Abstract: A constructing method of a genomic scar model comprises: (1) collecting known BRCAness positive samples and known BRCAness negative samples to form a training set; (2) analyzing copy number variation (CNV) in the training set to determine types and corresponding quantities of CNV; (3) determining BRCAness positive events and BRCAness negative events; (4) training to obtain weights of different types of the CNV determined in the step 2 through a machine learning method according to the BRCAness positive events and the BRCAness negative events in the training set, and then totalizing the weights of the different types of the CNV to obtain the genomic scar model for calculating genomic scar score (GSS).

Abstract: A method of presenting product information in a vending machine may include detecting audio information from a consumer and converting the audio information to a text string. The method may include identifying a keyword in the text string, and determining products from a product database associated with the keyword. The method may include returning a list of the products that correspond to the keyword.

Abstract: A vending machine includes a product storage cabinet having a housing defining a storage compartment for storing a product and a door movably connected to the housing. A product sensor is configured to detect removal of the product from the storage compartment. The vending machine further includes a control assembly configured to control operation of the vending machine. The control assembly includes a support structure, a control unit mounted on the support structure, a transceiver mounted on the support structure, and a power supply mounted on the support structure. The control assembly is configured to receive information from collected by the product sensor to determine an identity of the product removed from the storage compartment.

Abstract: A method for effectively cleaning vias (20034), trenches (20036) or recessed areas on a substrate (20010) using an ultra/mega sonic device (1003, 3003, 16062, 17072), comprising: applying liquid (1032) into a space between a substrate (20010) and an ultra/mega sonic device (1003, 3003, 16062, 17072); setting an ultra/mega sonic power supply at frequency f1 and power P1 to drive said ultra/mega sonic device (1003, 3003, 16062, 17072); after the ratio of total bubbles volume to volume inside vias (20034), trenches (20036) or recessed areas on the substrate (20010) increasing to a first set value, setting said ultra/mega sonic power supply at frequency f2 and power P2 to drive said ultra/mega sonic device (1003, 3003, 16062, 17072); after the ratio of total bubbles volume to volume inside the vias (20034), trenches (20036) or recessed areas reducing to a second set value, setting said ultra/mega sonic power supply at frequency f1 and power P1 again; repeating above steps till the substrate (20010) being cleaned.

Abstract: The present disclosure provides a novel compound effective in antagonizing EP4, which is a compound represented by Formula I, or a tautomer, stereoisomer, hydrate, solvate, pharmaceutically acceptable salt or prodrug of the compound represented by Formula I: wherein: R1 is selected from —CH3, —CHF2, and —CF3; R2 is selected from C2-C6 alkyl, C3-C6 cycloalkyl, C2-C6 halogen-substituted alkyl, C3-C6 halogen-substituted cycloalkyl; R3 is selected from hydrogen, halogen, C1-C2 alkyl, C1-C2 fluorine- or chlorine-substituted alkyl; R4 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 halogen-substituted alkyl, C1-C6 halogen-substituted alkoxyl.

Abstract: A self-service parcel cabinet, comprising: a main-body part (1), a sorting apparatus (2), a parking apparatus (3), and a control device. The main-body part is a hollow structure opened at the top. At least part of the hollow structure is formed by multiple self-service parcel lockers (11) surroundingly arranged. The parking apparatus is provided on top of the main-body part and comprises a drone landing pad (31). Provided on the drone landing pad is a channel allowing passing of a parcel delivered by the drone and directly facing the opening at the top.

Abstract: This application discloses a mobile device and method for managing installation of an application package (APK) in the mobile device. The device receives an installation request for installing the APK. The device retrieves a permission certificate for the APK according to the installation request. The permission certificate includes a cryptographic signature. The device determines validity of the permission certificate by verifying the cryptographic signature included in the permission certificate using a permission certification public key provided by a manufacturer of the device. The permission certification public key is stored in the device. The installation of the APK in the device is allowed when the permission certificate is determined to be valid. Using the method, the APK requires the device to grant specific high-risk permissions to the application upon installation.

Abstract: A safe early warning method and device for full-section tunneling of a tunnel featuring dynamic water and weak surrounding rock, comprising establishing a dynamic coordinate system with an origin thereof moving along a tunnel excavation line, recording the moving distance of the origin, conducting three-dimensional laser scanning with the origin as a center to obtain point cloud data including coordinate data, collecting surrounding rock data; conducting deformation fitting on the point cloud data, calculating a fitting residual error, removing a noisy point, and conducting preprocessing; combining data of preprocessed point cloud, surrounding rock, and the tunnel excavation line to construct a tunnel excavation dynamic model; conducting stress analysis according to the model and determining whether to send out a safety early warning signal.

Abstract: A system for controlling damages in cleaning a semiconductor wafer comprising features of patterned structures, the system comprising: a wafer holder for temporary restraining a semiconductor wafer during a cleaning process; an inlet for delivering a cleaning liquid over a surface of the semiconductor wafer; a sonic generator configured to alternately operate at a first frequency and a first power level for a first predetermined period of time and at a second frequency and a second power level for a second predetermined period of time, to impart sonic energy to the cleaning liquid, the first predetermined period of time and the second predetermined period of time consecutively following one another; and a controller programmed to provide the cleaning parameters, wherein at least one of the cleaning parameters is determined such that a percentage of damaged features as a result of the imparting sonic energy is lower than a predetermined threshold.

Abstract: The present technology is directed to compounds, compositions, and methods related to inhibition of ULK1 and treatment of cancers therefrom.

Abstract: An installation tool and method for spherical latticed shell structure is provided. The spherical latticed shell structure includes a plurality of latticed shell units. The installation tool includes a support frame, a hoisting system, a fixing frame and stay rope assemblies. The support frame is arranged on one side of a to-be-installed spherical latticed shell structure. The fixing frame is connected with the hoisting system. The hoisting system is arranged on the support frame for hoisting the fixing frame. The stay rope assemblies are connected with the fixing frame and the latticed shell units.

Abstract: Embodiments provide traceability of edits to a document, i.e., a verifiable and immutable provenance chain for the document. Systems and methods enable traceability of edits, by encoding, for states of the document, a fingerprint (e.g., a cryptographic hash of the document's contents) and an edit history within a block written to a distributed ledger (e.g., a blockchain). The ledger is maintained via a self-organizing peer-to-peer distributed ledger network. Once added to the ledger, the contents of a block (e.g., the document's fingerprint and edit history) are immutable and the integrity of the edit history encoded in the ledger is secure. The algorithm that generates the fingerprint is sensitive to edits of the document. The non-corruptible fingerprint encoded in the ledger is employable to detect any edits that are not included in the encoded edit history and/or inconsistent with a currently available version of the document.

Abstract: A control method and system for a distribution network with distributed mobile energy storage systems is disclosed which relates to the power field. The present invention manages the multiple distributed mobile energy storage systems in the distribution network in a unified way, to improve the flexibility of the distribution network, and enable the distributed mobile energy storage systems to fully smooth new energy generation fluctuations, implement peak cut, facilitate grid auxiliary services, and improve the power quality. The control method includes: acquiring, by a sub-station coordination system, data of the distributed mobile energy storage systems; receiving, by a master-station dispatching system, the data of the distributed mobile energy storage systems, and obtaining external data; generating, by the master-station dispatching system, a control instruction; and controlling, by the sub-station coordination system, the distributed mobile energy storage systems.

Abstract: This application discloses a network congestion control method, apparatus, device, and system, and a storage medium. In an example method, a first switch receives a target signaling packet that is sent by a second switch in a case in which a network congestion status is a target network congestion status. The target signaling packet carries flow source information. The first switch sends, based on the target signaling packet, target flow control information to a network device corresponding to the flow source information. The target flow control information is used to indicate flow control.

Abstract: A data processing method and apparatus based on instant messaging, a device, and a computer-readable storage medium.

Abstract: A nuclear waste cask with impact protection includes impact limiters comprising deformable energy-absorbing perforated sleeves. An impact amelioration system for nuclear fuel storage components includes impact limiter assemblies at the bottom cask to canister interface including impact limiter plugs frictionally engaging corresponding plug holes formed in the cask closure plate. A nuclear waste fuel storage system includes an unventilated cask including a heavy free-floating radiation shielding lid loosely coupled the top end of the cask in a movable manner via the anchor bosses which provides cask overpressurization protection. A nuclear waste cask includes an axially elongated rectangular cuboid cask body having a cavity for holding nuclear waste materials and cask locking mechanism including first locking protrusions on the lid which are selectively interlockable with mating second locking protrusions on the cask body to lock the lid to the cask body.

Abstract: A data synchronization device is provided, including a control module, a data block storage module and an encoding/decoding module. A data synchronization method using the device is also provided, including: selecting, by the control module, a data transmission network node and selecting the to-be-synchronized data block of a data transmission network node from the data storage module; encapsulating the to-be-synchronized data block in a specific format and then broadcasting the encapsulated data, where if there are two or more to-be-synchronized data blocks, the to-be-synchronized data blocks are encoded and then encapsulated; otherwise, the to-be-synchronized data block is directly encapsulated; processing, by the encoding/decoding module, the encapsulated data to obtain the to-be-synchronized data block, and finally inputting the obtained to-be-synchronized data block into the data block storage module.

Abstract: A system for identifying a product removed from a cabinet includes detecting visual characteristics of the product removed from the cabinet by a camera within the cabinet. The system may include detecting an identifier on the product removed from the cabinet by an identifier sensor, and comparing the visual characteristics and the identifier to a database of product information. The product removed from the cabinet may be identified based on the comparison of the visual characteristics and the identifier to the database of product information.