Abstract: This application provides a video message generation method and apparatus, an electronic device, and a storage medium. The video message generation method includes: receiving a comment instruction for a video; determining a target frame corresponding to the comment instruction in the video; obtaining input comment content of the target frame; and generating a video message based on the video, the target frame, and the comment content of the target frame.

Abstract: Provided is a flange (100) connected to an end of an insulating tube (10), the flange includes a flange plate (110) abutting the end of the insulating tube, a groove (111) recessed toward inside of the insulating tube is disposed on the flange plate, the groove is connected to the insulating tube, an inflation valve (120) is disposed within the groove, the groove is filled with sealing material (130) which covers the inflation valve. Provided are also insulator and insulated support post using the flange. The flange, the insulator and insulated support post help to protect the inflation valve from external force and the groove is filled with the sealing material to ensure the sealing performance of the flange.

Abstract: A file commenting method includes displaying file content in an instant messaging client, displaying comment content entered via a commenting operation performed on a portion of the file content, and displaying a session page when the commenting operation is completed, the session page including the portion of the file content, the comment content, and a file identifier corresponding to the file content.

Abstract: A split ring seal has: a first circumferential end and a second circumferential end; an inner diameter surface and an outer diameter surface; a first axial end face and a second axial end face. A circumferentially distributed first plurality of open channels are along the first axial end face. A circumferentially distributed second plurality of open channels are along the second axial end face.

Abstract: A split ring seal has: a first circumferential end and a second circumferential end; an inner diameter surface and an outer diameter surface; a first axial end face and a second axial end face. A circumferentially distributed first plurality of open channels are along the first axial end face. A circumferentially distributed second plurality of open channels are along the second axial end face.

Abstract: Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.

Abstract: Methods of identifying agents that modulate the interleukin-17 (IL-17) pathway are described. Said methods use detecting a level of granulocyte colony-stimulating factor (G-CSF) in a cell supernatant and/or detecting an expression level of one gene or a panel of genes of a cell treated with an agent. Also described are probes capable of detecting a gene or panel of genes and kits for identifying agents that modulate the IL-17 pathway.

Abstract: Disclosed are a compound containing a fused ring, a use thereof and a pharmaceutical composition containing same. Provided are a compound as shown in formula I-A, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof or a crystal form thereof. The compound can significantly reduce the levels of HBsAg, HBeAg and HBV DNA, and can be used for preparing a drug for treating hepatitis B, and has good market prospects.

Abstract: A transparent injection overmolded structure (100) encapsulating a real botanical matter (70) including at least one first transparent multilayer film member (50), at least one second transparent multilayer film member (60), a real botanical matter (70) disposed and encapsulated between the surface of the first transparent multilayer film member (50) and the surface of the second transparent multilayer film member (60) forming an integral transparent multilayered encapsulation structure (30), a base member (40) for receiving and attaching to the transparent multi-layered encapsulation structure (30), and an injection overmolded transparent plastic member (20) integral with and enveloping the base member (40) and the transparent multilayered encapsulation structure (30).

Abstract: A method of identifying a subject who is likely to be responsive to a treatment comprising an inhibitor of IL1?, or predicting the responsiveness of a subject to a treatment comprising an inhibitor of IL1?, comprising providing a sample from a subject; administering the inhibitor of IL1? to the sample; measuring levels of one or more biomarkers in the sample; and determining the pharmacodynamic or the pharmacokinetic effect of the inhibitor of IL1? based on the levels of the one or more biomarkers.

Abstract: A method of treating psoriasis in a patient by administering an IL-23 specific antibody, e.g., guselkumab, in a clinically proven safe and clinically proven effective amount and the patient achieves PASI90, PASI100 or IGA 0 or 1 score as measured 16, 24, 32, 40 and 48 weeks after initial treatment and the patient achieves higher efficacy than a patient treated with the secukinumab antibody.

Abstract: A method of determining a pharmacodynamics or pharmacokinetic effect of an inhibitor of IL 1? comprising providing a sample from a subject; administering the inhibitor of IL 1? to the sample; measuring levels of one or more biomarkers in the sample; and determining the pharmacodynamic or the pharmacokinetic effect of the inhibitor of IL 1? based on the levels of the one or more biomarkers.

Abstract: Disclosed are a compound containing a fused ring, a use thereof and a pharmaceutical composition containing same. Provided are a compound as shown in formula I-A, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof or a crystal form thereof. The compound can significantly reduce the levels of HBsAg, HBeAg and HBV DNA, and can be used for preparing a drug for treating hepatitis B, and has good market prospects.

Abstract: A method for predicting maintenance of response to IL-23 antibody therapy and treating a patient having psoriasis with extended dosing intervals after measuring at least one indicator from psoriasis patients before and during treatment with an IL-23 antibody is useful in the treatment of psoriasis.

Abstract: A method of treating psoriasis in a patient by administering an IL-23 specific antibody, e.g.

Abstract: A method for predicting maintenance of response to IL-23 antibody therapy and treating a patient having psoriasis with extended dosing intervals after measuring at least one indicator from psoriasis patients before and during treatment with an IL-23 antibody is useful in the treatment of psoriasis.

Abstract: Family of non-homopolymers synthesized from N-vinyl lactam, (meth)acrylic acid, hydrophobic (meth)acrylic ester of a straightchain or branched-chain alkyl alcohol and monomer selected from the group consisting of functionalized and unfunctionalized: dialkyl maleates, dialkyl fumarates, and combinations thereof. The non-homopolymers may exhibit solubility in one or more lower molecular weight alcohols and/or a glass transition temperature greater than 80° C.

Abstract: Described herein are multifunctional polymers comprising a first repeating unit having at least one pseudo-cationic moiety, a second repeating unit having at least a hydrophobic moiety, and a third repeating unit, where the weight-average molecular weight is less than about 10,000 Da. In one embodiment the polymers exhibit antimicrobial activity. Also provided are compositions formulated with the multifunctional polymers, and a method of providing antimicrobial activity.

Abstract: An aircraft system includes an aircraft fuselage, an auxiliary power unit and an air inlet assembly. The auxiliary power unit is within the aircraft fuselage. The auxiliary power unit may be configured as or otherwise include an engine. The air inlet assembly includes an inlet orifice, an inlet duct and a door. The inlet duct fluidly couples the inlet orifice with an airflow inlet of the engine. The door is configured to pivot about a generally horizontal pivot axis between an open position and a closed position. The door opens the inlet orifice in the open position and substantially closes the inlet orifice in the closed position.

Abstract: A total air temperature (TAT) sensor assembly is disclosed. The assembly includes a housing that accommodates a temperature sensor. The assembly also includes a first airfoil that includes a leading end and a trailing end and a second airfoil that includes a leading end and a trailing end. The first and second airfoils are disposed in a spaced-apart fashion that defines a curved passageway so incoming air can flow between the first and second airfoils before engaging the housing and the temperature sensor. The trailing ends of the airfoils are disposed on opposite sides of the housing and spaced apart from the housing to permit air flowing through the curved passageway to pass the housing.