Abstract: The present invention provides methods and compositions for sequentially and separately reducing infection and/or inflammation and regenerating tissue at a lesion site, by contacting the lesion site with a biodegradable scaffold that first delivers one or more agents at the lesion site to reduce infection and/or inflammation and then delivers one or more agents to regenerate tissue at the lesion site after inflammation is reduced.

Abstract: Disclosed are methods of forming three dimensional arrays of aligned nanofibers in an open, loose structure of any desired depth. The arrays are formed according to an electrospinning process utilizing two parallel conducting plates to align the fibers and rotating tracks to distribute the fibers throughout the array. Arrays can be used as formed, for instance in tissue engineering applications as three dimensional scaffolding constructs. As-formed arrays can be combined with other materials to form a composite 3-D structure. For instance, composite polymeric materials can be electrospun to form composite nanofibers within the array. Multiple polymeric materials can be electrospun at different areas of the array to form a composite array including materially different nanofibers throughout the array. The arrays can be loaded with other fibrous or non-fibrous materials to form a composite array. Arrays can also be rolled to form a uniaxial fiber bundle.

Abstract: Disclosed are devices and methods for targeted delivery of therapeutic agents. The devices include selectively permeable hollow fiber membranes which allow for the outward diffusion of therapeutic agents while the contents of the device are protected from host humoral and cellular immunologic attack. The methods include implanting the devices in the ears and/or eyes.

Abstract: Disclosed are devices and methods for improved viability of cells. In one embodiment of the present disclosure, a method for improved viability of cells is provided. The method includes providing a device having a body, an access port, and an insert. The body includes a selectively permeable hollow fiber membrane and the insert includes one or more scar suppression agents. The device is implanted whereby the scar suppression agent is delivered.