Abstract: A motorized apparatus for use in maintaining a pipe having a sidewall is provided. The motorized apparatus includes a body assembly sized to fit within and to travel along an interior cavity of the pipe. The body assembly includes a first end and a second end and extending along a longitudinal axis. The body assembly also includes a plurality of leg assemblies coupled circumferentially around the body assembly. Each leg assembly includes a telescoping portion, a bias member coupled to the telescoping portion, and a drive mechanism configured to interact with the sidewall as the body assembly travels along the pipe. The body assembly also includes at least one sensor configured to collect data associated with a force between the sidewall and the drive mechanism, and an actuator assembly coupled to each leg assembly and configured to independently actuate each the leg assembly.

Abstract: The present invention relates to compositions and methods for treating cancer, particularly to agents that inhibit the expression and/or activity of the protein second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (SMAC/Diablo). The inhibiting agents include RNA interference molecules silencing the expression of SMAC/Diablo and peptides modulating its interactions within the cell nucleus and mitochondria. The methods and agents of the present invention are useful in treating cancers associated with overexpression of SMAC/Diablo.

Abstract: An ultraviolet sensor that may include a group of serially connected photovoltaic diodes of alternating polarities; a selective blocking portion that is configured to prevent ultraviolet radiation from reaching photovoltaic diodes that belong to the group and are of a first polarity, while allowing the ultraviolet radiation to reach photovoltaic diodes that belong to the group and are of a second polarity; and an interface for providing an output signal of the group, the output signal is indicative of ultraviolet radiation sensed by the photovoltaic diodes that belong to the group and are of the second polarity.

Abstract: Described herein are compositions for use in the brazing of metal substrates. Methods of making and using these compositions are also described herein.

Abstract: The invention comprises providing electric stimuli, which are generated by forming the following ringing circuit: active electrode—inductive storage unit—passive electrode—interelectrode tissues—active electrode, the electric stimuli creating oscillations which are used as a test signal. In one variant of the method, the electrodes are successively applied (in another variant—moved uniformly) across the skin area. Every time the electrodes-to-skin contact is detected, the oscillation parameters are recorded after a delay. Moreover, the values of parameters can be averaged. The invention allows for both combined and disjointed (i.e. separated) electrode placement. An optimal zone for electropulse therapy is identified by a minimal or maximal value of one or more parameters of the aforementioned oscillations and the use of the principle of small asymmetry. The invention further provides for an increase in the accuracy with which zones optimal for electropulse therapy are identified and localized.

Abstract: An electrostatically controlled sensor includes a GaN/AlGaN heterostructure having a 2DEG channel in the GaN layer. Source and drain contacts are electrically coupled to the 2DEG channel through the AlGaN layer. A gate dielectric is formed over the AlGaN layer, and gate electrodes are formed over the gate dielectric, wherein each gate electrode extends substantially entirely between the source and drain contacts, wherein the gate electrodes are separated by one or more gaps (which also extend substantially entirely between the source and drain contacts). Each of the one or more gaps defines a corresponding sensing area between the gate electrodes for receiving an external influence. A bias voltage is applied to the gate electrodes, such that regions of the 2DEG channel below the gate electrodes are completely depleted, and regions of the 2DEG channel below the one or more gaps in the direction from source to drain are partially depleted.

Abstract: An example method includes creating, by a computing system and in response to user input, one or more virtual master devices and a plurality of virtual leaf devices in a virtual network system; selecting, by the computing system, data from one or more of real-time clock offset data, prerecorded clock offset data, or synthetically generated clock offset data; executing, by the computing system, a time synchronization simulation by applying a predefined clock offset generation algorithm to the selected data; and outputting, by the computing system, data indicative of results of the time synchronization simulation.

Abstract: A congealed product grinding and dispensing machine is disclosed. The machine has a housing with an aperture through a wall for dispensing ground soap chips. A product chute located within the housing feeds bar soap toward a rotary cutting tool which is driven by an electric motor within the housing. An actuator in circuit with the motor and a control circuit energizes the motor for a preset time period when the actuator is actuated. Another embodiment disclosed includes an inclined product chute which simplifies soap bar loading. Additional elements of the invention involve including a proximity sensor as the actuator and incorporating a programmable display into the machine housing, the display being in circuit with the actuator.

Abstract: A system for providing bi-directional visualization of authority of users over SACs in an enterprise-wide network, the system including functionality for providing user-wise visualization of the authority of a given user over at least one SAC in respect of which the user has authority, and functionality for providing SAC-wise visualization for a given SAC of the authority of at least one user over the given SAC.

Abstract: A wellness device is provided that utilizes interference frequencies. The wellness device applies frequencies modulated by one another to interfere with one another to create a unique frequency delivery to achieve a desired result.

Abstract: A method for indexing objects in a computerized system having an index, comprising identifying in the computerized system an at least one indexed object that meets an at least one criterion related to contents of the at least one indexed object, detecting an at least one non-indexed object having a property similar to an at least one property of the at least one indexed object that was identified, and indexing the at least one non-indexed object in the index, wherein the method is performed by the computerized system, and an apparatus for performing the same.

Abstract: Provided relates to the field of cytometry, specifically to flow cytometric methods and kits for improved diagnosis, prognosis and monitoring of tumors and other lesions involving immune cell infiltration. Further provided are embodiments of the subject matter which relate to compositions and methods providing high resolution quantitative means for immunophenotyping and immune modeling, and for identification of disease prognostic and therapy predictive biomarkers.

Abstract: Disclosed herein are methods of preparing composites from solid elastomer(s) and wet filler(s), as well as products, including composites, vulcanizates, and articles therefrom. The wet filler can have a liquid content of at least 15%. A resulting composite comprises the filler dispersed in the elastomer at a loading of at least 20 phr with a filler yield loss of no more than 10%, wherein the composite has a liquid content of no more than 10% by weight based on total weight of said composite.

Abstract: A tool holder includes a tool shank and a tool head connected to the tool shank. The tool head has a rear surface. An insert seat or a blade pocket is partially formed on both the tool head and the tool shank, and extends rearwardly of the tool head's rear surface. Adjacent to at least a portion of a shank side surface there is a reinforcement portion connecting the shank side surface and the tool head.

Abstract: An optical device includes a waveguide including a first medium, which is transparent and has a first index of refraction at a target wavelength and which has mutually-parallel first and second surfaces arranged so that light at the target wavelength propagates within the waveguide by internal reflection between the first and second surfaces. A coupling layer is disposed over the first surface of the waveguide and includes a second medium having a second index of refraction at the target wavelength, which is greater than the first index of refraction, and is patterned to define a periodic array of cylinders, which have respective cylinder axes perpendicular to the first surface and have respective heights and diameters that are smaller than the target wavelength, and which are spaced apart such that a distance between each of the cylinders and a neighboring cylinder in the array is less than the target wavelength.

Abstract: A system for monitoring actual access to data elements in an enterprise computer network and providing associated data, the system including an at least near real time data element audit subsystem providing audit output data including at least one of a time stamp, identification of an accessor, user depository stored data regarding the accessor, accessed data element data, affected data element data, type of access operation, source IP address of access and access outcome data, in at least near real time, relating to actual access to data elements in the enterprise computer network, and an additional data providing subsystem receiving in at least near real time at least a part of the audit output data and utilizing the at least part of the audit output data for providing additional data which is not part of the audit output data.

Abstract: An optical transmission device includes a waveguide including a transparent medium having mutually-parallel first and second surfaces arranged so that light propagates within the waveguide by internal reflection between the first and second surfaces. At least one light source is configured to inject coherent light into the waveguide. A first array of diffractive structures is applied to the waveguide and configured to couple respective beams of the coherent light out through the first surface of the waveguide. The device includes a second array of tunable optical phase modulators, which are overlaid on respective ones of the diffractive structures in the first array and are configured to apply different respective phase shifts to the respective beams, thereby modulating a far-field light pattern formed by interference between the beams.

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

Abstract: Disclosed herein are system, method, and computer program product embodiments for issuing assets and/or asset tokens using zero-knowledge proofs (“ZKPs”). An issuance system may receive a command to issue an asset. The issuance system may determine that issuing the assets would not violate administrator-defined or network-defined rules that may govern the types of assets and/or the quantity of assets that the issuance system may issue. The issuance system may then issue the assets and generate a ZKP corresponding to the issuance and indicating adherence to the rules while concealing information related to the asset token, such as the types of assets and/or quantity of assets. The issuance system may publish the ZKP to a blockchain so that verifier nodes may confirm that the issuance system adhered to the rules while still preventing access to the underlying issuance information.

Abstract: Techniques include receiving a backup request for backing up data on a production VVOL, to which is assigned physical space from storage devices in a first storage tier. When the production VVOL and a snapshot VVOL exist, and a write request is received to a data block on the production VVOL that is shared between the production VVOL and the snapshot VVOL, then the techniques include capturing a snapshot of the production VVOL by redirecting the write request to newly allocated space on the production VVOL, writing new data to the newly allocated space, and storing metadata referring to the original block(s) on the production VVOL. Based on an IO workload threshold, the techniques include copying, in a background process, the original version of the modified block from the production VVOL to a snapshot VVOL, to which is assigned physical storage space from storage devices in a second storage tier.