Abstract: The disclosed computer-implemented method includes analyzing, by a speech detection system, a media file to detect lip movement of a speaker who is visually rendered in media content of the media file. The method additionally includes identifying, by the speech detection system, audio content within the media file, and improving accuracy of a temporal correlation of the speech detection system. The method may involve correlating the lip movement of the speaker with the audio content, and determining, based on the correlation between the lip movement of the speaker and the audio content, that the audio content comprises speech from the speaker. The method may further involve recording, based on the determination that the audio content comprises speech from the speaker, the temporal correlation between the speech and the lip movement of the speaker as metadata of the media file. Various other methods, systems, and computer-readable media are disclosed.

Abstract: The disclosed computer-implemented method may include training a machine-learning algorithm to use look-ahead to improve effectiveness of identifying visemes corresponding to audio signals by, for one or more audio segments in a set of training audio signals, evaluating an audio segment, where the audio segment includes at least a portion of a phoneme, and a subsequent segment that includes contextual audio that comes after the audio segment and potentially contains context about a viseme that maps to the phoneme. The method may also include using the trained machine-learning algorithm to identify one or more probable visemes corresponding to speech in a target audio signal. Additionally, the method may include recording, as metadata of the target audio signal, where a probable viseme occurs within the target audio signal. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A shear-thinning therapeutic composition is provided along with methods of making and using the therapeutic composition.

Abstract: Disclosed is a use of a small-molecule AURKB inhibitor for treatment of non-small cell lung cancer. The small-molecule AURKB inhibitor is directed to a diindolylmethane compound of formula (I) or a stereoisomer, a tautomer, a solvate, a prodrug, a N-oxide or a pharmaceutically acceptable salt thereof.

Abstract: In one aspect, the disclosure relates to modified serine proteinase inhibitors with an enhanced affinity to components of the extracellular matrix, including glycosaminoglycans. The modified serine proteinase inhibitors maintain their original structure and bioactivity while simultaneously exhibiting a higher positive charge density at their glycosaminoglycan-binding surface. Furthermore, the ECM-binding affinity can be tuned by systematically increasing the number of cationic amino acid residues and/or decreasing the number of anionic amino acid residues at the glycosaminoglycan-binding surface. Also disclosed are vectors for producing the modified serine proteinase inhibitors and pharmaceutical conditions incorporating the modified serine proteinase inhibitors.

Abstract: Provided herein are coacervate compositions including cytokines, and methods of making and using the same. The coacervate can be formed by the mixing of an active agent, such as a drug or protein with the polyanion, such as heparin or heparan sulfate, and a custom-made polycation (e.g., PEAD or PELD). The coacervates can be used in the treatment of diseases and disorders where targeted treatment is desired, for example in treatment of cancers.

Abstract: The invention relates to biodegradable, biocompatible materials to promote regeneration of articular surfaces in the temporomandibular joint and, more particularly, to biomaterials and methods for facilitating fibrochondrocyte and chondrocyte growth in in-vitro and in-vivo environments. The materials include magnesium in solid form and polymer. The materials are effective to grow and regenerate fibrochondrocyte and chondrocyte cells, and restore bone cells.

Abstract: A shear-thinning therapeutic composition is provided along with methods of making and using the therapeutic composition.

Abstract: Provided herein are coacervate compositions including cytokines, and methods of making and using the same. The coacervate can be formed by the mixing of an active agent, such as a drug or protein with the polyanion, such as heparin or heparan sulfate, and a custom-made polycation (e.g., PEAD or PELD). The coacervates can be used in the treatment of diseases and disorders where targeted treatment is desired, for example in treatment of cancers.

Abstract: The disclosed computer-implemented method may include obtaining an audio sample from a content source, inputting the obtained audio sample into a trained machine learning model, obtaining the output of the trained machine learning model, wherein the output is a profile of an environment in which the input audio sample was recorded, obtaining an acoustic impulse response corresponding to the profile of the environment in which the input audio sample was recorded, obtaining a second audio sample, processing the obtained acoustic impulse response with the second audio sample, and inserting a result of processing the obtained acoustic impulse response and the second audio sample into an audio track. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.

Abstract: The disclosed computer-implemented method may include accessing an audio track that is associated with a video recording, identifying a section of the accessed audio track having a specific audio characteristic, reducing a volume level of the audio track in the identified section, accessing an audio segment that includes a synthesized voice and inserting the accessed audio segment into the identified section of the audio track, where the inserted segment has a higher volume level than the reduced volume level of the audio track in the identified section. The synthesized voice description can be used to provide additional information to a visually impaired viewer without interrupting the audio track that is associated with the video recording, typically by inserting the synthesized voice description into a segment of the audio track in which there is no dialog. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: An assessment system includes a storage device and a processing circuit. The processing circuit is coupled to the storage device and configured to execute the instructions stored in the storage device. The storage device is configured for storing instructions of extracting at least one feature parameter corresponding to at least one defect detected on an object respectively; determining at least one feature evaluation according to the at least one feature parameter respectively; weighting the at least one feature evaluation to calculate at least one weighted feature evaluation respectively; summing the at least one weighted feature evaluation to calculate at least one total score corresponding to at least one lesson-learnt case; and ranking the at least one total score corresponding to the at least one lesson-learnt case to find out a suspected root cause corresponding to one of the at least one lesson-learnt case with higher priority.

Abstract: Methods, systems, and devices for image processing are described. A device may support various filtering models relating to multidimensional graphics. The device may identify a target texel having a texel coordinate in an image, determine a set of neighboring texels based on the texel coordinate of the target texel, determine color values of multiple neighboring texels of the set of neighboring texels, compare the color values of the multiple neighboring texels of the set of neighboring texels, and process the target texel based on the comparing. In processing the target texel, the device may determine that the multiple neighboring texels may have same color values based on the comparing. The device may bypass a filtering operation on the target texel based on the multiple neighboring texels having the same color values. In an example of bypassing the filtering operation, the device may maintain a color value of the target texel.

Abstract: The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.

Abstract: Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.

Abstract: In various embodiments, a subtitle timing application detects timing errors between subtitles and shot changes. In operation, the subtitle timing application determines that a temporal edge associated with a subtitle does not satisfy a timing guideline based on a shot change. The shot change occurs within a sequence of frames of an audiovisual program. The subtitle timing application then determines a new temporal edge that satisfies the timing guideline relative to the shot change. Subsequently, the subtitle timing application causes a modification to a temporal location of the subtitle within the sequence of frames based on the new temporal edge. Advantageously, the modification to the subtitle improves a quality of a viewing experience for a viewer. Notably, by automatically detecting timing errors, the subtitle timing application facilitates proper and efficient re-scheduling of subtitles that are not optimally timed with shot changes.

Abstract: Methods are disclosed which combine electrospinning and a sacrificial template, such as with additive manufacturing (AM), to produce fibrous microvascular scaffolds which are biodegradable, porous, and easily handled. In one example, a process for fabricating a fibrous network construct is disclosed. The method includes electrospinning a first layer of fibrous material; printing a micropatterned sacrificial template; transferring the micropatterned sacrificial template onto the electrospun fibers; electrospinning a second layer of fibrous biomaterial onto the micropatterned sacrificial template thereby encapsulating the template and generating a construct with two layers; and removing the sacrificial template, producing a fibrous construct with channels or microstructures formed therein. Also disclosed are fibrous constructs and scaffolds produced by the provided methods.

Abstract: Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a disclosed method includes generating PGS fibers by blending PGS prepolymer with a heat resistant synthetic carrier polymer, wherein the blend is electrospun into micro- or nano-fibers, and the PGS prepolymer is cross-linked into PGS with heat without using chemical cross-linkers. In another example, a disclosed method includes electrospinning a PGS and gelatin blend, wherein the PGS and gelatin composition are cross-linked by heat curing without using chemical cross-linkers. In another example, the method includes preparing an electrospinning precursor solution comprising blending PGS prepolymer with poly(lactic-co-glycolic acid) (PLGA) and a chemical cross-linker; electrospinning the prepared blend; and exposing the electrospun blend to an organic solvent to remove the PLGA.