Abstract: The invention provides a cache management system comprising in various embodiments pre-load and pre-own functionality to enhance cache efficiency in shared memory distributed cache multiprocessor computer systems. Some embodiments of the invention comprise an invalidation history table to record the line addresses of cache lines invalidated through dirty or clean invalidation, and which is used such that invalidated cache lines recorded in an invalidation history table are reloaded into cache by monitoring the bus for cache line addresses of cache lines recorded in the invalidation history table. In some further embodiments, a write-back bit associated with each L2 cache entry records when either a hit to the same line in another processor is detected or when the same line is invalidated in another processor's cache, and the system broadcasts write-backs from the selected local cache only when the line being written back has a write-back bit that has been set.

Abstract: This invention is a cache memory employing a tag bypass controller to detect a memory access to the same cache line as a last cache miss address and a last cache hit address. This information is uses for efficient data accesses and forwarding. Registers store the last miss-address and the last hit-address and corresponding valid flags. These hardware features allow reduced tag-RAM accesses and greatly reduce the latency required to fully re-stock a missed cache line.

Abstract: The present invention relates to a hybridization signal amplification method (HSAM) that can be used to form nanostructures for use in drug delivery and diagnostics and may comprise molecules aimed at a specific target cell of interest. The nanostuctures may be used to treat infectious diseases and physiological disorders such as proliferative, genetic, neurological or metabolic disorders. The nanostructures of the invention comprise nucleic acid molecules having affinity pairs incorporated into their structure. These affinity pairs are formed from ligand and ligand binding moieties that bind to nucleic acid molecules. This bound entity is a complex, web-like structure that serves as a matrix or framework for delivery of therapeutic or diagnostic agents. Since the nanostructures of the invention are comprised of biocompatible and biodegradable materials, such as nucleic acid molecules and proteins, they provide a safe and easily degradable delivery system.

Abstract: A filament cut-back circuit comprises an impedance circuit coupled in series between either an AC voltage source and a primary filament winding, or a secondary filament winding and a filament. In response to an alternating voltage from the AC voltage source when coupled in series thereto or an alternating voltage from the secondary filament winding when coupled in series thereto, the impedance circuit operates as a short circuit when the alternating voltage is at a preheat frequency and operates as an open circuit when the alternating voltage is at an operating frequency.

Abstract: An improved method allowing for rapid sensitive and standardized detection of a target nucleic acid from a pathogenic microorganism or virus or normal or abnormal gene in a sample is provided. The method involves hybridizing a target nucleic acid to several non-overlapping oligonucleotide probes that hybridize to adjacent regions in the target nucleic acid, the probes being referred to capture/amplification probes and amplification probes, respectively, in the presence of paramagnetic beads coated with a ligand binding moiety. Through the binding of a ligand attached to one end of the capture/amplification probe and the specific hybridization of portions of the probes to adjacent sequences in the target nucleic acid, a complex comprising the target nucleic acid, the probes and the paramagnetic beads is formed. The probes may then ligated together to form a contiguous ligated amplification sequence bound to the beads, which complex may be denatured to remove the target nucleic acid and unligated probes.

Abstract: Methods and pharmaceutical compositions for the treatment of pain, preferably with lowered risk of induction of seizure in a patient.

Abstract: The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using the amplification methods disclosed herein.

Abstract: A filament cut-back circuit is disclosed. The filament cut-back circuit comprises an impedance circuit coupled in series between either an AC voltage source and a primary filament winding, or a secondary filament winding and a filament. In response to an alternating voltage from the AC voltage source when coupled in series thereto or an alternating voltage from the secondary filament winding when coupled in series thereto, the impedance circuit operates as a short circuit when the alternating voltage is at a preheat frequency and operates as an open circuit when the alternating voltage is at an operating frequency.

Abstract: The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using the amplification methods disclosed herein.

Abstract: A differential output buffer has a primary stage and a secondary stage that each directly drive differential outputs. Link transistors between the secondary stage and the differential outputs are eliminated. The primary stage continuously receives differential inputs applied to gates of n-channel sourcing and sinking transistors. The sources of the sourcing transistors and the drains of the sinking transistors are connected to the true and complement differential outputs. The secondary stage also has n-channel sourcing and sinking transistors directly connected to the differential outputs. Pulsed inputs applied to secondary-stage gates are normally low, disabling the sourcing and sinking transistors in the secondary stage to disable the secondary stage. However, during a switching transient, the pulsed inputs are pulsed on, allowing the secondary stage to drive a boost current to the differential outputs.

Abstract: The present invention is directed to apparatus and method for forming balloons with improved dimensional stability and balloons formed by the same. The method of the present invention provides for a very accurate control of the temperature profile of the balloon material during its making. The attributes of the balloon can be affected by how the balloon is treated during the blowing stage and after the initial blowing, i.e., heat-setting. Using the present method, the balloon will form more uniformly and evenly (e.g., wall thickness and outer diameter of the balloon). The present method significantly increases the dimensional stability of the balloon which provides a balloon that is more predictable, in use. The present heat-set process also provides the means for the working length to be located more accurately on dilation catheters and stent delivery systems.

Abstract: A phase-locked loop (PLL) includes a final mixer on its output. The final mixer subtracts out a noise or error term from the PLL's output to reduce noise and jitter. A first mixer generates the error term by subtracting a feedback clock from the reference clock. This error term is near D.C. since the feedback and reference clocks are at the same frequency. When this error term is subtracted from the PLL output, a secondary maxima in the noise plot at the PLL's loop bandwidth is removed. A feedback counter receives the output of the voltage-controlled oscillator (VCO) before the final mixer. Outer-band noise created by the VCO is subtracted out by the final mixer, using the error term generated by the first mixer. The mixers reduce noise generated by the VCO or from other sources in the PLL.

Abstract: An improved method allowing for rapid sensitive and standardized detection of a target nucleic acid from a pathogenic microorganism or virus or normal or abnormal gene in a sample is provided. The method involves hybridizing a target nucleic acid to several non-overlapping oligonucleotide probes that hybridize to adjacent regions in the target nucleic acid, the probes being referred to capture/amplification probes and amplification probes, respectively, in the presence of paramagnetic beads coated with a ligand binding moiety. Through the binding of a ligand attached to one end of the capture/amplification probe and the specific hybridization of portions of the probes to adjacent sequences in the target nucleic acid, a complex comprising the target nucleic acid, the probes and the paramagnetic beads is formed. The probes may then ligated together to form a contiguous ligated amplification sequence bound to the beads, which complex may be denatured to remove the target nucleic acid and unligated probes.

Abstract: A controlled medicament security enclosure system that houses liquid filled reservoirs which consists of a portable enclosure (20) formed with a top half (22) and a bottom half (24) that permanently snap together to form a secure inseparable repository for the reservoirs. Inside the enclosure is at least one glass vial (36) for storing the liquid medicament with each vial having a sliding piston stopper (42) within that seals the inside of the vial and slides to maintain the liquid air free regardless of the volume. An adapter socket (48) is removably attached to the stopper and includes a hollow needle that pierces the stopper and permits a flowpath for the liquid. A flexible outlet tube (62) along with connectors on each end transmit the medicament to a mechanical drug delivery system that has a peristaltic pump and a control module.

Abstract: The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using the amplification methods disclosed herein.

Abstract: There is provided a particulate conductive filler which comprises a noble metal coating formed over a non-noble metal coating over an inner carbon-based core. The conductive filler is used in conjunction with a polymer matrix to form composite materials for conductive applications.

Abstract: Methods and pharmaceutical compositions for the treatment of pain, preferably with lowered risk of induction of seizure in a patient.

Abstract: The present invention is directed to apparatus and method for forming balloons with improved dimensional stability and balloons formed by the same. The method of the present invention provides for a very accurate control of the temperature profile of the balloon material during its making. The attributes of the balloon can be affected by how the balloon is treated during the blowing stage and after the initial blowing, i.e., heat-setting. Using the present method, the balloon will form more uniformly and evenly (e.g., wall thickness and outer diameter of the balloon). The present method significantly increases the dimensional stability of the balloon which provides a balloon that is more predictable in use. The present heat-set process also provides the means for the working length to be located more accurately on dilation catheters and stent delivery systems.

Abstract: A process of bulk filling containers which includes the steps of arranging a number of containers upside down in a tray (24) that has a raised peripheral lip (26). This tray full of containers is then placed in a vacuum chamber (28) which is then evacuated to a predetermined level below atmospheric pressure. Liquid (36) is then introduced into the tray through a reservoir (38) and conduit (40) which penetrates the wall of the vacuum chamber and the vacuum within the chamber is gradually released at a rate that draws the liquid into the containers. At this point in the process unwanted liquid is rinsed away and the tray is removed from the chamber and turned right side up. The final step is to seal the top of the containers with an appropriate cap, barrier, tip or connection. A second embodiment adds a step to the process by positioning the containers upside down in a rack (74) and positioning the rack directly above the tray containing the liquid.

Abstract: An improved method allowing for rapid sensitive and standardized detection of a target nucleic acid from a pathogenic microorganism or virus or normal or abnormal gene in a sample is provided. The method involves hybridizing a target nucleic acid to several non-overlapping oligonucleotide probes that hybridize to adjacent regions in the target nucleic acid, the probes being referred to capture/amplification probes and amplifications probes, respectively, in the presence of paramagnetic beads coated with a ligand binding moiety. Through the binding of a ligand attached to one end of the capture/amplification probe and the specific hybridization of portions of the probes to adjacent sequences in the target nucleic acid, a complex comprising the target nucleic acid, the probes and the paramagnetic beads is formed. The probes may then ligated together to form a contiguous ligated amplification sequence bound to the beads, which complex may be denatured to remove the target nucleic acid and unligated probes.