Patents by Inventor Xuefei Tan

Xuefei Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of p38 kinase
    Patent number: 6821966
    Abstract: The invention is directed to methods to inhibit p38-&agr; kinase using compounds of the formula and the pharmaceutically acceptable salts thereof, or a pharmaceutical composition thereof, wherein represents a single or double bond; B is —Wi—COXjY wherein Y is COR2 or an isostere thereof and R2 is hydrogen or a noninterfering substituent, each of W and X is a spacer of 2-6 Å, and each of i and j is independently 0 or 1; each R3 is independently a noninterfering substituent, where n is 0-3; Z3 is NR7 or O; wherein R7 is H or a noninterfering substituent; one Z2 is CA or CR8A and the other is CR1, CR12, NR6 or N wherein each R1, R6 and R8 is independently hydrogen or noninterfering substituent; wherein A is: such that Z1 is CR5 or N wherein R5 is hydrogen or a noninterfering substituent; each of l and k is an integer from 0-2 wherein the sum of l and k is 0-3; Ar is an aryl group substituted with 0-5 noninterfering substituents, wherein two noninterfe
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: November 23, 2004
    Assignee: Scios, Inc.
    Inventors: Sundeep Dugar, John Perumattam, Gregory Luedtke, Xuefei Tan, Qing Lu
  • Piperidine/piperazine-type inhibitors of p38 kinase
    Publication number: 20040176382
    Abstract: The invention is directed to inhibition of p38-&agr; kinase using compounds of the formula 1
    Type: Application
    Filed: January 13, 2004
    Publication date: September 9, 2004
    Inventors: Babu Mavunkel, Sundeep Dugar, Gregory Luedtke, Glenn Mcenroe, Xuefei Tan
  • Piperidine/piperazine-type inhibitors of p38 kinase
    Patent number: 6696443
    Abstract: Certain compounds which contain a piperidine moiety flanked by aryl groups are inhibitors of p38-&agr; kinase and thus useful in the treatment of a variety of conditions characterized by inappropriate p38-&agr; kinase activity.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: February 24, 2004
    Assignee: Scios, Inc.
    Inventors: Babu Mavunkel, Sundeep Dugar, Gregory Luedtke, Xuefei Tan, Glenn McEnroe
  • Indole-type inhibitors of p38 kinase
    Publication number: 20030100588
    Abstract: The invention is directed to inhibition of p38-a kinase using compounds of the formula 1
    Type: Application
    Filed: November 20, 2001
    Publication date: May 29, 2003
    Inventors: Gregory Luedtke, Richland Tester, Sundeep Dugar, Qing Lu, John Perumattam, Xuefei Tan
  • Inhibitors of p38 kinase
    Publication number: 20030092717
    Abstract: The invention is directed to methods to inhibit p38-&agr; kinase using compounds of the formula 1
    Type: Application
    Filed: November 20, 2001
    Publication date: May 15, 2003
    Inventors: Sundeep Dugar, John Perumattam, Gregory Luedtke, Xuefei Tan, Qing Lu
  • Piperidine/piperazine-type inhibitors of p38 kinase
    Publication number: 20020198214
    Abstract: The invention is directed to inhibition of p38-&agr; kinase using compounds of the formula 1
    Type: Application
    Filed: November 20, 2001
    Publication date: December 26, 2002
    Inventors: Babu Mavunkel, Sundeep Dugar, Gregory Luedtke, Xuefei Tan, Glenn McEnroe