Abstract: The present invention relates to a signal peptide for reducing the end heterogeneity of a heterologous polypeptide. Specifically, the present invention relates to a signal peptide for protein expression. The present invention further relates to a recombinant polypeptide, a preparation method therefor, and a composition containing a recombinant polypeptide.

Abstract: The present disclosure relates to an anti-PD-1 antibody pharmaceutical composition and use thereof. Specifically, the present disclosure provides a pharmaceutical composition, comprising an anti-PD-1 antibody and a buffer solution.

Abstract: A non-stick electrode comprises an electrode an electrically insulating sheath disposed thereon. The electrically insulating sheath has an opening on a surface of the electrode through which an electrical current is transmitted or received to or from an opposing electrode respectively. The electrode protrudes through the opening in the insulating sheath. An electrically conducting interlayer is disposed on the electrode such that it contacts the electrode at the opening in the electrically insulating sheath. The electrically conducting interlayer comprises a material that decomposes at a temperature that is greater than a temperature of a metal that is liquified on contact with the non-stick electrode.

Abstract: Disclosed is a preparation method for an antibody medicament conjugate, comprising steps for synthesizing and purifying same.

Abstract: A method includes receiving, by a computer, a destination address. The computer can obtain historical fulfillment data for the destination address. The computer can then determine one or more temporary transporter locations based on the historical fulfillment data for the destination address. The computer can determine a waypoint location from the one or more temporary transporter locations. The computer can provide the waypoint location.

Abstract: Certain aspects of the present disclosure are directed to a regulator. The regulator generally includes a source follower circuit and a low-voltage assist circuit. The low-voltage assist circuit generally includes a first transistor having a gate coupled to an output node of the source follower circuit, a voltage comparison circuit having a first input coupled to a source of the first transistor and a second input coupled to a control input node of the source follower circuit, and a second transistor having a gate coupled to an output of the voltage comparison circuit and a drain coupled to the output node of the source follower circuit.

Abstract: A pharmaceutical composition, comprising an antibody drug conjugate in a buffer solution. The antibody drug conjugate has a structure represented by the general formula (Pc-L-Y-D). The pharmaceutical composition further comprises sugar and a surfactant.

Abstract: The present invention provides a PD-L1 antibody pharmaceutical composition and use thereof. In particular, the present invention provides a pharmaceutical composition comprising the PD-L1 antibody or an antigen-binding fragment thereof in a succinate buffer. In addition, the pharmaceutical composition may also contain a sugar and a nonionic surfactant.

Abstract: According to various aspects of the present disclosure, methods, systems, and media for data migration are provided. In some embodiments, the systems may include: at least one computer-readable storage medium including a set of instructions for migrating data records; and at least one processor in communication with the computer-readable storage medium, wherein when executing the set of instructions, the at least one processor is directed to: query data in a data storage system comprising a plurality of slave nodes; determine, from a plurality of data records in the slave nodes, at least one candidate data record that satisfies a first condition; identify, from the slave nodes, at least one candidate slave node that satisfies a second condition; and in response to determining that the number of the at least one candidate slave node is not less than a threshold value, migrate the candidate data record to a target slave node.

Abstract: A method for assigning connections between IO pad pins and connectors on an integrated circuit (IC) die. A pattern (300) including a physical layout of connectors (302) and pad pins (304) is associated with a mapping of connections between the connectors (302) and the pad pins (304). A processor (204) identifies instances (402, 404) of the pattern (300) within a design image (400) of an integrated circuit (IC) die using a machine learning model. The design image (400) includes a physical layout of connectors (414) and pad pins (416). For each identified instance (402, 404) of the pattern (300) within the design image (400), the mapping of connections is assigned to respective connectors (414) and pad pins (416) in the identified instance (402, 404).

Abstract: Provided are a pharmaceutical composition containing an anti-IL-4R antibody and the use thereof. The pharmaceutical composition contains an anti-IL-4R antibody or an antigen-binding fragment thereof in a histidine-acetic acid buffer agent, a viscosity modifier, a surfactant, and a stabilizer.

Abstract: Disclosed are tools for friction stir processing and methods of using the same. Also disclosed herein are methods of repairing surface defects using the disclosed friction stir processing tools.

Abstract: A method includes partitioning, within an interposer IC design on which are disposed a first die and a second die, a first bump array into first cluster regions of bumps and a second bump array into second cluster regions of bumps. Creating multiple sub-channels between respective bump cluster regions. Identifying a set of trunk areas positioned between the first bump array and the second bump array, each trunk area to include net lines, each sub-channel to include at least one trunk area of the set of trunk areas. Identifying connector regions to route the net lines between adjacent trunk areas of the set of trunk areas. Assigning, based on layers available for routing, a routing layer to each net line that is to be routed in each respective sub-channel. The method includes routing, based on the assigning, the net lines through the set of trunk areas and the connector regions.

Abstract: A method for calibrating a light smart watch includes: providing an FPC soft board under a dial, a size of the FPC soft board matching a size of the dial, the FPC soft board is divided into a plurality of partitions, each partition is insulated from other partitions, and each of watch hands and each partition form a capacitor in turn when the watch hands run; detecting a capacitance change amount of each partition, determining positions of partitions where the watch hands are currently located, and determining a current time indicated by the watch hands, according to the positions of partitions where the watch hands are currently located; comparing the current time indicated by the watch hands with a current time of a mobile terminal to determine a time error; and adjusting the watch hands, according to the time error to run in sync with the time of the mobile terminal.

Abstract: Aspects of the present disclosure generally relate to methods and apparatus for continuous current sensing for a single-inductor multiple-output (SIMO) regulator. One example method includes operating a plurality of switches of the SIMO regulator, via a plurality of control signals, according to a plurality of switching states using a switching controller, sensing currents associated with at least a portion of the plurality of switches of the SIMO regulator using a plurality of current sense circuits, and selectively outputting a sense current from one of the plurality of current sense circuits based on a change in the plurality of controls signals occurring between a transition from a first switching state to a second switching state of the plurality of switching states.

Abstract: A pharmaceutical composition containing an SOST antibody or an antigen-binding fragment thereof in an acetic acid-sodium acetate buffer solution is described. In addition, the pharmaceutical composition can also contain sugar, a nonionic surfactant or other excipients. After being stored for several months, the pharmaceutical composition exhibits good antibody stability.

Abstract: The present disclosure provides a method and device for stitching wind turbine blade images, and a storage medium. The method includes performing edge detection on a plurality of images of the blade of the wind turbine to determine a blade region for each of the plurality of images; and for each pair of images among the plurality of images of the blade of the wind turbine, which are captured successively, stitching a front end of a former one of the pair of images captured successively and a rear end of a latter one of the pair of images captured successively, wherein the front end is far away from a root of the blade of the wind turbine, and the rear end is close to the root of the blade of the wind turbine.

Abstract: Provided is an engineered immune cell comprising on its surface a recognition molecule that comprises a binding moiety specifically binding to a target molecule on the surface of a target cell, wherein the target molecule comprises an extracellular domain, and wherein the immune cell is capable of killing a target cell that comprises on its surface the target molecule. In one aspect, the binding moiety specifically binds to a distal portion of the extracellular domain, and the immune cell is capable of killing a target cell that comprises on its surface both the target molecule and the recognition molecule. In another aspect, the binding moiety specifically binds to a proximal portion of the extracellular domain, and the engineered immune cell has no or reduced capability of killing a target cell comprising on its surface both the target molecule and the recognition molecule.

Abstract: Provided are anti-CD4 immune cell receptors that comprise an extracellular domain comprising a CD4 binding moiety that specifically binds to an epitope within a certain domain of CD4, a transmembrane domain, and an intracellular signaling domain. Also provided are engineered immune cells comprising such anti-CD4 immune cell receptors and uses thereof.

Abstract: A method includes obtaining a first preview picture collected by a camera, where an angle of view FOV of the camera is a first FOV value. The camera collects the first preview picture based on a second FOV value, and the second FOV value is less than the first FOV value. The method further includes adjusting the second FOV value to a third FOV value when it is detected that a quantity of at least one target human face in the first preview picture is greater than a first preset value, where the third FOV value is greater than the second FOV value, and the third FOV value is less than or equal to the first FOV value; and outputting an image that is photographed by the camera based on the third FOV value.