfeng Lin, Fabian Dey
  • Xanthone derivatives for the treatment of hepatitis B virus disease
    Patent number: 10611748
    Abstract: The present invention provides novel compounds having the general formula: wherein R1 to R6, X, Y, A1 and A2 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: April 7, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Dongdong Chen, Wenming Chen, Song Feng, Lu Gao, Hong Shen, Xuefei Tan, Li Wang