Abstract: Disclosed are a nebulization cup and application in nebulized inhalation administration thereof, and especially application in nebulized inhalation administration of a preventive and/or therapeutic drug for a respiratory disease (such as SARS-CoV-2 vaccine). After adding an antistatic agent, the nebulization cup can effectively maintain the stability of drug mist within a certain period of time, with stable particle size, less drug residue in the cup, thus ensuring effective inhalable amount, and the administration operation is simple and convenient, thus the nebulization cup can significantly improve the inoculation efficiency and can be used for large-scale inoculation.

Abstract: Use of phosphorus-based material in preparation of medicament for treating tumors. The phosphorus-based material is selected from a material which is convertible to produce phosphate ions in an acidic environment, and the phosphorus-based material can be converted by tumor cells phagocytosis to produce a large number of phosphate ions to change the intraceullar environment and extracellular environment, thereby inhibiting proliferation of tumor cells and inducing death of tumor cells. This process has no significant effect on normal cell activities. By applying the phosphorus-based material to the preparation of a medicament for treating tumor in a manner as mentioned above, the amplification and metastasis of tumor cells can be effectively inhibited, thereby the metastasis of the tumor cells and recurrence of the tumor can be prevented more effectively, improving the therapeutic effect of the tumor. The phosphorus-based material has little effect on normal cells and tissues in the course of treatment.

Abstract: Provided are an ionizable lipid compound of formula I for nucleic acid delivery and an LNP composition thereof, which can efficiency and stably deliver a biologically active substance to a target cell or an organ. The mRNA LNP prepared by using the lipid compound as a cationic lipid has better stability and transfection efficiency, and can cause a higher specific antibody response in an experimental animal body.

Abstract: A chain saw includes a housing, a working head, a protective member, and a pumping mechanism. The working head includes a guide plate and a cutting element arranged around the guide plate. The cutting element moves around the guide plate to implement cutting. The protective member is movably mounted on the housing, and at least partially covered on the working head. The pumping mechanism is configured to deliver a lubricating medium to the working head. The pumping mechanism is configured to output the lubricating medium as triggered by movement of the protective member. When the working head is in a working state, the protective member is pushable by a to-be-cut object to move in a direction away from the working head, to trigger the pumping mechanism to output the lubricating medium.

Abstract: A garden tool with a blowing function includes a housing having an air inlet; a blowing tube, connected with the housing, wherein the blowing tube is provided with an air outlet for air to be blown out; a fan, rotating around a fan axis, for making air flow and blowing the air out from the air outlet; and a motor, configured for driving the fan to rotate around the fan axis; wherein when the motor operates at a maximum rotational speed, blowing force F and noise LP of the garden tool with a blowing function satisfy following relationships: 16 N?F?23 N, and 53 dBA?LP<57 dBA; or 23 N<F?40 N, and 53 dBA?LP?0.0121F2?0.0603F+53.065 dBA.

Abstract: A single-tube blowing suction device, including a body, an airflow generation apparatus, a collection apparatus, and a blowing-suction tube. The airflow generation apparatus has an air inlet portion and an air outlet portion and is rotatably mounted on the body. The airflow generation apparatus rotates relative to the body to enable the single-tube blowing suction device to switch between a suction mode and a blowing mode. In the suction mode, the air inlet portion is in fluid communication with a first end of the blowing-suction tube, and the air outlet portion is in fluid communication with a connection port of the collection apparatus. In the blowing mode, the air outlet portion is in fluid communication with the first end of the blowing-suction tube. In the single-tube blowing suction device of the present invention, one tube is used for both blowing and suction.

Abstract: A garden blower, wherein an air inlet shield is connected to an axial inlet, and comprises a plurality of shield holes for an air flow to pass through. The sum of the ventilation area of the plurality of shield holes defines the total effective ventilation area of the air inlet shield. An extension rod extends in the longitudinal direction, and an operating handle and an air duct portion are separated from each other in the longitudinal direction by means of the extension rod. The linear velocity of a blade edge of an axial fan is greater than 80 m/s, and the total effective ventilation area of the air inlet shield is less than 12000 mm2.

Abstract: Provided are a cell strain HEK293.CS for reducing the production of a replication competent adenovirus, and a construction method and the use thereof. HEK293.CS is a safe adenovirus-producing cell line constructed by knocking out a gene fragment homologous to the Ad5 adenovirus E1 gene in HEK293 and providing a template plasmid to replace said gene fragment with a non-homologous sequence that stabilizes the expression of the E1 gene. Compared with the unmodified HEK293 cell strain, HEK293.CS shows no decrease in growth ability and virus production ability, but does not produce a detectable RCA. HEK293.CS can be used for the mass culture of a recombinant human type 5 adenovirus, and reducing the probability of RCA production in the manufacture process of drugs such as vaccines and antibodies.

Abstract: Provided are an mRNA or an mRNA composition, and an mRNA vaccine comprising the mRNA or the mRNA composition. The mRNA or the mRNA composition comprises an mRNA sequence encoding an S protein of a novel coronavirus SARS-CoV-2 or a variant thereof, and an mRNA sequence encoding an RBD in the S protein or a variant thereof. Further provided are the applications of the mRNA or the mRNA composition, and the mRNA vaccine comprising the mRNA or the mRNA composition in preparation of a medication for preventing and/or treating a disease caused by a novel coronavirus SARS-CoV-2 infection.

Abstract: A single-tube blowing suction device, including a body, an airflow generation apparatus, a collection apparatus, and a blowing-suction tube. The airflow generation apparatus has an air inlet portion and an air outlet portion and is rotatably mounted on the body. The airflow generation apparatus rotates relative to the body to enable the single-tube blowing suction device to switch between a suction mode and a blowing mode. In the suction mode, the air inlet portion of the airflow generation apparatus is in fluid communication with a first end of the blowing-suction tube, and the air outlet portion is in fluid communication with a connection port of the collection apparatus. In the blowing mode, the air outlet portion is in fluid communication with the first end of the blowing-suction tube. In the single-tube blowing suction device of the present invention, one tube is used for both blowing and suction.

Abstract: The disclosure provides a microcapsule type thermochromic pigment and a preparation method and use thereof, and a thermochromic ink and use thereof. The microcapsule type thermochromic pigment provided by the disclosure includes a core material and a wall material wrapping the core material, wherein the core material includes the following components: a leuco dye, a developer and stearic acid 2-[4-(phenylmethoxy)phenyl]ethyl ester, and the wall material is self-emulsifying polyurethane or self-emulsifying epoxy resin.

Abstract: The present invention relates to a garden blower. The garden blower includes: an extension rod; an air duct portion, disposed on one end of the extension rod; a motor; a fan; and an operating handle, spaced apart from the air duct portion in a longitudinal direction, where a ratio of a length of the air duct portion in the longitudinal direction to a length of the entire garden blower in the longitudinal direction is less than or equal to 60%, and a weight of the garden blower does not exceed 2 kg.

Abstract: The embodiments relates to garden blower, including: an enclosure, including a main body part located on back end and a blowing pipe located on front end and extending axially, the enclosure disposed with an air inlet and an air outlet communicated with external environment; a power device, connected to the enclosure; a fan component, driven by the power device and generating airflows; the fan component includes at least two-level fans, further includes a first-level fan and a second-level fan axially disposed front and back, the garden blower includes a first air inlet passage allowing entrance of the airflows generated by the first-level fan and a second air inlet passage allowing entrance of the airflows generated by the second-level fan, and the airflows entering the first air inlet passage and the airflows entering the second air inlet passage are converged into the blowing pipe and are blown to the outside.

Abstract: The disclosure provides a microcapsule type thermochromic pigment and a preparation method and use thereof, and a thermochromic ink and use thereof. The microcapsule type thermochromic pigment provided by the disclosure includes a core material and a wall material wrapping the core material, wherein the core material includes the following components: a leuco dye, a developer and stearic acid 2-[4-(phenylmethoxy)phenyl]ethyl ester, and the wall material is self-emulsifying polyurethane or self-emulsifying epoxy resin.

Abstract: Use of phosphorus-based material in preparation of medicament for treating tumors. The phosphorus-based material is selected from a material which is convertible to produce phosphate ions in an acidic environment, and the phosphorus-based material can be converted by tumor cells phagocytosis to produce a large number of phosphate ions to change the intraceullar environment and extracellular environment, thereby inhibiting proliferation of tumor cells and inducing death of tumor cells. This process has no significant effect on normal cell activities. By applying the phosphorus-based material to the preparation of a medicament for treating tumor in a manner as mentioned above, the amplification and metastasis of tumor cells can be effectively inhibited, thereby the metastasis of the tumor cells and recurrence of the tumor can be prevented more effectively, improving the therapeutic effect of the tumor.

Abstract: The present invention provides a single-tube blowing suction device, including a body (1), an airflow generation apparatus, a collection apparatus, and a blowing-suction tube (2). The airflow generation apparatus has an air inlet portion and an air outlet portion. The airflow generation apparatus is rotatably mounted on the body (1). The airflow generation apparatus rotates relative to the body (1) to enable the single-tube blowing suction device to switch between a suction mode and a blowing mode. In the suction mode, the air inlet portion of the airflow generation apparatus is in fluid communication with a first end (21) of the blowing-suction tube (2), and the air outlet portion of the airflow generation apparatus is in fluid communication with a connection port of the collection apparatus. In the blowing mode, the air outlet portion of the airflow generation apparatus is in fluid communication with the first end (21) of the blowing-suction tube.